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Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory biomarkers and susceptibility to diabetic nephropathy in Asian Indians

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World Journal of Diabetes 2017年第2期8卷 66-73页

作者： Amar Gautam Stuti Gupta Mohit Mehndiratta Mohini Sharma Kalpana Singh om P Kalra Sunil Agarwal Jasvinder K Gambhir Department of Medicine University College of Medical Sciences (University of Delhi) and G.T.B. Hospital Molecular Diagnostic Laboratory Department of Biochemistry University College of Medical Sciences (University of Delhi) and G.T.B. Hospital

AIM To investigate the association of NFKB1 gene-94 ATTG insertion/deletion(rs28362491) polymorphism with inflammatory markers and risk of diabetic nephropathy in Asian *** A total of 300 subjects were recruited(100 each), normoglycemic,(NG); type 2 diabetes mellitus(T2DM) without any complications(DM) and T2 DM with diabetic nephropathy [DM-chronic renal disease(CRD)]. Analysis was carried out by polymerase chain reaction-restriction fragment length polymorphism and ELISA. Pearson's correlation, analysis of variance and logistic regression wereused for statistical *** The allelic frequencies of-94 ATTG insertion/deletion were 0.655/0.345(NG), 0.62/0.38(DM) and 0.775/0.225(DM-CRD). The-94 ATTG ins allele was associated with significantly increased levels of urinary monocyte chemoattractant protein-1(u MCP-1); u MCP-1(P = 0.026) and plasma tumor necrosis factor-alpha(TNF-α); TNF-α(P = 0.030) and almost doubled the risk of diabetic nephropathy(OR = 1.91, 95%CI: 1.080-3.386, P = 0.025).CONCLUSION-94 ATTG ins/ins polymorphism might be associated with increased risk of developing nephropathy in Asian Indian subjects with diabetes mellitus.

关键词： Diabetic nephropathy Inflammation NFKB1 -94 ATTG ins/del polymorphism Urinary monocyte chemoattractant protein-1 Tumor necrosis factor-alpha

A Practical Solution for Location Estimation in Manually Deployed Wireless Sensor Networks

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Wireless Sensor Network 2011年第4期3卷 117-120页

作者： om Prakash Sahu Tarun Dubey 不详

This paper addresses the existing research and adds another aspect of functionality by incorporating pertinent sensor nodes to provide a dynamic location discovery and estimation. The software used provides an easy graphical user interface to visualize a particular location in accordance with geographical latitude and longitude. A simple real time location estimation technique is worked out for wireless sensor networks based on manual deployment of sensors. The proposed scheme finds more efficient solutions with less quantity of sensors as compared to existing deployment schemes. The set up is evaluated exclusively in real environments using IRIS sensor nodes supported by a global positioning system module to provide visualization of an outdoor location. The results are offered by Google Earth application.

关键词： Wireless Sensor Network (WSN) Global Positioning System (GPS) Localization Sensor Node IRIS Sensor

Designing Intrusion Detection System for Web Documents Using Neural Network

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Communications and Network 2010年第1期2卷 54-61页

作者： Hari om Tapas K. Sarkar 不详

Cryptographic systems are the most widely used techniques for information security. These systems however have their own pitfalls as they rely on prevention as their sole means of defense. That is why most of the organizations are attracted to the intrusion detection systems. The intrusion detection systems can be broadly categorized into two types, Anomaly and Misuse Detection systems. An anomaly-based system detects com-puter intrusions and misuse by monitoring system activity and classifying it as either normal or anomalous. Misuse detection systems can detect almost all known attack patterns;they however are hardly of any use to de-tect yet unknown attacks. In this paper, we use Neural Networks for detecting intrusive web documents avail-able on Internet. For this purpose Back Propagation Neural (BPN) Network architecture is applied that is one of the most popular network architectures for supervised learning. Analysis is carried out on Internet Security and Acceleration (ISA) server 2000 log for finding out the web documents that should not be accessed by the unau-thorized persons in an organization. There are lots of web documents available online on Internet that may be harmful for an organization. Most of these documents are blocked for use, but still users of the organization try to access these documents and may cause problem in the organization network.

