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Coronary artery disease and heart failure:Late-breaking trials presented at American Heart Association scientific session 2023

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World Journal of Cardiology 2024年第7期16卷 389-396页

作者： Avilash Mondal Sashwath Srikanth Sanjana Aggarwal Naga R Alle olufemi odugbemi Ikechukwu Ogbu Rupak Desai Department of Internal Medicine Nazareth HospitalPhiladelphiaPA 19152United States Department of Internal Medicine East Carolina University GreenvilleGreenvilleNC 27834United States Department of Internal Medicine Hamdard Institute of Medical Sciences and ResearchNew Delhi 110062India Department of Medicine Narayana Medical CollegeNelloreAndhra Pradesh 524003India Department of Internal Medicine Lincoln Medical CenterBronxNY 10451United States Department of Internal Medicine Mountainview Hospital Sunrise GMELas VegasNV 89108United States Independent Researcher AtlantaGA 30079United States

The late-breaking science presented at the 2023 scientific session of the American Heart Association paves the way for future pragmatic trials and provides meaningful information to guide management strategies in coronary artery disease and heart failure(HF).The dapagliflozin in patient with acute myocardial infarction(DAPA-MI)trial showed that dapagliflozin use among patients with acute MI without a history of diabetes mellitus or chronic HF has better cardiometabolic outcomes compared with placebo,with no difference in cardiovascular *** MINT trial showed that in patients with acute MI and anemia(Hgb<10 g/dL),a liberal transfusion goal(Hgb≥10 g/dL)was not superior to a restrictive strategy(Hgb 7-8 g/dL)with respect to 30-day all-cause death and recurrent *** ORBITA-2 trial showed that among patients with stable angina and coronary stenoses causing ischemia on little or no antianginal therapy,percutaneous coronary intervention results in greater improvements in anginal frequency and exercise times compared with a sham *** ARIES-HM3 trial showed that in patients with advanced HF who received a HeartMate 3 levitated left ventricular assist device and were anticoagulated with a vitamin K antagonist,placebo was noninferior to daily aspirin with respect to the composite endpoint of bleeding and thrombotic events at 1 *** TEAMMATE trial showed that everolimus with low-dose tacrolimus is safe in children and young adults when given≥6 months after cardiac *** patients being treated for HF with reduced ejection fraction(HFrEF)with specific out-of-pocket(OOP)costs for multiple medication options at the time of the clinical encounter may reduce‘contingency planning’and increase the extent to which patients are taking the medications decided *** primary outcome,which was cost-informed decisionmaking,defined as the clinician or patient mentioning costs of HFrEF medication,occurred in 49%of encounters with the checklist only

关键词： Heart failure Coronary artery disease Clinical trials Myocardial infarction Cardiovascular outcome Percutaneous coronary intervention Blood transfusion Cardiac transplant

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Spontaneous coronary artery dissection-associated takotsubo syndrome: A systematic review of case reports

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World Journal of Cardiology 2023年第8期15卷 406-414页

作者： Aditi Bhanushali Muskan Kohli Ananya Prakash Svaapnika Rao Sarvepalli Anchal Pandey olufemi odugbemi Nafisa Reyaz Bansi Trambadia Sadhu Aishwarya Reddy Shaylika Chauhan Rupak Desai Department of Internal Medicine Mayo ClinicRochesterMN 55902United States Department of Population Health&Leadership University of New HavenWest HavenCT 06516United States Department of Medicine Vydehi Institute of Medical Sciences and Research CenterBangalore 560066KarnatakaIndia Department of Medicine G.S.V.M.Medical CollegeKanpur 208002Uttar PradeshIndia Department of Internal Medicine Lincoln Medical and Mental Health CentreBronxNY 10451United States Department of Medicine Jawaharlal Nehru Medical College&HospitalAligarh 202002UPIndia Master of Public Health Mount SinaiNew YorkNY 10029United States Department of Medicine Osmania Medical CollegeHyderabad 500095TelanganaIndia Department of Internal Medicine Geisinger Health SystemWikes-BarrePA 18702United States Independent Researcher Independent ResearcherAtlantaGA 30079United States

