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World Journal of Gastroenterology 2004年第15期10卷 2278-2280页

作者： Engin Altintas Necdet Akkus Ramazan Gen M.Rami Helvaci orhan sezgin Dilek Oguz Division of Gastroenterology Mersin UniversitySchool of MedicineMersinTurkey Cardioiogy Department Mersin UniversitySchool of MedicineMersinTurkey Internal Medicine Department Mersin UniversitySchool of MedicineMersinTurkey Gastroenterology

AIM:Portopulmonary hypertension is a serious complication of chronic liver *** aim was to search into the effect of terlipressin on systolic pulmonary artery pressure among cirrhotic patients. METHODS:Twelve patients(6 males and 6 females)with liver cirrhosis were recruited in the *** blood gas samples were obtained in sitting position at *** enhanced echocardiography and measurements of systolic pulmonary artery pressure were performed before and after the intravenous injection of 2 mg terlipressin. RESULTS:Of 12 patients studied,the contrast enhanced echocardiography was positive in 5,and the positive findings in contrast enhanced echocardiography were reversed to normal in two after terlipressin *** mean systolic pulmonary artery pressure was 25.5±3.6 mmHg before terlipressin injection,and was 22.5+2.5 mmHg after terlipressin(P=0.003).The systolic pulmonary artery pressure was above 25 mmHg in seven of these 12 patients. After the terlipressin injection,systolic pulmonary artery pressure was<25 mmHg in four of these cases(58.3% vs 25%,P=0.04). CONCLUSION:Terlipressin can decrease the systolic pulmonary artery pressure in patients with liver cirrhosis.

关键词： Blood Pressure Adult Antihypertensive Agents Echocardiography Female Humans Liver Cirrhosis Lypressin derivatives Male Middle Aged Pulmonary Artery

Erythrocyte Membrane Protein Band 3 Predicts Interferon Ribavirin-Induced Anemia

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Open Journal of Regenerative Medicine 2019年第2期8卷 5-16页

作者： Engin Altintas Serap Yalin orhan sezgin Enver Ucbilek Anil Tombak Arzu Kanik Department of Gastroenterology Faculty of Medicine University of Mersin Mersin Turkey Faculty of Pharmacy University of Mersin Mersin Turkey Department of Biostatistics Faculty of Medicine University of Mersin Mersin Turkey

Aim & Background: It was proposed that the differences in erythrocyte membrane protein contents—especially band 4—take a role in the serious anemia related to interferon plus ribavirin (I/R). The aim of this study is to evaluate whether the erythrocyte membrane protein contents predict anemia related to I/R or not. Methods: 180 mcg interferon α 2a once a week and weight adjusted ribavirin daily were given for 48 weeks to fifty patients with chronic hepatitis C. It was diagnosed as anemia when haemoglobin concentration was Results: Anemia developed in 17 patients (34%). The levels of erythrocyte membrane proteins were as;spectrin: 20.468 ± 2.5902, ankyrin: 4.576 ± 1.2706, B3: 19.240 ± 2.8358, B4.1: 5.628 ± 1.8832, and B4.2: 5.848 ± 1.8030. When the relation between the development of anemia and erythrocyte membrane proteins was investigated, a relation was only found at B3 which was not statistically significant (p = 0.058). When ROC analysis was performed, 95% CI p = 0.035 for B3 (0.517 - 0.792) was found. In patients whose B3 level was below 17.7%, the sensitivity of anemia development risk was calculated as 64.7% and the specificity thereof was calculated as 66.7%. Erythrocyte membrane protein contents by gender were only different at B3 (p = 0.042). Anemia developed in 17 patients (34%). 14 of these patients were of female and 3 were of male gender;the gender played a significant role in terms of anemia (p = 0.003). Conclusions: Erythrocyte membrane protein B3 is not only useful in predicting the patient under the risk of developing anemia, but also it may be useful in preventing it and it may explain why women inclined to anemia.

