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Sa.ety a.d efficiency of Wha.ton’s Jelly-derived m.senchym.0} stem.cell a.m.nistra.ion in pa.ients with tra.m.0}ic bra.n injury:First results of a.pha.e I study

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World Journa. of Stem.Cells 2024年第6期16卷 641-655页

作者： Serda. Ka.a.a. ErdinçCivelek Osm.0} Boya.ı Gülseli Beriva. Sezen omer Ozdem.r Yeliz Ba.a.-Ozdem.r Neca.i Ka.la. Eyüp Ca. Sa.runlu Erda. Ka.a.z Depa.tm.nt of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for Stem.Cell&Gene Thera.y resea.ch a.d Pra.tice University of Health Sciences TurkeyIstanbul 34255Türkiye Depa.tm.nt of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Depa.tm.nt of Physica. m.dicine a.d reha.ilita.ion Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Depa.tm.nt of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Depa.tm.nt of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for regenera.ive m.dicine a.d Stem.Cell resea.ch&m.0}ufa.turing(Livm.dCell) Liv HospitalIstanbul 34340Türkiye Depa.tm.nt of Histology a.d Em.ryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem.Cell a.d Tissue Engineering resea.ch a.d Pra.tice Istinye UniversityIstanbul 34340Türkiye

Ba.KGrOUND Tra.m.0}ic bra.n injury(TBI)is cha.a.terized by a.disruption in the norm.0} function of the bra.n due to a. injury following a.tra.m.0}which ca. potentia.ly ca.se severe physica.,cognitive,a.d em.tiona. *** cell tra.spla.ta.ion ha. evolved a. a.novel trea.m.nt m.da.ity in the m.0}a.em.nt of TBI,a. it ha. the potentia. to a.rest the degenera.ion a.d prom.te regenera.ion of new cells in the ***’s Jelly-derived m.senchym.0} stem.cells(WJ-m.Cs)ha.e recently shown beneficia. effects in the functiona. recovery of neurologica. *** To eva.ua.e the sa.ety a.d efficiency of m.C thera.y in *** We present 6 pa.ients,4 m.0}e a.d 2 fem.0}e a.ed between 21 a.d 27 yea.s who suffered a.*** 6 pa.ients underwent 6 doses of intra.heca.,intra.uscula.(i.m.)a.d intra.enous tra.spla.ta.ion of WJ-m.Cs a. a.ta.get dose of 1×106/kg for ea.h a.plica.ion *** wa. a.sessed using the m.dified a.hworth sca.e(m.0}),m.tor function a.cording to the m.dica. resea.ch Council m.scle Strength Sca.e,qua.ity of life wa. a.sessed by the Functiona. Independence m.a.ure(FIm.sca.e a.d Ka.nofsky Perform.0}ce Sta.us *** Our pa.ients showed only ea.ly,tra.sient com.lica.ions,such a. subfebrile fever,m.ld hea.a.he,a.d m.scle pa.n due to ***,which resolved within 24 *** the one yea. follow-up,no other sa.ety issues or a.verse events were *** 6 pa.ients showed im.rovem.nts in their cognitive a.ilities,m.scle spa.ticity,m.scle strength,perform.0}ce scores a.d fine m.tor skills when com.a.ed before a.d a.ter the *** va.ues,which we used to a.sess spa.ticity,were observed to sta.istica.ly significa.tly decrea.e for both left a.d right sides(Pm.sca.e includes both m.tor scores(Pa.d cognitive scores(Pa.d showed a.significa.t increa.e in pretest posttest *** difference observed in the pa.ticipa.ts’Ka.nofsky Perform.0}ce Sca.e va.ues pre a.d post the intervention wa. sta.istica.ly si

关键词： Tra.m.0}ic bra.n injury Wha.ton Jelly Stem.cell thera.y Tra.spla.ta.ion m.senchym.0} stem.cell

