检索结果-南通市图书馆

Partial closure with a self-made fenestrated device of secundum atrial septal defect with severe pulmonary artery hypertension in adults

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2021年第6期18卷 498-504页

作者： Tullio Tesorio Luigi Salemme Sebastiano Verdoliva Marco Ferrone Paola Tesorio Eustaquio Maria onorato Unitàdi Cardiologia Interventistica Emodinamica Casa di Cura MontevergineVia Mario MalzoniMercoglianoItaly Centro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)University School of MilanMilanItaly

Secundum atrial septal defect(ASD)repres-ents one of the most common congenital heart diseases,accounting for up to 10%of all congenital heart *** is often diagnosed in adulthood due to the absence of clinical symptoms.[1]By the age of 40 years,90%of untreated patients have symptoms of exertional dyspnea,fatigue,pal-pitation,sustained arrhythmia,or even evidence of heart failure.

关键词： septal sustained atrial

Micro-RNAs in hepatitis B virus-related chronic liver diseases and hepatocellular carcinoma

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2018年第9期10卷 558-570页

作者： Evangelista Sagnelli Nicoletta Potenza Lorenzo onorato Caterina Sagnelli Nicola Coppola Aniello Russo Department of Mental Health and Public Medicine Section of Infectious DiseasesUniversity of Campania Luigi Vanvitelli DISTABIF University of Campania "Luigi Vanvitelli"

MicroRNAs(miRNAs) are small non-coding RNAs that modulate gene expression at the post-transcriptional level by affecting both the stability and translation of complementary mRNAs. Several studies have shown that mi RNAs are important regulators in the conflicting efforts between the virus(to manipulate the host for its successful propagation) and the host(to inhibit the virus),culminating in either the elimination of the virus or its persistence. An increasing number of studies report a role of miRNAs in hepatitis B virus(HBV) replication and pathogenesis. In fact,HBV is able to modulate different host miRNAs,particularly through the transcriptional transactivator HBx protein and,conversely,different cellular miRNAs can regulate HBV gene expression and replication by a direct binding to HBV transcripts or indirectly targeting host factors. The present review will discuss the role of miRNAs in the pathogenesis of HBVrelated diseases and their role as a biomarker in the management of patients with HBV-related disease and as therapeutic targets.

关键词： Hepatitis B virus infection MicroRNAs Hepatitis B virus pathogenesis Molecular mechanisms

Preliminary study of gravimetric anomalies in the Magallanes-Fagnano fault system,South America

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geodesy and Geodynamics 2018年第1期9卷 42-49页

作者： Juan Manuel Alcacer María Romina onorato Laura P.Perucca Silvia Miranda CONICET-Av.lgnacio de La Roza(oeste)590 J5402DCSSan JuanArgentina Departmento Geofisica Universidad Nacional de San JuanAv.Ignacio de ga Roza(oeste)590J5402DC5San JuanArgentina CIGEOBIO-CONICET Gabinete de Neotect6nica y Geomorfologfa(INGEO)Facultad de Ciencias ExactasFfsicas y NaturalesUniversidad Nacional de San JuanAv.lgnacio de La Roza(oeste)590J5402DCSSan JuanArgentina

The main objective of this research is to recognize several geological structures associated with the shear zones of the MFFS（Magallanes-Fagnano fault system） by the analysis and interpretation of gravimetric anomalies. Besides, to compare the gravimetrical response of the cortical blocks that integrate the region under study, which is related to the different morphotectonic domains recognized in the region. This research was developed employing data obtained from World Gravity 1.0, which includes earth and satellite gravity data derived from the EGM2008 model. The study and interpretation of the MFFS from the analysis and processing of the gravimetric data, allowed appreciation of a noticeable correlation with the most superficial cortical structure.

关键词： Gravimetry Isostatic anomaly Magallanes-Fagnano fault system Argentina

A case of paradoxical brain embolism presenting as a typical lacunar stroke

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Health 2011年第4期3卷 249-252页

作者： Gian Paolo Anzola F. Casilli E. onorato 不详

A 59 year old white male presented with a clinical picture typical of lacunar stroke. However, a thorough diagnostic work up showed that the most probable mechanism of stroke was paradoxical brain embolism through a patent foramen ovale. The clinical-neuroradiological mismatch that ultimately lead to the correct interpretation is discussed.

