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Mitigation of indomethacin-induced gastric mucosal lesions by a potent specific type V phosphodiesterase inhibitor

World Journal of Gastroenterology 2009年第40期15卷 5091-5096页

作者： Kemal Karakaya Volkan Hanci Sibel Bektas Murat Can Hamdi B Ucan Ali Ugur Emre Oge Tasc1lar Is1l Ozkocak Turan Mustafa Comert okta. irkorucu Guldeniz Karadeniz Cakmak Department of General Surgery Zonguldak Karaelmas UniversityMedical Faculty Department of Anesthe-siology Zonguldak Karaelmas UniversityMedical Faculty Department of Pathology Zonguldak Karaelmas UniversityMedical Faculty Department of Biochemistry Zonguldak Karaelmas UniversityMedical Faculty

AIM: To investigate the gastroprotective effect of vardenafil against indomethacin-induced gastric damage. METHODS: Forty-eight female Wistar albino rats were randomly divided into 6 groups. Group 1 received saline only. Group 2 (indomethacin) received indomethacin. Rats in group 3 and 4 were pretreated with different doses of famotidine. Group 5 and 6 were pretreated with different doses of vardenafil. Rats in groups 3 to 6 received 25 mg/kg indomethacin 30 min after pretreatment. The animals were sacrificed 6 h later and their stomachs were opened. Gastric lesions were counted and measured. The stomach of each animal was divided in two parts for histopathological examinations and nitric oxide (NO) and malondialdehyde (MDA) assays, respectively. RESULTS: There were no gastric mucosal lesion in the saline group but all rats in the indomethacin group had gastric mucosal ulcerations (ulcer count; 6.25 ± 3.49, and mean ulcer area; 21.00 ± 12.35). Ulcer counts werediminished with famotidine 5 mg/kg (4.12 ± 2.47, P > 0.05), 20 mg/kg (2.37 ± 4.43, P < 0.05), vardenaf il 2 mg/kg (4.37 ± 3.06), and vardenafil 10 mg/kg (1.25 ± 1.38, P < 0.05) compared to the indomethacin group. Gastric mucosal lesion areas were diminished with famotidine 5 mg/kg (8.62 ± 2.97, P < 0.001), famotidine 20 mg/kg (0.94 ± 2.06, P < 0.001), vardenafil 2 mg/kg (6.62 ± 5.87, P < 0.001), and vardenafil 10 mg/kg (0.75 ± 0.88, P < 0.001) compared to the indomethacin group. MDA levels were signif icantly higher in indometh-acin group (28.48 ± 14.51), compared to the famotidine 5 mg/kg (6,21 ± 1.88, P < 0.05), famotidine 20 mg/kg (5.88 ± 1.60. P < 0.05), vardenaf il 2 mg/kg (15.87 ± 3.93, P < 0.05), and vardenafil 10 mg/kg (10.97 ± 4.50, P < 0.05). NO concentration in gastric tissues of the fa-motidine groups were significantly increased (P < 0.05), but the NO increases in the vardenafil groups were not statistically significant. Histopathology revealed dimin-ished gastric damage for pretreatment groups co

关键词：胃疾病治疗 METHODS 胃黏膜

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Appendiceal mucocele: Case reports and review of current literature

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World Journal of Gastroenterology 2008年第14期14卷 2280-2283页

作者： Kemal Karakaya Figen Barut Ali Ugur Emre Hamdi Bulent Ucan Guldeniz Karadeniz Cakmak okta. irkorucu Oge Tascilar Yucel Ustundag Mustafa Comert Department of General Surgery Zonguldak Karaelmas University Zonguldak 67600 Turkey Department of Pathology Zonguldak Karaelmas University Zonguldak 67600 Turkey Department of Gastroenterology Zonguldak Karaelmas University Zonguldak 67600 Turkey

The mucocele of the appendix is an uncommon disorder which is often asymptomatic but sometimes causes acute appendicitis-like symptoms. Sometimes, patients with mucocele can present with confusing symptoms. Preoperative suspicion and diagnosis of appendiceal mucocele are important. Ultrasonography and computed tomography are useful tools for the diagnosis of appendiceal mucocele. It may be also recognised by colonoscopy as a smooth submucosal lesion of the cecum. Optima management of the mucocele could be achieved through accurate preoperative diagnosis. Preoperative diagnosis is a major component for minimizing intra-operative and post-operative complications. We herein report five cases and discuss the diagnostic methods and surgical treatment.

