Oxidative stress in brickmakers of Juárez City, Chihuahua, México: Case-control study

作     者：Leobardo Manuel Gómez-Oliván Alba Yadira Corral-Avitia Katya Aimeé Carrasco-Urrutia Navor Armando González-Granados Marcela Galar-Martínez Nadia Neri-Cruz Hariz Islas-Flores Octavio Dublan-García 

作者机构：Facultad de Enfermería y Nutriología Universidad Autónoma de Chihuahua Chihuahua México Laboratorio de Ciencias Ambientales Instituto de Ciencias Biomédicas Universidad Autónoma de Ciudad Juárez Juárez México Laboratorio de Toxicología Acuática Departamento de Farmacia Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional México City México Laboratorio de Toxicología Ambiental Facultad de Química Universidad Autónoma del Estado de México Toluca México 

出 版 物：《Advances in Bioscience and Biotechnology》 (生命科学与技术进展（英文）)

年 卷 期：2012年第3卷第7期

页      面：1051-1059页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Oxidative Stress Brickmakers Chronic Exposure Biomarkers Juárez City 

摘      要：A case-control study was conducted in a brickmaker’s community in Juarez City, Chihuahua in Mexico. This population has been chronically exposed to a wide spectrum of potentially health-damaging pollutants that include coarse, fine and ultrafine particles, carbon monoxide (CO), oxides of nitrogen and sulphur, transitional metals, polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds and bioaerosols. Lipid peroxidation level (LPX) and protein carbonyl content (PCC) help to evaluate oxidized protein content and activity of the antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were evaluated in blood samples of study participants. The group of occupationally exposed (OE) workers consisted of 30 individuals ranging in age from 25 to 55 years, with a mean of 15 years in a brick production-related job. The control group included 30 volunteers who were neither environmentally nor occupationally exposed to brick production activities and whose sociodemo-graphic characteristics were similar to the OE group. Results indicate that none of workers used any type of protective equipment (respirator or face mask, gloves, coveralls) during brick manufacturing. LPX and PCC significantly increased (p 0.5) in the OE group compared to the control group. SOD, CAT and GPx activity was significantly increased (p 0.5) in the OE group compared to the control group. Therefore, evaluation of stress oxidative biomarkers is advisable in order to assay chronic exposure to workers in brick manufacturing.