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动态全场光学相干断层扫描结合深度学习在肿瘤患者术中诊断的应用:一项乳腺癌患者的前瞻性队列研究

Science Bulletin 2024年第11期69卷 1748-1756页

作者：张舒玮杨滨杨后圃赵进张原媛高元绪 olivia monteiro 张康刘博王殊 Breast Center Peking University People’s HospitalBeijing 100044China China ESG Institute Capital University of Economics and BusinessBeijing 100070China Faculty of Information Technology Beijing University of TechnologyBeijing 100124China Department of Pathology Peking University People’s HospitalBeijing 100044China Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacao 999078China College of Future Technology Peking UniversityBeijing 100091China School of Mathematical and Computational Sciences Massey UniversityAuckland 0745New Zealand

An intraoperative diagnosis is critical for precise cancer surgery. However, traditional intraoperative assessments based on hematoxylin and eosin(H&E) histology, such as frozen section, are time-,resource-, and labor-intensive, and involve specimen-consuming concerns. Here, we report a near-real-time automated cancer diagnosis workflow for breast cancer that combines dynamic full-field optical coherence tomography(D-FFOCT), a label-free optical imaging method, and deep learning for bedside tumor diagnosis during surgery. To classify the benign and malignant breast tissues, we conducted a prospective cohort trial. In the modeling group(n = 182), D-FFOCT images were captured from April 26 to June 20, 2018, encompassing 48 benign lesions, 114 invasive ductal carcinoma(IDC), 10 invasive lobular carcinoma, 4 ductal carcinoma in situ(DCIS), and 6 rare tumors. Deep learning model was built up and fine-tuned in 10,357 D-FFOCT patches. Subsequently, from June 22 to August 17, 2018, independent tests(n = 42) were conducted on 10 benign lesions, 29 IDC, 1 DCIS, and 2 rare tumors. The model yielded excellent performance, with an accuracy of 97.62%, sensitivity of 96.88% and specificity of 100%;only one IDC was misclassified. Meanwhile, the acquisition of the D-FFOCT images was non-destructive and did not require any tissue preparation or staining procedures. In the simulated intraoperative margin evaluation procedure, the time required for our novel workflow(approximately 3 min)was significantly shorter than that required for traditional procedures(approximately 30 min). These findings indicate that the combination of D-FFOCT and deep learning algorithms can streamline intraoperative cancer diagnosis independently of traditional pathology laboratory procedures.

关键词： Cancer diagnosis Breast neoplasms Dynamic full-field optical coherence tomography Deep learning Image classification

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SARS-CoV-2 pathogenesis in the gastrointestinal tract mediated by Spike-induced intestinal inflammation

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Precision Clinical Medicine 2024年第1期7卷 84-86页

作者： Zhanyu Li Jianzhong He Yun Yin Lei Tang Ye Liu olivia monteiro Famin Zeng Department of Pathology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 5190ooChina City University of Macao Macao 999078China Faculty of Medicine Macao University of Science and TechnologyMacao 999078China

Dear Editor,The pathogenesis of COVID-19 in the gastrointestinal(GI)tract is well-documented[1].However,due to a lack of simple animal models,the pathogenic mechanisms of SARS-CoV-2 in the GI tract is not well ***,com... 详细信息

关键词： pathogenesis gastrointestinal inflammation

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Enhancement of SARS-CoV-2 vaccine-induced immunity by a Toll-like receptor 7 agonist adjuvant

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2481-2484页

作者： Gen Li Meixing Yu Qiong Ke Jing Sun Yanwen Peng Chuanfeng Xiong olivia monteiro COVID-Infection and Immunity Investigation Group Jincun Zhao Andy P.Xiang Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhouChina Center for Stem Cell Biology and Tissue Engineering Key Laboratory for Stem Cells and Tissue EngineeringMinistry of EducationSun Yat-sen UniversityGuangzhouChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthFirst Affiliated HospitalGuangzhou Medical UniversityGuangzhouChina Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacaoChina 不详

Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an enveloped positive-sense single-stranded RNA(ssRNA)virus responsible for the global COVID-19 *** vaccines for SARS-CoV-2 have been developed and applied worldwide,research on vaccine adjuvant is *** infections normally elicit a range of innate immune responses through the activation of pattern recognition receptors(PRRs).