关键词： intrusion detection system neural network back propagation network anomaly detection misuse detection

Surveying the genomic landscape of silage-quality traits in maize(Zea mays L.)

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The Crop Journal 2023年第6期11卷 1893-1901页

作者： Jatin Sharma Shubham Sharma Krishna Sai Karnatam om Prakash Raigar Chayanika Lahkar Dinesh Kumar Saini Sushil Kumar Alla Singh Abhijit Kumar Das Priti Sharma Ramesh Kumar Department of Plant Breeding and Genetics Punjab Agricultural UniversityLudhianaPunjab 141004India School of Agricultural Biotechnology Punjab Agricultural UniversityLudhianaPunjab 141004India ICAR-Indian Institute of Maize Research LudhianaPunjab 141004India Department of Plant and Soil Science Texas Tech UniversityLubbockTX 79409-2122USA

Despite the longstanding importance of silage as a critical feed source for ruminants,its quality improvement has been largely *** numerous quantitative trait loci(QTL)and genes affecting silage quality in maize have been reported,only a few have been effectively incorporated into breeding *** this gap,the present study undertook a comprehensive meta-QTL(MQTL)analysis involving 523 QTL associated with silage-quality traits collected from 14 published *** the 523 QTL,405 were projected onto a consensus map comprising 62,424 genetic markers,resulting in the identification of 60 MQTL and eight *** average confidence interval(CI)of the MQTL was 3.9-fold smaller than that of the source *** of the 60 identified MQTL were classified as breeder’s MQTL owing to their small CIs,involvement of more QTL,and large contribution to phenotypic ***-third of the MQTL co-localized with DNA marker-trait associations identified in previous genomewide association mapping studies.A set of 78 high-confidence candidate genes influencing silage quality were identified in the MQTL *** genes and associated markers may advance marker-assisted breeding for maize silage quality.

关键词： Meta-QTL Silage quality Maize GWAS Candidate genes

Current challenges in treatment options for visceral leishmaniasis in India: a public health perspective

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Infectious Diseases of Poverty 2016年第1期5卷 165-179页

作者： om Prakash Singh Bhawana Singh Jaya Chakravarty Shyam Sundar Infectious Disease Research Laboratory Department of MedicineInstitute of Medical SciencesBanaras Hindu UniversityVaranasiIndia

Visceral leishmaniasis(VL)is a serious parasitic disease causing considerable mortality and major disability in the Indian *** is most neglected tropical disease,particularly in terms of new drug development for the lack of financial *** elimination campaign has been running in India since 2005 that aim to reduce the incidence of VL to below 1 per 10,000 people at sub-district *** of the major components in this endeavor is reducing transmission through early case detection followed by complete *** progress has been made during the recent years in the area of VL treatment,and the VL elimination initiatives have already saved many lives by deploying them effectively in the endemic ***,many challenges remain to be overcome including availability of drugs,cost of treatment(drugs and hospitalization),efficacy,adverse effects,and growing parasite ***,better emphasis on implementation research is urgently needed to determine how best to deliver existing interventions with available anti-leishmanial *** is essential that the new treatment options become truly accessible,not simply available in endemic areas so that they may promote healing and save *** this review,we highlight the recent advancement and challenges in current treatment options for VL in disease endemic area,and discuss the possible strategies to improve the therapeutic outcome.

关键词： Visceral leishmaniasis Treatment Drug resistance Multidrug therapy

A Feature Subset Selection Technique for High Dimensional Data Using Symmetric Uncertainty

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Journal of Data Analysis and Information Processing 2014年第4期2卷 95-105页

作者： Bharat Singh Nidhi Kushwaha om Prakash Vyas Department of Information Technology Indian Institute of Information Technology Allahabad India

With the abundance of exceptionally High Dimensional data, feature selection has become an essential element in the Data Mining process. In this paper, we investigate the problem of efficient feature selection for classification on High Dimensional datasets. We present a novel filter based approach for feature selection that sorts out the features based on a score and then we measure the performance of four different Data Mining classification algorithms on the resulting data. In the proposed approach, we partition the sorted feature and search the important feature in forward manner as well as in reversed manner, while starting from first and last feature simultaneously in the sorted list. The proposed approach is highly scalable and effective as it parallelizes over both attribute and tuples simultaneously allowing us to evaluate many of potential features for High Dimensional datasets. The newly proposed framework for feature selection is experimentally shown to be very valuable with real and synthetic High Dimensional datasets which improve the precision of selected features. We have also tested it to measure classification accuracy against various feature selection process.

