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Venous adventitial cystic disease is a very rare disease that can cause deep vein thrombosis:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8170-8175页

作者： Miju Bae Up Huh chung Won Lee Jong Won kim Department of Thoracic and Cardiovascular Surgery Pusan National University School of MedicineBusan 49241South Korea Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Venous adventitial cystic disease(VACD)is a rare disease characterized by cysts,filled with a gelatinous mucous substance similar to joint fluid,in the adventitia of blood vessels adjacent to the *** is often misdiagnosed as deep vein thrombosis(DVT),femoral varices,venous tumors,or *** SUMMARY A 69-year-old woman visited our hospital with a complaint of swelling in the right lower *** patient was diagnosed with DVT and prescribed apixaban at an outpatient *** 3 wk,the patient was hospitalized again because of sudden swelling in the right lower *** diagnosed VACD and performed surgery for cyst removal as well as patch angioplasty and thrombectomy of the right common femoral *** patient received anticoagulants for 6 mo and has been doing well without recurrence for 1 year *** Recurrent VACD requires complete removal of the connections to the joint cavity to prevent recurrence.

关键词： Adventitia Cysts Edema Joints Venous thrombosis Case report

Exacerbated VEGF up-regulation accompanies diabetes-aggravated hemorrhage in mice after experimental cerebral ischemia and delayed reperfusion

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Neural Regeneration Research 2022年第7期17卷 1566-1575页

作者： Angela Ka Wai Lai Tsz chung Ng Victor Ka Lok Hung Ka Cheung Tam Chi Wai Cheung Sookja kim chung Amy Cheuk Yin Lo Department of Ophthalmology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administration RegionChina Department of Anesthesiology Laboratory and Clinical Research Institute for PainThe University of Hong KongHong Kong Special Administration RegionChina Macao University of Science and Technology TaipaMacao Special Administration RegionChinaSchool of Biomedical SciencesThe State Key Laboratory of Pharmaceutical BiotechnologyThe University of Hong KongHong Kong Special Administration RegionChina

Reperfusion therapy is the preferred treatment for ischemic stroke,but is hindered by its short treatment window,especially in patients with diabetes whose reperfusion after prolonged ischemia is often accompanied by exacerbated *** mechanisms underlying exacerbated hemorrhage are not fully *** study aimed to identify this mechanism by inducing prolonged 2-hour transient intraluminal middle cerebral artery occlusion in diabetic Ins2Akita/+mice to mimic patients with diabetes undergoing delayed mechanical *** results showed that at as early as 2 hours after reperfusion,Ins2Akita/+mice exhibited rapid development of neurological deficits,increased infarct and hemorrhagic transformation,together with exacerbated down-regulation of tight-junction protein ZO-1 and upregulation of blood-brain barrier-disrupting matrix metallopeptidase 2 and matrix metallopeptidase 9 when compared with normoglycemic Ins2+/+*** indicated that diabetes led to the rapid compromise of vessel integrity immediately after reperfusion,and consequently earlier death and further aggravation of hemorrhagic transformation 22 hours after *** observation was associated with earlier and stronger up-regulation of pro-angiogenic vascular endothelial growth factor(VEGF)and its downstream phospho-Erk1/2 at 2 hours after reperfusion,which was suggestive of premature angiogenesis induced by early VEGF up-regulation,resulting in rapid vessel disintegration in diabetic *** reticulum stress-related pro-apoptotic C/EBP homologous protein was overexpressed in challenged Ins2Akita/+mice,which suggests that the exacerbated VEGF up-regulation may be caused by overwhelming endoplasmic reticulum stress under diabetic *** conclusion,the results mimicked complications in patients with diabetes undergoing delayed mechanical thrombectomy,and diabetes-induced accelerated VEGF up-regulation is likely to underlie exacerbated hemorrhagic transformat

关键词： blood-brain barrier brain injury diabetes mellitus hemorrhagic transformation infarct ischemia/reperfusion injury middle cerebral artery occlusion mouse model stroke vascular endothelial growth factor

The role of complement C5a receptor in DPSC odontoblastic differentiation and in vivo reparative dentin formation

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International Journal of Oral Science 2022年第1期14卷 71-79页

作者： Muhammad Irfan Ji-Hyun kim Hassan Marzban David AReed Anne George Lyndon FCooper Seung chung Department of Oral Biology University of Illinois at ChicagoChicagoUSA Department of Human Anatomy and Cell Science University of ManitobaWinnipegCanada