关键词： Anemia Erythrocyte Membrane Protein Interferon Ribavirin

Polymorphisms in methylenetetrahydrofolate reductase gene: Their impact on liver steatosis and fibrosis of chronic hepatitis c patients

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Open Journal of Gastroenterology 2014年第2期4卷 73-80页

作者： Engin Altintas Zuhal Mert Altintas orhan sezgin Enver Ucbilek Erdinc Nayir Mehmet Emin Erdal Ayse Polat Gulhan Orekeci Department of Biostatistics Faculty of Medicine University of Mersin Mersin Turkey Department of Medical Biology and Genetic Faculty of Medicine University of Mersin Mersin Turkey Department of Pathology Faculty of Medicine University of Mersin Mersin Turkey Gastroenterology Department Faculty of Medicine University of Mersin Mersin Turkey

Aim & Background: The mechanism of steatosis in Hepatitis C virus infection is multifactorial;therefore, it is complex and unclear. The aim of this study was to investigate the effects of methylentetrahydrofolate reductase (MTHFR) gene polymorphisms on the course of chronic hepatitis C virus infection and the development of steatosis due to hepatitis C virus. Methods: This study included 109 patients with chronic hepatitis C virus infection. Necroinflammatory activity, degrees of fibrosis and steatosis and MTHFR gene polymorphisms were investigated. Polymerase chain reaction-restriction fragment length polymorphism was used to determine MTHFR C677T and A1298C polymorphisms. Results: Fibrosis was correlated with age (r = 0.336, p = 0.002), platelet (r = ?0.448, p < 0.0001), ALT (r = 0.241, p = 0.026), AST (r = 0.361) and GGT (r = 0.224, p = 0.039). Steatosis was only correlated with fibrosis. MTHFR C677T and A1298C polymorphisms did not have a significant effect on the degree of steatosis (p = 0.857, p = 0.202 respectively). There was a relation between MTHFR C677T and the degree of fibrosis but not A1298C (p = 0.014, p = 0.187 respectively). Conclusion: We found that MTHFR C677T polymorphism contributed to the development of fibrosis in patients with chronic hepatitis C virus infection.

关键词： Fibrosis Hepatitis C Gene Polymorphism Methylenetetrahydrofolate Reductase Steatosis

String cloud and domain walls with quark matter for a higher dimensional FRW universe in self creation cosmology

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Chinese Physics C 2016年第4期40卷 49-55页

作者： Halife Caglar sezgin Aygun Institute for Natural and Applied Sciences Canakkale Onsekiz Mart University 17020 Canakkale Turkey Canakkale Onsekiz Mart University Arts and Sciences Faculty Department of Physics Terzioglu Campus 17020 Turkey

In this study, we research a higher dimensional flat Friedmann-Robertson-Walker（FRW） universe in Barber＇s second theory when strange quark matter（SQM） and normal matter（NM） are attached to the string cloud and domain walls. We obtain zero string tension density for this model. We obtain dust quark matter *** result agrees with Kiran and Reddy, Krori et al, Sahoo and Mishra and Reddy. In our solutions the quark matter transforms to other particles over time. We also obtain two different solutions for domain walls with quark and normal matters by using a deceleration parameter. Also, the features of the obtained solutions are discussed and some physical and kinematical quantities are generalized and discussed. Our results are consistent with Y？lmaz,Adcox et al and Back et al in four and five dimensions.

关键词： quark universe strange creation cloud scalar walls string quantities momentum

Medical Radiation Exposure and Human Carcinogenesis-Genetic and Epigenetic Mechanisms

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Biomedical and Environmental Sciences 2014年第9期27卷 718-728页

作者： Yildiz Dincer Zeynep sezgin Department of Medical Biochemistry Istanbul University Cerrahpasa Medical Faculty Department of Medical Biochemistry Yeni Yuzy?l University Medical Faculty

Ionizing radiation （IR） is a potential carcinogen. Evidence for the carcinogenic effect of IR radiation has been shown after long-term animal investigations and observations on survivors of the atom bombs in Hiroshima and Nagasaki. However, IR has been widely used in a controlled manner in the medical imaging for diagnosis and monitoring of various diseases and also in cancer therapy. The collective radiation dose from medical imagings has increased six times in the last two decades, and grow continuously day to day. A large number of evidence has revealed the increased cancer risk in the people who had frequently exposed to x-rays, especially in childhood. It has also been shown that secondary malignancy may develop within the five years in cancer survivors who have received radiotherapv, because of IR-mediated damage to healthy cells. In this article, we review the current knowledge about the role of medical x-ray exposure in cancer development in humans, and recently recognized epigenetic mechanisms in IR-induced carcinogenesis.