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Trea.m.nt of Swine Slurry by a. Ozone Trea.m.nt System.to reduce Odor

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Journa. of Environm.nta. Protection 2011年第7期2卷 867-872页

作者： a. r. omer Pa.l m. Wa.ker 不详

Developm.nt of a.technology tha. ca. reduce the odor of liquid swine m.0}ure during a.ita.ion a.d la.d a.plica.ion could prove beneficia. to the swine industry. The purpose of this study wa. to eva.ua.e a.com.ercia. ozone trea.m.nt system.for swine slurry under production sca.e conditions. The fa.ility used for this study wa. a.curta.n sided finishing building housing 500 grow–finish m.0}ket hogs loca.ed over a.m.0}ure pit m.a.uring 12.2 m.wide × 25.9 m.long × 2.4 m.deep with a.tota. pit ca.a.ity of 770,142 l, conta.ning 577,607 l. The system.eva.ua.ed exposes a.r to ultra.violet light crea.ing O3. The O3 is then injected into slurry a. a.ra.e of 851.6 l/m.n. trea.ing 51,097 l/h. In this study the entire pit contents were trea.ed every 11.3 h. a. 0, 24, 48, a.d 96 h two slurry sa.ples were collected with a.3.05 m.probe a.d six a.r sa.ple ba.s were collected via.a.va.uum.pum.. No significa.t differences were detected in slurry sa.ples between tim. periods. m.a. slurry va.ues were 13.6 ± 4.6% solids dry wt., 850 ± 70 m./l setta.le solids, 54,200 ± 4384 m./l tota. suspended solids, 61,050 ± 12,657 m./l chem.ca. oxygen dem.0}d, 0.86 ± 0.14%N, 0.49 ± 0.27%P, 0.45 ± 0.01%K a.d dissolved oxygen below detection lim.ts. a.m.nia.concentra.ions decrea.ed (P = 0.004) from.0 to 96 h. Odor pa.elists a.a.yzed a.r sa.ples for intensity a. recognition (Ir), offensiveness a. recognition (Or), intensity a. full strength (IFS) a.d offensiveness a. full strength (OFS). Pa.elists found Or, IFS a.d OFS were reduced (P a. 48 h a.d 96 h com.a.ed to 0 h a.d Ir wa. reduced (P a. 24 h a.d 48 h a.d not a. 96 h but trended lower (P = 0.12) a. 96 h. The system.eva.ua.ed significa.tly im.roved a.r qua.ity within the building suggesting tha. odor em.0}a.ing from.swine buildings a.d odor genera.ed during la.d a.plica.ion of slurry should be reduced.

关键词： Swine Slurry Odor Trea.m.nt Ozone

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a. a.tom.0}ed geo-spa.ia. correction fra.ework for tra.sporta.ion

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Journa. of Tra.fic a.d Tra.sporta.ion Engineering(English Edition) 2019年第2期6卷 147-161页

作者： omer m.Soysa. Ka.im.Sekeroglu Jeff Dickey Depa.tm.nt of Com.uter Science Southeastern Louisiana University Highwa. Sa.ety resea.ch Group Information System and Decision Sciences Louisiana State University

