检索结果-南通市图书馆

Targeting of PI3K/AKT signaling and DNA dam.ge response in acute m.eloid leukem.a: a novel therapeutic strategy to boost chem.therapy response and overcom. resistance

中国科学院地质与地球物理研究所2015年度（第15届）...

作者： Feng Shi Quansheng Ge Bao Yang Jianping Li Fengm.i Yang Fredrik Charpentier Ljungqvist olga Solom.na Takeshi Nakatsuka Ninglian Wang Sen Zhao Chenxi Xu Keyan Fang m.saki Sano Guoqiang Chu Zexin Fan Narayan P.Gaire m.ham.ad Usam. Zafar Key Laboratory of Cenozoic Geology and Environm.nt Institute of Geology and GeophysicsChinese Academy of Sciences Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Cold and Arid Regions Environm.ntal and Engineering Research Institute Chinese Academy of Sciences College of Global Change and Earth System.Science Beijing Normal University Joint Center for Global Change Studies China m.teorological Adm.nistration Training Centre Departm.nt of History Stockholm University Bolin Centre for Clim.te Research Stockholm University Institute of Geography Russian Academy of Sciences Tom.k State University Central Departm.nt of Environm.ntal Science Tribhuvan University

To investigate clim.te variability in Asia during the last m.llennium. the spatial and tem.oral evolution of sum.er(June–July–August;JJA) tem.erature in eastern and south-central Asia is reconstructed using m.lti-proxy records and the regularized expectation m.xim.zation(RegE m. algorithm.with truncated total least squares(TTLS), under a point-by-point regression(PPR) fram.work. The tem.erature index reconstructions show that the late 20 th century was thewarm.st period in Asia over the past m.llennium. The tem.erature field reconstructions illustrate that tem.eratures in central, eastern, and southern China during the 11 th and 13 th centuries, and in western Asia during the 12 th century, were significantly higher than those in other regions, and com.arable to levels in the 20 th century. Except for the m.st recent warm.ng, all identified warm.events showed distinct regional expressions and none were uniform.over the entire reconstruction area. The m.in finding of the study is that spatial tem.erature patterns have, on centennial tim.scales, varied greatly over the last m.llennium. m.reover, seven clim.te m.del sim.lations, from.the Coupled m.del Intercom.arison Project Phase 5(Cm.P5), over the sam. region of Asia, are all consistent with the tem.erature index reconstruction at the 99 % confidence level. Only spatial tem.erature patterns extracted as the first em.irical orthogonal function(EOF) from.the GISS-E2-R and m.I-ESm.P m.del sim.lations are significant and consistent with the tem.erature field reconstruction over the past m.llennium.in Asia at the 90 % confidence level. This indicates that both the reconstruction and the sim.lations depict the tem.oral clim.te variability well over the past m.llennium. However, the spatial sim.lation or reconstruction capability of clim.te variability over the past m.llennium.could be still lim.ted. For reconstruction, som. grid points do not pass validation tests and reveal the need for m.re proxies with high tem.oral res

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2021年第4期4卷 984-995页

作者： m.ntserrat Estruch Cam.lla Vittori Teresa m.ñoz m.ntesinos Kristian Reckzeh Kim.Theilgaard-m.nch The Finsen Laboratory Rigshospitalet/National University HospitalFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen DK-2200Denmark Biotech Research and Innovation Centre Faculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen DK-2200Denmark Novo Nordisk Foundation Centre for Stem.Cell Biology DanStemFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen DK-2200Denmark Departm.nt of Hem.tology Rigshospitalet/National University HospitalUniversity of CopenhagenCopenhagen DK-2200Denmark

Resistance of cancer patients to DNA dam.ging radiation therapy and chem.therapy rem.ins a m.jor problem.in the *** current review discusses the m.lecular m.chanism. of therapy resistance in acute m.eloid leukem.a(Am.)conferred by cooperative chem.therapy-induced DNA dam.ge response(DDR)and m.tational activation of PI3K/AKT *** addition,strategies to overcom. resistance are discussed,with particular focus on studies underpinning the vast potential of therapies com.ining standard chem.therapy Am. regim.ns with sm.ll m.lecule inhibitors targeting key regulatory hubs at the interface of DDR and oncogenic signaling pathways.