BACKGROUND Spontaneous coronary artery dissection(SCAD)is underdiagnosed and requires comprehensive angiographic *** SCAD occurrences have a comparable clinical appearance as takotsubo syndrome(TTS)or exist simultaneously,making it challenging for clinicians to treat and *** reports lack consolidated AIM To conduct a systematic review of available case reports on SCAD in order to investigate its potential association with *** SCAD-associated TTS case reports were reviewed after thoroughly screening PubMed,EMBASE,Scopus,and Google Scholar databases till January *** reports described demographics,comorbidities,imaging,management,and *** Twelve articles about 20 female patients were analyzed.30%of patients(n=6,>60 years)were elderly(mean age 56.2±9.07 years,range 36-70 years).Canada has 9 cases,United States 3,Australia 3,Sweden 2,Japan,Denmark,and France *** 5 reports identified emotional stressors in these cases while 4 reports showed physical triggers for *** had hypertension,2 had hyperlipidemia,and 1 had prediabetes.5 patients(25%)smoked.10(50%)troponin-positive myocardial infarction patients reported chest discomfort.11(55%)of 20 instances had TTS/SCAD.12(60%)of 20 patients exhibited ST elevation and 3(15%)had T wave inversion on electrocardiogram.19/20 patients had elevated troponin.9(45%)of 20 people had apical akinesis with TTS ballooning on cardiac *** 20 exhibited echocardiographic wall motion abnormalities.19(95%)of 20 coronary angiography cases had SCAD.10 of 19 SCAD patients had left anterior descending,2 diagonal,and 2 left circumflex coronary artery involvement.7 of 20 patients had left ventricular ejection fraction(LVEF)*** averaged 38.78±7.35%.5(25%)of the 20 cases underwent dual antiplatelet ***(15%)of 20 cases experienced occasional ectopic ventricular complexes,Mobitz ll AV block,and paroxysmal atrial *** 20 cases recovered and *** Given the clin

关键词： Spontaneous coronary artery dissection Takotsubo syndrome Takotsubo cardiomyopathy Systematic review Coronary angiography Cardiology

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Yield and mechanical properties of veneer from Brachystegia nigerica

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Journal of Forestry Research 2012年第2期23卷 295-298页

作者： Babatola olufemi Department of Forestry and Wood Technology Federal University of TechnologyP.M.B.704AkureNigeria

In an effort to find suitable wood from natural forest to meet the demand for veneer products, the yield and tensile strength of veneers produced from Brachystegia nigerica were investigated. Two trees of B. nigerica were separately selected from 10 different natural forest zones while two logs were obtained from each tree. The logs were debarked and steamed in a vat prior to rotary peeling and slicing for veneer production. The optimum steam temperature was determined by considering different temperatures： 50℃, 60℃, 70℃, 80℃ and 90℃ for 24 h. Thereafter, optimum steam time was determined at the optimum temperature by considering durations of 24, 48, 72 and 96 h. The average taper of 0.75 mm per 1.0 m length was recorded for B. nigerica, indicating that the logs were reasonably cylindrical; thereby its logs are good for the production of veneer. The yield ranged from 44% to 61% with an average of 52% of the log input. The tensile strength of the veneer was tested perpendicular to grain and both peeled and sliced veneers had the highest tensile strength between 70℃ and 90℃, suggesting that softening of wood polymers, especially lignin, is between 70℃ and 90℃. The optimum temperature and time for veneer production are 70℃ and 48 h, respectively. Commercial production of veneer from B. nigerica is feasible based on the yield and mechanical properties of the obtained veneer, thereby encouraging the expansion of the scope of its utilization.

关键词： veneer Brachystegia nigerica yield tensile strength optimum steam temperature optimum steam time

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Effect of methanol extract of Ricinus communis seed on reproduction of male rats

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Asian Journal of Andrology 2006年第1期8卷 115-121页

作者： Yinusa Raji Ahmed Kolade Oloyo Ayodele olufemi Morakinyo Department of Physiology College of MedicineUniversity of IbadanIbadan 23 402Nigeria

