检索结果-南通市图书馆

Microphysiological systems for solid tumor immunotherapy:opportunities and challenges

Microsystems & Nanoengineering 2023年第6期9卷 77-106页

作者： Sara Abizanda-Campo María Virumbrales-Muñoz Mouhita Humayun Ines Marmol David J.Beebe Ignacio Ochoa Sara oliv.n Jose M.Ayuso Department of Dermatology University of Wisconsin-MadisonMadisonWIUSA University of Wisconsin Carbone Cancer Center MadisonWIUSA Department of Biomedical Engineering University of WisconsinMadisonWIUSA Tissue Microenvironment Lab(TME lab) Aragón Institute of Engineering Research(I3A)University of ZaragozaZaragozaSpain Instituto de Investigación Sanitaria Aragón(IISA) ZaragozaSpain Centro Investigación Biomédica en Red.Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN)ZaragozaSpain Department of Obstetrics and Gynecology University of Wisconsin-MadisonMadisonWIUSA Department of Biological Engineering Massachusetts Institute of Technology CambridgeCambridgeMAUSA Department of Pathology&Laboratory Medicine University of WisconsinMadisonWIUSA

Immunotherapy remains more effective for hematologic tumors than for solid *** of the main challenges to immunotherapy of solid tumors is the immunosuppressive microenvironment these tumors generate,which limits the cytotoxic capabilities of immune effector cells(e.g.,cytotoxic T and natural killer cells).This microenvironment is characterized by hypoxia,nutrient starvation,accumulated waste products,and acidic ***-hijacked cells,such as fibroblasts,macrophages,and T regulatory cells,also contribute to this inhospitable microenvironment for immune cells by secreting immunosuppressive cytokines that suppress the antitumor immune response and lead to immune ***,there is a strong interest in developing new drugs and cell formulations that modulate the tumor microenvironment and reduce tumor cell immune *** systems(MPSs)are versatile tools that may accelerate the development and evaluation of these therapies,although specific examples showcasing the potential of MPSs remain *** in microtechnologies have led to the development of sophisticated microfluidic devices used to recapitulate tumor *** resulting models,also known as microphysiological systems(MPSs),are versatile tools with which to decipher the molecular mechanisms driving immune cell antitumor cytotoxicity,immune cell exhaustion,and immune cell exclusion and to evaluate new targeted ***,we review existing microphysiological platforms to study immuno-oncological applications and discuss challenges and opportunities in the field.

关键词： immunotherapy versatile solid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cerebrovascularβ-dystroglycan immunoreactivity in vertebrates:not detected in anurans and in the teleosts Ostariophysi and Euteleostei

引用

Integrative Zoology 2020年第1期15卷 16-31页

作者： Mihály KÁLMÁN David L.LŐRINCZ oliv.r M.SEBŐK Csilla ARI Erzsébet OSZWALD Hiroaki SOMIYA Veronika JANCSIK Department of Anatomy Histology and EmbryologySemmelweis UniversityBudapestHungary University of Leicester Dept.of NeurosciencePsychology and BehaviourLeicesterUnited Kingdom Hyperbaric Neuroscience Research Lab. Dept of PsychologyUniversity of South FloridaTampaFloridaUSA Department of Environmental Biology Chubu UniversityChubuJapan Department of Anatomy Veterinary UniversityBudapestHungary

The aim of the present paper was to check for the presence of cerebrovascular dystroglycan in vertebrates,because dystroglycan,which is localized in the vascular astroglial end-feet,has a pivotal function in glio-vascular *** mammalian brains,the immunoreactivity ofβ-dystroglycan subunit delineates the *** results of the present study demonstrate similar patterns in other vertebrates,except for anurans and the teleost groups Ostariophysi and *** this study,we investigated 1 or 2 representative species of the main groups of Chondrichthyes,teleost and non-teleost ray-finned fishes,urodeles,anurans,and *** also investigated 5 mammalian and 3 bird *** were obtained from breeders or *** presence ofβ-dystroglycan was investigated immunohistochemically in free-floating ***-embedding electron microscopical immunohistochemistry on Heterodontus japonicus shark brains demonstrated that in Elasmobranchii,β-dystroglycan is also localized in the perivascular glial end-feet despite the different construction of their blood-brain *** results indicated that the cerebrovascularβ-dystroglycan immunoreactivity disappeared separately in anurans,and in teleosts,in the latter group before its division to Ostariophysi and ***munohistochemistry in muscles and western blots from brain homogenates,however,detected the presence ofβ-dystroglycan,even in anurans and all teleosts.A possible explanation is that in the glial end-feet,β-dystroglycan is masked in these animals,or disappeared during adaptation to the freshwater habitat.

