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Quantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor,aging,and Parkinson’s disease

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Nano Research 2023年第5期16卷 7119-7133页

作者： Alexander V.Romashchenko Dmitrii V.Petrovskii Sergey Yu.Trotsky Ksenia N.Morozova Nina B.illarionova Maria V.Zhukova Elena V.Kiseleva Marina B.Sharapova Daniil S.Zuev Konstantin E.Kuper Sergey Yu.Taskaev Anna i.Kasatova Dmitrii A.Kasatov olga i.solovieva ivan A.Razumov Ludmila A.Gerlinskaya Mikhail P.Moshkin Yuri M.Moshkin The Federal Research Center institute of Cytology and Genetics SB RASAcademician Lavrentiev Avenue10Novosibirsk 630090Russia international tomography center Institutskaya st.3ANovosibirsk 630090Russia G.K.Boreskov institute of Catalysis SB RASAcademician Lavrentiev Avenue5Novosibirsk 630090Russia The Federal Research Center Budker institute of Nuclear Physics SB RASAcademician Lavrentiev Avenue11Novosibirsk 630090Russia institute of Computational Technologies Academician M.A.Lavrentiev avenue6Novosibirsk 630090Russia institute of Gene Biology Russian Academy of SciencesMoscow 117334Russia institute of Molecular and Cellular Biology SB RASAcad.Lavrentiev Ave8/2Novosibirsk 630090Russia Federal Research Centre of Biological Systems and Agrotechnologies RASst.January 929Orenburg 460000Russia

Nanoparticles(NPs)can be transported via the nose-to-brain(N_(2)B)***,quantitative data on their spatiotemporal dynamics and regulation of the N_(2)B transport are largely *** surveyed metal oxide/hydroxide NPs as magnetic resonance imaging(MRi)contrasts for quantitative N_(2)B *** containing divalent transition metals were the only ones capable of N_(2)B *** T1-weighted(T1W)MRi,we showed that Mn_(3)O_(4)-NPs were readily engulfed by olfactory receptor neurons(ORNs)without disrupting olfactory sensing,we mapped their N_(2)B *** neurons,the Mn_(3)O_(4)-NPs were localized to the cytosol,mitochondria,vesicles,moved at mixed fast and slow axonal transport velocities intraand extra-vesicularly through *** NPs’axonal transport is dependent on neuronal activity and microtubule *** Mn_(3)O_(4)-NPs were trans-synaptically transmitted through at least four synapses across the olfactory ***-synaptic transmission of the NPs was dependent on N-type Ca^(2+)channels and NMDA receptors but blocked by GABAB receptor activation.A five-parameter Weibull signal increase/decrease model fitted to the T1W MRi data allowed for estimating kinetic parameters of Mn_(3)O_(4)-NP accumulation/*** and relative accumulation rates,but not elimination,correlated negatively with the number of synapses from ORNs,indicating a coupling of the NPs’N_(2)B transport with spontaneous neuronal ***,olfactory stimuli(2,5-dimethylpyrazine and acetophenone)significantly modulated and rerouted the Mn_(3)O_(4)-NP N_(2)B transport odor ***,the NPs’trans-synaptic transmission was impaired by aging and the onset of Parkinson’s *** data suggest new approaches to diagnostics,functional neuroimaging,controlling N_(2)B drug delivery.

关键词： Mn_(3)O_(4)nanoparticles magnetic resonance imaging(MRi) nose-to-brain transport trans-synaptic transmission olfactory stimulation

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Vibrational Suspension of Two Cylinders in a Rotating Liquid-Filled Cavity with a Time-Varying Rotation Rate

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Fluid Dynamics & Materials Processing 2024年第9期20卷 2127-2137页

作者： olga Vlasova Laboratory of Vibrational Hydromechanics Perm State Humanitarian Pedagogical UniversityPermSibirskaya614990Russia