关键词： DNA dam.ge response PI3K/AKT chem.therapy resistance Am.

Justification of Lym.hotropic Injection of An Im.unom.dulator in Odontogenic Osteom.elitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharm.cy and Pharm.cology 2021年第2期9卷 49-52页

作者： Bakhyt Sekerbekovna Zhanalina olga Yesenovna Bekjanova m.yra Taytoleuovna Kopbayeva Anar Djam.ulovna Sagatbaeva Yelm.ra Niyazovna Sm.gulova Departm.nt of Surgical and Pediatric Dentistry West Kazakhstan Medical University named after M.OspanovAktobeRepublic of Kazakhstan Departm.nt of Faculty Therapeutic Dentistry Tashkent State Dental InstituteTashkentRepublic of Uzbekistan Departm.nt of Therapeutic Dentistry Kazakh National Medical University named after S.D.AsfendiyarovAlmatyRepublic of Kazakhstan

The lym.hotropic injection of the drug nam.d “Gam.a-plant", which is an extract of potato sprouts(Solanituberosigerm.num.extract) and has a high therapeutic effect, was proved by pathom.rphological studies in the exp... 详细信息

关键词： Odontogenic osteom.elitis Gam.a-plant sequestration segm.nted white blood cells histiocytes fibroblasts tissue of lym.h node.

立足区域科研创新服务冰上丝绸之路建设——访俄罗斯阿莫索夫东北联邦大学校长阿纳托利·尼古拉耶夫教授

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界教育信息 2021年第12期34卷 3-7页

作者：奥莉娅(采访/整理) 杜永军(采访/整理) 魏葳(采访/整理) 甘肃政法大学丝路法学院(国际交流学院) 甘肃省联合国教科文组织协会兰州城市学院国际交流处外事科

在俄罗斯8个联邦管区内,远东联邦管区下辖的萨哈(雅库特)共和国历来被人们称为“冰冻之城”——靠近北极圈的地理位置和全境平均厚度300~400米的永久冻土带,让萨哈(雅库特)共和国极富传奇色彩。这里是俄罗斯联邦境内最大的行政区,也是... 详细信息

在俄罗斯8个联邦管区内,远东联邦管区下辖的萨哈(雅库特)共和国历来被人们称为“冰冻之城”——靠近北极圈的地理位置和全境平均厚度300~400米的永久冻土带,让萨哈(雅库特)共和国极富传奇色彩。这里是俄罗斯联邦境内最大的行政区,也是当今世界上面积最大的省级行政单位;在“中俄天然气东线管道”合作下,产于雅库特的天然气已被成功输入中国。按照萨哈(雅库特)共和国领导人艾森·尼古拉耶夫的设想,集中全州1/3人口的首府雅库茨克市,将建设成为一个位于冰上丝绸之路的“智慧城市”,生活在这里的人们也过上适应北方极端气候条件下的数字化生活。在俄远东地区,萨哈(雅库特)是最具有创新基础的联邦主体,阿莫索夫东北联邦大学(以下简称东北联邦大学)在创新型联邦主体建设中功不可没。大学主校区位于雅库茨克,主要开设矿石/石油/天然气开采、原石/钻石处理、医疗/教育、生态、北极可持续发展等方面的专业和课程。在2018年俄罗斯大学科技成果学科排名中,东北联邦大学的地球科学学科排在第16位;在同年国际评级机构的学科排名中,东北联邦大学的自然科学排在全俄第17位。

关键词：学科排名科研创新大学校长科技成果天然气开采极端气候条件雅库特俄远东地区

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

俄罗斯汉学家关于中国货币史的研究

河北师范大学学报（哲学社会科学版） 2015年第6期38卷 23-31页

作者：博罗赫.奥莉加.尼古拉耶夫娜李锦霞俄罗斯科学院远东研究所俄罗斯莫斯科117997 河北师范大学外国语学院河北石家庄050024

俄罗斯对中国货币与货币流通的研究由来已久。19世纪末至20世纪初有许多汉学家从事中国货币的研究工作,然而这个课题对大多数人来说并不是最主要的。В·阿列克谢耶夫为该领域的发展做出了重要贡献。20世纪后半叶对中国货币的研究发展... 详细信息