关键词： High Dimensional Datasets Feature Selection Classification Predominant Feature

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CTA对大脑中动脉动脉瘤形态学研究

CTA对大脑中动脉动脉瘤形态学研究

作者： HARI om JOSHI 吉林大学

学位级别：硕士

研究背景：尽管已有很多学者研究了颅内动脉瘤，但是在动脉瘤破裂的危险因素间的多重相关性的研究仍然不多。近几十年来，许多研究者通过研究动脉瘤的形态学参数来预测动脉瘤破裂的风险，但是仍没有找到可以确切预测动脉瘤破裂风险... 详细信息

研究背景：尽管已有很多学者研究了颅内动脉瘤，但是在动脉瘤破裂的危险因素间的多重相关性的研究仍然不多。近几十年来，许多研究者通过研究动脉瘤的形态学参数来预测动脉瘤破裂的风险，但是仍没有找到可以确切预测动脉瘤破裂风险的独立参数。从这些研究中，我们已经了解了很多关于动脉瘤的知识。在很多研究人员中，动脉瘤的形态被认为是一个潜在的颅内动脉瘤破裂的因素。本研究致力于研究已被多名学者定义的不同形态学参数对动脉瘤破裂风险的预测。本文中动脉瘤形态的多个参数都显示与动脉瘤的破裂风险有相关性。在很多已经被认为可能预测动脉瘤破裂风险的形态学参数中，结果显示这些形态学参数可以作为预测动脉瘤破裂风险的因素。本研究通过研究动脉瘤患者CTA图像，比较不同形态学参数在预测动脉瘤破裂风险上的差异及统计学意义。研究目的：通过CT血管造影（CTA）研究大脑中动脉（MCA）动脉瘤的形态学特征。材料与方法：本研究搜集2011年1月至2012年1月到吉林大学第一医院就诊的患者，共62例患者，其中26例患者中，发现27个未破裂动脉瘤，另外36例患者，发现36个破裂动脉瘤。其中11例患者为双侧大脑中动脉动脉瘤，其他患者为单发或多发动脉瘤。只有发生在大脑中动脉的动脉瘤计入统计，其他部位动脉瘤不计入统计。除囊状动脉瘤外，梭形与霉菌性动脉瘤不计入本研究。医院计算机系统PACS（图片存档和通信系统）记录了每个病人的医疗记录，包括既往病史、影像学检查、治疗过程及结果。该系统通过回顾性分析为我们提供有用的信息。本研究通过CTA工作站后处理获得动脉瘤的形态学参数，并统计分析动脉瘤形态参数对动脉瘤破裂风险评估的意义。结果：统计发现，动脉瘤的各种形态学参数在评价预测动脉瘤破裂风险上均有显著性差异。 1.动脉瘤尺寸比SR作为唯一一个预测动脉瘤破裂风险的独立指标，也是最重要的形态学参数（p＜0.001，AUC0.78）。 2.动脉瘤其他形态学参数也可以预测其破裂风险，如最大动脉瘤高度Hmax（p≤0.001, AUC0.78）,、深度Hpr（p≤0.001, AUC0.77）,、高宽比AR （p=0.002,AUC0.73）及动脉瘤体积（p≤0.001, AUC0.75）。然而，Logistic回归分析显示这些形态参数不能作为预测动脉瘤破裂的独立指标。 3.动脉瘤（包括破裂及未破裂动脉瘤）好发于女性，右侧多于左侧。动脉瘤患者年龄大多分布在51-60岁，未破裂动脉瘤平均年龄55.59岁，破裂动脉瘤平均年龄52.56岁。结论：基于动脉瘤多种形态学参数的研究，CTA是预测动脉瘤破裂风险的重要影像学方法。尺寸比SR是最重要且最有意义的一个形态学参数。

