Nuclear Factor-Kappa B and Other Oxidative Stress Biomarkers in Serum of Autistic Children
Nuclear Factor-Kappa B and Other Oxidative Stress Biomarkers in Serum of Autistic Children作者机构：Department of Toxicology and Narcotics National Research Centre Cairo Egypt Department of Medical Biochemistry National Research Centre Cairo Egypt Department of Pediatrics Faculty of Medicine Cairo University Cairo Egypt
出 版 物：《Open Journal of Molecular and Integrative Physiology》 (分子和综合生理学期刊（英文）)
年 卷 期：2015年第5卷第1期
页 面：18-27页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Autism Spectrum Disorder Oxidative Stress Redox-Sensing Transcription Factor
摘 要：The aim of the present study was to investigate the status of oxidative stress in the serum of children affected with autism spectrum disorder. Twenty autistic children aged 3 to 12 years, were gender and age-matched with 20 typically developing children. Changes in the levels of the redox-sensing transcription factor nuclear factor-kappa B (NF-κB) was measured in serum of autistic children and controls. Other oxidative stress biomarkers such as malondialdehyde, reduced glutathione, total antioxidant capacity, catalase activity, and paraoxonase 1 activity were determined in serum as well. Significant increase was observed in serum NF-κB of autistic children compared to that in controls (by 138.6%). There was also marked increase in malondialdehyde level by 87.3% in autistic patients. Meanwhile, there were significant decreases in reduced glutathione (by 24%), catalase activity (by 40.8%), paraoxonase 1 activity (by 36.6%), and total antioxidant capacity (by 36.5%) compared to the control group. These data clearly demonstrate increased oxidative stress in serum of autistic children and suggest that the NF-κB signaling pathway is activated in autism, possibly due to increased oxidative burden.
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