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Optical prediction of single muscle fiber force production using a combined biomechatronics and second harmonic generation imaging approach

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Light(Science & Applications) 2018年第1期7卷 289-302页

作者： Dominik Schneidereit Stefanie Nübler Gerhard Prölß Barbara Reischl Sebastian Schürmann oliver J müller oliver Friedrich Institute of medical Biotechnology Friedrich-Alexander-University(FAU)Erlangen-NürnbergPaul-Gordan-Str.391052 ErlangenGermany Erlangen Graduate School in Advanced Optical Technologies(SAOT) FAU Erlangen-NürnbergPaul-Gordan-Str.791052 ErlangenGermany muscle Research Center Erlangen(mURCE) Friedrich-Alexander-University Erlangen-NürnbergErlangenGermany Department of Internal medicine III University of KielArnold-Heller-Str.324105 KielGermany DZHK(German Center for Cardiovascular Research)Partner Site Hamburg/Kiel/Lübeck KielGermany

Skeletal muscle is an archetypal organ whose structure is tuned to match *** magnitude of order in muscle fibers and myofibrils containing motor protein polymers determines the directed force output of the summed force vectors and,therefore,the muscle’s power performance on the structural *** and function can change dramatically during disease states involving chronic *** remodeling of the cytoarchitecture has been pursued using noninvasive and label-free multiphoton second harmonic generation(SHG)***,structure parameters can be extracted as a measure of myofibrillar order and thus are suggestive of the force output that a remodeled structure can still ***,to date,the parameters have only been an indirect measure,and a precise calibration of optical SHG assessment for an exerted force has been elusive as no technology in existence correlates these *** engineered a novel,automated,high-precision biomechatronics system into a multiphoton microscope allows simultaneous isometric Ca2+-graded force or passive viscoelasticity measurements and SHG *** this mechamorph system,we studied force and SHG in single EDL muscle fibers from wt and mdx mice;the latter serves as a model for compromised force and abnormal myofibrillar *** present Ca2+-graded isometric force,pCa-force curves,passive viscoelastic parameters and 3D structure in the same fiber for the first ***,we provide a direct calibration of isometric force to morphology,which allows noninvasive prediction of the force output of single fibers from only multiphoton images,suggesting a potential application in the diagnosis of myopathies.

关键词： structure harmonic fibers

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Fatigability Assessment Using the Fatigue Index Kliniken Schmieder (FKS) Is Not Compromised by Depression

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Health 2016年第14期8卷 1485-1494页

作者： Christian Dettmers markus Riegger oliver müller manfred Vieten Kliniken Schmieder Konstanz Konstanz Germany Lurija Institut Kliniken Schmieder Allensbach Konstanz Germany Sportwissenschaften Universit?t Konstanz Konstanz Germany Zentrum für Psychiatrie Reichenau Konstanz Germany

Background: Attractor-based kinematic gait analysis using the Fatigue Index Kliniken Schmieder (FKS), have been suggested as a sensitive tool to determine motor fatigability in persons with multiple Sclerosis (pwmS). Hypothesis: Depression does not affect the FKS to a similar degree as in pwmS. methods: We recruited 32 patients with major depression. Data were collected with two accelerometers attached to both ankles. Data were recorded for one minute at the beginning and at the end of the treadmill test. Attractor attributes were used to analyze the data. Results: The mean Fatigue Index Kliniken Schmieder (FKS) was 2.1. The change of the attractor (δm) was 3.7 and the change of variability (δD) was 0.6. mean values were clearly below values of pwmS with fatigability from a previous publication. However, the individual level values from six individuals—five of them showed pain related comorbidity besides depression—fell within the lower pathological range. There was no correlation between Hamilton depression scale and the attractor attributes (δm and δD). Discussion: Depression does not affect gait as motor fatigability does in pwmS. Results from subjects with pain during the treadmill test show a moderately increased variability and moderately altered attractors.

