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Nucle.r Factor-Kappa B and Othe. Oxidative.Stre.s Biomarke.s in Se.um.of Autistic Childre.

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Ope. Journal of m.le.ular and Inte.rative.Physiology 2015年第1期5卷 18-27页

作者： omar m. e. abdel-salam e.1}n R. Youne.s Nadia A. m.ham.e. Walaa A. Abu e.ham.d De.artm.nt of Toxicology and Narcotics National Research Centre Cairo Egypt De.artm.nt of m.dical Bioche.0}stry National Research Centre Cairo Egypt De.artm.nt of Pe.iatrics Faculty of Medicine Cairo University Cairo Egypt

The.aim.of the.pre.e.t study was to inve.tigate.the.status of oxidative.stre.s in the.se.um.of childre. affe.te. with autism.spe.trum.disorde.. Twe.ty autistic childre. age. 3 to 12 ye.rs, we.e.ge.de. and age.m.tche. with 20 typically de.e.oping childre.. Change. in the.le.e.s of the.re.ox-se.sing transcription factor nucle.r factor-kappa B (NF-κB) was m.asure. in se.um.of autistic childre. and controls. Othe. oxidative.stre.s biomarke.s such as m.londialde.yde. re.uce. glutathione. total antioxidant capacity, catalase.activity, and paraoxonase.1 activity we.e.de.e.m.ne. in se.um.as we.l. Significant incre.se.was obse.ve. in se.um.NF-κB of autistic childre. com.are. to that in controls (by 138.6%). The.e.was also m.rke. incre.se.in m.londialde.yde.le.e. by 87.3% in autistic patie.ts. m.anwhile. the.e.we.e.significant de.re.se. in re.uce. glutathione.(by 24%), catalase.activity (by 40.8%), paraoxonase.1 activity (by 36.6%), and total antioxidant capacity (by 36.5%) com.are. to the.control group. The.e.data cle.rly de.0}nstrate.incre.se. oxidative.stre.s in se.um.of autistic childre. and sugge.t that the.NF-κB signaling pathway is activate. in autism. possibly due.to incre.se. oxidative.burde..

关键词： Autism Spe.trum Disorde. Oxidative Stre.s Re.ox-Se.sing Transcription Factor

GRe.N SYNTHe.IS OF ANTIBACTe.IAL CHITOSAN FILm. LOADe. WITH SILVe. NANOPARTICLe.

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Chine.e.Journal of Polym.r Scie.ce 2013年第7期31卷 984-993页

作者： Ne.m. A. Re.ad omar e. abdel salam e.ab F. Abadir Farid A. Harraz Sanitary & e.vironm.ntal e.gine.ring De.artm.nt Housing & Building National Research Center De.artm.nt of Che.0}cal e.gine.ring Faculty of EngineeringCairo University Advance. m.te.ials Te.hnology De.artm.nt Central Metallurgical R & D Institute

An e.o-frie.dly che.0}cal re.uction m.thod was succe.sfully use. for the.pre.aration of chitosan （CTS） com.osite.film. loade. with silve. nanoparticle. （AgNPs） by se.f asse.0}ly m.thod using poly（e.hyle.e.glycol） as both re.ucing and stabilizing age.t. UV-Vis spe.tra of the.pre.are. chitosan loade. silve. nanoparticle. （CTSLAg） film. re.e.l that full re.uction of silve. ions to silve. nanoparticle. take. place.at 90 ℃. The.e.fe.t of re.ction conditions on the.silve. nanoparticle. form.tion was inve.tigate. using UV-Vis spe.trophotom.te.. The.m.rphology of the.film. was te.te. by scanning e.e.tron m.croscopy （Se.0}. The.DSC curve. showe. that the.CTSLAg film.had a favorable.com.atibility and he.t stability. AgNPs we.e.confirm.d by XRD and UV-Vis spe.troscopy. The.Te.0}findings re.e.le. that the.silve. nanoparticle. synthe.ize. we.e.sphe.ical in shape.with uniform.dispe.sal, and by incre.sing CTS：Pe. ratio large. silve. nanoparticle. could be.obtaine.. The.re.ults of antibacte.ial study re.e.l that the.pre.are. nanoe.m.osite.film. e.hibite. pote.tial inhibition.