The dynamics of rotating hydrodynamic systems containing phase inclusions are interesting due to the related widespread occurrence in nature and *** influence of external force fields on rotating systems can be used to control the dynamics of inclusions of various *** inclusions is of current interest for space *** low gravity,even a slight vibration effect can lead to the appearance of a force acting on phase inclusions near a solid *** vibrations are applied to multiphase hydrodynamic systems,the oscillating body intensively interacts with the fluid and introduces changes in the related flow *** in the fluid flow lead to the appearance of an averaged *** a result,the body is repelled from the cavity boundary and takes a position at a certain distance from *** vibrationally-induced movement of phase inclusions in liquids can be used to improve various technological processes(for example,when degassing and cleaning liquids from solid inclusions,mixing various components,etc.).This study presents a relevant methodology to study the averaged vibrational force acting on a pair of free cylindrical bodies near the oscillating wall of a *** is paid to the region of moderate and low dimensionless frequencies when the size of the inclusion is consistent with the thickness of the Stokes boundary *** dynamics of these bodies is considered in a horizontal cylindrical cavity with a fluid undergoing modulated *** average lift force of a vibrational nature is measured by the method of quasi-stationary suspension of bodies whose density differs from the density of the liquid in a static centrifugal force *** developed technique makes it possible to determine the dependence of the lift force on vibration parameters and the distance from the oscillating boundary at which solid inclusions are *** is shown that in the region of moderate dimensionless frequencies,the averag

关键词： Solid bodies rotational oscillations viscous fluid lift force

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Large-scale genome-wide SNP analysis reveals the rugged(and ragged)landscape of global ancestry,phylogeny,and demographic history in chicken breeds

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 324-340页

作者： Natalia V.DEMENTiEVA Yuri S.SHCHERBAKOV olga i.STANiSHEVSKAYA Anatoly B.VAKHRAMEEV Tatiana A.LARKiNA Artem P.DYSiN olga A.NiKOLAEVA Anna E.RYABOVA Anastasiia i.AZOVTSEVA olga V.MiTROFANOVA Grigoriy K.PEGLiVANYAN Natalia R.REiNBACH Darren K.GRiFFiN Michael N.ROMANOV Russian Research institute of Farm Animal Genetics and Breeding-Branch of the L.K.Ernst Federal Research Centre for Animal Husbandry.Pushkin St.Petersburg196601Russia School of Biosciences University of KentCanterburyCT27NJUK L.K.Ernst Federal Research Center for Animal Husbandry DubrovitsyPodolskMoscow Oblast142132Russia

The worldwide chicken gene pool encompasses a remarkable,but shrinking,number of divergently selected breeds of diverse *** study was a large-scale genome-wide analysis of the landscape of the complex molecular architecture,genetic variability,and detailed structure among 49 *** populations represent a significant sample of the world's chicken breeds from Europe(Russia,Czech Republic,France,Spain,UK,etc.),Asia(China),North America(USA),and Oceania(Australia).Based on the results of breed genotyping using the illumina 60K single nucleotide polymorphism(SNP)chip,a bioinformatic analysis was carried *** included the calculation of heterozygosity/homozygosity statistics,inbreeding coefficients,and effective population *** also included assessment of linkage disequilibrium and construction of phylogenetic *** multidimensional scaling,principal component analysis,and ADMiXTURE-assisted global ancestry analysis,we explored the genetic structure of populations and subpopulations in each *** overall 49-population phylogeny analysis was also performed,and a refined evolutionary model of chicken breed formation was proposed,which included egg,meat,dual-purpose types,and ambiguous *** a large-scale survey of genetic resources in poultry farming using modern genomic methods is of great interest both from the viewpoint of a general understanding of the genetics of the domestic chicken and for the further development of genomic technologies and approaches in poultry *** general,whole genome SNP genotyping of promising chicken breeds from the worldwide gene pool will promote the further development of modern genomic science as applied to poultry.

关键词： Chicken genome diversity Single nucleotide polymorphism(SNP)analysis Gene pool Global ancestry Phylogeny Demographic history

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K^(+) channel-mediated retarded maturation of interneurons and its role in neurodevelopmental disorders

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Neural Regeneration Research 2024年第7期19卷 1403-1404页

作者： Kaizhen Li Daria Savitska olga Garaschuk Laboratory of Systems Neuroscience Department of PhysiologyUniversity of BernBernSwitzerland institute of Physiology Department of NeurophysiologyEberhard Karls University of TübingenTübingenGermany

De novo mutations in genes encoding K^(+)channels are implicated in many severe neurodevelopmental ***,mutations in KCNA2,encoding the Shaker-type voltage-gated K^(+)channel Kv1.2,and KCNJ2,encoding the inwardly rectifying K^(+)channel Kir2.1,associate with focal and generalized epilepsies,brain atrophy,autism,ataxia and hereditary spastic paraplegia(Syrbe et al.,2015;Masnada et al.,2017;Cheng et al.,2021).

