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Impact of Different Embolic Agents for Transarterial Chemoembolization (TACE) Procedures on Systemic Vascular Endothelial Growth Factor (VEGF) levels

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Journal of Clinical and Translational Hepatology 2016年第4期4卷 288-292页

作者： Andreas Schicho Claus Hellerbrand Kristina Krüger lukas P.Beyer Walter Wohlgemuth Christoph Niessen Ernst Hohenstein Christian Stroszczynski Philippe l.pereira Philipp Wiggermann Department of Radiology University Hospital Regensburg Regensburg Germany Friedrich-Alexander University Erlangen-Nürnberg Institute of Biochemistry(Emil-Fischer Zentrum) Erlangen Germany Clinic for Radiology Minimally-invasive Therapies and Nuclear Medicine SLK Kliniken Heilbronn GmbH Heilbronn Germany

Background and Aims:Intermediate stage hepatocellular carcinoma (HCC) can be treated by transarterial chemoem-bolization (TACE).However,there appear to be side effects,such as induction of proangiogenic factors,*** endothelial growth factor (VEGF),which have been shown to be associated with a poor *** prospective study was designed to compare serum VEGF level response after TACE with different embolic agents in patients with ***:Patients were assigned to one of three different TACE regimens:degradable starch microspheres (DSM) TACE,drugeluting bead (DEBDOX) TACE or lipiodol TACE (cTACE).All patients received 50 mg doxorubicin/m2 body surface area (BSA) during *** VEGF levels were assessed before TACE treatment,24 h post-treatment and 4 weeks ***:Twenty-two patients with 30 TACE treatments were *** to baseline VEGF levels,a marked increase was observed for 24 h post-TACE (164% of baseline level) and during the 4-week follow-up (170% of baseline level) only for the cTACE arm (p levels were only 114% and 123% for DEBDOX and 121% and 124% for DSM,***:Conventional TACE using lipiodol shows marked increase in blood levels of the proangiogenic factor VEGF,while DEBDOX and DSM TACE induce only a moderate VEGF response.

关键词： Transarterial chemoembolization Vascular endothelial growth factor Embolic agents Hepatocellular carcinoma Angiogenesis

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C-reactive protein may be a prognostic factor for the whole gastroenteropancreatic neuroendocrine tumor group

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World Journal of Gastrointestinal Oncology 2019年第2期11卷 139-152页

作者： ?mer Koma? G?ksel Bengi ?zgül Sa?ol Mesut Akarsu Department of Internal Medicine Dokuz Eylul University Faculty of Medicine Department of Gastroenterology Dokuz Eylul University Faculty of Medicine Department of Pathology Dokuz Eylul University Faculty of Medicine

BACKGROUND long non-coding RNAs(lncRNAs) are a kind of single-stranded RNA of more than 200 nucleotides in length and have no protein-coding function. Amounting studies have indicated that lncRNAs could play a vital role in the initiation and development of cancers, including gastric cancer(GC). Considering the crucial functions of lncRNAs, the identification and exploration of novel lncRNAs in GC is *** To identify independent prognostic markers for the whole gastroenteropancreatic neuroendocrine tumor(GEP-NET) *** Ninety-three patients diagnosed with GEP-NETs within a specified period were included in this study. Patient data were retrospectively analyzed. The relationships between all independent variables and 5-year survival status calculated during the follow-up period(months) were assessed. In addition, the relationships between the independent variables were *** When 5-year survival rate was compared, a statistically significant relationship between the age at diagnosis, male gender, tumor size, tumor stage, liver and/or distant metastasis, and tumor grade determined by the Ki-67 level and mitotic count, and the level of C-reactive protein(CRP), was observed. The meansurvival(overall survival) of the study group was 102.5 ± 6.3(SD) mo. The percentages of 1, 3 and 5-year survival were 90%, 72%, and 61%, respectively. In63 of 93 patients, Ki-67 and the mitotic count determined the same grade. The Ki-67 levels in 29 patients and the mitotic count in only 1 patient were in the higher grade. The risk of death increased by 4% for every 1 year increase at the diagnosis age and was 2.0-fold higher for male patients, 3.0-fold higher for G3 according to the mitotic count, 3.7-fold higher for G3 according to the Ki-67 level, 12.7-fold higher for cases with tumor stage 3 or 4 by a 1 cm increase in the ratio of 9% in tumor size, and 6.1-fold higher for patients with liver metastasis for every 1 mg/dl increase in the ratio of 1.5% in CR