Aim： To investigate the effect of methanol extract of Ricinus communis seed （RCE） on male rats reproductive functions. Methods： Thirty-two male albino rats were divided into four groups. Groups 1, 2 and 3 were gavaged with 0.2 mL of 2.5% tween 80 （RCE vehicle; control） or 20 mg/（kg-d） and 40 mg/（kg-d） of RCE, respectively, for 30 days, and group 4 was also gavaged with 40 mg/（kg.d） of RCE, but was allowed a recovery periold of 30 days. Five untreated female rats were cohabited with male rats in each group from day 25 of RCE treatment for 5 days, except group 4, where cohabitation began on day 25 of the recovery period. All male rats were sacrificed 24 h after the experiments. The female rats were laparatomized on day 19 of pregnancy and the number and weight of litters were recorded. Results： There was a significant decrease （P 〈 0.01） in the weight of the reproductive organs, sperm functions and serum levels of testosterone in RCE treated rats. There was disorganization in the cytoarchitecture of the testes, disruption of the seminiferous tubules and erosion of the germinal epithelium. The number and weight of litters of rats in groups 2 and 4 decreased significantly （P 〈 0.05） but no changes were observed in group 3. RCE caused no changes in liver, kidney, heart or body weights in male rats. Conclusion： RCE has a reversible negative impact on male reproductive functions, which appears to be mediated via gonadal disruption in testosterone secretion. （Asian J Androl 2006 Jan; 8： 115-121）

关键词： Ricinus communis sperm fertility testosterone reproduction

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固相流动对垂直气井井筒压降影响的数值模拟(英文)

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石油勘探与开发 2012年第2期39卷 228-232页

作者： Adekomaya olufemi A 尼日利亚拉各斯大学石油与天然气工程学院

为了准确估算垂直气井井底压力,更精确地预测单井产量,在总结前人有关垂直井筒单相管流井筒压降计算方法的基础上,建立了固相流动对垂直气井井筒压降影响的数值模型。该模型考虑了直井中气相湍流、固相颗粒流动及Moody摩擦系数对井筒压... 详细信息

为了准确估算垂直气井井底压力,更精确地预测单井产量,在总结前人有关垂直井筒单相管流井筒压降计算方法的基础上,建立了固相流动对垂直气井井筒压降影响的数值模型。该模型考虑了直井中气相湍流、固相颗粒流动及Moody摩擦系数对井筒压降的影响,扩展了Adekomaya等(2011年)及Sukkar&Cornell提出的单相垂直管流井筒压降计算方法。模型计算结果表明,固相流动对井筒压降影响显著,而前人提出的计算模型未能考虑其影响;相同条件下,当有固相颗粒伴随流体产出时,井筒压降高于无固相颗粒产出时的井筒压降;固相含量越高、固相相对密度越大,井筒压降越大,压力随深度的增加降低越快。

关键词：井底压力固体流压降浊流垂直井

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Geothermo-mechanical alterations due to heat energy extraction in enhanced geothermal systems: Overview and prospective directions

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Deep Underground Science and Engineering 2024年第3期3卷 256-268页

作者： Mary C.Ngoma Oladoyin Kolawole olufemi Olorode John A.Reif Jr.Department of Civil and Environmental EngineeringNew Jersey Institute of TechnologyNewarkUSA Department of Petroleum Engineering Louisiana State UniversityBaton RougeUSA

Geothermal energy from deep underground (or geological) formations,with or without its combination with carbon capture and storage (CCS),can be a key technology to mitigate anthropogenic greenhouse gas emissions and meet the 2050 net‐zero carbon emission *** resources in low‐permeability and medium‐and high‐temperature reservoirs in sedimentary sequence require hydraulic stimulation for enhanced geothermal systems (EGS).However,fluid migration for geothermal energy in EGS or with potential CO_(2) storage in a CO_(2)‐EGS are both dependent on the in situ flow pathway network created by induced fluid *** thermo‐mechanical interactions can be complex and induce varying alterations in the mechanical response when the working fluid is water (in EGS) or supercritical CO_(2)(in CO_(2)‐EGS),which could impact the geothermal energy recovery from geological ***,there is a need for a deeper understanding of the heat extraction process in EGS and CO_(2)‐*** study presents a systematic review of the effects of changes in mechanical properties and behavior of deep underground rocks on the induced flow pathway and heat recovery in EGS reservoirs with or without CO_(2) storage in CO_(2) ‐***,we proposed waterless‐stimulated EGS as an alternative approach to improve heat energy extraction in ***,based on the results of our literature review and proposed ideas,we recommend promising areas of investigation that may provide more insights into understanding geothermo‐mechanics to further stimulate new research studies and accelerate the development of geothermal energy as a viable clean energy technology.