Therapeutic dentin regeneration remains difficult to achieve,and a majority of the attention has been given to anabolic strategies to promote dentinogenesis directly,whereas,the available literature is insufficient to understand the role of inflammation and inflammatory complement system on *** aim of this study is to determine the role of complement C5a receptor(C5aR)in regulating dental pulp stem cells(DPSCs)differentiation and in vivo dentin *** DPSCs were subjected to odontogenic differentiation in osteogenic media treated with the C5aR agonist and C5aR *** vivo dentin formation was evaluated using the dentin injury/pulp-capping model of the C5a-deficient and wildtype *** vitro results demonstrate that C5aR inhibition caused a substantial reduction in odontogenic DPSCs differentiation markers such as DMP-1 and DSPP,while the C5aR activation increased these key odontogenic genes compared to control.A reparative dentin formation using the C5a-deficient mice shows that dentin regeneration is significantly reduced in the C5a-deficient *** data suggest a positive role of C5aR in the odontogenic DPSCs differentiation and tertiary/reparative dentin *** study addresses a novel regulatory pathway and a therapeutic approach for improving the efficiency of dentin regeneration in affected teeth.

关键词： C5a vivo inflammation

Defect engineering of ternary Cu-In-Se quantum dots for boosting photoelectrochemical hydrogen generation

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Carbon Energy 2023年第12期5卷 215-228页

作者： Shi Li Sung-Mok Jung Wookjin chung Joo-Won Seo Hwapyong kim Soo Ik Park Hyo Cheol Lee Ji Su Han Seung Beom Ha In Young kim Su-Il In Jae-Yup kim Jiwoong Yang Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of Chemical Engineering Dankook UniversityYonginRepublic of Korea Department of Chemistry and Nanoscience College of Natural ScienceEwha Womans UniversitySeoulRepublic of Korea Energy Science and Engineering Research Center Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea

Heavy-metal-free ternary Cu–In–Se quantum dots(CISe QDs)are promising for solar fuel production because of their low toxicity,tunable band gap,and high light absorption *** defects significantly affect the photophysical properties of QDs,the influence on photoelectrochemical hydrogen production is not well ***,we present the defect engineering of CISe QDs for efficient solar-energy *** acid–base reactions between metal halide–oleylamine complexes and oleylammonium selenocarbamate are modulated to achieve CISe QDs with the controlled amount of Cu vacancies without changing their *** them,CISe QDs with In/Cu=1.55 show the most outstanding photoelectrochemical hydrogen generation with excellent photocurrent density of up to 10.7 mA cm-2(at 0.6 VRHE),attributed to the suitable electronic band structures and enhanced carrier concentrations/lifetimes of the *** proposed method,which can effectively control the defects in heavy-metal-free ternary QDs,offers a deeper understanding of the effects of the defects and provides a practical approach to enhance photoelectrochemical hydrogen generation.

关键词： copper-indium-selenide defect engineering photoelectrochemical hydrogen generation quantum dots solar hydrogen

Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network

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Light(Science & Applications) 2022年第7期11卷 1595-1606页

作者： Geon kim Daewoong Ahn Minhee Kang Jinho Park DongHun Ryu YoungJu Jo Jinyeop Song Jea Sung Ryu Gunho Choi Hyun Jung chung Kyuseok kim Doo Ryeon chung In Young Yoo Hee Jae Huh Hyun-seok Min Nam Yong Lee YongKeun Park Department of Physics Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea KAIST Institute for Health Science and Technology KAISTDaejeon 34141Republic of Korea Tomocube Inc. Daejeon 34109Republic of Korea Smart Healthcare&Device Research Center Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Biological Sciences Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Emergency Medicine Bundang CHA HospitalSeongnam-siGyeonggi-Do 13496Korea Division of Infectious Diseases Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Laboratory Medicine Seoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Department of Laboratory Medicine and Genetics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Applied Physics Stanford UniversityStanfordCA 94305USA Department of Physics Massachusetts Institute of TechnologyCambridgeMA 02139USA

The healthcare industry is in dire need of rapid microbial identification techniques for treating microbial *** infections are a major healthcare issue worldwide,as these widespread diseases often develop into deadly *** studies have shown that an early appropriate antibiotic treatment significantly reduces the mortality of an infection,this effective treatment is difficult to *** main obstacle to early appropriate antibiotic treatments is the long turnaround time of the routine microbial identification,which includes time-consuming sample ***,we propose a microscopy-based framework that identifies the pathogen from single to few *** framework obtains and exploits the morphology of the limited sample by incorporating three-dimensional quantitative phase imaging and an artificial neural *** demonstrate the identification of 19 bacterial species that cause bloodstream infections,achieving an accuracy of 82.5%from an individual bacterial cell or *** performance,comparable to that of the gold standard mass spectroscopy under a sufficient amount of sample,underpins the effectiveness of our framework in clinical ***,our accuracy increases with multiple measurements,reaching 99.9%with seven different measurements of cells or *** believe that our framework can serve as a beneficial advisory tool for clinicians during the initial treatment of infections.