关键词： DNAmethylation Medical Radiation Exposure and Human Carcinogenesis-Genetic and Epigenetic Mechanisms

AID4I:An Intrusion Detection Framework for Industrial Internet of Things Using Automated Machine Learning

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Computers, Materials & Continua 2023年第8期76卷 2121-2143页

作者： Anil sezgin Aytug Boyacı ATASAREN National Defence UniversityIstanbul34334Turkey Software in Motion Department Siemens AdvantaSiemens Corporate TechnologyIstanbul34870Turkey Department of Computer Engineering National Defence University Air Force AcademyIstanbul34149Turkey

By identifying and responding to any malicious behavior that could endanger the system,the Intrusion Detection System(IDS)is crucial for preserving the security of the Industrial Internet of Things(IIoT)*** benefit of anomaly-based IDS is that they are able to recognize zeroday attacks due to the fact that they do not rely on a signature database to identify abnormal *** order to improve control over datasets and the process,this study proposes using an automated machine learning(AutoML)technique to automate the machine learning processes for *** groundbreaking architecture,known as AID4I,makes use of automatic machine learning methods for intrusion *** automation of preprocessing,feature selection,model selection,and hyperparameter tuning,the objective is to identify an appropriate machine learning model for intrusion *** studies demonstrate that the AID4I framework successfully proposes a *** integrity,security,and confidentiality of data transmitted across the IIoT network can be ensured by automating machine learning processes in the IDS to enhance its capacity to identify and stop threatening *** a comprehensive solution that takes advantage of the latest advances in automated machine learning methods to improve network security,AID4I is a powerful and effective instrument for intrusion *** preprocessing module,three distinct imputation methods are utilized to handle missing data,ensuring the robustness of the intrusion detection system in the presence of incomplete *** selection module adopts a hybrid approach that combines Shapley values and genetic *** Parameter Optimization module encompasses a diverse set of 14 classification methods,allowing for thorough exploration and optimization of the parameters associated with each *** carefully tuning these parameters,the framework enhances its adaptability and accuracy in identifying potential

关键词： Automated machine learning intrusion detection system industrial internet of things parameter optimization

A Model Predictive Control for Microgrids Considering Battery Aging

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Journal of Modern Power Systems and Clean Energy 2020年第2期8卷 296-304页

作者： Ugur Can Yilmaz Mustafa Erdem sezgin Murat Gol Department of Electrical and Electronics Engineering Middle East Technical UniversityAnkaraTurkey

The increasing number of distributed energy resources(DERs),advancing communication and computation technologies,and reliability concerns of the customers have caused an intense interest in the concept of *** DERs are the biggest motivation of the microgrids due to their intermittent generation characteristics,they constitute a risk for system *** storage systems(BSSs)stand as one of the most effective solutions for this reliability ***,the inappropriate use of BSS creates other operational problems in power *** order to deal with these concerns explicitly in microgrids,an optimized microgrid central controller(MGCC)is the key factor,which controls the realtime operation of a *** work proposes a model predictive control(MPC)based MGCC that will provide optimal control of the microgrid,considering economic and operational *** proposed system will minimize the energy cost of the microgrid by utilizing mixed-integer linear programming(MILP)assuming the presence of DERs and BSS as well as the bi-directional grid ***,the aging effect of BSS will be considered in the proposed optimization problem which will provide an up-to-date system *** proposed method is evaluated using real load and photovoltaic(PV)generation data.

关键词： Microgrid optimization battery storage model predictive control mixed-integer linear programming

跨学科讲座中的元话语特性:深入解读EAP笔记的实质内涵

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Chinese Journal of Applied Linguistics 2024年第2期47卷 332-363,366页

作者：哈蒂斯·塞兹金埃切·泽希尔·托普卡亚塞尔柱克大学外国语学院土耳其恰纳卡莱马特大学英语教学系土耳其

学术讲座作为高等院校学生获取知识的主要途径之一,对学生而言具有不可或缺的重要性。为了确保学生能够充分吸收讲座内容,做笔记成为了一项至关重要的技能。事实上,记笔记的能力以及笔记的质量与学生的学习成绩之间存在着密切的关联。因... 详细信息