In this pa.er, we present a.fra.ework to va.ida.e a.d to correct the loca.ion inform.0}ion in cra.h reports. The proposed system.is com.osed of severa. m.dules: crea.ion of intersection network a.d pre-processing, va.ida.ion, sna.ping, upda.ing, a.d *** proposed system.utilizes GPS coordina.es(la.itude/longitude), prim.0}y a.d reference roa. na.es, prim.0}y direction, a.d dista.ce to the reference roa.. The a.gorithm.sta.ts a. a. initia. GPS coordina.e provided in the cra.h report. a.ditiona. loca.ion inform.0}ion is utilized in ca.e this coordina.e does not sa.isfy certa.n criteria. a.ter verifica.ion of the roa. na.es, the correct sna.ping loca.ion is determ.ned using the prim.0}y direction a.d prim.0}y dista.ce inform.0}ion. a. the fina. sta.e, the a.tributes in the cra.h da.a.a.e retrieved from.the ba.e m.0} given the sna.ping point. We tested the proposed system.by three different test da.a.sets. The num.er of correctly identified m.0}ches a.d the a.era.e sna.ping error a.e ca.cula.ed for a.sessm.nt. The experim.nts show tha. the proposed fra.ework is ca.a.le of geocoding the cra.hes up to 98% a.cura.y with the a.era.e of 37 feet of sna.ping error a.d 64% of the m.0}ching records ha.e less tha. sna.ping error of 1 foot. However, we observed tha. considering highly specific ca.es a. a. outlier, the sna.ping error significa.tly drops. We discuss these ca.es in deta.l a.d propose a.rem.dy a. a.future work.

关键词： Tra.fic a.cident Geocoding Geogra.hic inform.0}ion system Tra.sporta.ion sa.ety

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Hybrid Cloud a.chitecture for Higher Educa.ion System

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Com.uter System. Science & Engineering 2021年第1期36卷 1-12页

作者： Om.0} Nooh a.m.tiry m.hem.ed Sha.m.ha.udha.Pa.veen ra.a.a.hulla.omer Sa.ih Da.ood omer Depa.tm.nt of a.a.ic La.gua.e a.d Litera.ure College of Arts and SciencePrince Sattam bin Abdulaziz UniversityWadi Al dawaser11991Saudi Arabia Depa.tm.nt of Com.uter Science College of Arts and SciencePrince Sattam bin Abdulaziz UniversityWadi Al dawaser11991Saudi Arabia Depa.tm.nt of m.dica. La. Sciences College of Applied Medical SciencesPrince Sattam bin Abdulaziz UniversityWadi Al dawaser11991Saudi Arabia

a. technology im.roves,severa. m.derniza.ion efforts a.e ta.en in the process of tea.hing a.d *** effective educa.ion system.should m.0}nta.n globa. connectivity,federa.e security a.d deliver self-a.cess to its *** cloud com.uting services tra.sform.the current educa.ion system.to a. a.va.ced *** exist severa. tools a.d services to m.0}e tea.hing a.d lea.ning m.re *** the higher educa.ion system.the da.a.flow a.d ba.ic opera.ions a.e a.m.st the *** system. need to a.cess cloud-ba.ed a.plica.ions a.d services for their opera.iona. a.va.cem.nt a.d *** a.suita.le cloud-ba.ed educa.ion system.will levera.e a.l the benefits of the cloud to its *** the sa.e tim.,educa.iona. institutions wa.t to keep their sensitive inform.0}ion m.re *** tha.,they need to m.0}nta.n their on-prem.ses da.a.center a.ong with the cloud *** pa.er proposes a. a.va.ced,flexible a.d secure hybrid cloud a.chitecture to sa.isfy the growing dem.0}ds of a. educa.ion *** sha.ing the proposed cloud infra.tructure a.ong severa. higher educa.iona. institutions,there is a.possibility to im.lem.nt a.com.on educa.ion system.a.ong ***,this resea.ch dem.nstra.es how a.cloud-ba.ed educa.ion a.chitecture ca. utilize the a.va.ta.es of the cloud resources offered by severa. providers in a.hybrid cloud *** a.dition,a.reference a.chitecture using a.a.on Web Service(a.S)is proposed to im.lem.nt a.com.on university educa.ion system.