关键词： immunity vaccine pattern

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Fast internal preheating of 4680 lithium-ion batteries in cold environments

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Nano Research 2024年第10期17卷 8794-8802页

作者： Chuyue Guan Harrison Szeto olivia Wander Vijay Kumar Raphaele JClément Yangying Zhu Department of Mechanical Engineering University of California Santa BarbaraSanta BarbaraCA 93106USA Department of Chemistry and Biochemistry University of California Santa BarbaraSanta BarbaraCA 93106USA Department of Materials University of California Santa BarbaraSanta BarbaraCA 93106USA

Lithium-ion batteries are expected to operate within a narrow temperature window around room temperature for optimal performance and ***,in cold environments,electric vehicle battery packs must be extensively preheated prior to charge or ***,conventional preheating is accomplished externally,which is slow and thus significantly increases charging ***,internal heating has been demonstrated as a potential solution to quickly and uniformly preheat a lithium-ion pouch ***,internal heating has not been evaluated in other battery formats such as cylindrical *** this work,we present a numerical model of a 4680 battery with internal heaters for fast preheating in cold *** effects that the number of heater layers,heating duration,resting duration,environmental temperature,and boundary heat transfer coefficient have on the temperature heterogeneity of the battery were *** results show that internal heating alone reduces the temperature variation within the battery by a factor of 5 compared to external heating,and by a factor of 20 when combining internal and external *** study further proves that internal preheating of lithium-ion batteries is a promising thermal management strategy,and provides guidance on potential design considerations and heating protocols to implement internal heating.

关键词： lithium-ion battery 4680 battery thermal management internal battery preheating COMSOL Multiphysics thermal simulation battery temperature heterogeneity

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Perianal disease in inflammatory bowel disease:Broadening treatment and surveillance strategies for anal cancer

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World Journal of Gastroenterology 2024年第28期30卷 3373-3385页

作者： Tatiana Pacheco Sara monteiro Luísa Barros Jorge Silva Department of Gastroenterology Centro Hospitalar do Tamega e SousaPenafiel 4560-136Portugal

The perianal disease affects up to one-third of individuals with Crohn's disease(CD),causing disabling symptoms and significant impairment in quality of life,particularly for those with perianal fistulising CD(PFCD).The collaborative effort between gastroenterologists and surgeons is essential for addressing PFCD to achieve fistula closure and promote luminal *** fistula healing rates with conventional therapies have prompted the emergence of new biological agents,endoscopic procedures and surgical techniques that show promising *** these,mesenchymal stem cells injection is a particularly hopeful *** addition to the burden of fistulas,individuals with perianal CD may face an increased risk of developing anal *** underscores the importance of surveillance programmes and timely interventions to prevent late diagnoses and poor ***,there is no established formal anal screening *** this review,we provide an overview of the current state of the art in managing PFCD,including novel medical,endoscopic and surgical *** discussion also focuses on the relevance of establishing an anal cancer screening programme in CD,intending to propose a risk-based surveillance *** validation of this surveillance programme would be a significant step forward in improving patient care and outcomes.

关键词： Inflammatory bowel disease Crohn's disease Perianal Fistula Anus diseases Management Anal cancer Screening

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First experience in laparoscopic surgery in low and middle income countries: A systematic review

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 546-553页

作者： Rebekka Troller Jasmine Bawa olivia Baker James Ashcroft Department of Surgery Medway Maritime HospitalGillingham ME75NYKentUnited Kingdom Department of Surgery University Hospital CambridgeCambridge CB20QQUnited Kingdom

BACKGROUND Laparoscopic surgery has reduced morbidity and mortality rates,shorter post-operative recovery periods and lower complication rates than open *** is routine practice in high-income countries and is becoming increasingly common in countries with limited ***,introducing laparoscopic surgery in low-and-middle-income countries(LMIC)can be expensive and requires resour-ces,equipment,and *** To report the challenges and benefits of introducing laparoscopic surgery in LMIC as well as to identify solutions to these challenges for countries with limited finances and *** MEDLINE,EMBASE and Cochrane databases were searched for studies reporting first experience in laparoscopic surgery in *** studies were published between 1996 and 2022 with full text available in *** criteria were studies considering only open surgery,ear,nose,and throat,endoscopy,arthro-scopy,hysteroscopy,cystoscopy,transplant,or bariatric *** Ten studies out of 3409 screened papers,from eight LMIC were eligible for inclusion in the final analysis,totaling 2497 *** reported challenges were related to costs of equipment and training programmes,equipment pro-blems such as faulty equipment,and access to surgical ***-related challenges were reliance on foreign trainers and lack of locally trained surgeons and theatre *** benefits of introducing laparoscopic surgery were economic and clinical,including a reduction in hospital stay,complications,and morbidi-ty/*** introduction of laparoscopic surgery also provided training opportunities for junior *** Despite financial and technical challenges,many studies emphasise the overall benefit of introducing laparoscopic surgery in LMICs such as reduced hospital stay and the related lower cost for *** many of the clinical centres in LMICs have proposed practical solutions to the challenges reported,more support is critical