关键词： Chitosan Silve. nanoparticle. Antibacte.ial activity.

Adsorptive.re.0}val of iron and m.ngane.e.ions from.aque.us solutions with m.croporous chitosan/polye.hyle.e.glycol ble.d m.m.rane

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Journal of e.vironm.ntal Scie.ce. 2012年第8期24卷 1425-1432页

作者： Ne.m. A.Re.ad omar e.abdel salam e.ab F.Abadir Farid A.Harraz Sanitary&e.vironm.ntal De.artm.nt Housing&Building National Research Center87 el Tahrir st.DokkiEgypt De.artm.nt of Che.0}cal e.gine.ring Faculty of EngineeringCairo UniversityGizaEgypt Advance. m.te.ials Te.hnology De.artm.nt Central Metallurgical R&D InstituteHelwanEgypt

m.croporous chitosan （CS） m.m.rane. we.e.dire.tly pre.are. by e.traction of poly（e.hyle.e.glycol）（Pe.） from.CS/Pe. ble.d m.m.rane.and we.e.e.am.ne. for iron and m.ngane.e.ions re.0}val from.aque.us solutions. The.diffe.e.t variable. affe.ting the.adsorption capacity of the.m.m.rane. such as contact tim., pH of the.sorption m.dium. and initial m.tal ion conce.tration in the.fe.d solution we.e.inve.tigate. on a batch adsorption basis. The.affinity of CS/Pe. ble.d m.m.rane.to adsorb Fe.II） ions is highe. than that of m.（II） ions, with adsorption e.uilibrium.achie.e. afte. 60 m.n for Fe.II） and m.（II） ions. By incre.sing CS]Pe. ratio in the.ble.d m.m.rane.the.adsorption capacity of m.tal ions incre.se.. Am.ng all param.te.s, pH has the.m.st significant e.fe.t on the.adsorption capacity, particularly in the.range.of 2.9-5.9. The.incre.se.in CS/Pe. ratio was found to e.hance.the.adsorption capacity of the.m.m.rane.. The.e.fe.ts of initial conce.tration of m.tal ions on the.e.te.t of m.tal ions re.0}val we.e.inve.tigate. in de.ail. The.e.pe.im.ntal data we.e.be.te. fitte. to Fre.ndlich e.uation than Langm.ir. In addition, it was found that the.iron and m.ngane.e.ions adsorbe. on the.m.m.rane. can be.e.fe.tive.y de.orbe. in 0.1 m.l/L HCl solution （up to 98% de.orption e.ficie.cy） and the.ble.d m.m.rane. can be.re.se. alm.st without loss of the.adsorption capacity for iron and m.ngane.e.ions.

关键词： chitosan ble.d m.m.rane iron and m.ngane.e.ions adsorption

Pre.e.tive.e.fe.ts of cannabis on ne.rotoxic and he.atotoxic activitie. of m.lathion in rat

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Asian Pacific Journal of Tropical m.dicine 2018年第4期11卷 272-279页

作者： omar m.e.abdel-salam Am.ny A Sle.m.e.1}n R Youne.s Fatm. A.m.rsy De.artm.nt of Toxicology and Narcotics National Research Centre De.artm.nt of Pharm.cology National Research Centre De.artm.nt of m.dical Bioche.0}stry National Research Centre De.artm.nt of Pathology National Research Centre

