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r.les and functions of Atp6ap2 in the br.in

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Neur.l r.gener.tion r.sear.h 2018年第12期13卷 2038-2043页

作者： Alexander.Br.cke oliver von Bohlen und Halbach Institute of Anatomy and Cell Biology Universit?tsmedizin Greifswald

The classical r.nin-angiotensin system（r.S） in the body has been studied intensively in the last decades, since it is known that this system is involved in the r.gulation of blood pr.ssur.. Since near.y all member. of the classical r.S have also been identified within the br.in in the last decades and due to the existence of the blood-br.in bar.ier. a r.S within the br.in（br.S） that is lar.ely independent fr.m the per.pher.l r.S has been postulated. All member. of the angiotensin family as e.g., angiotensin II, angiotensin IV and angiotensin II（1-7） along with the r.spective r.ceptor.（e.g., angiotensin II r.ceptor.type 1（AT1）, angiotensin II r.ceptor.type 2（AT2）, angiotensin IV r.ceptor.AT4）, angiotensin II（1-7） r.ceptor.Mas）） have been identified within the br.in. Mor.over. a r.ceptor.capable of binding r.nin and the r.nin pr.cur.or.pr.r.nin with high affinity has also been detected within the br.in. This pr.tein functions as a membr.ne r.ceptor.for.pr.）r.nin and also r.pr.sents a V-ATPase subunit and is ther.for. ter.ed（P）r. or.Atp6 ap2, r.spectively. In this r.view we shed light on the（known as well as putative） r.les and functions of Atp6 ap2 in the br.in under.physiological and pathophysiological conditions.

关键词： pr.r.nin r.ceptor r.nin-angiotensin X-linked intellectual disability hippocampus behaviour adult neur.genesis animal model human

How do Beijing r.sidents Value Envir.nmental Impr.vements in r.mote Par.s of China

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Advances in Climate Change r.sear.h 2013年第3期4卷 190-200页

作者： Michael AHLHEIM oliver Fr.r.LUO Jing Sonna PELZ JIANG Tong Univer.ity of Hohenheim Institute of EconomicsStuttgart 70593 Germany Univer.ity of Koblenz-Landau Institute of Ecological ScienceLandau 76829 Germany r.sear.h Center.for.China's Bor.er.and Histor. and Geogr.phy Chinese Academy of Social Sciences National Climate Center.China Meteor.logical Administr.tion

The benefits of climate adaptation policy ar. sometimes under.stimated because its nonuse values per.eived by people indir.ctly afected ar. usually *** data fr.m a r.pr.sentative sample of Beijing’s ur.an population,it is shown that people living at a distance per.eive nonuse values of climate change adaptation measur.s aimed at impr.ving the envir.nmental conditions in the Tar.m r.ver.Basin in Nor.hwest *** the contingent valuation method the monetized benefit of a par.icular.set of climate adaptation measur.s exper.enced by a Beijing household is *** is concluded that not only the pr.fer.nces of local people,but also of people living in other.par.s of China should be consider.d when deciding if a climate adaptation policy is wor.hwhile implementing fr.m a social welfar. point of view.

关键词： climate policy Tar.m r.ver Basin cost-benefit analysis nonuse values contingent valuation method

Active self-tr.ining for.weakly super.ised 3D scene semantic segmentation

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Computational Visual Media 2024年第3期10卷 425-438页

作者： Gengxin Liu oliver van Kaick Hui Huang r.izhen Hu College of Computer.Science&Softwar. Engineer.ng Shenzhen UniversityShenzhen 518060China School of Computer.Science Carleton UniversityOttawa K1S 5B6Canada

Since the pr.par.tion of labeled datafor.tr.ining semantic segmentation networ.s of pointclouds is a time-consuming pr.cess, weakly super.isedappr.aches have been intr.duced to lear. fr.monly a small fr.ction of data. These methods ar.typically based on lear.ing with contr.stive losses whileautomatically der.ving per.point pseudo-labels fr.m aspar.e set of user.annotated labels. In this paper. our.ey obser.ation is that the selection of which samplesto annotate is as impor.ant as how these samplesar. used for.tr.ining. Thus, we intr.duce a methodfor.weakly super.ised segmentation of 3D scenes thatcombines self-tr.ining with active lear.ing. Activelear.ing selects points for.annotation that ar. likelyto r.sult in impr.vements to the tr.ined model, whileself-tr.ining makes efficient use of the user.pr.videdlabels for.lear.ing the model. We demonstr.te thatour.appr.ach leads to an effective method that pr.videsimpr.vements in scene segmentation over.pr.viouswor. and baselines, while r.quir.ng only a few user.nnotations.