关键词： CO_(2)-EGS enhanced geothermal systems geomechanics geothermal energy underground thermal energy

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Analyzing thermal maturity effect on shale organic matter via PeakForce quantitative nanomechanical mapping

Rock Mechanics Bulletin

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Rock Mechanics Bulletin 2024年第3期3卷 38-52页

作者： Chioma Onwumelu Oladoyin Kolawole Stephan Nordeng olufemi Olorode Harold Hamm School of Geology and Geological Engineering University of North DakotaGrand ForksND58202USA John A.Reif Jr.Department of Civil and Environmental EngineeringNew Jersey Institute of TechnologyNewarkNJ07102USA Craft and Hawkins Department of Petroleum Engineering Louisiana State UniversityBaton RougeLA70803USA

Organic-rich shales have gained significant attention in recent years due to their pivotal role in unconventional hydrocarbon *** shale rocks undergo thermal maturation processes that alter their mechanical properties,making their study essential for subsurface ***,characterizing the mechanical properties of organic-rich shale is often challenging due to its multiscale nature and complex *** work aims to bridge that knowledge gap to fully understand the nanomechanical properties of Shale organic matter at various thermal maturation *** study employs PeakForce Quantitative Nanomechanical Map-ping(PF-QNM)using Atomic Force Microscopy(AFM)to investigate how changes at the immature,early mature,and peak mature stages impact the mechanical properties of the Bakken Shale organic ***-QNM provides reliable mechanical measurements,allowing for the quantification and qualification of shale constituents'elastic modulus(E).We also accounted for the effect of probe type and further analyzed the impact of probe wear on the nanomechanical properties of shale organic *** immature shale,the average elastic modulus of organic matter is approximately 6 GPa,whereas in early mature and peak mature shale,it decreases to 5.5 GPa and 3.8 GPa,*** reveal a mechanical degradation with increasing thermal maturation,as evidenced by a reduction in Young's modulus(E).Specifically,the immature shale exhibits an 8%reduction in E,while the early mature and peak mature shales experience more substantial reductions of 31%and 37%,*** phenomenon could be attributed to the surface probing of low-modulus materials like bitumen generated during *** findings underscore the potential of AFM PF-QNM for assessing the nanomechanical characteristics of complex and heterogeneous rocks like ***,it also highlights the need for standardized mea-surement practices,considering the diverse components in these

关键词： Rock mechanics Nanomechanics Shale Organic matter Atomic force microscopy Nanomechanical mapping

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Toxicological and histopathological effects of Dennettia tripetala seed used as grain protectant,food,and medicine

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Food Quality and Safety 2017年第3期1卷 211-219页

作者： Luke Chinaru Nwosu Chris Olukayode Adedire Emmanuel Oludele Ogunwolu Michael olufemi Ashamo Food Technology Programme Department of BiologyFederal University of TechnologyAkureOndo State and Department of Crop and Environmental Protection University of AgricultureMakurdiBenue StateNigeria Department of Crop and Soil Science Faculty of AgricultureUniversity of Port HarcourtP.M.B.5323Port HarcourtRivers StateNigeria

The study revealed the safety of Dennettia tripetala seed on man and the *** male rats weighing 0.158-0.168 kg housed in standard cages with free access to food and water were used for the *** median lethal dose(LD50)was estimated using revised up and down *** LD50 for *** seed extract was 5785 mg/kg and this evoked paralysis in rats for 4 days coupled with discharge from the eyes and eventual *** least weight gain by the animals administered 75%seed powder of ***(4338.75 mg/kg)was an index of high powder concentration,whereas the weight loss experienced by group V animals is strongly attributed to chemical assault by permethrin designated as a standard *** high values of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and urea in the groups administered 75%permethrin powder(4338.75 mg/kg)and 75%*** seed powder is an index of liver and kidney injury and *** presence of normal serum levels of ALT,AST,alkaline phosphatase,and creatinine;normal liver and kidney structures;and normal weight gains in the animal groups fed basal diet(control)and basal diet plus 25%*** is a strong indication that 25%*** seed powder(1446.25 mg/kg)supplementation is not toxic to the liver and kidney and therefore supports normal organ *** LD50 recorded strongly indicates that *** has a moderately high safety *** of less than 50%(2892.5 mg/kg)is recommended in the safe use of the plant material as grain protectant,food,and *** botanical insecticide,***,is safer than the conventional synthetic insecticide,permethrin,on account of the latter showing evidence of kidney damage.