Obje.tive. To inve.tigate.the.e.fe.t of Cannabis sativa e.tract on the.de.e.opm.nt of ne.roand he.ato-toxicity cause. by m.lathion inje.tion in rats. m.thods: The.e.tract of Cannabis sativa was obtaine. from.the.plant re.in by chloroform.tre.tm.nt. Δ~9-Te.rahydrocannabinol conte.t of the.e.tract(20%) was quantifie. using gas chrom.tography–m.ss spe.trom.try. The.dose. of cannabis e.tract we.e.e.pre.se. as Δ~9-te.rahydrocannabinol conte.t of 10 or 20 m./kg. m.lathion(150 m./kg) was intrape.itone.lly adm.niste.e. followe. afte. 30 m.n by the.cannabis e.tract(10 or 20 m./kg, subcutane.usly). Rats we.e.e.thanize. 4 h late.. m.londialde.yde.m.A), re.uce. glutathione.GSH), nitric oxide.and paraoxonase.1(PON-1) activity we.e.de.e.m.ne. in brain and live.. Brain 5-lipoxyge.ase.and butyrylcholine.te.ase.BChe. activity we.e.m.asure. as we.l. Histopathological e.am.nation of brain and live. tissue.was also pe.form.d. Re.ults: Com.are. to controls, m.lathion re.ulte. in incre.se. oxidative.stre.s in brain and live.. m.A and nitric oxide.conce.trations we.e.significantly incre.se.(Pe.re.se. with re.pe.t to control le.e.s(Pm.lathion also significantly inhibite. PON-1 and BChe.activitie. but had no e.fe.t on brain 5-lipoxyge.ase. Brain m.A conce.trations we.e.not alte.e. by cannabis tre.tm.nt. Cannabis at 20 m./kg, howe.e., cause. significant incre.se.in nitric oxide.and re.tore. the.GSH and PON-1 activity. Brain BChe.activity significantly de.re.se. by 26.1%(Pe. tre.tm.nt with 10 m./kg cannabis. Cannabis showe. no e.fe.t on brain 5-lipoxyge.ase. On the.othe. hand, rats tre.te. with cannabis e.hibite. significantly highe. le.e.s of live. m.A, nitric oxide.and PON-1 activity com.are. with the.m.lathion control group. Rats tre.te. with only m.lathion e.hibite. spongiform.change., ne.ronal dam.ge.in the.ce.e.ral corte. and de.e.e.ation of som. Purkinje.ce.ls in the.ce.e.e.lum. The.e.we.e.also he.atic vacuolar de.e.e.ation and dilate. an

关键词： Cannabis sativa m.lathion Live. dam.ge Brain dam.ge Oxidative.stre.s Paraoxonase 5-Lipoxyge.ase

Ne.roprote.tion by m.soprostol against rote.one.induce. ne.rotoxicity in rat brain

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Asian Pacific Journal of Tropical m.dicine 2018年第1期11卷 40-47页

作者： omar m.e.abdel-salam Am.ny A Sle.m.e.1}n R Youne.s Nadia A m.ham.e. e.ayat A omara De.artm.nt of Toxicology and Narcotics National Research Centre De.artm.nt of Pharm.cology National Research Centre De.artm.nt of m.dical Bioche.0}stry National Research Centre De.artm.nt of Pathology National Research Centre

Obje.tive. To inve.tigate.the.e.fe.t of the.prostaglandin e. analogue.m.soprostol on oxidative.stre.s and ne.rode.e.ation cause. by subcutane.us rote.one.adm.nistration in rats. m.thods:Rote.one.was adm.niste.e. in a dose.of 1.5 m./kg e.e.y othe. day for 2 we.ks. Starting from.the.1 st day of rote.one.inje.tion, rats we.e.subcutane.usly tre.te. with m.soprostol at dose. of10, 100 or 1 000 μg/kg. Rats we.e.e.aluate. for brain lipid pe.oxidation(m.londialde.yde.m.A), re.uce. glutathione.GSH), nitric oxide.NO) le.e.s, and paraoxonase.1(PON-1) *** conce.trations of the.anti-apoptotic prote.n B ce.l/lym.hom.-2(Bcl-2) we.e.de.e.m.ne. in the.striatum. Histopathologic e.am.nation and the.e.pre.sion of inducible.nitric oxide.synthase.iNOS) in the.ce.e.ral corte. and striatum.we.e.also pe.form.d. Re.ults: Com.are. with the.ve.icle.tre.te. group, rote.one.cause. a significant incre.se.in brain lipid proxidation(m.A)by 61%(Pm.anie. by an incre.se.in NO by 73.1%(Pe.re.se.in GSH conce.tration by 29.4%(Pe.re.se. by63.0%(Pe.re.se. by 27.9%(Pe.pe.t to the.corre.ponding control value. Brain se.tions from.rote.one.tre.te. rats showe. e.te.sive.dark pyknotic and apoptotic nucle. in ne.rons, shrunke. cytoplasm.and pe.ine.ronal *** also cause. pronounce. e.pre.sion of iNOS in the.ce.e.ral corte. and *** with m.soprostol at dose. of 100 and 1 000 μg/kg re.ulte. in de.re.se. brain m.A(by 16.5%-23.0%)(Pe.e.s(by 37.1%-40.7%)(Pe.se. GSH conce.trations(by 18.8%-30.1%)(Pe.se. by80.0%-114.8%(Pm.soprostol at 100 and 1 000 μg/kg, re.pe.tive.y. In addition,m.soprostol tre.tm.nt re.tore. striatal Bcl-2 conce.trations to its norm.l value. m.soprostol tre.tm.nt re.ulte. in m.rke.ly re.uce. brain injury and de.re.se. iNOS e.pre.sion in the.ce.e.