关键词： anurans cerebrovascular dystroglycan elasmobranchs teleosts

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生料的反应活性和易烧性及其对耐火材料技术性能的影响

引用

国外材料科学与工程 1994年第1期3卷 27-36页

作者： oliv.WS 刘飚

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Myotilin基因病:主要临床和肌肉病理表型

引用

世界核心医学期刊文摘(神经病学分册) 2006年第2期 23-24页

作者： oliv. M. Goldfarb L.G. Shatunov A. 高宗恩 Institut de Neuropatologia IDIBELL-Hospital de Bellvitge C/Feixa Llarga s/n 08907 Hospitalet de Llobregat Spain.Dr

Mutations in myotilin gene (MYOT) have been associated with variable syndromes including limb girdle muscular dystrophy type 1A (LGMD1A) and a subgroup of myofibrillar myopathy (MFM/MYOT). We studied six Spanish patients from three unrelated kindreds and seven patients without family histo ry. Three previously reported and two novel disease-associated MYOT mutations w ere identified in this group of patients. The disease is characterized by the on set at the age of 42-77 years with muscle weakness initially in distal or proxi mal leg muscles, eventually spreading to other muscle groups of the lower and up per extremities. Associated signs of cardiomyopathy, respiratory failure and per ipheral neuropathy are present in a fraction of patients. Myopathological featur es of focal myofibrillar destruction resulting in intracytoplasmic deposits, str ongly immunoreactive to myotilin, multiple rimmed and centrally or subsarcolemma lly located non-rimmed vacuoles and streaming Z-lines, were observed in each p atient studied. The Spanish cohort, the largest group of patients studied so far , shares phenotypic features with both LGMD1A and MFM/MYOT variants thus establi shing a continuum of phenotypic manifestations characteristic of myotilinopathy, an emerging neuromuscular disorder.

关键词：基因病 Myotilin 表型

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Oxidative stress in brickmakers of Juárez City, Chihuahua, México: Case-control study

引用

Advances in Bioscience and Biotechnology 2012年第7期3卷 1051-1059页

作者： Leobardo Manuel Gómez-oliv.n Alba Yadira Corral-Avitia Katya Aimeé Carrasco-Urrutia Navor Armando González-Granados Marcela Galar-Martínez Nadia Neri-Cruz Hariz Islas-Flores Octavio Dublan-García Facultad de Enfermería y Nutriología Universidad Autónoma de Chihuahua Chihuahua México Laboratorio de Ciencias Ambientales Instituto de Ciencias Biomédicas Universidad Autónoma de Ciudad Juárez Juárez México Laboratorio de Toxicología Acuática Departamento de Farmacia Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional México City México Laboratorio de Toxicología Ambiental Facultad de Química Universidad Autónoma del Estado de México Toluca México

A case-control study was conducted in a brickmaker’s community in Juarez City, Chihuahua in Mexico. This population has been chronically exposed to a wide spectrum of potentially health-damaging pollutants that include coarse, fine and ultrafine particles, carbon monoxide (CO), oxides of nitrogen and sulphur, transitional metals, polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds and bioaerosols. Lipid peroxidation level (LPX) and protein carbonyl content (PCC) help to evaluate oxidized protein content and activity of the antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were evaluated in blood samples of study participants. The group of occupationally exposed (OE) workers consisted of 30 individuals ranging in age from 25 to 55 years, with a mean of 15 years in a brick production-related job. The control group included 30 volunteers who were neither environmentally nor occupationally exposed to brick production activities and whose sociodemo-graphic characteristics were similar to the OE group. Results indicate that none of workers used any type of protective equipment (respirator or face mask, gloves, coveralls) during brick manufacturing. LPX and PCC significantly increased (p < 0.5) in the OE group compared to the control group. SOD, CAT and GPx activity was significantly increased (p < 0.5) in the OE group compared to the control group. Therefore, evaluation of stress oxidative biomarkers is advisable in order to assay chronic exposure to workers in brick manufacturing.

关键词： Oxidative Stress Brickmakers Chronic Exposure Biomarkers Juárez City

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

No Effects of Meteorological Factors on the SARS-CoV-2 Infection Fatality Rate

引用

Biomedical and Environmental Sciences 2021年第11期34卷 871-880页

作者： SOLANES Aleix LAREDO Carlos GUASP Mar FULLANA Miquel Angel FORTEA Lydia GARCIA-oliv. Ignasi SOLMI Marco SHIN Jae II URRA Xabier RADUA Joaquim Institut d'lnvestigacions Biomediques August Pi i Sunyer(IDIBAPS) BarcelonaSpain Department of Psychiatry and Forensic Medicine Autonomous University of BarcelonaBarcelonaSpain Neurosciences Unit Hospital ClinicBarcelonaSpain Adult Psychiatry and Psychology Department Institute of NeurosciencesHospital ClinicBarcelonaSpain Biomedical Network Research Centre on Mental Health(CIBERSAM) Instituto de Salud Carlos IIIMadridSpain Department of Medicine University of BarcelonaBarcelonaSpain Department of Medicine Autonomous University of BarcelonaBarcelonaSpain Pneumology Department Hospital Germans Trias i PujolBadalonaSpain Neurosciences Department University of PaduaPaduaItaly Padua Neuroscience Center PaduaItaly Department of Psychosis Studies Institute of PsychiatryPsychology and NeuroscienceKing's College LondonLondonUK Department of Pediatrics College of MedicineYonsei UniversitySeoul 03722Korea Centre for Psychiatric Research and Education Department of Clinical NeuroscienceKarolinska InstitutetStockholmSweden

