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Bioengineered silver nanoparticles induced apoptosis through upregulation of caspase 3 and caspase 8 proteins in breast adenocarcinoma MDA-MB-231 cells and impede angiogenesis

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Particuology 2024年第12期95卷 252-264页

作者： Shahnaz Majeed Nurul Izzah Binti Abu Bakar Mohammad Danish Afzan Binti Mahmad Mohamad Nasir Mohamad Ibrahim Norul Aini Zakariya Sreenivas Patro Sisinthy Ravindran Muthukumarasamy Abdulaziz M.Alanazi Mohammed Tahir Ansari ohoud a.jefri Faculty of Pharmacy and Health Sciences Universiti Kuala LumpurRoyal College of Medicine PerakIpoh30450Malaysia Bioresource Technology Section School of Industrial TechnologyUniversiti Sains Malaysia11800PenangMalaysia Laboratory Department Universiti Kuala LumpurRoyal College of Medicine PerakIpoh30450Malaysia School of Chemical Sciences Universiti Sains Malaysia11800PenangMalaysia School of Pharmacy Faculty of Science and EngineeringUniversity of Nottingham MalaysiaSemenyih-43500SelangorMalaysia Department of Chemistry Faculty of ScienceIslamic University of MadinahMadinah42351Saudi Arabia Department of Biological Science Faculty of ScienceKing Abdulaziz University Jeddah21589Saudi Arabia Department of Biology Faculty of ScienceTaibah UniversityAl-Madinah Al MunawarahSaudi Arabia Nanotechnology Group Faculty of Science and EngineeringUniversity of Nottingham MalaysiaSemenyih-43500SelangorMalaysia

In recent years,a lot of research has been done on silver nanoparticles(SNP)due to their numerous applications in the biomedical,pharmaceutical,and drug delivery *** this present study SNP were green synthesized using Melicope lunu-ankenda(***-ankenda)leaf *** addition of AgNO3 causes a color change.L-arginine addition results in further colour changes confirming conjugation.A UV–Vis spectrophotometric examination showed that the absorption peak for SNP was 435 nm,while the peak for L-arginine SNP(cSNP)was 422 *** analysis confirmed the association of amides and amines with *** spherical nature of the silver was disclosed by SEM,and its elemental character is verified by *** thermal stability of the nanoparticles is determined by TGA analysis,while TEM examination verifies their spherical *** the MTT assay,these cSNP exhibited outstanding toxicity analysis(IC5038.72μg/ml)against MDA-MB-231 *** cSNP causes damage to the mitochondria(JC1 staining),which causes oxidative stress and the production of ROS with 83%of DCF expression in cancer ***,as demonstrated by the Comet assay and DAPI,these cSNP cause good DNA damage in the treated ***,using flow cytometry,cSNPs potentially trigger apoptosis by triggering the expression of caspase 3 and caspase 8 ***,through CAM,cSNP demonstrated strong anti-angiogenesis activity by reducing the number of blood vessel *** findings suggest that cSNP may be crucial for drug delivery and cancer treatment.

关键词： Silver nanoparticles TEM Anti-angiogenesis DAPI ROS

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The Anaphase-Promoting Complex/Cyclosome in Control of Plant Development

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Molecular Plant 2012年第6期5卷 1182-1194页

作者： jefri Heyman Lieven De Veylder Department of Plant Systems Biology VIB and Department of Plant Biotechnology and Bioinformatics Ghent University Technologiepark 927 B-9052Gent Belgium

Temporal controlled degradation of key cell division proteins ensures a correct onset of the different cell cycle phases and exit from the cell division program. In light of the cell cycle, the Anaphase-Promoting Complex/Cyclosome （APC/C） is an important conserved multi-subunit ubiquitin ligase, marking targets for degradation by the 26S protea- some. However, whereas the APC/C has been studied extensively in yeast and mammals, only in the last decade has the plant APC/C started to unveil its secrets. Research results have shown the importance of the APC/C core complex and its activators during gametogenesis, growth, hormone signaling, symbiotic interactions, and endoreduplication onset. In addition, recently, the first plant APC/C inhibitors have been reported, allowing a fine-tuning of APC/C activity during the cell cycle. Together with the identification of the first APC/C targets, a picture emerges of APC/C activity being essential for many different developmental processes.

关键词： cell cycle CDC20 CCS52 endoreduplication gametogenesis ubiquitination.

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The regeneration factors ERF114 and ERF115 regulate auxin-mediated lateral root development in response to mechanical cues

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Molecular Plant 2022年第10期15卷 1543-1557页

作者： Balkan Canher Fien Lanssens Ai Zhang Anchal Bisht Shamik Mazumdar jefri Heyman Sebastian Wolf Charles W.Melnyk Lieven De Veylder Department of Plant Biotechnology and Bioinformatics Ghent UniversityGhent B-9052Belgium VIB Center for Plant Systems Biology Ghent B-9052Belgium Department of Plant Biology Linnean Center for Plant BiologySwedish University of Agricultural SciencesAlmas alle 575651 UppsalaSweden Department of Plant Biochemistry Center for Plant Molecular Biology(ZMBP)University of Tubingen72076 TubingenGermany

Plants show an unparalleled regenerative capacity,allowing them to survive severe stress conditions,such as injury,herbivory attack,and harsh weather *** potential not only replenishes tissues and restores damaged organs but can also give rise to whole plant *** the intertwined nature of development and regeneration,common upstream cues and signaling mechanisms are largely ***,we demonstrate that in addition to being activators of regeneration,ETHYLENE RESPONSE FACTOR 114(ERF114)and ERF115 govern developmental growth in the absence of wounding or *** ERF114 and ERF115 activity enhances auxin sensitivity,which is correlated with enhanced xylem maturation and lateral root formation,whereas their knockout results in a decrease in lateral ***,we provide evidence that mechanical cues contribute to ERF114 and ERF115 expression in correlation with BZR1-mediated brassinosteroid signaling under both regenerative and developmental ***,cell wall integrity surveillance via mechanosensory FERONIA signaling suppresses their expression under both *** together,our data suggest a molecular framework in which cell wall signals and mechanical strains regulate organ development and regenerative responses via ERF114-and ERF115-mediated auxin signaling.

关键词： lateral root ERF114 mechanical stress cell wall integrity FERONIA auxin

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Variable <i>β</i>-globin haplotypes in Saudi <i>β</i>thalassemia population

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Open Journal of Genetics 2013年第3期3卷 171-173页

作者： Jameela Shinwari Tahani Alshehri Asma I. Tahir Abdullah Al jefri Abdulkareem AlMomen Dana Bakheet Mohammad AlAnazi Arjumand Warsy Nada Al Tassan Biochemistry Department College of Science King Saud University Riyadh KSA Department of Genetics Research Centre King Faisal Specialist Hospital & Research Centre Riyadh KSA Hematology Department King Khalid University Hospital King Saud University Riyadh KSA Pediatric Hematology/Oncology Department King Faisal Specialist Hospital & Research Centre Riyadh KSA

Twenty two haplotypes were generated from a pool of 60 unrelated Saudi β thalassemia major patients using previously described restriction sites in the β globin gene. Linkage disequilibrium analysis of the polymorphic sites was also conducted, a few identified haplotypes were novel while the remainder was previously reported, haplotype1222212 was the most frequent haplotype in the study group and a strong linkage disequilibrium between two polymorphic restriction sites in these β thalassemia patients was uncovered.

关键词： SNPs Haplotype Linkage Disequilibrium Restriction Sites

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