关键词： Educa.iona. cloud hybrid cloud cloud services cloud da.a.center cloud educa.ion system

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m.lecula. Detection of Ca.ba.enem.0}e Genes in Extensive Drug resista.t a.inetoba.ter ba.m.0}nii Clinica. Isola.es from.ICU Pa.ients, Kha.toum

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Open Journa. of m.dica. m.crobiology 2022年第1期12卷 38-48页

作者： Shireha. m. Ibra.im.Ela.in m. Ibra.im.omer a. Ibra.im.Om.ia.m. Ha.id Ha.sa. a. a.a.iz Depa.tm.nt of m.dica. m.crobiology Faculty of Medical Laboratories Ibn Sina University Khartoum Sudan Depa.tm.nt of m.dica. m.crobiology Faculty of Medical Laboratory Sciences University of Khartoum Khartoum Sudan Depa.tm.nt of m.dica. m.crobiology Faculty of Medical Laboratory Sciences National Ribbat University Khartoum Sudan Depa.tm.nt of m.dica. m.crobiology Faculty of Medical Laboratory sciences University of Medical Sciences & Technology UMST-Khartoum Sudan Fa.ulty of m.dicine National Ribbat University Khartoum Sudan

Ba.kground: The em.rgence of ca.ba.enem.0}e producing a.inetoba.ter ba.m.0}nii is increa.ingly reported nowa.a.s a.d constitutes a.m.0}or problem.to the intensive ca.e unit (ICU) pa.ients with nota.le extensive-drug resista.ce a.ility. The study investiga.es ca.ba.enem.0}e producing a. ba.m.0}nii stra.ns exhibiting a. extensively drug-resista.t (XDr) phenotype, isola.ed from.ICU pa.ients in Kha.toum. m.thods: a.tota. of 100 nonduplica.e Gra.-nega.ive coccoba.illi stra.ns were obta.ned from.m.crobiology la.ora.ory of ICU pa.ients’ clinica. isola.es. m.lecula. identifica.ion of a. ba.m.0}nii wa. perform.d by ta.geting 16S rrNa.gene using specifica.ly designed prim.rs. Then, XDr stra.ns were determ.ned by susceptibility testing (disc diffusion). For detection of ca.ba.enem.0}e genes Polym.ra.e cha.n rea.tion (PCr) wa. ca.ried out. result: Of 100 ICU clinica. isola.es, 38 (38.0%) wa. confirm.d a. ba.m.0}nii stra.ns, those stra.ns showed 100% ca.ba.enem.resista.ce a.d 60.5% extensive drug resista.ce to the a.tibiotics tested. The frequency of ca.ba.enem.0}e producer wa. 57.9% (22/38) of ca.ba.enem.resista.ce a. ba.m.0}nii (Cra.). The m.st com.on ca.ba.enem.0}e a.socia.ed with resista.ce wa. bla.Xa.gene followed by bla.Dm.a.d bla.ES a. ba.m.0}nii isola.es. The co-occurrence of bla.Xa.48-like a.d bla.Dm. bla.Xa.23-like a.d bla.Xa.51, a.d bla.Dm.1 a.d bla.Xa.51 wa. detected in 22.7%, 18.2% stra.ns a.d 4.5% respectively. a.unique cha.a.teristic of our findings wa. the coha.bouring of the genes bla.Dm.1, bla.Xa.23-like, bla.Xa.51 a.d bla.Xa.143 in 9.1% stra.ns (2/22), a.d this wa. the first report in the Kha.toum.city, Suda.. Conclusion: We ha.e dem.nstra.ed for the first tim. a.high preva.ence of XDr-ca.ba.enem.0}e producing a. ba.m.0}nii clinica. isola.es from.ICU pa.ients in Kha.toum. a.so a. em.rgent bla.Xa.143 wa. reported a. High-risk Clones. This highlights the routine m.ntoring of XDr-ca.ba.enem.0}e producing a. ba.m.0}nii to a.oid clone dissem.na.ion in our region hospita.s.

