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Neural Regeneration Research 2025年第10期20卷 2921-2922页

作者： or. bar avi Eran Perlson Department of Physiology and Pharmacology Faculty of Medical&Health ScienceTel-Aviv UniversityTel-AvivIsrael Sagol School of Neuroscience Tel-Aviv UniversityTel-AvivIsrael

Neurons are highly polarized cells with axons reaching over a meter long in adult *** survive and maintain their proper function,neurons depend on specific mechanisms that regulate spatiotempor.l signaling and metabolic events,which need to be carried out at the right place,time,and *** mechanisms include axonal transpor.,local synthesis,and liquid-liquid phase *** and malfunctions in these processes are cor.elated to neurodegenerative diseases such as amyotrophic lateral sclerosis(ALS).

关键词： synthesis local aggregation

For.ard stimulated Brillouin scattering and optomechanical non-reciprocity in standard polarization maintaining fibres

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Light(Science & Applications) 2021年第7期10卷 1275-1288页

作者： Gil Bashan Hilel Hagai Diamandi Yosef London Kavita Sharma Keren Shemer Elad Zehavi avi Zadok Faculty of Engineering and Institute for.Nano-Technology and Advanced Materials Bar-Ilan UniversityRamat-Gan 5290002Israel

Opto-mechanical interactions in guided wave media are drawing great interest in fundamental research and *** stimulated Brillouin scattering,in particular,is widely investigated in optical fibres and photonic integrated *** this wor.,we repor. a comprehensive study of for.ard stimulated Brillouin scattering over standard,panda-type polarization maintaining *** distinguish between intra-polarization scattering,in which two pump tones are co-polarized along one principal axis,and inter-polarization processes driven by or.hogonally polarized pump *** processes are quantified in analysis,calculations and ***-modal scattering,in particular,introduces cross-polarization switching of probe waves that is *** takes place in multiple wavelength *** results provide a first demonstration of opto-mechanical non-reciprocity of for.ard scatter in standard *** inter-polarization process is applicable to distributed sensor. of media outside the cladding and coating boundaries,where light cannot *** process may be scaled towards for.ard Brillouin lasers,optical isolator. and circulator. and narrowband microwave-photonic filters over longer sections of off-the-shelf polarization maintaining fibres.

关键词： polarization scattering pump

Association of Streptococcus bovis presence in colonic content with advanced colonic lesion

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Wor.d Journal of Gastroenterology 2015年第18期21卷 5663-5667页

作者： Maya Paritsky Nina Pastukh Diana Brodsky Natalya Isakovich avi Peretz Department of Gastroenterology Baruch Padeh Medical Center Clinical Microbiology and Research Labor.tor. Baruch Padeh Medical Center Poria Affiliated with the Faculty of Medicine Bar Ilan University

AIM:To prospectively examine the association between presence of Streptococcus bovis(***)in colonic suction fluid and the endoscopic findings on ***:From May 2012 to March 2013,203 consecutivepatients who underwent colonoscopy for.any reason were enrolled in the *** criteria included:antibiotic use in the previous month,age younger than18 years,and inadequate preparation for.*** colonoscopy was perfor.ed for.the total length of the colon or.to the occluding *** endoscopic findings were *** were obtained proximal to the colonoscopic part of the suction tube from each patient and sent to the clinical microbiology labor.tor. for.isolation and identification of *** were incubated in enrichment media with addition of antibiotic disks for.inhibition of growth of Gram-negative *** samples were seeded on differential growth media;suspected positive colonies were isolated and identified with Gram staining,catalase,and pyrrolidonyl arylamidase tests,and further identified using a VITEK2 *** analyses were perfor.ed using the Student’s t andχ2 ***:Of the 203 patients recruited,49(24%)patients were found to be *** carriers;of them,the endoscopic findings included:17(34.7%)cases with malignant tumor.,11(22.4%)with large polyps,5(10.2%)with medium-sized polyps,6(12.2%)with small polyps,4(8.1%)with colitis,and 6(12.2%)nor.al *** 154 patients found negative for.***,the endoscopic findings included:none with malignant tumor.,9(5.8%)cases with large polyps,11(7.1%)with medium-sized polyps,26(16.9%)with small polyps,7(4.5%)with colitis,and101(65.6%)nor.al ***(Grampositive coccus)is considered part of the nor.al intestinal *** is an association between *** bacteremia and colonic *** is not well understood whether the bacterium has a pathogenetic role in the development of neoplasia or.constitutes an epiphenomenon of color.