关键词： m.soprostol Rote.one Brain oxidative.stre.s B ce.l/lym.hom.-2 Paraoxonase

Ace.ylcholine.te.ase.butyrylcholine.te.ase.and paraoxonase.1 activitie. in rats tre.te. with cannabis,tram.dol or both

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Asian Pacific Journal of Tropical m.dicine 2016年第11期9卷 1066-1071页

作者： omar m.e.abdel-salam e.1}n R.Youne.s Yasse. A.Khadrawy Am.ny A.Sle.m De.artm.nt of Toxicology and Narcotics National Re.e.rch Ce.tre Cairo De.artm.nt of m.dical Bioche.0}stry National Re.e.rch Ce.tre Cairo De.artm.nt of Physiology National Re.e.rch Ce.tre Cairo De.artm.nt of Pharm.cology National Re.e.rch Ce.tre Cairo

Obje.tive.To inve.tigate.the.e.fe.t of Cannabis sativa re.in and/or tram.dol,two com.only drugs of abuse.on ace.ylcholine.te.ase.and butyrylcholine.te.ase.activitie. as a possible.choline.gic biomarke.s of ne.rotoxicity induce. by the.e.***:rats we.e.tre.te. with cannabis re.in(5,10 or 20 m./kg)(e.uivale.t to the.active.constitue.t A'-te.rahydrocannabinol),tram.dol(5,10 and 20 m./kg) or tram.dol(10 m./kg)com.ine. with cannabis re.in(5,10 and 20 m./kg) subcutane.usly daily for 6 ***(AChe. and butyrylcholine.te.ase.BChe. activitie. we.e.m.asure. in brain and *** also m.asure. the.activity of paraoxonase.1(PONl) in se.um.of rats tre.te. with the.e.***:(i) AChe.activity in brain incre.se. afte. 10-20 m./kg cannabis re.in(by 16.3%-36.5%).AChe.activity in brain did not change.afte. tre.tm.nt with 5-20 m./kg *** adm.nistration of both cannabis re.in(5,10 or 20 m./kg) and tram.dol(10 m./kg) re.ulte. in de.re.se. brain AChe.activity by 14.1%,12.9%and 13.6%,re.pe.tive.y;(ii) BChe.activity in se.um.was m.rke.ly and dose.de.e.de.lly inhibite. by cannabis re.in(by 60.9%-76.9%).BChe.activity also de.re.se. by 17.6%-36.5%by 10-20m./kg tram.dol and by 57.2%-63.9%by the.cannabis re.in/tram.dol com.ine. tre.tm.nt;(iii)Cannabis re.in at dose.of 20 m./kg incre.se. se.um.PONl activity by 25.7%.In contrast,tram.dol give. at 5,10 and 20 m./kg re.ulte. in a dose.de.e.de.t de.re.se.in se.um.PON1 activity by 19%,36.7%,and 46.1%,***,tre.tm.nt with cannabis re.in plus tram.dol re.ulte. in 40.2%,35.8%,30.7%inhibition of PONl activity com.are. to the.saline.***:the.e.data sugge.t that cannabis re.in e.e.ts diffe.e.t e.fe.ts on AChe.and BChe.activitie. which could contribute.to the.m.m.ry proble.0} and the.de.line.in cognitive.function in chronic use.s.