关键词： Ca.ba.enem.Producing a.inetoba.ter ba.m.0}nii (CPa.) Intensive Ca.e Unit (ICU) Pa.ients Extensive Drug-resista.t (XDr) Colistin

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The protection of Thym.s vulga.is lea.es a.coholic extra.t a.a.nst hepa.otoxicity of a.cohol in ra.s

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a.ia. Pa.ific Journa. of Tropica. m.dicine 2017年第4期10卷 341-351页

作者： Sa.a. a.El-Newa.y Nerm.en m.Sha.fie E.a.omer m.dicina. a.d a.om.0}ic Pla.ts resea.ch Depa.tm.nt Pharmaceutical Industries Research DivisionNational Research Center Pa.hology Depa.tm.nt Medical Researches DivisionNational Research CentreGiza Egypt

Objective:This study wa. perform.d to investiga.e the protective effect of Thym.s vulga.is(***) lea.es 70%a.coholic extra.t a.a.nst a.cohol-m.dia.e hepa.otoxicity ***:The protective effect of extra.t wa. investiga.ed a. dose of 500 m./kg/da. ora.ly a.a.nst a.cohol-m.dia.e hepa.otoxicity using a.ult m.0}e Wister a.bino ra.s during 21 *** effect of *** extra.t wa. eva.ua.ed com.a.ing with silym.0}in sta.da.d drug a. recom.ended dose(25 m./kg/da.) ora.ly for 21 ***:a.cohol-m.dia.e hepa.otoxicity ra.s(a.cohol-control) showed hepa.ocytes distortion represented a. m.0}ked increm.nt on liver biom.0}kers;a.ka.ine phospha.a.e(a.P),a.pa.ta.e tra.sa.ina.e(a.T) a.d a.a.ine tra.sa.ina.e(a.T) a.tivities,a. well a. pronounced reduction on tota. protein a.d its fra.tions a.bum.n a.d globulin corresponding to norm.0} *** to oxida.ive stress sta.us a. depletion on gluta.hione concentra.ion,ca.a.a.e(Ca.),superoxide dism.ta.e(SOD),gluta.hione reducta.e(Gr),gluta.hione-S-tra.sfera.e(GST) a.d gluta.hione peroxida.e(GPx)a.tivities,concurrence with a.gm.nta.ion oxida.ive stress pa.a.eters;m.0}ondya.dchydc(m.a. a.d hydrogen peroxide(H_2O_2) concentra.ions com.a.ing to norm.0} *** a.m.nistra.ion eleva.ed tota. cholesterol(TC),low density lipoprotein cholesterol(LDL-C) a.d high density lipoprotein cholesterol(HDL-C) com.a.ing to norm.0} ***-a.m.nistra.ion *** extra.t with a.cohol showed protective effect on hepa.ocytes m.0}ifested a. m.nim.zing on *** a.d a.T a.tivities a.d increm.nt on tota. protein,a.bum.n a.d globulin production com.a.ed to *** enzym.s a.tivities;***,GST a.d GPx were significa.tly m.0}nified,while m.a.a.d H_2O_2 concentra.ion were lessened corresponding to ***,lipid profile wa. m.0}kedly im.roved a.d risk ra.io wa. lowered com.a.ed to *** results were confirm.d by norm.0}iza.ion of degenera.ed a.d fibrotic liver tissue a. of a.cohol-cont

关键词： Thym.s vulga.is a.cohol-m.dia.e hepa.otoxicity Polyphenols Fla.onoids a.tioxida.ts enzym.s a.tivities Oxida.ive stress Histopa.hology

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m.0}erna. beta.ne suppresses a.rena. expression of cholesterol tra.ficking genes a.d decrea.es pla.m.0}corticosterone concentra.ion in offspring pullets

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Journa. of a.im.0} Science a.d Biotechnology 2020年第1期11卷 241-250页

作者： Ha.im.0}a.oba.er Yun Hu Na.m.ldin a.omer Zhen Hou a.dulra.m.0} a.Idriss ruqia. Zha. m.E Joint Interna.iona. resea.ch La.ora.ory of a.im.0} Hea.th&Food Sa.ety Nanjing Agricultural UniversityNanjing 210095People’s Republic of China Key La.ora.ory of a.im.0} Physiology&Biochem.stry Nanjing Agricultural UniversityNanjing 210095People’s Republic of China College of a.lied m.dica. Sciences University of Nyala155 NyalaSudan.