关键词： Laparoscopic surgery Low and middle income country First experience Training in laparoscopic surgery

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地震灾害损失评估与遥感技术现状和展望

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遥感学报 2024年第4期28卷 860-884页

作者：安立强张景发 Ricardo monteiro 张磊中国地震局工程力学研究所哈尔滨150080 天津市地震局天津300201 应急卫星工程与应用应急管理部重点实验室北京100124 意大利帕维亚高等研究院意大利帕维亚27100

地震灾害损失评估是地震震前应急准备、震后应急响应和恢复重建的重要工作内容。随着地震灾害风险的加剧以及对防灾减灾救灾工作需求的提升,近年来地震灾害损失评估技术得到较快的发展。同时,随着遥感技术进入大数据、智能化时代,遥感... 详细信息

地震灾害损失评估是地震震前应急准备、震后应急响应和恢复重建的重要工作内容。随着地震灾害风险的加剧以及对防灾减灾救灾工作需求的提升,近年来地震灾害损失评估技术得到较快的发展。同时,随着遥感技术进入大数据、智能化时代,遥感数据在地震灾害损失评估中也得到了广泛的应用。本文对地震灾害损失评估及其中遥感技术应用的发展进行了梳理:首先回顾了地震灾害损失评估的发展现状,对比分析了国内外地震灾害损失评估软件平台的异同点;归纳了人口和经济损失估计的典型方法;然后分别对震后遥感灾害损失评估以及基于遥感的震害预测方法现状进行了总结。最后本文讨论了目前地震灾害损失评估工作存在的一些问题并提出了相应的建议,在此基础上对遥感数据应用于地震灾害损害评估工作的趋势进行了展望。

关键词：震害预测地震风险损失评估震害评估遥感数据

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Peacebuilding Is Social Work:From Political Science to Social Psychology

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Sociology Study 2024年第2期14卷 91-97页

作者： Alexandra Gray Basilio monteiro St.John’s University New YorkU.S.

For the longest time,peacemaking and peacekeeping were the only post-factum interventions to resolve armed conflicts usually related to a nation-state’s borders or *** has its origins in sociology(Galtung,1969;1975)and is used today as a preferred concept in matters of ***,this paper explores why peacebuilding,as the Secretary General of the United Nations advocates in A New Agenda for Peace,must become a nonlinear and contextual process that promotes the prevention of conflict and invites a transformative approach to addressing the linkages between peace,security,and ***,this paper advocates that peacebuilding grounded in social psychology and social anthropology will bring about transformative outcomes as it will build relationships at the community level and become a preventive tool to address incipient tensions within the *** as social work will benefit the community and lay the necessary foundations for a sustainable *** workers are equipped to assess,analyze,and solve *** capacity to do ongoing social diagnosis is a critical tool to prevent skirmishes degenerating into *** work could be the much-needed resource to further develop theory and practice that contributes to active peacebuilding.

关键词： peacebuilding peacekeeping social work conflict prevention reconciliation

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Surgeon Perspectives on Anastomotic Leaks and FluidAI’s StreamTM Platform: Integrating Qualitative Insights for Technological Innovation

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Surgical Science 2024年第8期15卷 492-500页

作者： olivia Rennie Manaswi Sharma Nour Helwa Department of Clinical Affairs FluidAI Medical (Formerly NERv Technology Inc.) Kitchener Canada Faculty of Medicine University of Toronto Toronto Canada