关键词：黏液囊肿阑尾诊断方法手术治疗

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Lipoma within inverted Meckel’s diverticulum as a cause of recurrent partial intestinal obstruction and hemorrhage: A case report and review of literature

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World Journal of Gastroenterology 2007年第7期13卷 1141-1143页

作者： Güldeniz Karadeniz Cakmak Ali Ugur Emre Oge Tascilar Sibel Bekta■ Bulent Hamdi Uan okta. irkorucu Kemal Karakaya Yucel Ustundag Mustafa Comert Department of Surgery Zonguldak Karaelmas Uni-versity School of Medicine Kozlu-Zonguldak Turkey Department of Pathology Zonguldak Karaelmas University School of Medicine Kozlu-Zonguldak Turkey Department of Gastroenterology Zonguldak Karaelmas University School of Medicine Kozlu-Zonguldak Turkey

Lipoma within an inverted Meckel's diverticulum presen- ting with hemorrhage and partial intestinal obstruction is an exceptional clinical entity. We report a case of 47-year-old male with a history of recurrent episodes of partial intestinal obstruction and melena due to a subserosal lipoma located in the base of an inverted Meckel's diverticulum. According to our knowledge, this is the first case of a lipoma within a Meckel's diverticulum giving rise to this clinical scenario without the existence of heterotrophic gastric or pancreatic tissues.

关键词：脂肪瘤盲肠囊肠阻塞肠出血

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Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma:Feasible or not?

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World Journal of Gastroenterology 2007年第41期13卷 5476-5480页

作者： Oge Tascilar Gldeniz Karadeniz Cakmak Ishak Ozel Tekin Ali Ugur Emre Bulent Hamdi Ucan okta. irkorucu Kemal Karakaya Mesut Gl Hseyin Blent Engin Mustafa Comert Department of Surgery Zonguldak Karaelmas UniversityThe School of MedicineKozlu-Zonguldak 67600Turkey Department of Immunology Zonguldak Karaelmas UniversityThe School of MedicineKozlu-Zonguldak 67600Turkey Department of Medical Oncology Zonguldak Karaelmas UniversityThe School of MedicineKozlu-Zonguldak 67600Turkey

AIM: To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice. METHODS: Twenty-six patients (16 men,10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression. RESULTS: Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However,NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage Ⅱ?disease who experienced no active disease at 30 mon follow-up. CONCLUSION: As a consequence of the limited number of cases in our series,it might not be possible to make a generalisation,nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.

关键词：结肠直肠癌预后癌细胞细胞转移

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Protective effects of erythropoietin against acute lung injury in a rat model of acute necrotizing pancreatitis

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World Journal of Gastroenterology 2007年第46期13卷 6172-6182页

作者： Oge Tascilar Güldeniz Karadeniz Cakmak Ishak Ozel Tekin Ali Ugur Emre Bulent Hamdi Ucan Burak Bahadir Serefden Acikgoz okta. irkorucu Kemal Karakaya Hakan Balbaloglu Gürkan Kertis Handan Ankarali Mustafa Comert Department of Surgery Zonguldak Karaelmas UniversitySchool of MedicineKozlu-Zonguldak 67600Turkey Department of Immunology Zonguldak Karaelmas UniversitySchool of MedicineKozlu-Zonguldak 67600Turkey Department of Pathology Zonguldak Karaelmas UniversityThe School of MedicineKozlu-Zonguldak 67600Turkey Department of Biochemistry Zonguldak Karaelmas UniversitySchool of MedicineKozlu-Zonguldak 67600Turkey Department of Biostatistics Zonguldak Karaelmas UniversitySchool of MedicineKozlu-Zonguldak 67600Turkey

