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Antitumor efficacy of multi-target in situ vaccinations with CpG oligodeoxynucleotides,anti-OX40,anti-PD1 antibodies,and aptamers

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The Journal of Biomedical Research 2023年第3期37卷 194-212页

作者： Anastasia S.Proskurina Vera S.Ruzanova Genrikh S.Ritter yaroslav R.Efremov Zakhar S.Mustafin Sergey A.Lashin Ekaterina A.Burakova Alesya A.Fokina Timofei S.Zatsepin Dmitry A.Stetsenko olga y.leplina Alexandr A.Ostanin Elena R.Chernykh Sergey S.Bogachev Institute of Cytology and Genetics Siberian Branch of the Russian Academy of SciencesNovosibirsk 630090Russia Department of Natural Sciences Novosibirsk State UniversityNovosibirsk 630090Russia Department of Physics Novosibirsk State UniversityNovosibirsk 630090Russia Department of Chemistry Moscow State UniversityMoscow 119991Russia Research Institute of Fundamental and Clinical Immunology Novosibirsk630099Russia

To overcome immune tolerance to cancer,the immune system needs to be exposed to a multi-target action ***,we investigated the activating effect of CpG oligodeoxynucleotides(ODNs),mesyl phosphoramidate CpG ODNs,anti-OX40 antibodies,and OX40 RNA aptamers on major populations of immunocompetent cells ex *** analysis of the antitumor effects of in situ vaccination with CpG ODNs and anti-OX40 antibodies,as well as several other combinations,such as mesyl phosphoramidate CpG ODNs and OX40 RNA aptamers,was *** against programmed death 1(PD1)checkpoint inhibitors or their corresponding PD1 DNA aptamers were also added to vaccination regimens for analytical *** scenarios were considered:a weakly immunogenic Krebs-2 carcinoma grafted in CBA mice;a moderately immunogenic Lewis carcinoma grafted in C57Black/6 mice;and an immunogenic A20 B cell lymphoma or an Ehrlich carcinoma grafted in BALB/c *** anti-PD1 antibodies(CpG+αOX40+αPD1)to in situ vaccinations boosts the antitumor *** to be used instead of antibodies,aptamers also possess antitumor activity,although this effect was less *** strongest effect across all the tumors was observed in highly immunogenic A20 B cell lymphoma and Ehrlich carcinoma.

关键词： immunogenicity Krebs-2 carcinoma Lewis carcinoma Ehrlich carcinoma A20 B cell lymphoma mesyl phosphoramidate

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Microbial phenolic metabolites are associated with better frontal lobe cognition

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Food Science and Human Wellness 2024年

作者： Inés Domínguez-López Isabella Parilli-Moser Anna Vallverdú-Queralt Anna Tresserra-Rimbau Cinta Valls-Pedret Zenaida Vázquez-Ruiz olga Casta?er Ramon Estruch Emili Ros Rosa M.Lamuela-Raventós Lipid Clinic， Endocrinology and Nutrition Service， Institut d'Investigacions Biomèdiques August Pi i Sunyer， Hospital Clínic 08036 Barcelona， Spain Unit of Cardiovascular Risk and Nutrition， Institut Hospital del Mar de Investigaciones Médicas (IMIM) Department of Preventive Medicine and Public Health， University of Navarra Departament de Nutrició， Ciències de l'Alimentació i Gastronomía， Facultat de Farmacia， Universitat de Barcelon (UB)， Av.de Joan XXII Department of Endocrinology， Hospital Clinic IDIBAPS， Barcelona， Spain Department of Internal Medicine， Hospital Clinic， Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS)， University of Barcelona CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN)， Instituto de Salud Carlos III Institut de Nutrició i Seguretat Alimentària (INSA)， Universitat de Barcelona (UB)

With increasing life expectancy， neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. Preventive strategies include following healthy diets， such as the Mediterranean diet， which is particularly rich in polyphenols， bioactive compounds with neuroprotective properties. The aim of this study was to assess the association of microbial phenolic metabolites (MPM) with cognition. This cross-sectional analysis was performed with 200 participants of the PREDIMED trial (Barcelona-Clinic recruitment center). A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM (protocatechuic acid， enterodiol glucuronide， enterolactone glucuronide， urolithin B glucuronide， and vanillic acid glucuronide)， and cognitive function was evaluated with neuropsychological tests. Multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and MPM， and a score was calculated as the weighted sum of MPM. A higher MPM score was associated with better frontal lobe function. Among individual metabolites， vanillic acid glucuronide was correlated with frontal cognitive performance. Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2. A higher score for urinary multi-MPM was associated with better frontal cognitive performance in an older Mediterranean population.