关键词： Gastroenteropancreatic neuroendocrine tumors C-reactive protein Prognostic factor Neuroendocrine tumors Gastrointestinal system

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Native and exotic seed dispersal by the stone marten(Martes foina):implications for the regeneration of a relict climactic forest in central Portugal

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Integrative Zoology 2019年第3期14卷 280-292页

作者： lúcia pereira Ana VASQUES Paula MAIA Maria João RAMOS pereira Carlos FONSECA Milena MATOS CESAM-Centre for Environmental and Marine Studies-Wildlife Research Unit Department of BiologyUniversity of AveiroAveiroPortugal CESAM-Centre for Environmental and Marine Studies-Department of Environment and Planning University of AveiroAveiroPortugal Erasmus University College Life Sciences DepartmentRotterdamthe Netherlands Institute of Biosciences PPGBANDepartment of ZoologyUniversidade Federal do Rio Grande do SulBrazil Bioliving Association FrossosAlbergaria-a-VelhaPortugal

The stone marten(Martes foina)is a carnivorous mammal that often consumes fleshy fruits,thus potentially promoting seed *** present study was developed in Bussaco National Forest,central Portugal,and aimed to assess the potential role of the stone marten in dispersing native and exotic plants in different forest landscape *** from stone marten scats and fleshy fruits were collected monthly and were thereafter identified and sowed in a nursery,following a randomized experimental *** emergence was monitored *** linear models were used to test for differences in time and success of emergence between seeds from scats and fruits of 3 native species(Rubus ulmifolius,Arbutus unedo and Celtis australis)and 1 exotic plant species with invasive behavior(Prunus laurocerasus).Fruit consumption by the stone martens significantly increased and accelerated the germination of the native *** but had no effect on the other 2 native species or on the invasive *** suggested that stone martens contribute to gene flow and forest regeneration by dispersing native plant ***,although the germination was not enhanced in the invasive species,the preference of stone martens for these fruits may potentially contribute to the proliferation of *** study represents a contribution to better understanding the fauna and flora interactions,enabling for a more conscious and effective decision-making in forest management.

关键词： germination invasive species Martes foina Prunus laurocerasus relict climactic forest

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Cr（V）involvementin the toxicity pathway of testicular damage

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Asian Journal of Andrology 2002年第2期4卷 153-155页

作者： M.l.pereira T.M.Santos 等 DepartmentofBiology Departmentofchemistry UniversityofAveriro3810－193AveiroPortugal

Aim: The functional integrity of the blood-testis barrier (BTB) in male mice exposed to Cr(V) was studied in order to clarify the mechanism underlying testicular injury. Methods: Adult male mice were subcutaneously injected repeated doses of 8.02 mmol (0.5 ml) of Cr/*** for 5 days. Animals receiving a similar volume of bis(hydroxyethyl)-aminotris(hydroxymethyl)methane buffer (BT) were used as controls. The animals were sacrificed on day 6 and small fragments of seminiferous tubules, approximately 8-10 mm length, were incised and sutured at both ends. They were exposed in vitro to horseradish peroxidase-containing culture medium for 10 minutes. Tissues were then fixed and processed for ultrastructural studies. Results: Controls and Cr(V)-treated group resulted in the uptake of the tracer by Sertoli cells. However, the major finding consisted in the permeability of the BTB only in the Cr(V)-group, as evidenced by the presence of the tracer within the junctions between the neighbouring Sertoli cells. Conclusion: The BTB is disrupted in mice submitted to Cr(V). The permeability of the BTB is a crucial feature to be investigated for the understanding of lesions within the seminiferous tubule.

