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Size and time dependent internalization of label-free nano-graphene oxide in human macrophages

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Nano Research 2017年第6期10卷 1980-1995页

作者： Rafael g. Mendes Angelo Mandarino Britta Koch Anne K. Meyer Alicja Bachmatiuk Cordula Hirsch Thomas gemming oliver g. schmidt Zhongfan Liu Mark H. Rummeli College of Physics Optoelectronics and Energy & Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215006 China IFW Dresden Institute for Solid State and Materials Research P.O. Box D-01171 Dresden Germany Centre of Polymer and Carbon Materials Polish Academy of Sciences M. Curie-Sklodowskiej 34 Zabrze 41-819 Poland EMPA - Swiss Federal Laboratories for Materials Science and Technology Lerchenfeldstrasse 5 9014 St. Gallen Switzerland Material Systems for Nanoelectronics Chemnitz University of Technology Reichenhainer Sir. 70 09107 Chemnitz Germany ing National Laboratory for Molecular Sciences College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

graphene oxide shows great promise as a material for biomedical applications, e.g., as a multi-drug delivery platform. With this in view, reports of studies on the interaction between nanosized graphene oxide flakes and biological cells are beginning to emerge. However, the number of studies remains limited, and most used labeled graphene oxide samples to track the material upon endocytosis. Unfortunately, the labeling process alters the surface functionality of the graphene oxide, and this additional funcfionalization has been shown to alter the cellular response. Hence, in this work we used label-free graphene oxide. We carefully tracked the uptake of three different nanoscale graphene oxide flake size distributions using scanning/transmission electron microscopy. Uptake was investigated in undifferentiated human monocyte cells （THP-1） and differentiated macrophage cells. The data show clear size dependence for uptake, such that larger graphene oxide flakes （and clusters） are more easily taken up by the cells compared to smaller flakes. Moreover, uptake is shown to occur very rapidly, within two min of incubation with THP-1 cells. The data highlights a crucial need for cellular incubation studies with nanoparticles, to be conducted for short incubation periods as certain dependencies （e.g., size and concentration） are lost with longer incubation periods.

关键词： graphene oxide THP-1 cells label-free uptake size dependence

Parallel Factories for Smart Industrial Operations:From Big AI Models to Field Foundational Models and Scenarios Engineering

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IEEE/CAA Journal of Automatica Sinica 2022年第12期9卷 2079-2086页

作者： Jingwei Lu Xingxia Wang Xiang Cheng Jing Yang oliver Kwan Xiao Wang Qingdao Academy of Intelligent Industries Qingdao 266114 The State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100190 Motion g Inc.Singapore 068898Singapore IEEE School of Artificial Intelligence Anhui UniversityHefei 230031

The rapid advancement of fundamental theories and computing capacity has brought artificial intelligence,internet of things, extended reality, and many other new intelligent technologies into our daily lives. Due to the lack of interpretability and reliability guarantees, it is extremely challenging to apply these technologies directly to real-world industrial systems. Here we present a new paradigm for establishing parallel factories in metaverses to accelerate the deployment of intelligent technologies in real-world industrial systems: QAII-1.0. Based on cyber-physical-social systems,QAII-1.0 incorporates complex social and human factors into the design and analysis of industrial operations and is capable of handling industrial operations involving complex social and human behaviors. In QAII-1.0, a field foundational model called Eu Artisan combined with scenarios engineering is developed to improve the intelligence of industrial systems while ensuring industrial interpretability and reliability. Finally, parallel oil fields in metaverses are established to demonstrate the operating procedure of QAII-1.0.

关键词： Cyber-physical-social system(CPSS) Industry5.0 Metaverses Parallel factories Parallel intelligence

Molecular changes in hepatic metabolism and transport incirrhosis and their functional importance

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World Journal of gastroenterology 2016年第1期22卷 72-88页

作者： Christoph g Dietrich oliver götze Andreas geier Bethlehem Center of Health Department of Internal MedicineD-52222 Stolberg(Rhineland)Germany University of Würzburg Division of HepatologyDepartment of Internal Medicine IID-97080 WürzburgGermany

Liver cirrhosis is the common endpoint of many hepatic diseases and represents a relevant risk for liver failure and hepatocellular *** progress of liver fibrosis and cirrhosis is accompanied by deteriorating liver *** review summarizes the regulatory and functional changes in phase Ⅰ and phaseⅡmetabolic enzymes as well as transport proteins and provides an overview regarding lipid and glucose metabolism in cirrhotic ***,phase Ⅰ enzymes are generally down regulated transcriptionally,while phaseⅡenzymes are mostly preserved transcriptionally but are reduced in their *** proteins are regulated in a specific way that resembles the molecular changes observed in obstructive *** and glucose metabolism are characterized by insulin resistance and catabolism,leading to the disturbance of energy expenditure and *** non-invasive tests,especially breath tests,for components of liver metabolism are *** heterogeneity and complexity of changes in hepatic metabolism complicate the assessment of liver function in individual ***,studies in humans are rare,and species differences preclude the transferability of data from rodents to *** clinical practice,some established global scores or criteria form the basis for the functional evaluation of patients with liver cirrhosis,but difficult treatment decisions such as selection for transplantation or resection require further research regarding the application of existing non-invasive tests and the development of more specific tests.