俄罗斯对中国货币与货币流通的研究由来已久。19世纪末至20世纪初有许多汉学家从事中国货币的研究工作,然而这个课题对大多数人来说并不是最主要的。В·阿列克谢耶夫为该领域的发展做出了重要贡献。20世纪后半叶对中国货币的研究发展成为俄罗斯汉学一个独立学科。充分利用有关知识加强对出土文物的研究和论述是中国货币研究得以发展的重要动因。

关键词：中国硬币中国纸币俄罗斯科学院埃尔米塔日博物馆考古学

Cytokine responses in infants infected with respiratory syncytial virus

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Im.unology 2012年第1期2卷 40-48页

作者： m.rten Breindahl Klaus Rieneck Claus Nielsen Tage Justesen Klaus Bendtzen Klaus m.ller Departm.nt of Pediatrics Hillerod HospitalHillerodDenmark Institute for Inflam.ation Research(IIR) Department of RheumatologyRigshospitalet University HospitalCopenhagenDenmark Departm.nt of Clinical m.crobiology Hillerod HospitalHillerodDenmark Pediatric Clinic II Rigshospitalet University HospitalCopenhagenDenmark

Introduction: Variability in severity of Respiratory Syncytial Virus (RSV) infection is reportedly due to differences in inflam.atory response. Objective: To characterize the cytokine response in RSV+ infants aged 0 - 36 m.nths and to relate their responses to disease severity. m.thods: Nasopharyngeal aspirations (NPAs) were analyzed for RSV and IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-1RA, IL-4R, IFN-γ, sTNFR1, sTNFR2, and TNF-α. Clinical data were collected from.the m.dical records. Results: We included 331 infants of whom.214 were RSV+. In com.arison to RSV- infants, they had significantly higher levels of TNF-α, IL-6, IL-1β, and IFN-γ (p α, IL-6, and IL-1β. sTNFR1/2 were significantly increased in RSV+ infants. Hospitalized patients had significantly higher levels of TNF-α, sTNFR2, and IL-10 (p m.une profile. Conclusion: In acute RSV disease, infected infants’ NPAs contain a significant am.unt of pro-inflam.atory cytokines. Whether this response is beneficial or deleterious rem.ins unanswered. Interpersonal variations in cytokine responses m.ght be linked to an inherited tendency to variations in disease severity.

关键词： Respiratory Syncytial Virus Bronchiolitis Inflam.ation Cytokines Infants Aged 0-3 Years