关键词： artificial neural exploit

Effect of solid-solution strengthening on deformation mechanisms and strain hardening in medium-entropy V_(1-x)Cr_(x)CoNi alloys

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Journal of Materials Science & Technology 2022年第13期108卷 270-280页

作者： Hyun chung Dae Woong kim Woo Jin Cho Heung Nam Han Yuji Ikeda Shoji Ishibashi Fritz Körmann Seok Su Sohn Department of Materials Science and Engineering Korea UniversitySeoul 02841South Korea Center for High Entropy Alloys Pohang University of Science and TechnologyPohang 37673South Korea Department of Materials Science and Engineering and Research Institute of Advanced Materials Seoul National UniversitySeoul 08826South Korea Institute for Materials Science University of StuttgartPfaffenwaldring 55Stuttgart 70569Germany Computational Materials Design Max-Planck-Institut für Eisenforschung GmbHMax-Planck-Strabe 1Düsseldorf 40237Germany Research Center for Computational Design of Advanced Functional Materials(CD-Fmat) National Institute of Advanced Industrial Science and Technology(AIST)TsukubaIbaraki 305-8568Japan Department of Materials Science and Engineering Delft University of TechnologyMekelweg2Delft 2628 CDthe Netherlands

High-and medium-entropy alloys(HEAs and MEAs)possess high solid-solution *** investigations have been conducted on its impact on yield strength,however,there are limited reports regarding the relation between solid-solution strengthening and strain-hardening *** addition,no attempt has been made to account for the dislocation-mediated plasticity;most works focused on twinning-or transformation-induced plasticity(TWIP or TRIP).In this work we reveal the role of solidsolution strengthening on the strain-hardening rate via systematically investigating evolutions of deformation structures by controlling the Cr/V ratio in prototypical V_(1-x)Cr_(x)CoNi *** the TWIP of CrCoNi with the dislocation slip of V_(0.4)Cr_(0.6)CoNi,the hardening rate of CrCoNi was superior to slip-band refinements of V_(0.4)Cr_(0.6)CoNi due to the dynamic Hall-Petch ***,as V content increased further to V_(0.7)Cr_(0.3)CoNi and VCoNi,their rate of slip-band refinement in V_(0.7)Cr_(0.3)CoNi and VCoNi with high solid-solution strength surpassed that of *** it is generally accepted in conventional alloys that deformation twinning results in a higher strain-hardening rate than dislocation-mediated plasticity,we observed that the latter can be predominant in the former under an activated huge solid-solution strengthening *** high solid-solution strength lowered the cross-slip activation and consequently retarded the dislocation rearrangement rate,i.e.,the dynamic *** delay in the hardening rate decrease,therefore,increased the strain-hardening rate,results in an overall higher strain-hardening rate of V-rich alloys.

关键词： Medium-entropy alloy Tensile property Solid-solution strength Strain-hardening rate Stacking fault energy

Altered thalamic subregion functional networks in patients with treatment-resistant schizophrenia

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World Journal of Psychiatry 2022年第5期12卷 693-707页

作者： Woo-Sung kim Jie Shen Uyanga Tsogt Soyolsaikhan Odkhuu Young-Chul chung Department of Psychiatry Jeonbuk National UniversityJeon-ju 54907South Korea

BACKGROUND The thalamus plays a key role in filtering information and has extensive interconnectivity with other brain regions.A large body of evidence points to impaired functional connectivity(FC)of the thalamocortical pathway in ***,the functional network of the thalamic subregions has not been investigated in patients with treatment-resistant schizophrenia(TRS).AIM To identify the neural mechanisms underlying TRS,we investigated FC of thalamic sub-regions with cortical networks and voxels,and the associations of this FC with clinical *** hypothesized that the FC of thalamic subregions with cortical networks and voxels would differ between TRS patients and *** In total,50 patients with TRS and 61 healthy controls(HCs)matched for age,sex,and education underwent resting-state functional magnetic resonance imaging(rs-fMRI)and clinical *** on the rs-fMRI data,we conducted a FC analysis between thalamic subregions and cortical functional networks and voxels,and within thalamic subregions and cortical functional networks,in the patients with TRS.A functional parcellation atlas was used to segment the thalamus into nine *** between altered FC and TRS symptoms were *** We found differences in FC within thalamic subregions and cortical functional networks between patients with TRS and *** addition,increased FC was observed between thalamic subregions and the sensorimotor cortex,frontal medial cortex,and lingual *** abnormalities were associated with the pathophysiology of *** Our findings suggest that disrupted FC within thalamic subregions and cortical functional networks,and within the thalamocortical pathway,has potential as a marker for *** findings also improve our understanding of the relationship between the thalamocortical pathway and TRS symptoms.