关键词： liver cirrhosis drug metabolism transport breath tests lipid metabolism glucose metabolism

Maturation of sperm volume regulation in the rat epididymis

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Asian Journal of Andrology 2010年第4期12卷 578-590页

作者： oliver S. Damm Trevor g. Cooper Centre of Reproductive Medicine and Andrology of the University Miinster D-48149 Miinster Germany

Sperm maturation in the epididymis may involve differences between mature and immature spermatozoa in their volume regulatory osmolyte response. Spermatozoa obtained from the rat caput and cauda epididymidis were examined for their ability to regulate volume after transfer from in situ epididymal osmolality （measured to be 343 ± 13 and 365 ± 19 mmol kg^-1, respectively） to that of the female tract in single- and multiple-step protocols. Cells withstood the single-step treatment better than the multistep protocol. Sperm volume estimates by flow cytometric measure- ments of forward scatter of cells with intact head membranes was more sensitive than those by assessing cell coiling microscopically. At osmolalites below 210 mmol kg l both caput and cauda cells ruptured, limiting the use of flow cytometry. Above this critical value, the use of quinine showed that both caput and cauda cells could regulate volume, but cauda cells were the more effective. Of several organic osmolytes studied, myo-inositol, glutamate and KCl caused only temporary and slight swelling of spermatozoa cells in hypotonic medium. Spermatozoa of both maturities seemed to use potassium as the preferred osmolyte for regulating volume.

关键词： rat sperm sperm maturation volume regulation

The ChatgPT After: Building Knowledge Factories for Knowledge Workers with Knowledge Automation

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自动化学报:英文版 2023年第11期10卷 2041-2044页

作者： Yutong Wang Xiao Wang Xingxia Wang Jing Yang oliver Kwan Lingxi Li Fei-Yue Wang State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190China School of Artificial Intelligence Anhui UniversityHefei 230039China Motion g Inc068898Singapore Department of Electrical and Computer Engineering Purdue School of Engineering and TechnologyIndiana University-Purdue University IndianapolisIndiana 46202-5132 USA IEEE

Briefing: This perspective introduces the concept and framework of knowledge factories with knowledge machines for knowledge workers to achieve knowledge automation for Industry 5.0 and intelligent *** The big hit of Chat gPT makes it imperative to contemplate the practical applications of big or foundation models [1]-[5]. However, as compared to conventional models, there is now an increasingly urgent need for foundation intelligence of foundation models for real-world industrial applications.

关键词： Automation template Chat gPT

ON KARUSH-KUHN-TUCKER POINTS FOR A SMOOTHINg METHOD IN SEMI-INFINITE OPTIMIZATION

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Journal of Computational Mathematics 2006年第6期24卷 719-732页

作者： oliver Stein Department o.f Mathematics-C RWTH Aachen University Germany

We study the smoothing method for the solution of generalized semi-infinite optimization problems from （O. Stein, g. Still： Solving semi-infinite optimization problems with interior point techniques, SIAM J. Control Optim., 42（2003）, pp. 769-788）. It is shown that Karush-Kuhn-Tucker points of the smoothed problems do not necessarily converge to a Karush-Kuhn-Tucker point of the original problem, as could be expected from results in （F. Facchinei, H. Jiang, L. Qi： A smoothing method for mathematical programs with equilibrium constraints, Math. Program., 85（1999）, pp. 107-134）. Instead, they might merely converge to a Fritz John point. We give, however, different additional assumptions which guarantee convergence to Karush-Kuhn：Tucker points.

关键词： generalized semi-infinite optimization Stackelberg game Constraint qualifi-cation Smoothing NCP function.

Epidemiology of injuries in male and female youth football players:A systematic review and meta-analysis

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Journal of Sport and Health Science 2022年第6期11卷 681-695,F0003页

作者： Francisco Javier Robles-Palazón Alejandro López-Valenciano Mark De Ste Croix Jon L.oliver Alberto garcía-gómez Pilar Sainz de Baranda Francisco Ayala Department of Physical Activity and Sport Faculty of Sport SciencesCampus of Excellence Mare NostrumUniversity of MurciaMurcia 30720Spain Centre for Sport Studies King Juan Carlos UniversityMadrid 28933Spain School of Sport and Exercise University of GloucestershireGloucester GL29HWUK Youth Physical Development Centre School of Sport and Health SciencesCardiff Metropolitan UniversityCardiff CF236XDUK Sport Performance Research Institute New Zealand(SPRINZ) Auckland University of TechnologyAuckland 0632New Zealand Operative Research Centre Miguel Hernández University of ElcheElche 03202Spain