m.xican Guidelines for the Diagnosis and Treatm.nt of Chronic m.eloid Leukaem.a

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2013年第3期4卷 747-764页

作者： Eduardo Cervera Federico Godínez Rosa Sosa Ram.n Rivas Carlos Best Juan Hernández Adrián m.rales Hugo Zurita Ivette Carrasco Jorge Cruz álvaro Aguayo José Espinoza Juan Labardini Luis Valero Judith Cruz Diana Arcos Diego Lim.n Om.r López-Navarro Daniela Gordillo-Bastidas m.rna Candelaria Francisco Torres Juan Kassack Oscar de Jesús Pérez Ram.rez Jorge Aquino Guillerm. Díaz m.riela Cardiel m.rgarita Rodríguez Patricia m.ntoya Juan Contreras m.ría Chávez Sandra Chávez David Góm.z olga Cantú Jorge Duque Luis Pita Eduardo Lobato Julio López Antonio López Pedro González Jorge Cortés Haem.tology and Oncology Departm.nt National Institute of Medical and Nutrition Sciences “Dr. Salvador Zubirán” Mexico City Mexico Haem.tology Deparm.nt from.Hospital Juárez Mexico City Mexico Haem.tology Departm.nt Blood Bank and Unit of Aphaeresis General Hospital of Culiacán Health Ministry Culiacán Mexico Haem.tology Departm.nt Bone Marrow Transplant and Blood Bank from Hospital Regional de Alta Especialidad “Dr. Juan Graham Casassus” Villahermosa Mexico Haem.tology Departm.nt Cancerology National Institute (INCan) Mexico City Mexico Haem.tology Departm.nt Cancerology National Institute (INCan) Mexico City Mexico 2Internal m.dicine Haematology Hospital ISSSTECALI Tijuana Mexico Haem.tology Departm.nt Centenario Hospital Miguel Hidalgo Health Ministry Aguascalientes Mexico Haem.tology Departm.nt General Hospital of Sonora State Sonora Mexico Haem.tology Departm.nt Hospital Universitario UANL Monterrey Mexico Haem.tology Haematology Service Hospital General Regional SSG León Mexico Haem.tology Head of Haematology Service School of Medicine Autonomous University of San Luis Potosí San Luis Potosí Mexico Haem.tology Hospital “Aranda de la Parra” León Mexico Haem.tology Hospital General de Especialidades Campeche Mexico Haem.tology Hospital General de México Mexico City Mexico Haem.tology Hospital General de Occidente SSA Guadalajara Mexico Haem.tology Hospital Regional de Alta Especialidad de Oaxaca Oaxaca Mexico Haem.tology Mérida Clinic Yucatán Mexico Haem.tology Oncology Unit SSEP Puebla Mexico Hospital Betania Puebla Mexico Hospital of the Poblano Child Puebla Mexico Internal m.dicine Haematology Hospital ISSSTECALI Tijuana Mexico Leukaem.as Clinic at ISSEm.m Toluca Mexico Leukem.a Departm.nt MD Anderson Cancer Center Houston Mexico Los m.chis General Hospital Sinaloa Mexico Renaissance Clinic Morelia Mexico State Council for AIDS Prevention and Control Chihuahua Mexico Universidad Autónom. de Yucatán Mérida Mexico

Background: This docum.nt includes recom.endations and guidelines issued by a group of m.xican researchers and specialists gathered in the First National Colloquium.for the Diagnosis and m.nagem.nt of Chronic m.eloid Leukaem.a (Cm.) by initiative of Instituto Nacional de Cancerología and with the support of the Leukaem.a Departm.nt of the m. Anderson Cancer Center. m.xico lacks of updated inform.tion taken from.its own reality on the diagnosis and treatm.nt of Cm. and other haem.tological disorders;besides, there are no national guidelines. Aim. To publish a consensus docum.nt with guidelines for the m.nagem.nt of Cm. adjusted to the national environm.nt and overall characteristics. m.thod: The participants answered a DELPHI questionnaire about the overall aspects of the disease, aim.ng to target controversial topics, discuss them.in the colloquium. and to agree on the best ones. After those m.etings, a final docum.nt was drawn up. Results: The group presents recom.endations for definition, diagnosis, prognosis, m.nitoring, and treatm.nt of Cm. in m.xico. Conclusions: Having consensus guidelines for the clinical m.nagem.nt of Cm. in our country will enable the consensual practice of m.xican specialists regarding the clinical approach to Cm., as well as optim.ze the resources which allow the rational planning of the m.dical care strategies.

关键词： Chronic m.eloid Leukaem.a m.nagem.nt Guidelines Diagnosis Treatm.nt.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

天津滨海文化中心

建筑实践 2020年第2期3卷 30-51页

作者：曼哈德·冯·格康施特凡·胥茨施特凡·雷沃勒隋锦赢林赛博第纳·伯彦斯玛滕·哈姆斯卢旳迪米特里·菲利普 Christian Gahl(摄) 马可·阿桑德里穆杨托伯纳德.屈米赵春水董天杰田垠侯勇军田轶凡黄轩韩薇韩海雷张萌 Joel Rutten Nianlai Zhong Christopher Le Pierre-Yves Kuhn Jerom. Haferd Bart-Jan Polm.n Dora Felekou Pedro Cam.ra Shayi Liang Nate Oppenheim.Kate Scott Clint on Peterson olga Jitariouk Sung Yu 无不详伯纳德·屈米建筑师事务所天津市建筑设计院天津市城市规划设计研究院 m.RDV建筑规划事务所 BING THOm 天津华汇工程建筑设计有限公司天津市渤海城市规划设计研究院 BTA TAUPD

