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Effects of co-administration of Ganoderma terpenoid extract with chloroquine on inflammatory markers and antioxidant status in Plasmodium berghei-infected mice

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Journal of Integrative Medicine 2020年第6期18卷 522-529页

作者： olarewaju M.oluba oghenerobor B.Akpor Feyikemi D.Adebiyi Sunday J.Josiah olayinka o.alabi Ayoola o.Shoyombo Augustine o.olusola Department of Biochemistry Food Safety&Toxicology Research UnitCollege of Pure&Applied SciencesLandmark UniversityOmu-AranKwara State 251101Nigeria Department of Microbiology College of Pure&Applied SciencesLandmark UniversityOmu-AranKwara State 251101Nigeria Department of Chemical Sciences Joseph Ayo Babalola UniversityIkeji-ArakejiOsun State 233121Nigeria Department of Medical Biochemistry College of Basic Medical SciencesIgbinedion UniversityOkadaEdo State 302110Nigeria Department of Animal Science College of Agricultural SciencesLandmark UniversityOmu-AranKwara State 251101Nigeria Department of Biochemistry Adekunle Ajasin UniversityAkungba AkokoOndo State 342111Nigeria

objective:To understand the protective effects of Ganoderma terpenoid extract(GTE)against Plasmodium berghei-malarial infection in mice,the present study was carried out to evaluate the effects of GTE in combination with chloroquine disulphate(CQ)on erythrocyte-selected inflammatory markers and antioxidant defense status in ***-infected ***:***-infected mice were divided into six groups:infected control(IC)group,administered 1 mL Tween 20;GTE100 and GTE250 groups,administered 100 and 250 mg/kg GTE,respectively;GT100+CQ and GT250+CQ groups,co-administered 100 and 250 mg/kg GTE plus 30 mg/kg CQ,respectively;and CQ group,administered 30 mg/kg CQ.A separate group of non-infected mice were given 1 m L Tween 20,and served as a normal control group(NC).Extract and drug were dissolved in Tween20 and administered orally once daily for 12 consecutive *** the end of the treatment period,mice were anesthetized with chloroform and sacrificed by cervical *** was prepared from blood obtained from each *** evaluated at the end of the treatment period include parasitemia,red blood cell count,hematocrit,malondialdehyde(MDA),glutathione(GSH),catalase(CAT),glutathione peroxidase(GPx),superoxide dismutase(SoD),tumor necrosis factor-a(TNF-a),and interleukin-10(IL-10).Results:Infected mice treated with a combination of GTE and CQ(GT100+CQ and GT250+CQ groups)showed significantly reduced parasitemia levels(Pompared to those administered GTE alone as well as *** improvement in body weight(Po observed in infected mice treated with a combination of GTE and CQ(GT100+CQ and GT250+CQ groups),compared to mice receiving GTE alone(GTE100 and GTE250 groups).Plasma MDA and TNF-a concentrations were significantly lowered,and IL-10 concentration was significantly increased in GT100+CQ and GT250+CQ groups,relative to the IC group(Poncentration and SoD,CAT and GPx activities were significantly higher in GT100+

关键词： Ganoderma Terpenes Malaria oxidative stress Antioxidants Anti-inflammatory agents

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