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Human African trypanosomiasis in endemic focus of Abraka,Nigeria

Asian Pacific Journal of Tropical Medicine 2010年第6期3卷 448-450页

作者： onyebiguwa patrick goddey nmorsi Clement Isaac Igho Benjamin Igbinosa Duncan Ogheneocovo Umukoro Dafe Palmer Aitaikuru Tropical Disease Research Unit Department of ZoologyAmbrose Alli UniversityEkpomaNigeria Family Medicine Department Delta State UniversityAbraka Department of Science Laboratory Technology Delta State PolytechnicOtefeOghara

Objective:To investigated the prevalence of human African trypanosomiasis(HAT),a neglected tropical disease caused by Trypanosoma brucei gambiens in an endemic focus of Nigeria,as it relates to age,sex and occupational ***:A total of 474 human subjects were screened using card agglutination test for trypanosomiasis *** samples were further investigated for parasite positivity in blood/serum and cerebrospinal fluid(CSF).Results:Of the 474 screened,44(9.3%) were seropositive with seroprevalence of 22(9.6%) in Urhouka,14(9.5%) in Umeghe and 8(7.9%) for *** number of seropositives,observed for weakly,moderately and strongly positives for the three communities were 4,7 and 11 in Urhouka,4,5 and 5 in Umeghe and 3,2 and 3 in Ugonu *** the 16 volunteers with detected parasite in their blood,4 of them were weakly positive,5 of them were moderately positive and 7 of them strongly positive.4 volunteers from Urhouka community were found parasites in their CSF and they were all strongly *** difference between the seroprevalence of males and females was not statistically significant(OR=1.14,95%CI=0.37-3.4,P>0.05).The prevalence difference between age group 21-30 years old and the youngest and oldest age groups was statistically significant(OR=3.5,95%CI= 1.08-12.57,P0.05),It was observed that farmers had significantly higher prevalence of HAT infection as well as greater risk of Trypanosoma brucei gambiense infection than inhabitants with other occupations (OR=3.25,95%CI=0.99-11.79,P<0.05).Conclusions:Human activities such as farming and visits to the river have been identified as major risk factors to *** the breakdown of HAT control program has been advanced for the rise in HAT in Abraka,an endemic focus in Nigeria.

关键词： Human African trypanosomiasis Trypanosoma brucei gambiense Seropositivity Risk factors Nigeria

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Serum cytokines profiles in Nigerian children with Ascaris lumbricoides infection

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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 288-291页

作者： nmorsi onyebiguwa patrick goddey Irior Dominic Osagie Abu Maliki Tropical Diseases Research Unit Department of ZoologyAmbrose Alli UniversityEkpomaNigeria

Objective:To investigate the cytokines pr of ile in the serum of some Nigerian children with Ascaris lumbricoides(***) infection and relations between the intensity of infection, age and the concentration of these ***:Feacal samples from consenting children were examined using formol ether concentration techniques and Kato-Katz thick smear *** of 96 children comprising 76 *** infection and 20 controls were subjected to enzymes-linked immunosorbent ***:The mean sera concentration of tumor necrosis factor alpha(TNF-α),interleukin-4(IL-4),interleukin-5(IL-5),interleukin- 10(IL-10) were(16.7±7.6) pg/mL,(4.6±0.8)pg/mL,(391.6±52.0) pg/mL and(181.2±30.4) pg/mL,*** control subjects had the following mean serum cytokines:TNF-α(2.9±1.8) pg/m,IL-4(4.0±0.1) pg/mL,IL-5(125.1±50.1) pg/mL,IL-10(74.5±54.2) pg/ mL,*** difference between the sera cytokines concentration of the *** infected children and their controls were statistically significant for TNF-α,IL- 5 and IL-10(χ~2= 9.99,P< 0.05;χ~2 = 137.24,P < 0.05;χ~2 = 44.30,P < 0.05,respectively). The intensity of infection correlated positively with TNF-α,and IL-5(r = 0.93 and 0.98, respectively) while IL-4 and IL- 10 correlated negatively with the intensity of infection(r = -0.62 and 0.99,respectively).TNF-α,IL-4 and IL-5 correlated positively with age(r = 0.19,0.33 and 0.66,respectively).The mean cytokines between those with mild and moderate infections were statistically significant for TNF-α,IL-5 and IL-10(χ~2 = 3.60,4.52 and 5.30, respectively).The ratio of TNF-α:IL-10 was ***:Elevated IL-5,IL-10 and TNF-αfound in the sera of the volunteers with Ascariasis implicates these cytokines as key mediators in the host responses to *** infection in our studied area.

关键词： IL-4 IL-5 IL-10 TNF-α Ascaris lumbricoides Children Nigeria

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