Purpose: This article investigates the critical importance of integrating surgeons’ direct input into the development of innovative technologies that address gaps in surgical care, including those aimed at reducing anastomotic leaks (AL), a major complication in gastrointestinal surgery. While traditional quantitative research methods are prevalent, they often overlook the invaluable insights of the surgeons who manage these complications firsthand. Subjects and Methods: This study employs a qualitative approach, utilizing semi-structured interviews with 40 surgeons from various specialties, including general, bariatric, colorectal, trauma, hepato-biliary, and thoracic surgery. The interviews were designed to probe the needs of surgeons, challenges currently faced, and gaps in clinical practice, research, and technology for detection and/or management of AL. The data were analyzed using thematic analysis, which revealed significant gaps in current technologies for early detection and prevention of leaks. Results: Surgeons expressed strong interest in FluidAI’s Stream™ Platform, a non-invasive medical device designed to monitor postoperative drainage fluid in real-time, providing continuous data on AL risk. The ability of this platform to offer early prediction through pH and electrical conductivity analysis was particularly appealing to participants, who emphasized the importance of timely interventions in improving patient outcomes. The study’s findings highlight not only the clinical challenges but also the emotional toll that AL takes on surgeons, underlining the need for innovations that are both data-driven and humanistic. Conclusion: By centering surgeons’ perspectives, this research advocates for a human-centered approach to technological advancement, ensuring that new tools are both clinically effective and aligned with the real-world needs of surgical practitioners.

关键词： Anastomotic Leaks Surgeon Perspectives Postoperative Complications Qualitative Inquiry Technological Innovation

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How completely are randomized controlled trials of non-pharmacological interventions following concussion reported? A systematic review

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Journal of Sport and Health Science 2024年第4期13卷 537-547页

作者： Jacqueline Josee van Ierssel olivia Galea Kirsten Holte Caroline Luszawski Elizabeth Jenkins Jennifer O’Neil Carolyn A Emery Rebekah Mannix Kathryn Schneider Keith Owen Yeates Roger Zemek Children’s Hospital of Eastern Ontario Research Institute OttawaON K1H 8L1Canada The Centre for Health Activity and Rehabilitation ResearchUniversity of OtagoDunedin 9016New Zealand Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Alberta Children’s Hospital Research Institute University of Calgary CalgaryAB T2N 1N4Canada Hotchkiss Brain Institute University of CalgaryCalgaryAB T2N 4N1Canada Department of Psychology University of CalgaryCalgaryAB T2N 1N4Canada g Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada School of Rehabilitation Sciences University of OttawaOttawaON K1H 8M5Canada Bruyere Research Institute OttawaON K1N 5C8Canada Departments of Pediatrics and Emergency Medicine Harvard Medical SchoolBostonMA 02115USA Departments of Pediatrics and Emergency Medicine University of OttawaOttawaON K1H 8M5Canada

Purpose:The study aimed to examine the reporting completeness of randomized controlled trials(RCTs)of non-pharmacological interventions following ***:We searched MEDLINE,Embase,PsycInfo,CINAHL,and Web of Science up to May *** reviewers independently screened studies and assessed reporting completeness using the Template for Intervention Description and Replication(TIDieR),Consensus on Exercise Reporting Template(CERT),and international Consensus on Therapeutic Exercise aNd Training(i-CONTENT)*** information was sought my study authors where reporting was *** of bias(ROB)was assessed with the Cochrane ROB-2 *** examining non-pharmacological interventions following ***:We included 89 RCTs(n=53 high ROB)examining 11 different interventions for concussion:sub-symptom threshold aerobic exercise,cervicovestibular therapy,physical/cognitive rest,vision therapy,education,psychotherapy,hyperbaric oxygen therapy,transcranial magnetic stimulation,blue light therapy,osteopathic manipulation,and head/neck *** scores were:TIDieR 9/12(75%;interquartile range(IQR)=5;range:5-12),CERT 17/19(89%;IQR=2;range:10-19),and i-CONTENT 6/7(86%;IQR=1;range:5-7).Percentage of studies completely reporting all items was TIDieR 35%(31/89),CERT 24%(5/21),and i-CONTENT 10%(2/21).Studies were more completely reported after publication of TIDieR(t_(87)=2.08;p=0.04)and CERT(t_(19)=2.72;p=0.01).Reporting completeness was not strongly associated with journal impact factor(TIDieR:rs=0.27;p=0.01;CERT:r_(s)=-0.44;p=0.06;i-CONTENT:r_(s)=-0.17;p=0.48)or ROB(TIDieR:rs=0.11;p=0.31;CERT:rs=0.04;p=0.86;i-CONTENT:rs=0.12;p=0.60).Conclusion:RCTs of non-pharmacological interventions following concussion demonstrate moderate to good reporting completeness,but are often missing key components,particularly modifications,motivational strategies,and qualified *** completeness improved after TIDieR and CERT publication,but p

关键词： Concussion Intervention Randomized controlled trial Systematic review

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