关键词： Cannabis sativa Tram.dol Choline.te.ase. m.m.ry Cognitive.de.line

e.aluation of the.8th AJCC staging syste.0}for pathologically ve.sus clinically stage. pancre.tic ade.ocarcinom.: A tim. to re.isit a dogm.?

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He.atobiliary & Pancre.tic Dise.se. Inte.national 2018年第1期17卷 64-69页

作者： omar abdel-Rahm.n Clinical Oncology De.artm.nt Faculty of Medicine Ain Shams University

Background: The.8 th e.ition of the.Am.rican Joint Com.itte. on Cance.(AJCC) staging syste.0}for pancre.tic e.ocrine.ade.ocarcinom. has be.n re.e.se.. The.curre.t study se.ks to asse.s the.7 th and 8 th e.itions am.ng patie.ts re.iste.e. within the.surve.llance. e.ide.0}ology and e.d re.ults(Se.R) ***: Se.R database.2010–2013) has be.n acce.se. through Se.R*Stat program.and AJCC 8 th e.ition stage. we.e.re.onstructe. utilizing the.collaborative.stage.de.criptions. Kaplan–m.ie. analysis of ove.all survival and pancre.tic cance.-spe.ific survival analyse.(according to both 7 th and 8 th e.itions and according to whe.he. pathological or clinical staging we.e.conducte.) has be.n pe.form.d. m.ltivariate.analysis of factors affe.ting pancre.tic cance.-spe.ific survival was also conducte. through a Cox proportional hazard ***: A total of 18 948 patie.ts with pancre.tic ade.ocarcinom. we.e.ide.tifie. in the.pe.iod from.2010–2013. Pancre.tic cance.-spe.ific survival am.ng pathologically stage. patie.ts and according to the.8 th e.ition showe. significant diffe.e.ce. for all pair wise.com.arisons am.ng diffe.e.t stage.(P e.ce.t for the.com.arison be.we.n stage.IA and stage.IB(P = 0.307) and the.com.arison be.we.n stage.IB and stage.IIA(P = 0.116). m.re.ve., P value.for stage.IA vs IIA was 0.014; while.pancre.tic cance.-spe.ific survival according to the.7 th e.ition am.ng pathologically stage. patie.ts showe. significant diffe.e.ce. for all pair wise.com.arisons am.ng diffe.e.t stage.(P e.ce.t for the.com.arison be.we.n IA and IB(P = 0.072), the.com.arison be.we.n stage.IIA and stage.IIB(P = 0.065), the.com.arison be.we.n stage.IIA and stage.Ⅲ(P = 0.059) and the.com.arison be.we.n IIB and Ⅲ(P = 0.595).Am.ng clinically stage. patie.ts(i.e. those.who did not unde.go initial radical surge.y), the.prognostic pe.form.nce.of both 7 th and 8 th stage. for both ove.all survival and pancre.tic cance.-spe.ific survival was ***: Th

关键词： Pancre.tic cance. AJCC Se.R Prognosis

De.e.m.nation of de.ta-9-te.rahydrocannabinol conte.t of cannabis se.zure. in e.ypt

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Asian Pacific Journal of Tropical m.dicine 2017年第3期10卷 291-294页

作者： Ahm.d m.A.Soule.0}n Alaa e.-Din m.Gaafar omar m.abdel-salam Shaim.a A.e.She.ine. De.artm.nt of Phytoche.0}stry and Plant Syste.0}tic National Research CentreCairoEgypt De.artm.nt of Photoche.0}stry National Research CentreCairoEgypt De.artm.nt of Toxicology and Narcotics National Research CentreCairoEgypt

Obje.tive.To de.e.m.ne.the.de.ta-9-te.rahydrocannabinol(THC)conte.t of cannabis se.zure. in ***:Unhe.te. and he.te. e.tracts of cannabis se.zure. we.e.pre.are. from.the.drie. flowe.ing tops and le.ve.(m.rijuana)or from.the.re.in(hashish)and subje.te. to analysis using high pe.form.nce.liquid chrom.tography(HPLC).Re.ults:The.he.te. re.in e.tract had the.pe.k of THC in a re.ative.ratio of 31.34%,while.e.tracting the.re.in dire.tly without he.ting containe. only 18.34%of *** the.othe. hand,m.rijuana showe. m.nim.m.pe.ce.tage.of THC at 11.188% on he.ting and 9.55% without ***:The.e.re.ults indicate.the.high pote.cy of the.abuse. cannabis plant in the.illicit e.yptian m.rke..

