Effects of co-administration of Ganoderma terpenoid extract with chloroquine on inflammatory markers and antioxidant status in Plasmodium berghei-infected mice

作     者：Olarewaju M.Oluba Oghenerobor B.Akpor Feyikemi D.Adebiyi Sunday J.Josiah Olayinka O.Alabi Ayoola O.Shoyombo Augustine O.Olusola Olarewaju M.Oluba;Oghenerobor B.Akpor;Feyikemi D.Adebiyi;Sunday J.Josiah;Olayinka O.Alabi;Ayoola O.Shoyombo;Augustine O.Olusola

作者机构：Department of BiochemistryFood Safety&Toxicology Research UnitCollege of Pure&Applied SciencesLandmark UniversityOmu-AranKwara State 251101Nigeria Department of MicrobiologyCollege of Pure&Applied SciencesLandmark UniversityOmu-AranKwara State 251101Nigeria Department of Chemical SciencesJoseph Ayo Babalola UniversityIkeji-ArakejiOsun State 233121Nigeria Department of Medical BiochemistryCollege of Basic Medical SciencesIgbinedion UniversityOkadaEdo State 302110Nigeria Department of Animal ScienceCollege of Agricultural SciencesLandmark UniversityOmu-AranKwara State 251101Nigeria Department of BiochemistryAdekunle Ajasin UniversityAkungba AkokoOndo State 342111Nigeria 

出 版 物：《Journal of Integrative Medicine》 (结合医学学报（英文版）)

年 卷 期：2020年第18卷第6期

页      面：522-529页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Institute for Advance Medical Research and Training University College Hospital 

主　　题：Ganoderma Terpenes Malaria Oxidative stress Antioxidants Anti-inflammatory agents 

摘      要：Objective:To understand the protective effects of Ganoderma terpenoid extract(GTE)against Plasmodium berghei-malarial infection in mice,the present study was carried out to evaluate the effects of GTE in combination with chloroquine disulphate(CQ)on erythrocyte-selected inflammatory markers and antioxidant defense status in ***-infected ***:***-infected mice were divided into six groups:infected control(IC)group,administered 1 mL Tween 20;GTE100 and GTE250 groups,administered 100 and 250 mg/kg GTE,respectively;GT100+CQ and GT250+CQ groups,co-administered 100 and 250 mg/kg GTE plus 30 mg/kg CQ,respectively;and CQ group,administered 30 mg/kg CQ.A separate group of non-infected mice were given 1 m L Tween 20,and served as a normal control group(NC).Extract and drug were dissolved in Tween20 and administered orally once daily for 12 consecutive *** the end of the treatment period,mice were anesthetized with chloroform and sacrificed by cervical *** was prepared from blood obtained from each *** evaluated at the end of the treatment period include parasitemia,red blood cell count,hematocrit,malondialdehyde(MDA),glutathione(GSH),catalase(CAT),glutathione peroxidase(GPx),superoxide dismutase(SOD),tumor necrosis factor-a(TNF-a),and interleukin-10(IL-10).Results:Infected mice treated with a combination of GTE and CQ(GT100+CQ and GT250+CQ groups)showed significantly reduced parasitemia levels(P0.05)compared to those administered GTE alone as well as *** improvement in body weight(P0.05)was also observed in infected mice treated with a combination of GTE and CQ(GT100+CQ and GT250+CQ groups),compared to mice receiving GTE alone(GTE100 and GTE250 groups).Plasma MDA and TNF-a concentrations were significantly lowered,and IL-10 concentration was significantly increased in GT100+CQ and GT250+CQ groups,relative to the IC group(P0.05).GSH concentration and SOD,CAT and GPx activities were significantly higher in GT100+