关键词： Blood-testis barrier Cr(V) Horseradish peroxidase Integrity Spermatogenesis

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Cerium alleviates drought-induced stress in Phaseolus vulgaris

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Journal of Rare Earths 2020年第3期38卷 324-331页

作者： olívia Graziela Gelioli Salgado Jéssica Cristina Teodoro Joyce pereira Alvarenga Cynthia de oliveira Teotonio Soares de Carvalho Débora Domiciano Paulo Eduardo Ribeiro Marchiori luiz Roberto Guimaraes Guilherme Department of Soil Science Federal University of LavrasCP 3037Campus UFLALavras37200-000Brazil Department of Biology Federal University of LavrasCP 3037Campus UFLALavras37200-000Brazil

Extreme drought events are expected to be one of the main challenges for tropical agriculture and,consequently,for global food *** this reason,it is urgent to develop strategies to increase water use efficiency,as well as to increase crops’ ability to cope with *** rare earth elements(REEs) are known to alleviate damages in plants under abiotic stresses,we hypothesized that addition of Ce^3+to nutrient solution would promote the growth of common bean,especially under simulated drought *** test this hypothesis,we conducted an experiment evaluating the effect of six Ce^3+concentrations on the development and physiological traits of common bean grown in nutrient solution under normal condition and under induced drought stress,caused by the addition of polyethylene glycol6000 to the nutrient *** results show that Ce^3+alleviates water stress in common bean plants,increasing their survival rate and *** addition,Ce^3+application increases photosynthesis rate,chlorophyll content and water use efficiency under water ***,we observe no significant effect of Ce^3+on plants growing under normal ***,Ce3+seems to be a promising attenuator of drought stress for common bean.

关键词： Water stress Polyethylene glycol Rare earth elements Cerium nitrate Mitigation Common bean

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Interface networks in models of competing species

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第5期9卷 195-209页

作者： T.A.pereira J.Menezes l.losano Institute for Biodiversity and Ecosystem Dynamics University of Amsterdam Science Park 9041098 XH AmsterdamThe Netherlands Departamento de F´ısica Te´orica e Experimental Universidade Federal do Rio Grande do Norte 59078-970 RNBrazil Escola de Ciˆencias e Tecnologia Universidade Federal do Rio Grande do Norte Caixa Postal 1524 59072-970NatalRNBrazil Universidade Federal da Para´ıba 58051-970 Jo˜ao Pessoa PB BrazilCaixa Postal 152459072-970NatalRNBrazil

We study a subclass of the May–leonard stochastic model with an arbitrary,even number of species,leading to the rise of two competing partnerships where individuals are *** carrying out a series of accurate numerical stochastic simulations,we show that alliances compete each other forming spatial domains bounded by interfaces of empty *** solve numerically the mean field equations associated with the stochastic model in one and two spatial *** demonstrate that the stationary interface profile presents topological properties which are related to the asymptotic spatial distribution of species of enemy alliances far away from the interface ***,we introduce a theoretical approach to model the formation of stable interfaces using spontaneous breaking of a discrete *** show that all the results provided by the soliton topological model,presented here for the very first time,are in agreement with the stochastic simulations and may be used as a tool for understanding the complex biodiversity in nature.

关键词： Population dynamics numerical simulations topological defects.

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Crystal structure and magnetic properties of YbZn_(0.7)In_(1.3)

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Journal of Rare Earths 2011年第10期29卷 943-945页

作者： Yu.Verbovytskyy l.C.J.pereira A.P.Gon alves Department of Chemistry Nuclear and Technological InstituteNational Rd.102686-953SacavémPortugal

The new ternary YbZn0.7Inl.3 compound was synthesized in evacuated quartz ampoules at 900 ℃, followed by annealing at 400 ℃. It crystallized in the UHg2 structure type with a=0.47934（5） nm, c=0.36955（5） nm, V=0.073535（15） nm3. The shortest distances between the atoms in this structure were equal to 0.3696 nm （Yb-Yb）, 0.3328 nm （Yb-M） and 0.2767 nm （M M）, respectively. Magnetization measurements indicated that the title compound exhibited a paramagnetic behavior down to 2 K, with antiferromagnetic-like interactions. Calculated magnetic moment for YbZn0.7inl.3 （μeft =3.86μB/Yb） could indicate mixed valence state of Yb.

关键词： ytterbium intermetallics crystal structure magnetic measurements rare earths

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THE USE OF SUB 2μ PARTIClES TO ACHIEVE ENHANCED RESolUTION AND SPEED

THE USE OF SUB 2μ PARTICLES TO ACHIEVE ENHANCED RESOLUTION ...

