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Diabetes mellitus and male infertility

Asian pacific Journal of Reproduction 2018年第1期7卷 6-14页

作者： omolaoye temidayo s du Plessis stefan s Division of Medical Physiology Faculty of Medicine and Health SciencesStellenbosch UniversityTygerbergSouth Africa

Infertility is prevalent in about 10%-25% of couples in their reproductive age, analogous to 60-80 million infertile couples globally. Of these infertility cases, 10%-30% are exclusively attributed to a problem of the male. several diseases have been implicated as contributors to deteriorating male fertility and diabetes mellitus (DM) is included. DM, a chronic non-communicable disease, has been considered as one of the most appreciable health threats, as it affects 9% (422 million) of the world's population as of 2014. It is characterised by hyperglycaemia, which can result from the inability of the pancreaticβ-cells to secrete insulin or from the target tissue becoming insensitive to insulin. DM has been reported to influence male reproductive function through diverse pathways and mechanisms. The adverse effects of reactive oxygen species and successive development of oxidative stress that occur due to DM have been investigated and implicated by several studies. The products of non-enzymatic glycosylation are reported to be widely distributed in the reproductive tract of diabetic men. Additionally, DM has been implicated to impair the processes of male sexual acts. Data reported in this review were extracted from PubMed, Google scholar, science Direct and scopus with diabetes and male infertility as the key search words. In light of the aforementioned, the aim of this review is to provide brief background information on DM as well highlight and explain the likely mechanisms of male fertility which DM impacts.

关键词： Diabetes mellitus Male infertility Diabetic neuropathy Oxidative stress Reactive oxygen species Advanced glycated end products

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Descriptive histomorphological evaluation of the testis and caudal epididymis following treatment with rooibos(Aspalathus linearis),honeybush(Cyclopia intermedia)and sutherlandia(Lessertia frutescens)in healthy and streptozotocin-induced diabetic rats

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Asian pacific Journal of Reproduction 2021年第4期10卷 176-186,I0001,I0002页

作者： temidayo s.omolaoye stefan s.du P.lessis Department of Basic sciences College of MedicineMohammed Bin Rashid University of Medicine and Health SciencesDubaiUnited Arab Emirates Division of Medical Physiology Faculty of Medicine and Health SciencesStellenbosch UniversityTygerbergSouth Africa

Objective:To evaluate the testis and the cauda epididymis after treating both healthy and diabetic rats with rooibos(Aspalathus linearis),honeybush(Cyclopia intermedia),and sutherlandia(Lessertia frutescens),***:Ninety male Wistar rats were randomly divided into nine groups(n=10 per group).Fifty rats were randomized to receive tap water,0.1 M citrate buffer,2.0%fermented rooibos,4.0%fermented honeybush,or 0.2%unfermented *** was induced via a single intraperitoneal injection of streptozotocin(sTZ)at 45 mg/kg in 40 *** diabetic rats were randomized to receive tap water,2.0%fermented rooibos,4.0%fermented honeybush,or 0.2%unfermented *** were sacrificed after seven weeks of diabetic *** was collected for hormonal assay,while the testes and caudal epididymis were retrieved for histomorphological ***:Diabetic rats treated with 2.0%fermented rooibos exhibited a significant increase in fasting plasma glucose(FPG)versus the vehicle group(P=0.002),and a 3.6%decrease compared to the diabetic control group(P>0.05).Diabetic rats treated with honeybush or sutherlandia showed 23.6%and 15.4%decrease in FPG when compared to the diabetic control group,respectively(both P>0.05).The diabetic control rats had a significant decrease in the percentage of histologically normal seminiferous tubules compared to the control group(P=0.049).There was 21.0%,14.0%,and 5.4%rise in the percentage of normal seminiferous tubules in diabetic rats receiving rooibos,honeybush or sutherlandia,respectively,compared to the diabetic control *** infusion control groups(rooibos,honeybush and sutherlandia)showed normal seminiferous tubules,presence of spermatozoa in the epididymal lumen,and had normal overall *** testicular and epididymal morphology were altered in the diabetic control group,but these disruptions were mildly ameliorated by rooibos,honeybush,and ***:The detrimental effect

关键词： Testis Epididymis Rooibos Honeybush sutherlandia Diabetes Histomorphological evaluation streptozotocin.

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Testicular oxidative stress and apoptosis status in streptozotocin-induced diabetic rats after treatment with rooibos(Aspalathus linearis),honeybush(Cyclopia intermedia),and sutherlandia(Lessertia frutescens)infusions

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Asian pacific Journal of Reproduction 2021年第1期10卷 11-20页

作者： temidayo s.omolaoye shantal Windvogel stefan s.du Plessis Division of Medical Physiology Faculty of Medicine and Health SciencesStellenbosch UniversityTygerbergSouth Africa Department of Basic sciences College of MedicineMohammed Bin Rashid University of Medicine and Health SciencesDubaiUnited Arab Emirates Centre for Cardio-metabolic Research in Africa Stellenbosch UniversitySouth Africa

Objective:To investigate the testicular oxidative stress and apoptosis status,as well as the sperm functional parameters in streptozotocin(sTZ)induced diabetic rats following treatment with rooibos(Aspalathus linearis),honeybush(Cyclopia intermedia)and sutherlandia(Lessertia frutescens)***:Diabetes was induced by injecting fourteen-week-old adult male Wistar rats(250-300 g)with a single intraperitoneal injection of sTZ(45 mg/kg body weight).Fifty rats were randomly divided into five groups:the vehicle group received 0.1 M citrate buffer,the diabetic control group received 45 mg/kg sTZ,the diabetic+rooibos group received 45 mg/kg sTZ+2.0%rooibos,the diabetic+honeybush group received 45 mg/kg sTZ+4.0%honeybush,and the diabetic+sutherlandia group received 45 mg/kg sTZ+0.2%*** were sacrificed 7 weeks after induction of diabetes *** testes and epididymides were harvested and weighed after *** were retrieved from the cauda epididymis for motility,concentration,and morphology analysis,and the testis was used for all biochemical *** stress was determined by measuring malondialdehyde levels,catalase,and superoxide dismutase activities,while apoptotic biomarkers were evaluated by Western blotting ***:After induction of diabetes,rats in the diabetic control group,diabetic+rooibos group,diabetic+honeybush group,and diabetic+sutherlandia group presented with significantly elevated blood glucose levels as compared with the vehicle group(Ps in the diabetic control group had a reduction in sperm progressive motility,while rats in the diabetic+rooibos group and the diabetic+sutherlandia group displayed an increase in progressive motility as compared with the diabetic control *** diabetic control animals showed a 40.0%decrease in sperm concentration when compared to the vehicle group,and there were no significant differences in sperm kinematic and speed parameters between the *** add

关键词： Diabetes sperm Oxidative stress Apoptosis Rooibos Honeybush sutherlandia

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