关键词： CTA 大脑中动脉动脉瘤

SMILE术取出角膜基质透镜治疗角膜病变的临床研究

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SMILE术取出角膜基质透镜治疗角膜病变的临床研究

作者： om Prakash Pant 吉林大学

学位级别：硕士

背景:角膜变薄和穿孔是严重的角膜病变,最终导致失明甚至眼球丧失。眼表疾病、眼部感染、外伤、烧伤、免疫相关眼病以及复发性翼状胬肉、角膜缘皮样瘤和其他角膜疾病的手术并发症都可以引起角膜变薄;而且,某些系统性疾病如风湿病等也与... 详细信息

背景:角膜变薄和穿孔是严重的角膜病变,最终导致失明甚至眼球丧失。眼表疾病、眼部感染、外伤、烧伤、免疫相关眼病以及复发性翼状胬肉、角膜缘皮样瘤和其他角膜疾病的手术并发症都可以引起角膜变薄;而且,某些系统性疾病如风湿病等也与之密切相关。在角膜病变病例中,角膜变薄的部位可以出现在中央部位,也可以在靠近周边的部位,但以周边角膜组织变薄更为常见,因为在一些情况下,结膜、巩膜的感染可由靠近角膜缘部位蔓延至角膜,导致角膜感染的发生。角膜变薄可能会引起严重的散光,且伴随疾病的进展而严重影响患者视力水平,甚至完全遮挡视轴。此外,角膜溃疡穿孔可导致眼球解剖结构的完整性受到严重破坏,致使感染向眼球内部播散,甚至使患者丧失眼球。角膜穿孔是一种眼科急症,需要立即干预。角膜穿孔的病因可以是创伤性或非创伤性(细菌性、病毒性、真菌性角膜感染、自身免疫性角膜炎等)。在感染性角膜溃疡穿孔的病例中,细菌感染被认为是角膜溃疡穿孔最常见的感染因素。在一些炎症性疾病,如胶原血管病、酒糟鼻、韦格纳氏肉芽肿以及特发性溃疡均可导致角膜溃疡并伴发角膜穿孔。角膜变薄如果不治疗会导致角膜穿孔,从而引起各种并发症,如化脓性葡萄膜炎,眼内炎,继发性青光眼,视网膜脱离,交感型眼炎等,甚至最终需要眼球摘除,给患者造成巨大的心理和生理损伤。因此,一旦发现患者出现角膜变薄的情况下,应及早进行药物治疗。对于严重的角膜变薄与角膜穿孔,应根据角膜穿孔的部位、大小及时采取适当的临床干预措施,以预防这些并发症的发生。角膜穿孔的治疗主要包括角膜绷带境的应用,角膜缝合、自体结膜移植、多层羊膜移植和角膜移植等。当穿孔面积较小或仅存在角膜变薄时,可考虑应用角膜绷带镜,而多层羊膜移植术常常用于穿孔直径小于1.5 mm的病例中。然而,当上述治疗手段无效或患者角膜溃疡穿孔面积较大、合并眼内容物脱出时,角膜移植术则是唯一有效的治疗手段。角膜组织是世界上最常见的移植器官。根据美国眼库协会(Eye Bank Association of United States of America)统计分析报告,2013年共进行了72736例角膜移植手术。尽管角膜移植术是一种安全、有效的角膜穿孔治疗方法,但由于文化的差异和人们的传统观念的束缚,目前在我国角膜捐献的数量非常有限,人的角膜组织仍是一种稀缺的移植材料,角膜组织严重缺乏。而且角膜供体成本和保存运输成本也很高,这些因素使得虽然每年仍然存在多数需要进行角膜移植的患者,但却很难获得角膜移植的机会。2016年有数据统计,在过去的10年,我国角膜移植从每年5000例增加到每年8000例以上,对角膜组织的需求量仍然很大。在印度一项调查研究中,从2003年到2012年,接受角膜移植术的患者数量由8014例急剧增加到23050例,增加了将近两倍,但由于角膜捐献数量仍然严重短缺,许多患者仍需等待较长的时间。与此同时,调查数据显示几乎所有发展中国家的角膜移植率均在稳步上升,如在菲律宾,过去5年中平均每年角膜移植术可达约1529例;在巴西,2001年角膜移植术的数量为6193例,而2011年则达到了14838例;然而,供体角膜的数量与手术需求量严重不匹配仍是这些发展中国家开展角膜移植术的主要局限。微小切口基质透镜切除术(Small Incision Lenticule Extraction,SMILE)是一种新型的飞秒激光治疗屈光不正手术,用于矫正近视和近视散光。SMILE是一种微创、安全有效、可矫正100度至1000度近视的手术。与其它大多数眼部手术不同,该手术时间较短、疗效较好。由于其治疗安全可靠,近几年在国内开始受到医生和患者的广泛认可。在SMILE手术过程中,通过一个角膜小切口取出一片飞秒激光切除的角膜基质透镜。通常取出的角膜基质透镜就被作为医疗垃圾扔掉了,在我们的研究中,将此前未受重视的SMILE角膜基质透镜变废为宝,作为角膜移植的材料,用于治疗角膜局部变薄和角膜穿孔。此前,Pradhan等人首次提出,将近视眼患者在SMILE手术中取出的角膜基质透镜对远视患者进行移植,取得了良好的矫治远视的效果,且在为期一年的随访内,患者无任何无不良反应,结果证明SMILE角膜基质透镜移植是一种矫正远视的可行方法。吴等人曾报导了将SMILE角膜基质透镜作为“补丁”,移植于角膜溃疡穿孔患者共6例,均收到了良好的效果,研究的结果表明,SMILE角膜基质透镜移植对于角膜溃疡穿孔患者而言,不失为一种可维持眼球解剖结构完整性的、便捷有效的替代手术治疗方式。目的:本研究主要目的是以SMILE手术取出的角膜基质透镜作为角膜移植材料,评估角膜基质透镜在角膜病变治疗中的有效性,为其可能成为一种丰富供体来源的角膜移植材料提供理论依据。方法:对吉林大学第一医院眼科,SMILE取出的角膜基质透镜进行角膜移植术治疗的患者进行了回