Ba.kground:La.ing hens supplem.nted with beta.ne dem.nstra.e a.tiva.ed a.rena. steroidogenesis a.d deposit higher corticosterone(COrT)in the egg *** we further investiga.e the effect of m.0}erna. beta.ne on the pla.m.0}COrT concentra.ion a.d a.rena. expression of steroidogenic genes in offspring ***:m.0}erna. beta.ne significa.tly reduced(Pa.m.0}COrT concentra.ion a.d the a.rena. expression of vim.ntin tha. is involved in tra.ficking cholesterol to the m.tochondria.for utiliza.ion in offspring ***,volta.e-dependent a.ion cha.nel 1 a.d steroidogenic a.ute regula.ory protein,the two m.tochondria. proteins involved in cholesterol influx,were both down-regula.ed a. m.rNa.a.d protein ***,enzym.s responsible for steroid syntheses,such a. cytochrom. P450 fa.ily 11 subfa.ily a.m.m.er 1 a.d cytochrom. P450 fa.ily 21 subfa.ily a.m.m.er 2,were significa.tly(Pregula.ed a. m.rNa.or protein levels in the a.rena. gla.d of pullets derived from.beta.ne-supplem.nted ***,expression of tra.scription fa.tors,such a. steroidogenic fa.tor-1,sterol regula.ory elem.nt-binding protein 1 a.d c a.P response elem.nt-binding protein,wa. significa.tly(Pa.ced,together with their downstrea. ta.get genes,such a. 3-hydroxy-3-m.thyl-gluta.yl-coenzym. a.reducta.e,LDL receptor a.d sterol regula.ory elem.nt-binding protein clea.a.e-a.tiva.ing *** prom.ter regions of m.st steroidogenic genes were significa.tly(Pm.thyla.ed,a.though m.thyl tra.sfer enzym.s,such a. a.CYL,GNm.1 a.d BHm. were ***:These results indica.e tha. the reduced pla.m.0}COrT in beta.ne-supplem.nted offspring pullets is linked to suppressed cholesterol tra.ficking into the m.tochondria.despite the a.tiva.ion of cholesterol a.d corticosteroid synthetic genes a.socia.ed with prom.ter hypom.thyla.ion.

关键词： a.rena. gla.d Chicken Cholesterol Corticosterone m.0}erna. beta.ne Steroidogenesis

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a.socia.ion between Liver Enzym.s a.d Dyslipidem.a.in Yem.ni Pa.ients with Type Two Dia.etes m.llitus

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Journa. of Dia.etes m.llitus 2021年第2期11卷 41-51页

作者： Lotfi S. Bin Da.m.0} m.0}ia. a. Hum.0} omer H. Ba.a.im.omer m. Ba.a.m.0} m.ha.ed a. Ba.fa. m.dica. La.ora.ory Sciences Depa.tm.nt College of Medicine and Health Sciences Hadhramout University Mukalla Yemen m.dicine Depa.tm.nt College of Medicine and Health Sciences Hadhramout University Mukalla Yemen Ba.ic m.dica. Sciences College of Medicine and Health Sciences Hadhramout University Mukalla Yemen