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Scientific guidelines for preclinical research on potentised preparations manufactured according to current pharmacopoeias—the PrePoP guidelines

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Journal of Integrative Medicine 2024年第5期22卷 533-544页

作者： Alexander L.Tournier Leoni V.Bonamin Susann Buchheim-Schmidt Steven Cartwright Christoph Dombrowsky Paul Doesburg Carla Holandino Maria olga Kokornaczyk Everine B.van de Kraats Jesús Antonio López-Carvallo Papiya Nandy JoséManuel Mazón-Suástegui Fateme Mirzajani Bernard Poitevin Claudia Scherr Karin Thieves Sandra Würtenberger Stephan Baumgartner Institute of Complementary and Integrative Medicine University of Bern Institute of Integrative Medicine Witten/Herdecke University Homeopathy Research Institute Graduate Program on Environmental and Experimental Pathology Paulista University Department of Medical Science Deutsche Hom?opathie-Union DHU-Arzneimittel GmbH&Co.KG Cherwell Laboratory for Fundamental Research in Homeopathy Society for Cancer Research Hiscia Research Institute Laboratório Multidisciplinar de Ciências Farmacêuticas Universidade Federal do Rio de Janeiro World Water Community Departamento de Acuicultura Facultad de Ciencias del MarUniversidad Católica del Norte Centre for Interdisciplinary Research and Education Laboratorio de Homeopatía Acuícola y Semillas Marinas Centro de Investigaciones Biológicas del Noroeste Protein Research Center Shahid Beheshti University Department of Medical Laboratory Science College of ScienceKnowledge University Socie′te′Savante d’Hom′eopathie Sola Salus Institute for Homeopathic Research Scientific Society for Homeopathy

Objective: Pharmacopoeias regulate the manufacture of potentised pharmaceutical preparations used in different branches of complementary and integrative medicine. The physicochemical properties and biological activity of these preparations are often investigated in preclinical research, yet no guidelines for experimental research currently exist in this area. The present PrePoP guidelines aim to provide recommendations to promote high-quality, statistically sound, and reproducible preclinical research on potentised ***: Input was gathered from researchers nominated by the relevant scientific societies using a simplified Delphi consensus approach covering the most relevant aspects of basic research methodology in the field including appropriate controls, sample preparation and handling, and statistics. After three rounds of feedback, a consensus was finally reached on the most important aspects and considerations for conducting high-quality research on potentised ***: We present a series of recommendations on a range of topics including experimental controls,system stability, blinding and randomisation, environmental influences, and procedures for the preparation of potentised samples and controls, and we address some specific challenges of this research ***: This expert consensus process resulted in a robust set of methodological guidelines for research on potentised preparations and provides a valuable framework that will inform and improve the quality of subsequent research in this emerging field.

关键词： Research guidelines Fundamental research Basic research Complementary and integrative medicine Potentisation Potentised preparations

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Clustering of Pathogen-Response Genes in the Genome of Arabidopsis thaliana

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Journal of Integrative Plant Biology 2011年第10期53卷 824-834页

作者： olga A.Postnikova Natalia y.Minakova Alexander M.Boutanaev Lev G.Nemchinov United States Department of Agriculture Agricultural Research ServicePlant Sciences InstituteMolecular Plant Pathology Laboratory Institute of Basic Biological Problems Russian Academy of Sciences

Previously, we used heterologous expressed sequence tag （EST） mapping to generate a profile of 4 935 pathogen-response genes of Arabidopsis thaliana. In this work, we performed a computer analysis of this profile, revealing 1594 non-homologous clustered genes distributed among all A. thafiana chromosomes, whose co-regulation may be related to host responses to pathogens. To supplement computer data, we arbitrarily selected two clusters and analyzed their expression levels in A. thaliana ecotypes Col-0 and C24 during infection with the yellow strain of Cucumber mosaic virus CMV（y）. Ecotype Col-0 is susceptible to CMV（y）, whereas C24 contains the dominant resistance gene RCy1. Upon infection with CMV（y）, all clustered genes were significantly activated in the resistant ecotype C24. In addition, we demonstrated that posttranslational histone modifications associated with trimethylation of histone H3 lysine 27 are most likely involved in regulation of several cluster genes described in this study. Overall, our experiments indicated that pathogen-response genes in the genome of A. thaliana may be clustered and co-regulated.