关键词： Safety botanical insecticide permethrin supplementation kidney damage

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Spontaneous pneumothorax in a single lung transplant recipient-a blessing in disguise: A case report

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World Journal of Clinical Cases 2020年第14期8卷 3031-3038页

作者： Himanshu Deshwal Subha Ghosh Kathleen Hogan olufemi Akindipe Charles Randall Lane Atul C Mehta Division of Pulmonary Critical Care and Sleep MedicineNew York University Grossman School of MedicineNew YorkNY 10016United States Imaging Institute Section of Thoracic ImagingCleveland ClinicClevelandOH 44195United States Respiratory Institute Cleveland ClinicClevelandOH 44195United States

BACKGROUND End-stage chronic obstructive pulmonary disease(COPD)is one of the common lung diseases referred for lung *** to the international society of heart and lung transplantation,30%of all lung transplantations are carried out for COPD *** compared to bilateral lung transplant,singlelung transplant(SLT)has similar short-term and medium-term results for *** patients with severe upper lobe predominant emphysema,lung volume reduction surgery is an excellent alternative which results in improvement in functional status and long-term *** 2018,endobronchial valves were approved by the Food and Drug Administration for severe upper lobe predominant emphysema as they demonstrated improvement in lung function,exercise capacity,and quality of ***,the role of endobronchial valves in native lung emphysema in SLT patients has not been *** SUMMARY We describe an unusual case of severe emphysema who underwent a successful SLT 15 years ago and had gradual worsening of lung function suggestive of chronic lung allograft ***,her lung function improved significantly after a spontaneous pneumothorax of the native lung resulting in auto-deflation of large *** This case highlights the clinical significance of native lung hyperinflation in single lung transplant recipient and how spontaneous decompression due to pneumothorax led to clinical improvement in our patient.

关键词： Native lung hyperinflation Single lung transplant Pneumothorax Bronchoscopic lung volume reduction Endobronchial valve Case report

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Identification, isolation and characterization of the antifeedant constituent of Clausena anisata against Helicoverpa armigera （Lepidoptera： Noctuidae）

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Insect Science 2009年第3期16卷 247-253页

作者： olufemi O. R. Pitan O. O. Ayelaagbe Hong-Lei Wang Chen-Zhu Wang State Key Laboratory of Integrated Management of Pest insects and Rodents Institute of Zoology Chinese Academy of Sciences BeijingChina Department of Crop Protection University of Agriculture Abeokuta Department of Chemistry University of Ibadan IbadanNigeria

Hexane, petroleum ether, chloroform, ethyl acetate, methanol and water extracts of Clausena anisata [（Willd.） Hook E Ex Benth] leaves and roots were evaluated against Helicoverpa armigera （Hubner） for antifeedant activities. Antifeedant activity was confirmed, and was found to be higher in root extracts than those of the leaf. Chloroform and petroleum ether extracts of the root showed strongest antifeedant activities （DC50s [concentration （C） causing 50% deterrence compared with the control] 0.014% and 0.016% respectively）, and root extracts were fractionated using silica gel column chromatography. One fraction of the chloroform and one of the petroleum ether root extracts was active; and on the basis of mass spectroscopy and ^1H and ^13C nuclear magnetic resonance spectral data, the active compounds in the two fractions were confirmed to be identical, and identified as osthol [2H-1-Benzopyran-2-one, 7-methoxy-8-（3-methyl-2-butenyl）]. The highest concentration of osthol was found in the chloroform root extract. Antifeedant activities of the root extracts, as measured by DC50 values, were highly correlated with their osthol contents. Approximately 99% of the variation in bioactivity of the root extracts could be accounted for by variation in osthol content; osthol therefore, appeared to be an antifeedant component of C. anisata to H. armigera. This may provide a new approach to managing this pest.

关键词： active ingredient antifeedant Clausena anisata Helicoverpa armigera,osthol root

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