关键词： Accelerometer Assessment Attractor Depression Fatigue Gait Analysis Fatigability multiple Sclerosis

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The Wnt Pathway Target Gene CCND1 Changes mitochondrial Localization and Decreases mitochondrial Activity in Colorectal Cancer Cell Line SW480

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Journal of Biosciences and medicines 2016年第12期4卷 132-143页

作者： Annica Vlad-Fiegen Natalie Veronika Freytag Susanne Dorn oliver müller Sonja Eberth DLR Project management Agency German Aerospace Center Bonn Germany molecular Cancer Research Leibniz Institute DMSZ Braunschweig Germany Leibniz Research Centre for Working Environment and Human Factors Dortmund Germany University of Applied Sciences Kaiserslautern Zweibrücken Germany

mutations leading to constitutive activation of the Wnt pathway and its target genes are frequently observed in cancer. The Wnt pathway promotes cell proliferation and increasing evidence supports its role also in cancer cell metabolism. This study aims to elucidate the role of the Wnt/β-catenin target gene CCND1 in these processes in colorectal cancer. We analyzed whether knock-down of CCND1 affects cell cycle progression and energy metabolism in a colorectal cancer cell line. Down-regulation of CCND1 led to retardation of the cell cycle. The proportion of cells in the G0 phase increased, while the amount of cells in the S- and G2/m phase decreased. Interestingly, knock-down of CCND1 changed the perinuclear localization of mitochondria into a homogeneous distribution within the cytosol. In addition CCND1 knock-down led to an increase of the intracellular ATP level indicating that cyclin D1 reduced mitochondrial activity. Our findings suggest that in addition to its role in cell cycle regulation, the Wnt target gene CCND1 regulates mitochondrial localization and inhibits mitochondrial activity in colorectal cancer cells.

关键词： ATP Cyclin D1 Colorectal Cancer mitochondria Wnt

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Lactate is a potentially harmful substitute for brain glucose fuel:consequences for metabolic restoration of neurotransmission

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Neural Regeneration Research 2025年第5期20卷 1403-1404页

作者： oliver Kann Lennart Soder Babak Khodaie Institute of Physiology and Pathophysiology Heidelberg UniversityHeidelbergGermany Interdisciplinary Center for Neurosciences(IZN) Heidelberg UniversityHeidelbergGermany

The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).

关键词： consequences Figure restoration

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mechanical Characterisation of Densified Hardwood with Regard to Structural Applications

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Journal of Renewable materials 2020年第9期8卷 1091-1109页

作者： Katharina müller Walter Sonderegger oliver Kläusler michael Klippel Edwin Zea Escamilla Institute of Structural Engineering(IBK) Chair of Structural Engineering–Timber StructuresSwiss Federal Institute of Technology ZurichZurich8093Switzerland Swiss Wood Solutions AG 8600 DübendorfSwitzerlandPreviously at Institute for Building Materials(IfB)Chair of Wood Materials ScienceSwiss Federal Institute of Technology ZurichZurich8093Switzerland College of Civil Engineering Nanjing Forestry UniversityNanjing210037China Sustainable Building Center for Corporate Responsibility and SustainabilityUniversity of ZurichZurich8001Switzerland

The demand for high-performance,yet eco-friendly materials is increasing on all scales from small applications in the car industry,instrument or furniture manufacturing to greater dimensions like floorings,balcony furnishings and even *** offers a good choice on all of these scales and can be modified and improved in many different *** this study,two common European hardwood species,Beech(Fagus sylvatica L.)and Ash(Fraxinus excelsior L.)were densified in radial direction by thermo-mechanical treatment and the densified product was investigated in an extensive characterisation series to determine all relevant mechanical *** in the three main directions(longitudinal,tangential,radial)and tension perpendicular to the grain(tangential,radial)were tested and compared to reference specimens with native *** and modulus of elasticity were determined in all *** addition,a Life Cycle Assessment was carried out to evaluate the environmental impact associated to the densification *** experimental investigations showed that strength and stiffness of hardwood in the longitudinal and tangential directions improve significantly by radial densification,whereas some properties in the radial direction *** Life Cycle Assessment showed that artificial wood drying has higher impact than wood ***,the transport distance of the raw material highly influences the environmental impact of the final densified *** paper then also offers an overview of possible applications in structural timber *** hardwood is a viable option as local reinforcement,where high compressive or tensile strength is *** wood densification process offers an alternative to the use of carbon-intense steel components or hardwoods from tropical forests.