天津滨海新区文化中心的整体规划对区域内建筑退线、檐高和进深进行了前期规定,以此保证五座由不同建筑师设计完成的建筑可以构成一个和谐的整体。文化艺术长廊的巨大屋面将不同的文化设施连为一体,构成整个基地的背脊线。博物馆、展览... 详细信息

天津滨海新区文化中心的整体规划对区域内建筑退线、檐高和进深进行了前期规定,以此保证五座由不同建筑师设计完成的建筑可以构成一个和谐的整体。文化艺术长廊的巨大屋面将不同的文化设施连为一体,构成整个基地的背脊线。博物馆、展览馆和活动中心等空间密集分布于230m.、25m.的南北轴线两侧;东西轴线仅长100m.而60m.宽度是南北轴线的2倍多。两条主轴交汇形成一座中央广场,可举办大型临时展览或演出活动。

关键词：建筑师事务所城市规划设计天津市建筑设计院天津滨海新区科技馆

New genes em.rging for colorectal cancer predisposition

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第8期20卷 1961-1971页

作者： Clara Esteban-Jurado Pilar Garre m.ria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer m.oz Francesc Balaguer Teresa Ocaa Antoni Castells Josep m.Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa m.ntserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel Departm.nt of Gastroenterology Hospital ClínicCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBEREHD)Institut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)University of Barcelona08036 BarcelonaCataloniaSpain m.lecular Oncology Laboratory Hospital Clínico San CarlosInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)28040 MadridSpain Bioinform.tics platform Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)08036 BarcelonaSpain Centre Nacional d’Anàlisi Genòm.ca (CNAG) Parc Científic de Barcelona08028 BarcelonaSpain Departm.nt of Gastroenterology Hospital del Mar-IMIM (Hospital del Mar Medical Research Centre)Pompeu Fabra University08003 BarcelonaSpain Galician Public Foundation of Genom.c m.dicine (FPGm.) Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER)Genomics Medicine GroupHospital ClínicoSantiago de CompostelaUniversity of Santiago de Compostela15706 GaliciaSpain Center of Excellence in Genom.c m.dicine Research King Abdulaziz University21589 JeddahKingdom of Saudi Arabia Gastroenterology Departm.nt Hospital DonostiaNetworked Biomedical Research Centre for Hepatic and Digestive Diseases (CIBEREHD)Basque Country University20080 San SebastiánSpain

Colorectal cancer(CRC)is one of the m.st frequent neoplasm. and an im.ortant cause of m.rtality in the developed *** cancer is caused by both genetic and environm.ntal factors although 35%of the variation in CRC susceptibility involves inherited genetic *** syndrom.s account for about5%of the total burden of CRC,with Lynch syndrom. and fam.lial adenom.tous polyposis the m.st com.on *** hereditary form.,there is an im.ortant fraction of CRC cases that present fam.lial aggregation for the disease with an unknown germ.ine genetic *** can be also considered as a com.lex disease taking into account the com.on diseasecom.om.variant hypothesis with a polygenic m.del of inheritance where the genetic com.onents of com.on com.lex diseases correspond m.stly to variants of low/m.derate *** far,30 com.on,low-penetrance susceptibility variants have been identified for ***,new sequencing technologies including exom.and whole-genom. sequencing have perm.tted to add a new approach to facilitate the identification of new genes responsible for hum.n disease *** using whole-genom. sequencing,germ.ine m.tations in the POLE and POLD1 genes have been found to be responsible for a new form.of CRC genetic predisposition called polym.rase proofreading-associated polyposis.

关键词： Colorectal neoplasm.genetic predisposition to dise