Inhibitor of differentiation proteins do not influence prognosis of biliary tract cancer

作     者：Jan Harder Michael J Müller Matthias Fuchs Vera Gumpp Annette Schmitt-Graeff Richard Fischer Melanie Frank Oliver Opitz Jens Hasskarl 

作者机构：Department of Gastroenterology Hematology and Oncology Hegau-Bodensee-Hochrhein Kliniken 78221 SingenGermany Department of Hematology and Oncology University Medical Center Freiburg 79104 Freiburg Germany Comprehensive Cancer Center Freiburg Tumorzentrum Ludwig Heilmeyer University Medical Center Freiburg 79104 FreiburgGermany Institute of Pathology University Medical Center Freiburg 79104 Freiburg Germany Onkologie Dreil ndereck 79539 L rrach Germany iOMEDICO AG Freiburg 79108 Freiburg im Breisgau Germany 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第48期

页      面：9334-9342页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Biliary tract cancer Cholangiocarcinoma Inhibitor of differentiation Prognostic factors 

摘      要：AIM:To investigate the expression and clinical relevance of inhibitor of differentiation(ID)proteins in biliary tract ***:ID protein expression was analyzed in129 samples from patients with advanced biliary tract cancer(BTC)(45 extrahepatic,50 intrahepatic,and 34 gallbladder cancers),compared to normal controls and correlated with clinical an pathological ***:ID1-3 proteins are frequently overexpressed in all BTC subtypes *** correlation between increased ID protein expression and tumor grading,tumor subtype or treatment response was *** was influenced primary tumor localization(extrahepatic vs intrahepatic and gall bladder cancer,OS 1.5 years vs 0.9 years vs 0.7 years,P=0.002),by stage at diagnosis(OS 2.7 years in stageⅠv s 0.6 years in stageⅣ,P0.001),resection status and response to systemic *** a multivariate model,ID protein expression did not correlate with clinical ***,there was a trend of shorter OS in patients with loss of cytoplasmic ID4 protein expression(P=0.076).CONCLUSION:ID protein expression is frequently deregulated in BTC but does not influence clinical *** usefulness as prognostic biomarkers in BTC is very limited.