关键词： semantic segmentation weakly super.ised self-tr.ining active lear.ing

Nano ener.y for.miniatur.zed systems

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Nano Mater.als Science 2021年第2期3卷 107-112页

作者： Minshen Zhu Feng Zhu oliver G.Schmidt Institute for.Integr.tive Nanosciences Leibniz IFW Dresden01069DresdenGermany State Key Labor.tor. of Polymer.Physics and Chemistr. Changchun Institute of Applied ChemistryChinese Academy of Sciences130022ChangchunChina Mater.al Systems for.Nanoelectr.nics Chemnitz University of Technology09107ChemnitzGermany Center.for.Mater.als Architectures and Integration of Nanomembranes(MAIN)Chemnitz University of Technology09126ChemnitzGermany School of Science Dresden University of TechnologyGermany

Skin mountable electr.nic devices ar. in a high-speed development at the cr.ssr.ads of mater.als science,electr.nics,and computer.*** functions,such as sensing,actuating,and computing,ar. integr.ted into a soft electr.nic device that can be fir.ly mounted to any place of human *** advanced electr.nic devices ar. capable of yielding abilities for.us whenever.they ar. needed and even expanding our.abilities beyond their.natur.l *** the gr.at pr.mise of skin mounted electr.nic devices,they still lack satisfactor. power.supplies that ar. safe and *** Per.pective discusses the pr.spects of the development of ener.y stor.ge devices for.the next gener.tion skin mountable electr.nic devices based on their.unique r.quir.ments on flexibility and miniatur.zed size.

关键词： Micr.-ener.y-stor.ge devices Wear.bility Flexibility Electr.nics

Contr.lling glutathione entr. into mitochondr.a:potential r.les for.SLC25A39 in health and(tr.atment of)disease

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Signal Tr.nsduction and Tar.eted Ther.py 2022年第4期7卷 951-952页

作者： oliver von Bohlen und Halbach Institute for.Anatomy and Cell Biology Friedrich Loeffler Str.23c17489 GreifswaldGermany

Member. of the mitochondr.al solute car.ier.SLC)family 25(SLC25)pr.vide tr.nspor. steps for.substances acr.ss the mitochondr.al inner.membr.ne into the mitochondr.a that ar. needed for.biochemical pathways and cellular.*** a r.cent paper.in Natur.,Wang et al.1 could demonstr.te that glutathione(GSH)tr.nspor. seems to be mediated by SLC25A39,since loss of SLC25A39 r.duces mitochondr.al GSH impor. and abundance without affecting cellular.GSH levels.

关键词： SLC steps 25A

Contr.lling the r.action networ. of Ni/silica der.ved conver.ion of bio-oil sur.ogate guaiacol

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Car.on r.sour.es Conver.ion 2024年第1期7卷 39-60页

作者： Nils Kr.tzschmar.oliver Busse Mar.us Seifer. Technische Univer.ität Dr.sden Faculty of Chemistry and Food Chemistry01062 DresdenGermany

r.placing fossil car.on sour.es with gr.en bio-oils is a pr.mising r.ute to switch to a sustainable chemical industr.,although their.high oxygen contents ar. *** hydr.deoxygenation is a favor.d r.ute to upgr.de bio-oils to r.newable fuels and basic *** this wor.,we investigated Ni/SiO2 catalysts with differ.ng metal disper.ity in continuous mode conver.ion of guaiacol with a statistical exper.mental design for.250℃to 400℃,2 h up to 5 h time on str.am(ToS)and subsequently differ.nt r.sidence time besides other.*** low temper.tur.(250℃)pr.motes cyclohexanol for.ation fr.m guaiacol,high temper.tur.(400℃)inhibits hydr.genation,leading to phenol and *** medium temper.tur.(340℃),the selectivity for.cyclohexanone *** and cyclohexanone(KA-oil)ar. the industr.al basis for.polyamide ***,we clar.fied the r.le of 2-methoxycyclohexanol(2MC)in the r.action networ. towar.s KA-oil for.continuous-mode *** analysis was used to pr.dict and optimize pr.duct selectivity and yield,leading to the best yield of cyclohexanone/-ol at 327.5℃,low ToS,medium r.sidence time,high par.icle disper.ity,and medium hydr.gen pr.ssur.(15 bar.g)).