关键词：角膜移植术 SMILE 角膜损伤角膜变薄角膜穿孔

Relationship between Myopia and Optical Components - A Study among Chinese Hong Kong Student Population

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Eye Science 1996年第3期16卷 121-125页

作者： Peng Iob Lo Patrick CP Ho Joseph TF Lau Albert YK Cheung Ernst Goldschmidt Mark om Tso Eye Center Kiang Wu HospitalHong Kong Eye FoundationCenter for Clinical Trials and Epidemiological ResearchPrince of Wales HospitalCenter for Clinical Trials and Epidemiological ResearchPrince of Wales HospitalDepartment of Ophthalmology and Visual SciencesThe Chinese University of Hong KongDepartment of Ophthalmology and Visual SciencesThe Chinese University of Hong Kong MacaoHong KongHong KongHong KongHong KongHong Kong

Purpose: To establish the prevalence and severity of myopia among the Chinese Hong Kong students and to study the relationship between myopia and optical ***;One thousand and seventy-five freshmen of the 1993-1994 academic year in the Chinese University of Hong Kong underwent the eye examination including evaluation of refractive error, keratometry, and A-scan ultrasonic biometry. The data were analyzed with the SPSS/PC+4. 01 statistical package. Results: The prevalence of myopia was 91. 7% with the mean refraction being -4. 00 ± 2. 64D in this young adult population. The statistical analyses demonstrated a significant correlation between refractive value and axial length of the globe (r=-0. 78), vitreous length (r=-0. 76), anterior chamber depth (r=-0. 33), lens thickness (r = 0. 13) and corneal curvature (r = 0. 19). Conclusion: The refractive status is mainly dependent on the axial length. In general, the higher the myopia was, the longer the eyeball, the deeper the anterior chamber,

关键词： myopia optical component corneal curvature axial length anterior chamber depth lens thickness.