关键词： CMV H3K27me3 heterologous EST mapping clustering of defense-related genes.

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Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico

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World Journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés Gómez-De León yesica A López-Mora Valeria García-Zárate Ana Varela-Constantino Sergio U Villegas-De Leon Xitlaly J González-Leal Raúl del Toro-Mijares Anna C Rodríguez-Zúñiga Juan F Barrios-Ruiz Victor Mingura-Ledezma Perla R Colunga-Pedraza olga G Cantú-Rodríguez César H Gutiérrez-Aguirre Luz Tarín-Arzaga Elías E González-López David Gómez-Almaguer Hematology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKGROUND The impact of social determinants of health in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes the impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic hematopoietic stem cell transplantation(alloHSCT)in two of Mexico's largest public and private *** To evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients in *** In this retrospective cohort study,we included adolescents and adults≥16 years who received a matched sibling or haploidentical transplant from *** were selected without regard to their diagnosis and were sourced from both a private clinic and a public University Hospital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal healthcare program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo Leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-host-relapse-free survival,and non-relapse-mortality(NRM).Statistical analyses employed appropriate tests,Kaplan-Meier method,and Cox proportional hazard regression *** software included SPSS and R with tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 who lived out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).No differences in OS,event-free-survival,NRM,or graft-versus-host-relapse-free survival were observed for patients dia

关键词： Hematopoietic cell transplant Social determinants of health Geography Haploidentical Out-of-pocket Financial toxicity Survival Health services and outcomes Hematopoietic malignancy Aplastic anemia

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Promotion effects of alkali metals on iron molybdate catalysts for CO_(2)catalytic hydrogenation

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Journal of Energy Chemistry 2023年第10期85卷 291-300,I0009页

作者： yong Zhou Aliou Sadia Traore Deizi V.Peron Alan J.Barrios Sergei A.Chernyak Massimo Corda olga V.Safonova Achim Iulian Dugulan Ovidiu Ersen Mirella Virginie Vitaly V.Ordomsky Andrei y.Khodakov University of Lille CNRSCentrale LilleUniversity of ArtoisUMR 8181-UCCS-Unitéde Catalyse et Chimie du SolideLille F-59000France IPCMS UMR 7504 CNRSUniversitéde Strasbourg23 rue du LoessBP 43Cedex 267034 StrasbourgFrance PSI CH-5232 VilligenSwitzerland Fundamental Aspects of Materials and Energy Group Delft University of TechnologyMekelweg 15Delft 2629 JBNetherlands

CO_(2)hydrogenation is an attractive way to store and utilize carbon dioxide generated by industrial processes,as well as to produce valuable chemicals from renewable and abundant *** catalysts are commonly used for the hydrogenation of carbon oxides to ***-molybdenum catalysts have found numerous applications in catalysis,but have been never evaluated in the CO_(2)*** this work,the structural properties of iron-molybdenum catalysts without and with a promoting alkali metal(Li,Na,K,Rb,or Cs)were characterized using X-ray diffraction,hydrogen temperatureprogrammed reduction,CO_(2)temperature-programmed desorption,in-situ^(57)Fe Mossbauer spectroscopy and operando X-ray adsorption *** catalytic performance was evaluated in the CO_(2)*** the reaction conditions,the catalysts undergo the formation of an iron(Ⅱ)molybdate structure,accompanied by a partial reduction of molybdenum and carbidization of *** rate of CO_(2)conversion and product selectivity strongly depend on the promoting alkali metals,and electronegativity was identified as an important factor affecting the catalytic *** CO_(2)conversion rates were observed with the promoters having higher electronegativity,while low electronegativity of alkali metals favors higher light olefin selectivity.