关键词： disorders atrophy

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Averaged Dynamics of Fluids near the Oscillating interface in a Hele-Shaw Cell

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Fluid Dynamics & Materials Processing 2024年第4期20卷 847-857页

作者： Anastasia Bushueva olga Vlasova Denis Polezhaev Laboratory of Vibrational Hydromechanics Perm State Humanitarian Pedagogical UniversityPerm614990Russia

The steady flow in a Hele-Shaw cell filled with fluids with a high viscosity contrast in the presence of fluid oscillations is experimentally *** control of oscillatory dynamics of multiphase systems with interfaces is a challenging technological *** consider miscible(water and glycerol)and immiscible(water and high-viscosity silicone oil PMS-1000)fluids under subsonic oscillations perpendicular to the *** show that the interface shape depends on the amplitude and frequency of *** interface is undisturbed only in the absence of *** small amplitudes,the interface between water and glycerol widens due to *** the critical amplitude is reached,the interface becomes unstable to the fingering instability:Aqueous fingers penetrate the high-viscosity glycerol and induce intensive mixing of miscible fluids and associated decay of the *** the disappearance of the fingers,the interface takes a U-shape in the central part of the cell.A similar effect is observed for immiscible fluids:The oscillating interface tends to bend to the side of a high-viscosity ***,when the critical amplitude is reached,the fingering instability arises at the convex *** paper focuses on the causes of bending of the initially undisturbed interface between miscible or immiscible *** this purpose,we measure the steady flow velocity near the interface and in the bulk of a high-viscosity fluid using Particle image Velocimetry(PiV).

关键词： Hele-Shaw cell oscillations steady flow miscible fluids immiscible fluids interface

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Fine-needle aspiration technique under endoscopic ultrasound guidance:A technical approach for RNA profiling of pancreatic neoplasms

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2663-2672页

作者： Sabina Sherafedinovna Seyfedinova olga Aleksandrovna Freylikhman Polina Sergeevna Sokolnikova Konstantin Aleksandrovich Samochernykh Anna Aleksandrovna Kostareva olga Viktorovna Kalinina Evgeniy Gennadievich Solonitsyn Research Laboratory of Digestive Cancer Almazov Medical Research CentreSaint-Petersburg 197341Russia Research Laboratory of Molecular and Cellular Modeling and Gene Therapy Almazov Medical Research CentreSaint-Petersburg 197341Russia Head of Russian Neurosurgical institute Named after Prof.A.L.Polenova Russian Neurosurgical Institute Named after Prof.A.L.PolenovaSaint-Petersburg 191014Russia Head of institute of Molecular Biology and Genetics Almazov National Medical Research CentreSaint-Petersburg 197341Russia Research Laboratory of Autoimmune and Autoinflammatory Diseases Almazov National Medical Research CentreSaint-Petersburg 197341Russia