瞄准：为了调查外长的 erythro-poietin (EPO ) 的效果，在钠 taurodeoxycholate- 的一个试验性的模型的尖锐的肺损害(ALI ) 上的管理导致了尖锐引起坏死胰腺炎(ANP ) 。方法：47 只男 Wistar 白鼠随机被划分成 7 个组：假冒的组(n = 5... 详细信息

瞄准：为了调查外长的 erythro-poietin (EPO ) 的效果，在钠 taurodeoxycholate- 的一个试验性的模型的尖锐的肺损害(ALI ) 上的管理导致了尖锐引起坏死胰腺炎(ANP ) 。方法：47 只男 Wistar 白鼠随机被划分成 7 个组：假冒的组(n = 5 ) ， 3 个 ANP 组(n = 7 各个) 并且 3 个 EPO 组(n = 7 各个) 。ANP 被导致由后退进胆总管的 5% 钠 taurodeoxycholate 的注入。在 EPO 组的老鼠收到了 1000 U/kg 肌内的 EPO 立即在 ANP 的正式就职以后。在 ANP 组的老鼠相反被给 1 mL 生理盐水。所有动物被牺牲在手术后 24 h， 48 h 和 72 h。浆液 amilase， IL-2， IL-6 和肺织物 malondialdehyde (MDA ) 被测量。胸膜渗漏体积和肺 / 身体重量(LW/BW ) 比率是计算的。TNF-alpha， IL-2 和 IL-6 的织物层次组织化学地是屏蔽免疫。另外， ox-LDL 累积与免疫者荧光灯的染色被估计。在肺的组织病理学说的改变也被获得。结果：吝啬的胸膜渗漏体积，计算 LW/BW 比率，浆液 IL-6 和肺织物 MDA 层次比在 ANP 组在 EPO 组是显著地更低的。不，统计上，有效差量在这些组之中在浆液或 IL-2 的织物价值被观察。当时， ox-LDL 的肿瘤坏死 factor-alpha (TNF-alpha ) 和 IL-6 和累积的水平在 ANP 组的肺纸巾是明显的与 EPO 组相比，特别地在 72 h。组织病理学说的评估在外长的 EPO 管理以后在肺损害参数证实了改进，特别地在 48 h 和 72 h。结论：EPO 管理由禁止 polymorphonuclear (PMNL ) 在 ALI 参数导致重要减少累积，减少专业版的层次在每氧化的循环，保存微脉管的内皮房间正直和减少的氧化联系压力的类脂化合物的煽动性的 cytokines 并且因此，能在导致 ANP 的 ALI 被认为是一个 cytoprotective 代理人。

关键词：细胞因子红血球急性期物质急性肺炎胰腺炎

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桃树(Prunus persica Batsch)的白花中三叶豆甙的分离

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药学进展 1961年第Z1期 54-54页

作者： Tatsuo okta.金蓉鸞

作者从桃树(Prunus persica Batsch)的白花中分离出一种黄硷甙,分离方法是用甲醇的浸出物在醋酸乙酯中用柱形层析法而获得的,研究其水解产物和其甲基化甙的水解产物发现此甙是山萘酚—3半乳糖甙,其构造与三叶豆甙完全相符。所得純甙与... 详细信息

作者从桃树(Prunus persica Batsch)的白花中分离出一种黄硷甙,分离方法是用甲醇的浸出物在醋酸乙酯中用柱形层析法而获得的,研究其水解产物和其甲基化甙的水解产物发现此甙是山萘酚—3半乳糖甙,其构造与三叶豆甙完全相符。所得純甙与純三叶豆甙进行比

关键词：熔点熔解温度 Prunus persica Batsch

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