关键词： CO_(2)utilization Iron molybdate catalysts Promotion Alkali metals Light olefins In-situ characterization

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Novel method for the preparation of Cs-containing FAU（y） catalysts for aniline methylation

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Frontiers of Chemical Science and Engineering 2018年第1期12卷 70-76页

作者： olga A. Ponomareva Polina A. Shaposhnik Marina Vo Belova Boris A. Kolozhvari Irina I. Ivanova Department of Chemistry Lomonosov Moscow State University Moscow 119991 Russia A.V. Topchiev Institute of Petrochemical Synthesis Moscow Russia

Cs-containing FAU（y）-type zeolite catalysts were prepared by conventional and novel ion exchange procedures followed by incipient wetness impregnation with CsOH. The novel ion exchange procedure involved hydrothermal treatment of Nay zeolite in aqueous solution of CsCl at 140-200 ℃ for 6-24 h. The samples were characterized by low-temperature nitrogen adsorption, X-ray fluorescence analysis, X-ray powder diffraction, scanning electron microscopy, 23Na, 27Al and 133Cs magic angle spinning nuclear magnetic resonance, CO2 and NH3-Temperature programmed desorption. The results show that hydrothermal treatment at 200 ℃ allows to obtain higher degrees of ion-exchange （up to 83%） with respect to conventional method giving maximum 66%- 69%. Catalytic properties of Cs-containing FAU（y） were studied in aniline methylation. The yield of Nomethylani- line is shown to correlate with catalyst＇s basicity. The best catalyst performance was achieved over the catalyst with the highest ion-exchange degree impregnated with CsOH. The selectivity to N-methylaniline over this catalyst reached 96.4%.

关键词： FAU(y) zeolite ion exchange with cesium aniline alkylation N-methylaniline

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Variation in abundance and habitat relationship of three understory insectivorous birds in a disturbed landscape of Neotropical dry forest of Colombia

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Avian Research 2020年第3期11卷 265-276页

作者： Camilo Loaiza olga LMontenegro David King Manuel Spínola Lilibeth Arinda Palacio Agustín Rudas Instituto de Ciencias Naturales Universidad Nacional de ColombiaBogotáColombia Northern Research Station USDA Forest ServiceUniversity of Massachusetts204 Holdsworth HallAmherstMA 01003USA Instituto Internacional en Conservación y Manejo de Vida Silvestre Universidad NacionalApartado1350-3000 HerediaCosta Rica.

Background:Evaluating relationships between avian populations and their habitat is important for understanding the biology of these species and for management decisions that improve the effectiveness of restoration *** investigated how habitat variation along a disturbance gradient affected the abundance of three insectivorous bird species,White-bellied Antbird(Myrmeciza longipes),Barred Antshrike(Thamnophilus doliatus),and Pale-breasted Spinetail(Synallaxis albescens)in a Neotropical dry forest remnant in central ***:The study area,which is located in Magdalena Valley,is under ecological restoration after the construction of the“El Quimbo”hydroelectric dam,with a gradient of habitat conditions,from relatively advanced secondary growth to recently disturbed *** conducted bird surveys and quantified the habitat conditions from June 2018 to June *** compared the relative abundance of the birds among the three zones with increasing disturbance and modeled the relationship between the bird abundance with the micro-and landscape-habitat conditions,with Poisson generalized linear model ***:The relative abundance of the three bird species varied according to the habitat features and disturbance *** abundance of White-bellied Antbirds was higher in forests and thickets than shrubland fragments;Barred Antshrike was more abundant in shrubland and thickets than in forest fragments,and Pale-breasted Spinetail had the highest abundance in shrubland and the lowest in forest *** abundance of both White-bellied Antbird and Pale-breasted Spinetail did not differ among zones with different levels of disturbance,while the abundance of Barred Antshrike decreased in zones with more ***:There were significant differences in the habitat relationships of the three understory insectivorous species along the disturbance gradient,although these species were within the same trophic *** bird species prefer

关键词： Bird population ecology Generalized linear models Wildlife habitat restoration

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Carbon coating of air-sensitive insulating transition metal fluorides:An example study on α-Li3FeF6 high-performance cathode for lithium ion batteries

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Journal of Materials Science & Technology 2020年第20期52卷 107-115页