学术讲座作为高等院校学生获取知识的主要途径之一,对学生而言具有不可或缺的重要性。为了确保学生能够充分吸收讲座内容,做笔记成为了一项至关重要的技能。事实上,记笔记的能力以及笔记的质量与学生的学习成绩之间存在着密切的关联。因此,在EAP课程中,记笔记教学被视为一个不可或缺的组成部分,旨在培养学生良好的笔记习惯,从而助力他们取得更好的学术成绩。本研究旨在构建一个基于体裁的教学框架(Genre-Based Instruction,GBI),用于指导笔记教学的实践。为实现这一目标,本研究对八个跨学科讲座进行了深入分析。首先,我们依据Bouziri(2020)所建立的框架,对修辞功能进行了明确界定。随后,我们采纳了?del(2010)与Hyland(2005)共同提出的元话语框架,并据此确定了体现组织结构的元话语要素。经过深入研究,我们发现了修辞功能与元话语要素之间存在紧密的关联。也就是说,某些元话语项目可以作为使用某些修辞功能的信号。因此,记笔记的GBI框架是根据修辞功能与元话语要素之间的关联而构建的。

关键词：体裁跨学科学术讲座元话语笔记记录

Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis

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International Journal of Oral Science 2013年第2期5卷 92-97页

作者： Abdullah Seckin Ertugrul Ugur Arslan Recep Dursun Sema sezgin Hakki Department of Periodontology Faculty of DentistryYuzuncu Yil University Department of Microbiology Selcuklu Medical FacultySelcuk University Department of Dermatology Baskent Research Hospital Department of Periodontology Faculty of DentistrySelcuk University

Oral lichen planus （OLP） is a chronic inflammatory disease that is frequently detected in oral tissues. The aim of our study was to identify the prevalence of the detection of periodontopathogenic microorganisms （Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola in OLP patients and to compare with this prevalence of periodontopathogenic microorganisms in healthy non-OLP patients. Our study included 27 （18 chronic periodontitis （OLPP） and 9 gingivitis （OLPG）） patients diagnosed with OLP along with 26 （13 chronic periodontitis （HP） and 13 gingivitis （HG）） healthy non-OLP patients. The multiplex polymerase chain reaction （PCR）with subsequent reverse hybridization method （micro-IDent） was used for identifying periodontopathogenic microorganisms present in subgingival plaque samples. The percentages of detection for A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola in subgingival plaque samples taken from OLP patients （OLPG and OLPP） were 18.5%, 85.1%, 81.4%, 88.8% and 74%, respectively. Meanwhile, in the non-OLP patients （HG and HP）, these values were 7.6%, 50%, 46.1%, 73% and 57.7%, respectively. Thus, comparing the non-OLP groups with the OLP groups, the periodontopathogens＇ percentages of detection in the OLP groups were higher than those in the non-OLP groups. According to our study results, OLP patients have higher levels of infection with A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola than non-OLP patients. We argue that the high percentages in patients with OLP may help identify the importance of periodontopathoRenic microorganisms in the progress of periodontal diseases of OLP.

关键词： Aggregatibacter actinomycetemcomitans oral lichen planus Porphyromonas gingivalis Prevotel/a intermedia Tannerel/a forsythia Treponema denticola

Giant vesical diverticulum:A rare cause of defecation disturbance

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World Journal of Gastroenterology 2009年第31期15卷 3957-3959页

作者： Sami Akbulut Bahri Cakabay Arsenal sezgin Kenan Isen Ayhan Senol Department of Surgery Diyarbakir Education and Research Hospital Department of Pathology Diyarbakir Education and Research Hospital Department of Urology Diyarbakir Education and Research Hospital Department of Radiology Diyarbakir Education and Research Hospital

Vesical diverticula frequently result from bladder outlet obstructions. However, giant vesical diverticula which cause acute abdomen or intestinal obstruction are very rare. Our review of the English medical literature found 3 cases of bladder diverticula which caused gastrointestinal symptoms. Here, we present a 57-yearold man with a giant diverticulum of the urinary bladder who complained of abdominal pain, nausea and vomiting, constipation, no passage of gas or feces, and abdominal distension for 3 d. A 20 cm x 15 cm diverticulum was observed upon laparotomy. The colonic obstruction was secondary to external compression of the rectum against the sacrum by a distended vesical diverticulum. We performed a diverticulectomy and primary closure. Twelve months postoperatively, the patient had no difficulty with voiding or defecation.

关键词： Colonic obstruction Defecation Diverticulectomy Urinary bladder Vesical diverticulum