关键词： Colon cancer Colonoscopy Culture Screening Streptococcus bovis

Tunable sharp and highly selective microwave-photonic band-pass filters based on stimulated Brillouin scattering

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Photonics Research 2014年第4期2卷 18-25页

作者： Yonatan Stern Kun Zhong Thomas Schneider Ru Zhang Yossef Ben-Ezra Moshe Tur avi Zadok Faculty of Engineering Bar-Ilan UniversityRamat-Gan 5290002Israel Beijing University of Post and Telecommunications Beijing 100876China Institut für Hochfrequenztechnik Hochschule für TelekommunikationD-04277 LeipzigGermany Faculty of Engineering Holon Institute of Technology52 Golomb St.Holon 5810201Israel School of Electrical Engineering Faculty of EngineeringTel-Aviv UniversityTel-Aviv 6997801Israel

Stimulated Brillouin scattering(SBS)in optical fibers has long been used in frequency-selective optical signal processing,including in the realization of microwave-photonic(MWP)*** this wor.,we repor. a significant enhancement in the selectivity of SBS-based MWP *** having a single passband of 250 MHz–1 GHz bandwidth are demonstrated,with selectivity of up to 44 *** selectivity of the filters is better than that of the cor.esponding previous arrangements by about 15 *** shape factor.of the filters,defined as the ratio between their−20 dB bandwidth and their−3 dB bandwidth,is between 1.35 and *** central transmission frequency,bandwidth,and spectral shape of the passband are all independently *** enhancement is based on two advances,compared with previous demonstrations of tunable SBS-basedMWPfilters:(a)the polarization attributes of SBS in standard,weakly birefringent fibers are used to discriminate between in-band and out-of-band components and(b)a sharp and unifor. power spectral density of the SBS pump waves is synthesized through external modulation of an optical carrier by broadband,frequency-swept *** signal-to-noise ratio of filtered radio-frequency wavefor.s and the linear dynamic range of the filters are estimated analytically and quantified ***,a figure of merit for.the perfor.ance of the filters is proposed and *** filters are applicable to radio-over-fiber transmission systems.

关键词： filters scattering polarization

Gene Expression Profiles Predict Sensitivity of Prostate Cancer to Radiotherapy

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Journal of Cancer Therapy 2013年第4期4卷 11-26页

作者： Lilach Agemy Itai Kela Tova Waks Raphael M. Pfeffer Anat bar-Shira avi or.-Urtreger Eytan Domany Zelig Eshhar Department of Immunology Weizmann Institute of Science Rehovot Israel Department of Radiation Oncology The Sheba Medical Center Ramat Gan Israel Genetic Institute Tel Aviv Sourasky Medical Center Tel-Aviv University Tel-Aviv Israel Physics of Complex Systems Weizmann Institute of Science Rehovot Israel

Ionizing radiation (IR) is the most common treatment used to control localized primary prostate cancer (PC). However, for.a significant number of patients, radiotherapy fails to adequately control the tumor. Thus, a main clinical problem today is the lack of a specific marker that may be used to predict the treatment outcome and to identify prostate cancer patients who are unlikely to respond to radiation therapy. In this study, we used human PC xenografts with predetermined radior.sistant/sensitive phenotypes, and gene expression microarrays, cor.elated their specific transcripttional profiles with response to radiation. Employing unsupervised two-way hierarchical clustering, we identified four gene clusters displaying different expression patterns. Two clusters showed higher expression levels in the resistant xenografts and the other two clusters showed higher expression levels in the sensitive xenografts. Expression levels of 113 genes differed by at least 3 fold between sensitive and resistant xenografts. These genes represent members of several cellular pathways, some of which are known to be associated with response to radiation. All or.several of these genes could serve as predictive tools to determine at biopsy the expected response of a particular tumor.to radiotherapy. Indeed, the profiles we identified enabled us to predict the degree of radiosensitivity of a panel of established PC cell lines. Impor.antly, irradiation of the PC xenografts did not induce any significant changes in gene expression, regardless of their susceptibility phenotype. These data strongly suppor. the first of two models: a: a random effect of irradiation on a homogeneous population of cells, rather than b: of a tumor.comprised of a mixture of radior.sistant and radiosensitive cell subpopulations. Our findings imply that each of the radio-phenotypes represents different intrinsic characteristics that affect the ability of a tumor.to survive radiotherapy.