关键词： Hardwood densification high-performance construction materials thermo-mechanical treatment mechanical characterisation life cycle assessment timber structures

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Genotyping by sequencing reveals lack of local genetic structure between two German Ips typographus ***

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Forestry Research 2022年第1期2卷 1-5页

作者： markus müller mathias Niesar Ignaz Berens oliver Gailing Forest Genetics and Forest Tree Breeding Faculty for Forest Sciences and Forest EcologyUniversity of GöttingenBüsgenweg 237077 GöttingenGermany Center for Integrated Breeding Research(CiBreed) University of Goettingen37073 GöttingenGermany Landesbetrieb Wald und Holz NRW Team Forest and Climate ProtectionSteinmüllerallee 1351643 GummersbachGermany Landesbetrieb Wald und Holz NRW Nationalparkforstamt EifelUrftseestraße 3453937 Schleiden

The European spruce bark beetle(Ips typographus L.)is a serious pest in Norway spruce *** usually attacking freshly fallen trees or trees with a reduced defense system,also healthy trees can be infested during massive outbreaks of *** that can occur after catastrophic events such as drought periods or *** of the genetic structure of this species,especially on local scales is still *** local population structure was reported in some studies,others did not detect any differentiation among *** ***,we used genotyping by sequencing to infer the genetic structure of two *** populations in western Germany,which had a distance of approx.58 km from each *** on 16,830 SNPs we detected high genetic diversity,but very low genetic differentiation between the populations(F_(ST):0.001)and a lack of population *** results suggest a high dispersal ability of ***.

关键词： structure local structure

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Auto-regulatory feedback by RNA-binding proteins

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Journal of molecular Cell Biology 2019年第10期11卷 930-939页

作者： michaela muller-mcNicoll oliver Rossbach Jingyi Hui Jan medenbach Institute of Cell Biology and Neuroscience Goethe University FrankfurtMax-von-Laue-Strasse 13D-60438 Frankfurt am MainGermany Institute of Biochemistry Justus-Liebig-University GiessenHeinrich-Buff-Ring 17D-35392 GiessenGermany State Key Laboratory of molecular Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China Institute of Biochemistry I University of RegensburgUniversitaetsstrasse 31D-93053 RegensburgGermany

RNA-binding proteins(RBPs)are key regulators in post-transcriptional control of gene *** that alter their activity or abundance have been implicated in numerous diseases such as neurodegenerative disorders and various types of *** highlights the importance of RBP proteostasis and the necessity to tightly control the expression levels and activities of *** many cases,RBPs engage in an auto-regulatory feedback by directly binding to and influencing the fate oftheirown mRNAs,exerting control over their own *** this feedback control,RBPs employ a variety of mechanisms operating at all levels of posttranscriptional regulation of gene *** we review RBP-mediated autogenous feedback regulation that either serves to maintain protein abundance within a physiological range(by negative feedback)or generates binary,genetic on/off switches important for *** fate decisions(by positive feedback).

关键词： autogenous regulation protein homeostasis RNA-binding proteins post-transcriptional regulation of gene expressi on

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The World Stress map

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Episodes 2007年第3期30卷 197-201页

作者： Heidbach, oliver Fuchs, Karl müller, Birgit Wenzel, Friedemann Reinecker, John Tingay, mark Sperner, Blanka Geophysical Institute Karslruhe University 76187 Karlsruhe Hertzstr. 16 Germany Heidelberg Academy of Sciences and Humanities 69117 Heidelberg Karlst. 4 Germany Institute of Geosciences University of Tübingen 72076 Tübingen Sigwartstrasse 10 Germany School of Earth and Environmental Sciences University of Adelaide Adelaide SA 5005 DP313 Mawson Building Australia Geological Institute TU Bergakademie Freiberg 09599 Freiberg Bernhard-von-Cotta-Str. 2 Germany

Knowledge of the stress field in the Earth＇s crust is a key issue for the understanding of geodynamic processes, seismic hazard assessment, and stability of underground openings such as waste disposals, tunnels, mines or wells, and reservoir management. The World Stress map project is a collaborative project of academia, industry and governmental organizations that aims to understand the states and sources of tectonic stresses in the Earth＇s crust. We present the World Stress map at 1：46,000,000 scale as a result of more than two decades of international collaboration. The map reveals that the first-order pattern of stress is of plate-wide scale, indi- cating that plate boundary forces are the major control of the stress orientations and the tectonic regime.