Background:To conduct a systematic review and meta-analysis of epidemiological data of injuries in male and female youth football ***:Searches were performed in MEDLINE/PubMed,Web of Science,Cochrane Library,and SPORTDiscus *** were considered if they reported injury incidence rate in male and female youth(≤19 years old)football *** reviewers(FJRP and ALV)extracted data and assessed trial quality using the Strengthening the Reporting of Observational Studies in Epidemiology(STROBE)statement and the Newcastle Ottawa *** grading of Recommendations Assessment,Development,and Evaluation approach determined the quality of *** were combined using a Poisson random effects regression ***:Forty-three studies were *** overall incidence rate was 5.70 injuries/1000 h in males and 6.77 injuries/1000 h in *** injury incidence(14.43 injuries/1000 h in males and 14.97 injuries/1000 h in females)was significantly higher than training injury incidence(2.77 injuries/1000 h in males and 2.62 injuries/1000 h in females).The lower extremity had the highest incidence rate in both *** most common type of injury was muscle/tendon for males and joint/ligament for *** injuries were the most common in both *** incidence rate of injuries increased with advances in chronological age in *** male players presented higher match injury incidence than sub-elite *** females,there was a paucity of data for comparison across age groups and levels of ***:The high injury incidence rates and sex differences identified for the most common location and type of injury reinforce the need for implementing different targeted injury-risk mitigation strategies in male and female youth football players.

关键词： Incidence Muscle injuries Severity Soccer Young athletes

Insect host-parasite coevolution in the light of experimental evolution

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Insect Science 2014年第4期21卷 401-414页

作者： Niels A. g. Kerstes oliver Y. Martin Experimental Ecology Institute for Integrative Biology D‐USYS ETH Zurich Zurich Switzerland

The many ways parasites can impact their host species have been the focus of intense study using a range of approaches. A particularly promising but under-used method in this context is experimental evolution, because it allows targeted manipulation of known populations exposed to contrasting conditions. The strong potential of applying this method to the study of insect hosts and their associated parasites is demonstrated by the few available long-term experiments where insects have been exposed to parasites. In this review, we summarize these studies, which have delivered valuable insights into the evolution of resistance in response to parasite pressure, the underlying mechanisms, as well as correlated genetic responses. We further assess findings from relevant artificial selection studies in the interrelated contexts of immunity, life history, and reproduction. In addition, we discuss a number of well-studied Tribolium castaneum-Nosema whitei coevolution experiments in more detail and provide suggestions for research. Specifically, we suggest that future experiments should also be performed using nonmodel hosts and should incorporate contrasting experimental conditions, such as population sizes or envi- ronments. Finally, we expect that adding a third partner, for example, a second parasite or symbiont, to a host-parasite system could strongly impact （co）evolutionary dynamics.

关键词： artificial selection immunity Nosema reproduction resistance Tribolium

A general and Programmable Synthesis of graphene-Based Composite Aerogels by a Melamine-Sponge-Templated Hydrothermal Process

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CCS Chemistry 2020年第2期2卷 1-12页

作者： Jin ge Hong-Wu Zhu Yuan Yang Yufang Xie gang Wang Jin Huang Lu-An Shi oliver g.schmidt Shu-Hong Yu Division of Nanomaterials&Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleDepartment of ChemistryCAS Center for Excellence in NanoscienceInstitute of Biomimetic Materials and ChemistryUniversity of Science and Technology of ChinaHefei 230026China Institute for Integrative Nanosciences IFW Dresden01609 DresdenGermany Helmholtz-Zentrum Dresden-Rossendorf e.V. Institute of Ion Beam Physics and Materials Research01328 DresdenGermany Center for Advancing Electronics Dresden(cfaed)and Faculty of Chemistry and Food Chemistry Technische Universität Dresden01062 DresdenGermany

Three-dimensional(3D)graphene networks are performance boosters for functional nanostructures in energy-related *** tremendous intriguing nanostructures-decorated 3D graphene networks have been realized,on-demand decoration of nanostructures in the specified position of interest within the whole 3D graphene skeleton is still out of reach,shedding limitations on constructing more sophisticated components with programmable structures which offer enormous potential for the enhancement of performance and exploration of new ***,we report the melamine-sponge(MS)-templated hydrothermal method capable of realizing reduced graphene oxide(RgO)-nanostructure composite aerogels with programmable structures and *** key of this method is using the MS template to preset the structures of choice through programmable solution-processed immobilization of graphene oxide(gO)and ***,the hydrothermal treatment simultaneously removed the MS template and reduced the gO networks without changing the preset *** showcased nine typical RgO-nanostructures composite aerogels to demonstrate the versatility of the MS-templated hydrothermal method.

关键词： 3D graphene graphene aerogel templated assembly macroscopic assembly nanostructures