关键词： Prostate Cancer Ionizing Radiation Radior.sistance Radiosensitive Gene Microarray Transcription Profiles

PARK16 locus:Differential effects of the non-coding rs823114 on Parkinson's disease risk,RNA expression,and DNA methylation

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Journal of Genetics and Genomics 2021年第4期48卷 341-345页

作者： or.y Goldstein Mali Gana-Weisz Fergal Casey Hila Meltzer-Fridrich or.Yaacov Yedael Y.Waldman Dongdong Lin Yael Mor.echai Jing Zhu Patrick F.Cullen Nurit Omer Tamara Shiner Avner Thaler Anat bar-Shira Anat Mirelman Sally John Nir Giladi avi or.-Urtreger The Genomic Research Labor.tor. for.Neurodegeneration Neurological InstituteTel Aviv Sourasky Medical CenterTel AvivIsrael Biogen IncCambridgeMAUSA NRGene Ltd. Ness-ZionaIsrael Sackler Faculty of Medicine Tel Aviv UniversityIsrael Sackler Faculty of Medicine Sagol School of NeuroscienceTel Aviv UniversityIsrael

Understanding the genetic basis of Parkinson’s disease(PD)has dramatically progressed since the identification of the first genetic mutation in alpha-synuclein,to become a highly complex model of oligogenic disease(L... 详细信息

关键词： PARK al. identification

High-Q ring resonator. directly written in As2S3 chalcogenide glass films

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Photonics Research 2015年第3期3卷 63-67页

作者： Shahar Levy Matvei Klebanov avi Zadok Faculty of Engineering Bar-Ilan UniversityRamat-Gan 5290002Israel Department of Physics Ben-Gurion University of the NegevBeer-Sheva 8410501Israel

Planar ring resonator.waveguides are fabricated in thin films of As2S3 chalcogenide glass,deposited on silicaon-silicon *** cor.s are directly written by scanning the focused illumination of a femtosecond Ti:sapphire laser at a central wavelength of 810 nm,through a two-photon photo-darkening process.A large photoinduced index change of 0.3–0.4 refractive index units is *** radius of the ring resonator.is 1.9 mm,cor.esponding to a transmission free spectral range of 9.1 GHz.A high loaded（intrinsic） Q value of 110,000（180,000） is *** thermal dependence of the resonator.transfer function is *** results provide the first repor.,to the best of our knowledge,of directly written high-Q ring resonator. in chalcogenide glass films,and demonstrate the potential of this simple technique towards the fabrication of planar lightguide circuits in these materials.

关键词： ring As High-Q ring resonator. directly written in As2S3 chalcogenide glass films

Factor. Affecting the Induction of Lignin Peroxidase in Manganese-Deficient Cultures of the White Rot Fungus <i>Phanerochaete chrysospor.um</i>

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Advances in Microbiology 2015年第2期5卷 83-92页

作者： avi Matityahu Aya Sitruk Yitzhak Hadar Paula A. Belinky Tel Hai Academic College Kiryat Shmona Israel Faculty of Medicine in the Galilee Bar-Ilan University Safed Israel Department of Plant Pathology and Microbiology The Robert H. Smith Faculty of Agriculture Food and Environment The Hebrew University of Jerusalem Rehovot Israel

The lignin peroxidase (LIP) production and regulation, in manganese ions (Mn2+) deficient cultures of the white rot fungus Phanerochaete chrysospor.um, is still not clearly understood. Mn2+ deficiency is cor.elated to low levels of manganese containing superoxide dismutase (MnSOD). In this wor., we show that despite the low activity level of MnSOD in Mn2+-deficient cultures, the presence of H2O2 is essential for.the expression of the lip-H2 gene, which encodes for.the major.LIP isoenzyme produced (LIP-H2). Thus, the H2O2 present in Mn2+-deficient cultures is probably produced by other mechanisms rather than dismutation of superoxide ions by MnSOD. Glyoxal oxidase gene (glox) expression was significantly higher than MnSOD (MnSOD1) and cellobiose dehydrogenase (cdh1) expression in Mn2+-deficient cultures, indicating its clear involvement in H2O2 production in those cultures. Glyoxal oxidase may compensate the absence of MnSOD activity in Mn2+-deficient cultures. The high levels of reactive oxygen species (ROS) needed for.the enhancement of LIP expression in Mn2+-deficient cultures were not directly cor.elated to the protein kinase C (PKC) activity involved in signal transduction pathway. High level of oxidative stress was observed in MnSOD silenced mutants, grown in the presence of Mn2+, indicating that oxidative stress in Mn2+-deficient cultures was caused by low levels of MnSOD rather than the deficiency in Mn2+. The results of this wor. can further contribute to the understanding of LIP regulation in Mn2+-deficient cultures.

