Descriptive histomorphological evaluation of the testis and caudal epididymis following treatment with rooibos(Aspalathus linearis),honeybush(Cyclopia intermedia)and sutherlandia(Lessertia frutescens)in healthy and streptozotocin-induced diabetic rats
作者机构：Department of Basic SciencesCollege of MedicineMohammed Bin Rashid University of Medicine and Health SciencesDubaiUnited Arab Emirates Division of Medical PhysiologyFaculty of Medicine and Health SciencesStellenbosch UniversityTygerbergSouth Africa
出 版 物：《Asian pacific Journal of Reproduction》 (亚太生殖杂志（英文版）)
年 卷 期：2021年第10卷第4期
页 面：176-186,I0001,I0002页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Testis Epididymis Rooibos Honeybush Sutherlandia Diabetes Histomorphological evaluation Streptozotocin.
摘 要：Objective:To evaluate the testis and the cauda epididymis after treating both healthy and diabetic rats with rooibos(Aspalathus linearis),honeybush(Cyclopia intermedia),and sutherlandia(Lessertia frutescens),***:Ninety male Wistar rats were randomly divided into nine groups(n=10 per group).Fifty rats were randomized to receive tap water,0.1 M citrate buffer,2.0%fermented rooibos,4.0%fermented honeybush,or 0.2%unfermented *** was induced via a single intraperitoneal injection of streptozotocin(STZ)at 45 mg/kg in 40 *** diabetic rats were randomized to receive tap water,2.0%fermented rooibos,4.0%fermented honeybush,or 0.2%unfermented *** were sacrificed after seven weeks of diabetic *** was collected for hormonal assay,while the testes and caudal epididymis were retrieved for histomorphological ***:Diabetic rats treated with 2.0%fermented rooibos exhibited a significant increase in fasting plasma glucose(FPG)versus the vehicle group(P=0.002),and a 3.6%decrease compared to the diabetic control group(P0.05).Diabetic rats treated with honeybush or sutherlandia showed 23.6%and 15.4%decrease in FPG when compared to the diabetic control group,respectively(both P0.05).The diabetic control rats had a significant decrease in the percentage of histologically normal seminiferous tubules compared to the control group(P=0.049).There was 21.0%,14.0%,and 5.4%rise in the percentage of normal seminiferous tubules in diabetic rats receiving rooibos,honeybush or sutherlandia,respectively,compared to the diabetic control *** infusion control groups(rooibos,honeybush and sutherlandia)showed normal seminiferous tubules,presence of spermatozoa in the epididymal lumen,and had normal overall *** testicular and epididymal morphology were altered in the diabetic control group,but these disruptions were mildly ameliorated by rooibos,honeybush,and ***:The detrimental effect
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