BACKGROUND Early diagnosis of pancreatic ductal adenocarcinoma(PDAC)has been a longstanding *** prognosis of patients with PDAC depends on the stage at *** is necessary to identify biomarkers for the detection and differentiation of pancreatic tumors and optimize PDAC sample preparation procedures for DNA and RNA *** molecular studies are done using paraffin-embedded blocks;however,the integrity of DNA and RNA is often compromised in this ***,RNA isolated from human pancreatic tissue samples is generally of low quality,in part,because of the high concentration of endogenous pancreatic RNAse activity *** To assess the potential of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)to obtain specimens from pancreatic neoplasms for subsequent RNA molecular profiling,including next-generation sequencing(NGS).METHODS Thirty-four EUS-FNA samples were included in this study:PDAC(n=15),chronic pancreatitis(n=5),pancreatic cysts(n=14),mucinous cysts(mucinous cystic neoplasia/intraductal papillary mucinous neoplasia)n=7,serous cystic neoplasms n=5,and pseudocysts n=*** material consisted of cyst fluid and cyst wall samples obtained by through-the-needle biopsy(TTNB).Samples were stored at -80℃ until *** purity(A260/230,A260/280 ratios),concentration,and integrity(RiN)were ***-time polymerase chain reaction was conducted on all samples,and small RNA libraries were prepared from solid mass *** RNA was successfully extracted from 29/34(85%)EUS-FNA samples:100% pancreatic adenocarcinoma samples,100% chronic pancreatitis samples,70% pancreatic fluid cyst samples,and 50%TTNB *** relative expression of GAPDH and HPRT were obtained for all successfully extracted RNA samples(n=29)including lowquality RNA *** concentration and nonoptimal RiN values(no less than 3)of RNA extracted from EUS-FNA samples did not prevent NGS library *** suitability of cyst fluid samples

关键词： Endoscopic ultrasound-guided,fine-needle aspiration Pancreatic cancer Pancreatic cysts RNA extraction Through-the-needle biopsy Next-generation sequencing

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Environmental impact Assessment of Onshore Wind Farms in the Region of Central Greece Using a Modified RiAM Method

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Journal of Environmental & Earth Sciences 2024年第1期6卷 71-82页

作者： olga Korozi Dimitra G.Vagiona Department of Spatial Planning and Development Aristotle University of ThessalonikiThessaloniki 54124Greece

Wind energy is one of the most basic forms of renewable energy,which shows an increasing rate of development worldwide and also at the European ***,this rapid deployment of wind farms makes the need for an impact assessment of this type of projects on the natural and man-made environment *** present paper aims to identify and assess the environmental impacts of wind farm projects in the Region of Central Greece.A modified Rapid impact Assessment Matrix(RiAM)method is used for this *** methodology includes the identification of the existing onshore wind farm projects in the study area,the appropriate modifications of the RiAM method to respond to the characteristics of the projects and the study area,the qualitative assessment of their potential impacts during construction and operational phases and the computation of the Environmental Performance Grade(EPG)of projects based on the pro-posed modified RiAM *** results reveal that although there are some slight negative impacts on the natural environment of the study area,the examined wind farms contribute positively both to the atmosphere and to the socio-economic environment of the *** study extends the potential for using RiAM as a tool in environmental impact assessment studies of renewable energy projects.

关键词： Environmental impact assessment Environmental components Region of central Greece Rapid impact assessment matrix(RiAM) Environmental performance grade(EPG)

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Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium ions

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Chinese Journal of Polymer Science 2024年第5期42卷 604-611,I0007页

作者： Tatiana N.Nekrasova Andrei i.Fischer Natalia A.Nesterova Anatoliy V.Dobrodumov Anzhelika V.Garshinina olga D.Shuvaeva Natalya V.Zakharova Evgenii F.Panarin institute of Macromolecular Compounds Russian Academy of Sciences31 Bolshoy pr.St Petersburg199004Russia Smorodintsev Research institute of influenza Russian Ministry of Health15/17 ul.prof.PopovaSt Petersburg197376Russia

Water-soluble copolymers of p-methacrylamidobenzoic acid(MABA)with neutral comonomers(N-vinylpyrrolidone(VP),N-methyl-N-vinylacetamide(MVAA),N-methacryloyl glucosamine(MAG))and anionic comononer sodium styrene sulfonate(NaSS)were synthesized by radical *** interactions between the prepared copolymers and Tb^(3+)ions in aqueous solutions were studied;the significant influence of chemical structure of a comonomer on luminescence intensity of Tb^(3+)complexes with the copolymers was *** luminescence intensity of Tb^(3+)complexes with the copolymers containing N-vinylamide units(VP,MVAA)is three times more intense than that observed for the complexes between Tb^(3+)and MAG-containing *** the case of NaSS-containing copolymers,the luminescence intensity is controlled by the values of binding constants between Tb^(3+)and MABA and the content of MABA units in a *** studied copolymers and their complexes with Tb^(3+)have low cytotoxicity and a pronounced antiviral activity against human respiratory syncytial virus.