关键词： Lacunar Stroke Patent Foramen Ovale

Epidemiology and management of hepatitis C virus infections in immigrant populations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2019年第2期8卷 13-22页

作者： Nicola Coppola Loredana Alessio Lorenzo onorato Caterina Sagnelli Margherita Macera Evangelista Sagnelli Mariantonietta Pisaturo Department of Mental Health and Public Medicine Section of Infectious DiseasesUniversity of CampaniaVia:L.Armanni 580131 NaplesItaly Infectious Diseases Unit AORN Sant'Anna e San Sebastiano di Caserta81100 CasertaItaly

Background:At present,there is a continuous flow of immigrants from the south of the world to north-western *** immigrants originate from areas of high-prevalence of viral hepatitis and pose a challenge to the healthcare systems of the host *** of this study is to evaluate the prevalence and virological and clinical characteristics of hepatitis C virus(HCV)infection in immigrants and the strategies to identify and take care of the immigrants infected with *** body:We conducted an electronic literature search in several biomedical databases,including PubMed,Google Scholar,Scopus,Web of Science,using different combinations of key words:"HCV infection;chronic hepatitis C,immigrants;low-income countries".We included studies written in English indicating the epidemiological data of HCV infection in the immigrant population,studies that assessed the clinical presentation,clinical management and treatment with directly acting antiviral agent in immigrants,HCV infection is unevenly distributed in different countries,with worldwide prevalence in the general population ranging from 0.5 to 6.5%.In Western countries and Australia this rate ranges from 0.5 to 1.5%,and reaches 2.3%in countries of south-east Asia and eastern Mediterranean regions,3.2%in China,0.9%in India,2.2%in Indonesia and 6.5%in Pakistan;in sub-Saharan Africa the prevalence of HCV infection varies from 4 to 9%.Immigrants and refugees from intermediate/high HCV endemic countries to less-or non-endemic areas are more likely to have an increased risk of HCV infection due to HCV exposure in their countries of *** of the high HCV endemicity in immigrant populations and of the high efficacy of directly acting antiviral agent therapy,a campaign could be undertaken to eradicate the infection in this ***:The healthcare authorities should support screening programs for immigrants,performed with the help of cultural mediators and including educational aspects to break

关键词： HCV infection Chronic hepatitis C immigrant Directly acting antiviral agent Low-income country

Role of genetic polymorphisms in hepatitis C virus chronic infection

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2015年第9期3卷 807-822页

作者： Nicola Coppola Mariantonietta Pisaturo Caterina Sagnelli Lorenzo onorato Evangelista Sagnelli Department of Mental Health and Public Medicine Section of Infectious DiseasesSecond University of Naples Department of Clinical and Experimental Medicine and Surgery "F.Magrassi e A.Lanzara" Second University of Naples

AIM: To analyze the host genetics factors influencing the clinical course and the response to antiviral treatment in patients with chronic hepatitis C(CHC).METHODS: We conducted an electronic search on the Pub Med and MEDLINE(2000-2014) databases and Cochrane library(2000-2014). A total of 73 articles were retrieved and their data were extensively evaluated and discussed by the authors and then analyzed in this review ***: Several studies associated polymorphisms in the interleukin 28 B gene on chromosome 19(19q13.13) with a spontaneous viral clearance in acute hepatitis C and with the response to pegylated interferon(PegIFN)-based treatment in chronic hepatitis C patients. Other investigations demonstrated that inosine triphosphate pyrophosphatase genetic variants protect hepatitis C virus-genotype-1 CHC patients from ribavirin-induced anemia, and other studies that a polymorphism in the patatin-like phospholipase domain-containing protein 3 was associated with hepatic steatosis in CHC patients. Although not conclusive, some investigations suggested that the vitamin D-associated polymorphisms play an important role in the achievement of sustained virologic response in CHC patients treated with Peg-IFN-based antiviral therapy. Several other polymorphisms have been investigated to ascertain their possible impact on the natural history and on the response to treatment in patients with CHC, but the data are preliminary and warrant confirmation. CONCLUSION: Several genetic polymorphisms seem to influence the clinical course and the response to antiviral treatment in patients with CHC, suggesting individualized follow up and treatment strategies.