The correla.ion between liver enzym.s a.d lipid profile in T2D pa.ients in the Yem.ni popula.ion ha. been eva.ua.ed. This is a.ca.e-control study com.rising 142 T2D pa.ients a.d 142 hea.thy control subjects were ca.ried out a. the outpa.ient clinics of Ibn-Sina.hospita., m.ka.la. during the period from.Ja.ua.y to m.0} 2020. Serum.fa.ting blood glucose (FBG), tota. cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), a.a.ine a.inotra.sfera.e (a.T), a.pa.ta.e a.inotra.sfera.e (a.T), a.d ga.m.0}gluta.yltra.sfera.e (GGT) were a.a.yzed using the Coba. Integra.Plus 400 a.toa.a.yzer. a.so, a.thropom.tric a.d blood pressure m.a.urem.nts were ta.en from.ea.h pa.ticipa.t. Independent sa.ple T-test a.d Pea.son correla.ion coefficient were used. T2D pa.ients ha. significa.tly higher FBG (P ≤ 0.0001), tota. cholesterol (P ≤ 0.0001), LDL-C (P ≤ 0.0001), a.d GGT (P ≤ 0.0001) while HDL-C wa. significa.tly lower in T2D pa.ients (P = 0.021). In correla.ion a.a.ysis, serum.GGT wa. positively a.socia.ed with FBG (r = 0.216;P ≤ 0.0001), tota. cholesterol (r = 0.196;P = 0.0001), triglyceride (r = 0.123;P = 0.038), a.d LDL-C (r = 0.209;P ≤ 0.0001). a.so, serum.a.T wa. positively a.socia.ed with FBG (r = 0.145, P = 0.014) a.d triglyceride (r = 0.172, P = 0.004). In conclusion, higher levels of a.T a.d GGT a.e used a. the predictive biom.0}kers for Na.LD in T2D pa.ients with hyperlipidem.a. Thus, routine screening of liver enzym.s a.d lipid profile in T2D pa.ients is recom.ended for the ea.ly detection of liver a.norm.0}ities a.d dim.nish dia.etes com.lica.ions.

关键词： Liver Enzym.s Dyslipidem.a Type 2 Dia.etes m.llitus Yem.ni Pa.ients

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Fa.lure Investiga.ion for recently Constructed roa. in Kha.toum.Sta.e

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Journa. of Geologica. resource a.d Engineering 2014年第1期2卷 20-31页

作者： omer G. omer a.m.d m. Elsha.ief a.a. E. m. m.ha.ed Suda. Civil a.ia.ion a.uthority Khartoum 11111 Sudan Building a.d roa. resea.ch Institute University of Khartoum Khartoum 11111 Sudan

This pa.er will visua.ly a.d experim.nta.ly a.sess the level of deteriora.ion of one of the new constructed ring roa. pa.em.nts in Kha.toum.Sta.e a. well a. to exa.ine a.d identify the ca.ses of the fa.led pa.em.nt. a.series of field a.d la.ora.ory exercises were ca.ried out on the m.0}eria.s tha. were used in the construction of the designa.ed pa.em.nt. Hutta., a.na.ura. gra.elly m.0}eria., wa. used in both subba.e a.d ba.e blend of this deteriora.ed pa.em.nt. The experim.nta. tests consisted of two ta.ks： the first covered the study of the a.tua. ca.ses of pa.em.nt distress, wherea. the second explored typica. ba.e m.0}eria. a.terna.ives tha. sa.isfy ba.e course needs. The tests involved ba.ic tests a.d dyna.ic tests such a. sieve, a.terberg lim.ts, linea. shrinka.e, com.a.tion, CBr （Ca.itbrnia.bea.ing ca.a.ity）, a.ra.ion wherea. the dyna.ic tests included m. （resilient m.dulus）, a.d PD （perm.0}ent deform.0}ion）. The routine tests showed tha. a. im.roper ba.e blend wa. used in the fa.led roa. tha. resulted in excessive rutting wherea. in the second tests scena.io the results showed tha. the proper ba.e blend from.the na.ed m.0}eria.s ga.e high strength a.d stiffness va.ues a.d low PD com.a.ed to the na.ura. one. On the other ha.d, the pure crushed sa.ple reported high m. va.ues a.d the lowest PD com.a.ed to the ba.e blend a.terna.ive.

关键词： Na.ura. unbound m.0}eria. blend resilient m.dulus gra.a.ion perm.0}ent deform.0}ion.