关键词： Luminescence Water-soluble copolymers Lanthanide complexes Antiviral activity Cytotoxicity

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Detection and evaluation of different morphological forms of Mycoplasma hominis in human semen

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Asian Journal of Andrology 2024年第1期26卷 71-76页

作者： Elizaveta Bragina Tatyana Sorokina Avtandil Chogovadze Yulia Shevchenko Vyacheslav Chernykh olga Barkhatova irina Rakovskaya Research Centre for Medical Genetics Moscow 115522Russia A.N.Belozersky institute of Physico-Chemical Biology Lomonosov Moscow State University Moscow 119992Russia Reprolab Limited Liability Company Moscow 119333Russia N.i.Pirogov Russian National Research Medical University Moscow 117997Russia Federal Government Budgetary institution"National Research Center for Epidemiology and Microbiology Named after Honorary Academician N.F.Gamaleya of the Ministry of Health of the Russian Federation" Moscow 123098Russia

Recently discovered microcolonial forms of Mycoplasma hominis(***)and their impact on human spermatogenesis are *** spermatozoa of 125 fertile men(sperm donors;from Reprobank[Reproductive Tissue Bank,Moscow,Russial)and of 93 patients with fertility problems(from the Federal State Budgetary institution"Research Centre for Medical Genetics[RCMG]",Moscow,Russia)were *** colonies of *** and microcolonies were detected by molecular biological methods,culture of bacteria,and transmission electron *** unique structure of microcolonial cells,in which the cytoplasmic cylinder is surrounded by concentric electron-dense and electron-light layers with a periodicity of 12-14 nm,and the ability of microcolonial cells to attach to spermatozoa are *** patients with lower sperm quality,microcolonies of *** were detected 2.5 times more frequently than classical *** detection of microcolonies in the ejaculate and the frequent isolation of microcolonies from sperm samples of patients with fertility problems suggest that microcolonial cells may be one cause of infertility.

关键词： ejaculate fertility Mycoplasma hominis spermatogenesis transmission electron microscopy

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Aqueous electrochemical delithiation of cathode materials as a strategy to selectively recover lithium from waste lithium-ion batteries

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Journal of Energy Chemistry 2024年第1期88卷 144-153,I0004页

作者： Pier Giorgio Schiavi Andrea Giacomo Marrani olga Russina Ludovica D’Annibale Francesco Amato Francesca Pagnanelli Pietro Altimari Department of Chemistry Sapienza University of RomePiazzale Aldo Moro n.500185 RomeItaly

Lithium recovery from end-of-life Li-ion batteries(LiBs)through pyro-and hydrometallurgical recycling processes involves several refining stages,with high consumption of reagents and energy.A competitive technological alternative is the electrochemical oxidation of the cathode materials,whereby lithium can be deintercalated and transferred to an electrolyte solution without the aid of chemical extracting *** article investigates the potential to selectively recover Li from LiB cathode materials by direct electrochemical extraction in aqueous *** process allowed to recovering up to 98%of Li from high-purity commercial cathode materials(LiMn_(2)O_(4),LiCoO_(2),and Li Ni_(1/3)Mn_(1/3)Co_(1/3)O_(2))with a faradaic efficiency of 98%and negligible co-extraction of Co,Ni,and *** process was then applied to recover Li from the real waste LiBs black mass obtained by the physical treatment of electric vehicle battery *** black mass contained graphite,conductive carbon,and metal impurities from current collectors and steel cases,which significantly influenced the evolution and performances of Li electrochemical ***,due to concomitant oxidation of impurities,lithium extraction yields and faradaic efficiencies were lower than those obtained with high-purity cathode *** oxidation was found to occur within the voltage range investigated,but it could not quantitatively explain the reduced Li extraction *** fact,a detailed investigation revealed that above 1.3 V ***/Ag Cl,conductive carbon can be oxidized,contributing to the decreased Li *** on the reported experimental results,guidelines were provided that quantitatively enable the extraction of Li from the black mass,while preventing the simultaneous oxidation of impurities and,consequently,reducing the energy consumption of the proposed Li recovery method.

关键词： Lithium recovery Lithium-ion batteries recycling Electrochemical lithium extraction Lithium selective Extraction

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