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第十一届北京分析测试学术报告会暨展览会(BCEIA 2005)

作者： M.WOODRUFF C.BlYTHE S.ASPEY l.pereira H.RITCHIE Thermo Electron Corporation

In this poster we discuss the use of sub 2μparticles for use in *** in the use of current 3 and 5μparticles sizes have lead to interesting theories of how an expanded Van Deemter curve can be utilised with smaller *...

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Estimating Risk-aware Flexibility Areas for Electric Vehicle Charging Pools via AC Stochastic Optimal Power Flow

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Journal of Modern Power Systems and Clean Energy 2023年第4期11卷 1247-1256页

作者： Juan S.Giraldo Nataly Bañol Arias Pedro P.Vergara Maria Vlasiou Gerwin Hoogsteen Johann l.Hurink Energy Transition Studies Group Netherlands Organisation for Applied Scientific Research(TNO)Amsterdam1043 NTThe Netherlands Department of Electrical Engineering Mathematics and Computer ScienceUniversity of TwenteEnschede7522 NBThe Netherlands Intelligent Electrical Power Grids Group Electrical EngineeringMathematics and Computer ScienceDelft University of TechnologyDelft2628 CDThe Netherlands

This paper introduces an AC stochastic optimal power flow(SOPF)for the flexibility management of electric vehicle(EV)charging pools in distribution networks under *** AC SOPF considers discrete utility functions from charging pools as a compensation mechanism for eventual energy not served to their charging *** application of the AC SOPF is described where a distribution system operator(DSO)requires flexibility to each charging pool in a day-ahead time frame,minimizing the cost for flexibility while guaranteeing technical *** areas are defined for each charging pool and calculated as a function of a risk parameter involving the uncertainty of the *** show that all players can benefit from this approach,i.e.,the DSO obtains a riskaware solution,while charging pools/tasks perceive a reduction in the total energy payment due to flexibility services.

关键词： Electric vehicle flexibility management stochastic optimal power flow(SOPF) risk awareness compensation mechanism

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Ethyl and butyl acetate oxidation over manganese oxides

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Chinese Journal of Catalysis 2018年第1期39卷 27-36页

作者： olívia Salomé G.P.Soares Raquel P.Rocha Jose J.M.Orfao Manuel F.R.pereira José l.Figueiredo laboratory of Separation and Reaction Engineering‐laboratory of Catalysis and Materials (lSRE‐lCM) Faculty of Engineering University of Porto Rua Dr. Roberto Frias s/n 4200‐465 Porto Portugal

Mangenese oxides were synthesized using two new methods,a novel solvent‐free reaction and a reflux technique,that produced cryptomelane‐type products(K‐OMS‐2).Oxides were also synthesized using conventional methods and all specimens were applied to the oxidation of ethyl acetate and butyl acetate,acting as models for the volatile organic compounds found in industrial *** catalysts were also characterized using N2adsorption,X‐ray diffraction,scanning electron microscopy,temperature programmed reduction and X‐ray photoelectron *** of the manganese oxides was found to be very active during the oxidation of both esters to CO2,and the synthesis methodology evidently had a significant impact on catalytic *** K‐OMS‐2nanorods synthesized by the solvent‐free method showed higher activity than K‐OMS‐2materials prepared by the reflux technique,and samples with cryptomelane were more active than those prepared by the conventional *** catalyst with the highest performance also exhibited good stability and allowed90%conversion of ethyl and butyl acetate to CO2at213and202°C,*** differences in the catalyst performance were observed,clearly indicating that K‐OMS‐2nanorods prepared by the solvent‐free reaction were better catalysts for the selected VOC oxidations than the mixtures of manganese oxides traditionally obtained with conventional synthesis *** superior performance of the K‐OMS‐2catalysts might be related to the increased average oxidation state of the manganese in these *** correlations between the catalytic performance and the surface chemical properties were also identified,hig-hlighting the K‐OMS‐2properties associated with the enhanced catalytic performance of the materials.?2018,Dalian Institute of Chemical Physics,Chinese Academy of *** by Elsevier *** rights reserved.

关键词： Volatile organic compound Ethyl acetate Butyl acetate Manganese oxide Catalytic oxidation

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