关键词：世界应力地图合作计划政府组织构造

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Inhibitor of differentiation proteins do not influence prognosis of biliary tract cancer

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World Journal of Gastroenterology 2013年第48期19卷 9334-9342页

作者： Jan Harder michael J müller matthias Fuchs Vera Gumpp Annette Schmitt-Graeff Richard Fischer melanie Frank oliver Opitz Jens Hasskarl Department of Gastroenterology Hematology and Oncology Hegau-Bodensee-Hochrhein Kliniken 78221 SingenGermany Department of Hematology and Oncology University Medical Center Freiburg 79104 Freiburg Germany Comprehensive Cancer Center Freiburg Tumorzentrum Ludwig Heilmeyer University Medical Center Freiburg 79104 FreiburgGermany Institute of Pathology University Medical Center Freiburg 79104 Freiburg Germany Onkologie Dreil ndereck 79539 L rrach Germany iOmEDICO AG Freiburg 79108 Freiburg im Breisgau Germany

AIm:To investigate the expression and clinical relevance of inhibitor of differentiation(ID)proteins in biliary tract ***:ID protein expression was analyzed in129 samples from patients with advanced biliary tract cancer(BTC)(45 extrahepatic,50 intrahepatic,and 34 gallbladder cancers),compared to normal controls and correlated with clinical an pathological ***:ID1-3 proteins are frequently overexpressed in all BTC subtypes *** correlation between increased ID protein expression and tumor grading,tumor subtype or treatment response was *** was influenced primary tumor localization(extrahepatic vs intrahepatic and gall bladder cancer,OS 1.5 years vs 0.9 years vs 0.7 years,P=0.002),by stage at diagnosis(OS 2.7 years in stageⅠv s 0.6 years in stageⅣ,Pmic *** a multivariate model,ID protein expression did not correlate with clinical ***,there was a trend of shorter OS in patients with loss of cytoplasmic ID4 protein expression(P=0.076).CONCLUSION:ID protein expression is frequently deregulated in BTC but does not influence clinical *** usefulness as prognostic biomarkers in BTC is very limited.

关键词： Biliary tract cancer Cholangiocarcinoma Inhibitor of differentiation Prognostic factors

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Predicting solid state material platforms for quantum technologies

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npj Computational materials 2022年第1期8卷 1983-1997页

作者： oliver Lerstøl Hebnes marianne Etzelmüller Bathen Øyvind Sigmundson Schøyen Sebastian GWinther-Larsen Lasse Vines morten Hjorth-Jensen Sopra Steria Information Technology and ServicesN-4020StavangerNorway Department of Physics and Center for Computing in Science Education University of OsloN-0316OsloNorway Advanced Power Semiconductor Laboratory ETH Zürich8092ZürichSwitzerland menon Economics N-0369OsloNorway Department of Physics and Center for materials Science and Nanotechnology University of OsloN-0316OsloNorway Department of Physics and Astronomy and Facility for Rare Isotope Beams Michigan State UniversityEast LansingMI48824USA

Semiconductor materials provide a compelling platform for quantum technologies(QT).However,identifying promising material hosts among the plethora of candidates is a major ***,we have developed a framework for the automated discovery of semiconductor platforms for QT using material informatics and machine learning *** approaches were implemented to label data for training the supervised machine learning(mL)algorithms logistic regression,decision trees,random forests and gradient *** find that an empirical approach relying exclusively on findings from the literature yields a clear separation between predicted suitable and unsuitable *** contrast to expectations from the literature focusing on band gap and ionic character as important properties for QT compatibility,the mL methods highlight features related to symmetry and crystal structure,including bond length,orientation and radial distribution,as influential when predicting a material as suitable for QT.

关键词： quantum symmetry separation

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