关键词： Single nucleotide polymorphism Hepatitis C virus infection Interleukin 28B Inosine triphosphate pyrophosphatase Patatin-like phospholipase domaincontaining protein 3

Role of occult hepatitis B virus infection in chronic hepatitis C

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第42期21卷 11931-11940页

作者： Nicola Coppola Lorenzo onorato Mariantonietta Pisaturo Margherita Macera Caterina Sagnelli Salvatore Martini Evangelista Sagnelli Department of Mental Health and Public Medicine Section of Infectious Diseases Second University of Naples Division of Infectious Diseases AORN Sant’Anna e San Sebastiano di Caserta Department of Clinical and Experimental Medicine and Surgery "F. Magrassi e A. Lanzara" Second University of Naples

The development of sensitive assays to detect small amounts of hepatitis B virus(HBV) DNA has favored the identification of occult hepatitis B infection(OBI), a virological condition characterized by a low level of HBV replication with detectable levels of HBV DNA in liver tissue but an absence of detectable surface antigen of HBV(HBs Ag) in serum. The gold standard to diagnose OBI is the detection of HBV DNA in the hepatocytes by highly sensitive and specific techniques, a diagnostic procedure requiring liver tissue to be tested and the use of non-standardized non-commercially available techniques. Consequently, in everyday clinical practice, the detection of anti-hepatitis B core antibody(antiHBc) in serum of HBs Ag-negative subjects is used as a surrogate marker to identify patients with OBI. In patients with chronic hepatitis C(CHC), OBI has been identified in nearly one-third of these cases. Considerable data suggest that OBI favors the increase of liver damage and the development of hepatocellular carcinoma(HCC) in patients with CHC. The data from other studies, however, indicate no influence of OBI on the natural history of CHC, particularly regarding the risk of developing HCC.

关键词： Occult hepatitis B virus infection Silent hepatiti

Hepatitis B virus and hepatitis C virus infection inhealthcare workers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2016年第5期8卷 273-281页

作者： Nicola Coppola Stefania De Pascalis Lorenzo onorato Federica Calò Caterina Sagnelli Evangelista Sagnelli Department of Mental Health and Public Medicine Section of Infectious DiseasesSecond University of Naples80131 NaplesItaly Department of Clinical and Experimental Medicine and Surgery“F.Magrassi e A.Lanzara” Second University of Naples80131 NaplesItaly

Approximately 3 million healthcare workers per year receive an injury with an occupational instrument, with around 2000000 exposures to hepatitis B virus(HBV) and 1000000 to hepatitis C virus(HCV). Although an effective HBV vaccine has been available since the early eighties, and despite the worldwide application of universal vaccination programs started in the early nineties, HBV still remains a prominent agent of morbidity and mortality. There is no vaccine to limit the diffusion of HCV infection, which progresses to chronicity in the majority of cases and is a major cause of morbidity and mortality worldwide due to a chronic liver disease. Healthcare workers are frequently exposed by a mucosal-cutaneous or percutaneous route to accidental contact with human blood and other potentially infectious biological materials while carrying out their occupational duties. Mucosal-cutaneous exposure occurs when the biological material of a potentially infected patient accidentally comes in contact with the mucous membranes of the eyes or mouth or with the skin of a healthcare worker. Percutaneous exposure occurs when an operator accidentally injures himself with a sharp contaminated object, like a needle, blade or other sharp medical instrument. About 75% of the total occupational exposure is percutaneous and 25% mucosal-cutaneous, the risk of infecting a healthcare worker being higher in percutaneous than in mucosal-cutaneous exposure. All healthcare workers should be considered for HBV vaccination and should meticulously apply the universal prophylactic measures to prevent exposure to HBV and HCV.

关键词： Hepatitis B virus infection Hepatitis C virusinfection Needle-stick injury Healthcare workers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

重构后的景观

计算机光盘软件与应用（COMPUTER ARTS数码艺术） 2008年第3期 122-124页

作者：汤解 Taiyo onorato（图） Nico Krebs（图）

Taiyo onorato和Nico Krebs,对现实中正在流行的结构和构成形态烂熟于心。经过他们重构后的景观，完成了对现实的一次戏谑性的模仿,这表现在,重新描述后的公路景观、户外的卧室、山上种的薯条、泥地里的汽车。

关键词：公路景观重构重新描述