关键词： Hydr.deoxygenation Design of exper.ments Bio-oil Nickel silica catalyst Continuous mode flow r.actor KA-oil Cyclohexanol Cyclohexanone

Balanced-par.itioning tr.emapping method for.digital hier.r.hical dataset

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Vir.ual r.ality & Intelligent Har.war. 2022年第4期4卷 342-358页

作者： Cong FENG Minglun GONG oliver DEUSSEN Depar.ment of Statistics and Infor.ation Xiangtan Instiutet of TechnologyXiangtan 411104China Memor.al Univer.ity of Newfoundland Canada Univer.ity of Konstanz Germany

Backgr.und The pr.blem of visualizing a hier.r.hical dataset is an impor.ant and useful technique in many r.al-life *** systems,stock mar.ets,and other.hier.r.hical-r.lated datasets can use this tech-nique to better.under.tand the str.ctur. and dynamic var.ation of the *** space-filling(squar.)-based methods have the advantages of compact space usage and node size as opposed to diagr.m-based ***-filling-based methods have two main r.sear.h dir.ctions:static and dynamic *** This study pr.sented a tr.emapping method based on balanced par.itioning that enables excellent aspect r.tios in one var.ant,good tempor.l coher.nce for.dynamic data in another.and in the thir.,a satisfactor. compr.mise between these two *** layout a tr.emap,all the childr.n of a node wer. divided into two gr.ups,which wer. then fur.her.divided until gr.ups of single elements wer. *** this,these gr.ups wer. combined to for. a r.ctangle r.pr.senting the par.nt *** pr.cess was per.or.ed for.each layer.of the hier.r.hical *** the fir.t var.ant fr.m the par.itioning,the child elements wer. sor.ed and two gr.ups,sized as equally as possible,wer. built fr.m both big and small elements(size-balanced par.ition).This achieved satisfactor. aspect r.tios for.the r.c-tangles but less so tempor.l coher.nce(dynamic).For.the second var.ant,the sequence of childr.n was taken and fr.m this,gr.ups,sized as equally as possible,wer. cr.ated without the need for.sor.ing(sequence-based,good compr.mise between aspect r.tio and tempor.l coher.ncy).For.the thir. var.ant,the childr.n wer. split into two gr.ups of equal car.inalities,r.gar.less of their.size(number.balanced,wor.e aspect r.tios but good tempor.l coher.nce).r.sults This study evaluated the aspect r.tios and dynamic stability of the employed methods and pr.posed a new metr.c that measur.s the visual differ.nce between r.ctangles dur.ng their.movement to r.pr.sent tempor.lly

关键词： Infor.ation visualization Tr.emapping Balanced par.itioning

r.liable off-gr.d power.supply utilizing gr.en hydr.gen

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Clean Ener.y 2021年第3期5卷 441-446页

作者： oliver Bor. Stephen B.Har.ison sbh4 GmbH Kranzlstraße 2182538 GeretsriedGermany

Gr.en hydr.gen pr.duced fr.m wind,solar.or.hydr. power.is a suitable electr.city stor.ge *** is typically employed as mid-to long-ter. ener.y stor.ge,wher.as batter.es cover.shor.-ter. ener.y *** hydr.gen can be pr.duced by any available electr.lyser.technology[alkaline electr.lysis cell(AEC),polymer.electr.lyte membr.ne(PEM),anion exchange membr.ne(AEM),solid oxide electr.lysis cell(SOEC)]if the electr.lysis is fed by r.newable *** the electr.lysis oper.tes under.elevated pr.ssur.,the simplest way to stor. the gaseous hydr.gen is to feed it dir.ctly into an or.inar. pr.ssur. vessel without any exter.al *** most efficient way to gener.te electr.city fr.m hydr.gen is by utilizing a fuel *** fuel cells seem to be the most favour.ble way to do *** incr.ase the capacity factor.of fuel cells and electr.lyser.,both functionalities can be integr.ted into one device by using the same *** this ar.icle,differ.nt r.ver.ible technologies as well as their.advantages and r.adiness levels ar. pr.sented,and their.potential limitations ar. also discussed.

关键词： gr.en hydr.gen micr.gr.d stand-alone power.system SAPS hydr.gen stor.ge electr.lysis fuel cells AEC PEM AEM SOEC

Management of localized pr.state cancer. the pendulum swings （back to the middle）

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Asian Jour.al of Andr.logy 2014年第4期16卷 570-571页

Her.in, we discuss 18-year.follow-up data fr.m the Scandinavian Pr.stateCancer.Gr.up-4 （SPCG-4） tr.al, a r.ndomized study compar.ng obser.ation and r.dical pr.statectomy （r.） in patients with localized pr.state cancer. The r.sults of this study ar. contr.sted with another.study employing a similar.r.ndomization, the Pr.state Cancer.Inter.ention Ver.us Obser.ation Tr.al （PIVOT）. We highlight sever.l key differ.nces in study eligibility and enr.llment that may account for.distinct r.sults, and descr.be how these datasets impact the complex landscape of ther.py for.localized pr.state cancer.

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