关键词： Cannabis Hashish m.rijuana THC High pe.form.nce.liquid chrom.tography

Bougainville. spe.tabilis flowe.s e.tract prote.ts against the.rote.one.induce. toxicity

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Asian Pacific Journal of Tropical m.dicine 2017年第5期10卷 457-466页

作者： omar m.e.abdel-salam e.1}n R.Youne.s Nadia A.Ahm.d Saye. A.e.-Toum. Ahm.d m.A.Soule.1}n Ne.m.e. Shaffie.Dalia m.Aboue.fadl De.artm.nt of Toxicology and Narcotics National Research CentreCairoEgypt De.artm.nt of m.dical Bioche.0}stry National Research CentreCairoEgypt De.artm.nt of Che.0}stry of Tannins National Research CentreCairoEgypt De.artm.nt of Phytoche.0}stry and Plant Syste.0}tic National Research CentreCairoEgypt De.artm.nt of Pathology National Research CentreCairoEgypt

Obje.tive.To inve.tigate.the.e.fe.t of two e.tracts of Bougainville. spe.tabilis(B. spe.tabilis) flowe.s with ye.low and pink/purple.on brain oxidative.stre.s and ne.ronal dam.ge.cause. in rats by syste.0}c rote.one.inje.tion. m.thods:Rote.one.1.5 m./kg was give. thre. tim.s pe. we.k alone.or in com.ination with B. spe.tabilis flowe.s e.tracts(25 m. or 50 m.) via the.subcutane.us route.for 2 we.ks. Brain conce.trations of the.lipid pe.oxidation m.rke. m.londialde.yde.m.A),re.uce. glutathione.nitric oxide.nitrite.,the.pro-inflam.atory cytokine.inte.le.kin-1be.a(Il-1β) as we.l as butyrylcholine.te.ase.and paraoxonase.1(PON-1) activitie.,we.e.de.e.m.ne.. Histopathology and caspase.3 im.unohistoche.0}stry we.e.also pe.form.d. Re.ults:Rote.one.re.ulte. in significant incre.se. of brain m.A(the.product of lipid pe.oxidation),and nitric oxide.conte.t along with de.re.se. brain re.uce. glutathione. The.e.we.e.also m.rke. and significant inhibition of brain PON-1 and BCh e.activitie. and incre.se. Il-1β in brain of rote.one.tre.te. rats. B. spe.tabilis flowe.s e.tract itse.f re.ulte. in brain oxidative.stre.s incre.sing both lipid pe.oxidation and nitrite.conte.t whilst inhibiting PON-1 activity. The.ye.low flowe.s e.tract inhibite. BCh e.activity and incre.se. brain Il-1β. Whe. give. to rote.one.tre.te. rats,B. spe.tabilis e.tracts,howe.e.,de.re.se. lipid pe.oxidation while.the.r low adm.niste.e. dose. incre.se. brain GSH. Brain nitrite.de.re.se. by the.pink e.tract but showe. furthe. incre.se.by the.ye.low e.tract. e.the. e.tract,howe.e.,cause. furthe. inhibition of PON-1 activity while.the.ye.low e.tract re.ulte. in furthe. inhibition of BChe.activity. Histopathological studie. indicate. that both e.tracts prote.te. against brain,live. and kidne. dam.ge.cause. by the.toxicant. Conclusions:The.e.data indicate.that B. spe.tabilis flowe.s e.tracts e.e.t prote.tive.e.fe.t against the.toxic e.fe.ts of rote.one.on brain,live. and kidne.. B. spe.tabilis flowe.s e.tracts de.re.se.

关键词： Bougainville. spe.tabilis Flowe.s e.tract Rote.one Oxidative.stre.s Parkinson’s dise.se