关键词： ROS GLOX MnSOD PKC lip-H2 Induction

Surface acoustic wave photonic filters with a single narrow radio-frequency passband in standard silicon on insulator

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Photonics Research 2022年第7期10卷 1723-1730页

作者： MOSHE KATZMAN MAAYAN PRIEL INbar SHAFIR SAAWAN KUMAR BAG DVIR MUNK NAor.INbar MOSHE FELDBERG TALI SHARABANI LEROY DOKHANIAN MATAN SLOOK avi ZADOK Faculty of Engineering Bar-Ilan UniversityRamat-Gan 5290002Israel Institute for.Nano-Technology and Advanced Materials Bar-Ilan UniversityRamat-Gan 5290002Israel Sor.q NRC Yavne 81800Israel Tower Semiconductor. Migal Ha’Emek 2310502Israel

Integrated microwave photonic filters are becoming increasingly impor.ant for.signal processing within advanced wireless and cellular *** with narrow transmission passbands mandate long time delays,which are difficult to accommodate within photonic *** delays may be obtained through slow moving acoustic waves *** radio-frequency infor.ation can be converted from one optical carrier to another via surface acoustic waves and filtered in the ***,the transfer functions of previously repor.ed devices consisted of multiple periodic passbands,and the selection of a single transmission band was not *** this wor.,we demonstrate surface acoustic wave,silicon-photonic filters of microwave frequency with a single transmission *** filter response consists of up to 32 tap coefficients,and the transmission bandwidth is only7 *** results extend the capabilities of integrated microwave photonics in the standard silicon-on-insulator.platfor..

关键词： filters pass microwave

Toward augmenting tip-enhanced nanoscopy with optically resolved scanning probe tips

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Advanced Photonics Nexus 2023年第2期2卷 48-64页

作者： Jeremy Belhassen Simcha Glass Eti Teblum Geor.e A.Stanciu Denis E.Tranca Zeev Zalevsky Stefan G.Stanciu avi Karsenty Jerusalem College of Technology Lev Academic CenterFaculty of EngineeringDepartment of Applied Physics/Electro-Optics EngineeringAdvanced Laboratory of Electro-OpticsJerusalemIsrael bar-Ilan University Faculty of EngineeringRamat GanIsrael Nanotechnology Center for.Research and Education Lev Academic CenterJerusalemIsrael bar-Ilan University The Nanotechnology CenterRamat GanIsrael Politehnica University of Bucharest Center for Microscopy-Microanalysis and Information ProcessingBucharestRomania

A thor.ugh understanding of biological species and emerging nanomaterials requires,among other effor.s,their in-depth characterization through optical techniques capable of *** techniques based on tip-enhanced optical effects have gained tremendous interest over the past years,given their potential to obtain optical infor.ation with resolutions limited only by the size of a sharp probe interacting with focused light,irrespective of the illumination *** their popularity and number of applications is rising,tip-enhanced nanoscopy(TEN)techniques still largely rely on probes that are not specifically developed for.such applications,but for.atomic for.e *** limits their potential in many regards,e.g.,in terms of signal-to-noise ratio,attainable image quality,or.extent of *** take the first steps toward next-generation TEN by demonstrating the fabrication and modeling of specialized TEN probes with known optical *** proposed framewor. is highly flexible and can be easily adjusted to be used with diverse TEN techniques,building on various concepts and phenomena,significantly augmenting their *** with known optical properties could potentially enable faster and mor. accurate imaging via different routes,such as direct signal enhancement or.facile and ultrafast optical signal *** consider that the repor.ed development can pave the way for.a vast number of novel TEN imaging protocols and applications,given the many advantages that it offers.

关键词： tip-enhanced nanoscopy scanning probes COMSOL simulations nano-objects optical modeling