作者： Anna Basa Sławomir Wojtulewski Beata Kalska-Szostko Maciej Perkowski Elena Gonzalo olga Chernyayeva Alois Kuhn Flaviano García-Alvarado Institute of Chemistry University of Bialystokul.K.Ciolkowskiego 1K15-245 BialystokPoland Departamento de Química y Bioquímica Facultad de FarmaciaUniversidad CEU San Pablo28668 Boadilla del MonteMadridSpain Polish Institute of Physical Chemistry Kasprzaka St.44/5201-224 WarsawPoland CIC Energigune Parque Tecnologico de Alava01510 MinanoAlavaSpain

Li_(3)FeF_(6)has been the focus of research of fluorine-based cathode materials for lithium-ion *** of the low electronic conductivity of Li3 FeF6,the decrease of particle size,by an energyconsuming long-time ball milling process with carbon,is necessary to achieve a high electrochemical *** most successful method to enhance electrochemical activity,carbon coating,seemed to be impracticable,so far,for sensitive fluorides like Li3 *** this work,carbon coating on Li3 FeF6 particles has been successfully achieved for the first time,while avoiding both extended hydrolysis and Fe(Ⅲ)-Fe(Ⅱ)*** heat treatment and atmosphere,yielding the maximal transformation of organic carbon to both graphitised and disordered carbon,has been *** coating,with a thickness of approximately 2.5 nm,has been achieved by controlled thermal decomposition of glucose,under air,at 300℃.Raman and X-ray photoelectron spectroscopy(XPS)experiments have proved the existence of carbon and Fe2O3 on the surface of Li3FeF6 *** spectroscopy indicates the presence of organic residues from glucose *** to further reduce the orga nic carbon content results in a decrease of the amorphous carbon coating *** carbon-coated Li3 FeF6 nanoparticles deliver 122 mA h g^(-1)(85%of theoretical capacity)significantly higher than that of a noncoated sample(58 mA h g^(-1)).Even more,a significant beneficial effect of carbon coating on both capacity retention and coulombic efficiency is observed.

关键词： Lithium iron fluoride Hydrolysable fluoride Lithium battery Cathode Carbon coating

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Submicroscopic 11p13 deletion including the elongator acetyltransferase complex subunit 4 gene in a girl with language failure, intellectual disability and congenital malformations: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5296-5303页

作者： Jaime Toral-Lopez Luz María González Huerta olga Messina-Baas Sergio A Cuevas-Covarrubias Departamento de Genética Medica Centro Medico EcatepecISSEMYMEcatepec 55000México Programa de Maestría y Doctorado en Ciencias Médicas Odontológicas y de la Salud/Hospital Infantil de MéxicoUniversidad Nacional Autónoma de MéxicoMéxico 06720México Departamento de Biología Molecular Hospital General de MéxicoCuauhtémoc 06720México Departamento de Oftalmología Hospital General de MéxicoCuauhtémoc 06720México Genetica Hospital General de MéxicoCuauhtémoc 06726Mexico Sergio A Cuevas-CovarrubiasPrograma de Maestría y Doctorado en Ciencias MédicasOdontológicas y de la SaludUniversidad Nacional Autónoma de MéxicoMéxico 06720Mexico

BACKGROUND We described the main features of an infant diagnosed with facial dysmorphic,language failure,intellectual disability and congenital malformations to strengthen our understanding of the ***,treatment is only rehabilitation and surgery for cleft lip and *** SUMMARy The proband was a 2-years-8-months-old *** history was negative for congenital malformations or intellectual *** patient had microcephaly,upward-slanting palpebral fissures,depressed nasal bridge,bulbous nose and bilateral cleft lip and *** magnetic resonance imaging showed cortical atrophy and band *** motor and intellectual development is delayed.A submicroscopic deletion in 11p13 involving the elongator acetyltransferase complex subunit 4 gene(ELP4)and a loss of heterozygosity in Xq25-q26.3 were *** There is no treatment for the ELP4 deletion caused by a submicroscopic 11p3 *** describe a second case of deletion of the ELP4 gene without aniridia,which confirms the association between ELP4 gene with several defects and absence of this ocular *** clinical data in the deletion of the ELP4 gene as cleft palate,facial dysmorphism,and changes at level brain could be associated to this gene or be part of the effect of the recessives genes involved in the loss of heterozygosity region of Xq25-26.3.

关键词： Submicroscopic 11p13 deletion Elongator acetyltransferase complex subunit 4 gene Language failure Intellectual disability Congenital malformations Case report

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