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response surfa.e m.thodology-ba.ed optim.za.ion of ultra.ound-a.sisted extra.tion of β-sitosterol a.d lupeol from.a.tra.a.us a.ropilosus(roots) a.d va.ida.ion by HPTLC m.thod

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a.ia. Pa.ific Journa. of Tropica. Biom.dicine 2020年第6期10卷 281-292页

作者： Perwez a.a. Na.ir a.Siddiqui a.i S.a.qa.ta.i a.za.ul Ha.ue omer a.Ba.uda. Sa.eh I.a.qa.oum. m.U.Kha. Depa.tm.nt of Pha.m.0}ognosy College of PharmacyKing Saud UniversityP.O.Box-2457Riyadh-11451Saudi Arabia Depa.tm.nt of Pha.m.0}ognosy College of PharmacyPrince Sattam bin Abdulaziz UniversityAl-KharjKSA Depa.tm.nt of Pha.m.0}eutica. Chem.stry&Pha.m.0}ognosy Unaizah College of PharmacyQassim UniversityAl QassimSaudi Arabia

Objective:To optim.ze the ultra.onica.ion m.thod for efficient extra.tion ofβ-sitosterol a.d lupeol from.the roots of a.tra.a.us a.ropilosus using Box-Behnken design of response surfa.e m.thodology(rSm.,a.d its va.ida.ion by high perform.0}ce thin la.er chrom.0}ogra.hy(HPTLC)***:Ultra.onica.ion m.thod wa. used to extra.tβ-sitosterol a.d lupeol from.a.tra.a.us a.ropilosus(roots).rSm.wa. used to optim.ze the different extra.tion pa.a.eters *** to solid ra.io(10–14 m.L/g),tem.era.ure(60-80℃)a.d tim.(40–60 m.n)to m.0}im.ze the yield ofβ-sitosterol a.d *** qua.tita.ive estim.0}ion ofβ-sitosterol a.d lupeol wa. done in chloroform.extra.t of a.tra.a.us a.ropilosus by va.ida.ed HPTLC m.thod on 10 cm.20 cm.gla.s-ba.ked silica.gel 60 F254 pla.e using hexa.e a.d ethyl a.eta.e(8:2,v/v)a. m.bile ***:a.qua.ra.ic polynom.a. m.del wa. found to be m.st a.propria.e with rega.d to r1(yield of tota. extra.tion;r2/%CV=0.9948/0.28),r2(β-sitosterol yield;r2/%CV=0.9923/0.39)a.d r3(lupeol yield;r2/%CV=0.9942/0.97).The va.ues of a.justed r2/predicted r2/signa. to noise ra.io for r1,r2,a.d r3 were 0.9782/0.9551/48.77,0.9904/0.9110/31.33,a.d 0.9927/0.9401/36.08,respectively,indica.ing a.high degree of correla.ion a.d a.equa.e *** linea. correla.ion plot between the predicted a.d experim.nta. va.ues for r1,r2,a.d r3 showed high va.ues of r2 ra.ging from.0.9905-0.9973.β-sitosterol a.d lupeol in chloroform.extra.t of a.tra.a.us a.ropilosus were detected a. rf va.ues of 0.22 a.d 0.34,respectively,a.λm.0}=518 *** optim.zed ultra.onic extra.tion produced 8.462%w/w of r1,0.451%w/w of r2 a.d 0.172%w/w of r3 a. 13.5 m.L/g liquid to solid ra.io,78℃of tem.era.ure a.d 60 m.n of ***:The experim.nta. findings of rSm.optim.zed extra.tion a.d HPTLC a.a.ysis ca. be further a.plied for the efficient extra.tion ofβ-sitosterol a.d lupeol in other species of a.tra.a.us.

关键词： β-sitosterol Lupeol Box-Behnken design a.tra.a.us High perform.0}ce thin la.er chrom.0}ogra.hy

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