关键词： Treatment-resistant schizophrenia Thalamus Rs-fMRI Functional connectivity Thalamocortical pathway

Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virusinduced oxidative stress

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Acta Pharmaceutica Sinica B 2023年第1期13卷 174-191页

作者： Eun-Bin Kwon Wei Li Young Soo kim Buyun kim Hwan-Suck chung Younghoon Go Hyun-Jeong Ko Jae-Hyoung Song Young Ho kim Chun Whan Choi Jang-Gi Choi Korean Medicine(KM)Application Center Korea Institute of Oriental MedicineDaegu 41062Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea Natural Product Research Team BiocenterGyeonggido Business and Science AcceleratorGyeonggi-Do 16229Republic of Korea Laboratory of Microbiology and Immunology College of PharmacyKangwon National UniversityChuncheon 24341Republic of Korea

The development of drug-resistant influenza and new pathogenic virus strains underscores the need for antiviral ***,neuraminidase(NA)inhibitors are commonly used antiviral drugs approved by the US Food and Drug Administration(FDA)for the prevention and treatment of ***,we show that vitisin B(VB)inhibits NA activity and suppresses H1N1 viral replication in MDCK and A549 *** oxygen species(ROS),which frequently occur during viral infection,increase virus replication by activating the NF-κB signaling pathway,downmodulating glucose-6-phosphate dehydrogenase(G6PD)expression,and decreasing the expression of nuclear factor erythroid2-related factor 2(Nrf2)antioxidant response *** decreased virus-induced ROS generation by increasing G6PD expression and Nrf2 activity,and inhibiting NF-κB translocation to the nucleus through IKK *** addition,VB reduced body weight loss,increased survival,decreased viral replication and the inflammatory response in the lungs of influenza A virus(IAV)-infected *** together,our results indicate that VB is a promising therapeutic candidate against IAV infection,complements existing drug limitations targeting viral *** modulated the intracellular ROS by G6PD,Nrf2 antioxidant response pathway,and NF-κB signaling *** results demonstrate the feasibility of a multi-targeting drug strategy,providing new approaches for drug discovery against IAV infection.

关键词： Influenza Vitisin B Vitis vinifera L. Neuraminidase Reactive oxygen species NF-κB Multi-targeting Nrf2 G6PD

Hetero-deformation promoted strengthening and toughening in BCC rich eutectic and near eutectic high entropy alloys

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Journal of Materials Science & Technology 2023年第15期146卷 1-9页

作者： D.H.chung J.Lee Q.F.He Y.K.kim K.R.Lim H.S.kim Y.Yang Y.S.Na Department of Special Alloys Extreme Materials Research InstituteKorea Institute of Materials ScienceChangwonThe Republic of Korea Department of Mechanical Engineering City University of Hong KongKowloon TongKowloonHong KongChina Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyPohangThe Republic of Korea Center for Heterogenic Metal Additive Manufacturing Pohang University of Science and TechnologyPohangThe Republic of Korea Department of Materials Science and Engineering City University of Hong KongKowloon TongKowloonHong KongChina

Heterostructured eutectic high-entropy alloys(EHEAs)have attracted significant attention owing to their novel properties,such as balanced combinations of strength and fracture ***,the toughening/strengthening mechanisms of these EHEAs have not been thoroughly *** this study,we developed a series of dual-phase Al_((18–2x))Co_(30)Cr_((11+x))Fe_((11+x))Ni_(3)0(x=-1,0,1)eutectic and neareutectic HEAs containing face-centered cubic(FCC)and body-centered cubic(BCC)*** the high amount of BCC,which is referred to as the brittle phase,newly developed EHEAs exhibited superior fracture ***,we discovered that a fully eutectic HEA exhibited further improvements in both yield stress and fracture toughness,outperforming our off-eutectic and other previously reported *** combining experiments and theoretical models,we demonstrated that the synergistic increase in both strength and toughness in our fully eutectic HEA was derived from the high hetero-deformationinduced(HDI)strengthening/toughening associated with a high misorientation angle at the grain/phase boundaries.

关键词： Eutectic high entropy alloy Fracture toughness Heterogeneous structure Hetero deformation induced strengthening Misorientation angle