Objective Previous studies have shown that meteorological factors may increase COVID-19 mortality,likely due to the increased transmission of the ***,this could also be related to an increased infection fatality rate(IFR).We investigated the association between meteorological factors(temperature,humidity,solar irradiance,pressure,wind,precipitation,cloud coverage)and IFR across Spanish provinces(n=52)during the first wave of the pandemic(weeks 10–16 of 2020).Methods We estimated IFR as excess deaths(the gap between observed and expected deaths,considering COVID-19-unrelated deaths prevented by lockdown measures)divided by the number of infections(SARS-CoV-2 seropositive individuals plus excess deaths)and conducted Spearman correlations between meteorological factors and IFR across the *** We estimated 2,418,250 infections and 43,237 *** IFR was 0.03%in<50-year-old,0.22%in 50–59-year-old,0.9%in 60–69-year-old,3.3%in 70–79-year-old,12.6%in 80–89-year-old,and26.5%in≥*** did not find statistically significant relationships between meteorological factors and adjusted ***,we found strong relationships between low temperature and unadjusted IFR,likely due to Spain’s colder provinces’aging *** The association between meteorological factors and adjusted COVID-19 IFR is *** age differences or ignoring COVID-19-unrelated deaths may severely bias COVID-19 epidemiological analyses.

关键词： Climate COVID-19 Infection fatality rate SARS-CoV-2 Temperature Weather

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

实时经支气管超声引导针吸活检在肺癌分期中的应用

引用

中国肺癌杂志 2010年第5期13卷 406-409页

作者： Ignasi GARCIA-oliv. José SANZ-SANTOS Felipe ANDREO Eduard MONSó 南娟丁燕 Respiratory Service Hospital Universitari Germans Trias i Pujol Badalona Catalunya Spain Departament de Medicina. Universitat Autònoma de Barcelona Ciber de Enfermedades Respiratorias-CibeRes Bunyola Spain 天津医科大学总医院天津市肺癌研究所天津市肺癌转移与肿瘤微环境重点实验室

线性经支气管超声引导针吸活检(endobronchial ultrasound-guided transbronchial needle aspiration,EBUS-TBNA)是新引进的技术,它是实时超声下可视淋巴结的针吸活检。尽管有研究显示,其为肺癌纵隔分期的有效方法,但全世界多数机构并... 详细信息

线性经支气管超声引导针吸活检(endobronchial ultrasound-guided transbronchial needle aspiration,EBUS-TBNA)是新引进的技术,它是实时超声下可视淋巴结的针吸活检。尽管有研究显示,其为肺癌纵隔分期的有效方法,但全世界多数机构并未应用该技术。本报道旨在分享我们应用EBUS-TBNA的经验,并对相关文献做一简要概述。我们对有关该技术的已有文献进行综述,并特别介绍了我们应用该技术方面的经验。EBUS-TBNA用以探查肺癌患者的转移性纵隔淋巴结和/或肺门淋巴结是有效且安全的。在其它病理状态下,其亦为有效的诊断方法。

关键词： EBUS 线性经支气管超声引导针吸活检肺癌分期实时经支气管超声引导针吸活检

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

陕南杜仲林地土壤营养状况及施肥效应

引用

水土保持学报 2002年第4期16卷 94-97页

作者：陈竹君何景峰唐德瑞李群学衡智州李宏李孟生陈登位罗建民刘文英西北农林科技大学陕西杨陵712100 略阳县杜仲开发中心陕西略阳724300 宁强县林业局陕西宁强724400

分析了陕南杜仲主要产区林地土壤的营养状况及其与杜仲生长间的关系,并通过大田多点肥料对比试验评价了杜仲施肥的效果。结果表明,研究地区林地土壤养分普遍缺乏,其中以土壤有效养分的缺乏尤为严重。土壤全氮及有效磷含量高低是影响陕... 详细信息

分析了陕南杜仲主要产区林地土壤的营养状况及其与杜仲生长间的关系,并通过大田多点肥料对比试验评价了杜仲施肥的效果。结果表明,研究地区林地土壤养分普遍缺乏,其中以土壤有效养分的缺乏尤为严重。土壤全氮及有效磷含量高低是影响陕南杜仲生长的关键因素。施肥显著地促进了杜仲当年高度、胸径的生长及树体各部分生物量的累积;同时,林地施肥还表现出了明显的后效。

关键词：杜仲林土壤养分施肥肥效陕南地区树体生长

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：