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Bedside index for severity in acute pancreatitis:comparison with other scoring systems in predicting severity and organ failure

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Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 645-650页

作者： Ji young Park Tae joo Jeon Tae Hwan Ha Jin Tae Hwang Dong Hyun Sinn Tae-Hoon oh Won Chang Shin Won-Choong Division of Gastroenterology Department of Internal MedicineInje University Sanggye Paik Hospital

BACKGROUND:The early identification of severe acute pancreatitis is important for the management and for improving *** bedside index for severity in acute pancreatitis(BISAP)has been considered as an accurate method for risk stratification in patients with acute *** study aimed to evaluate the comparative usefulness of the ***:We retrospectively analyzed 303 patients with acute pancreatitis diagnosed at our hospital from March 2007to December ***,APACHE-II,Ranson criteria,and CT severity index(CTSI)of all patients were *** stratified the number of patiants with severe pancreatitis,pancreatic necrosis,and organ failure as well as the number of deaths by BISAP *** used the area under the receiveroperating curve(AUC)to compare BISAP with other scoring systems,C-reactive protein(CRP),hematocrit,and body mass index(BMI)with regard to prediction of severe acute pancreatitis,necrosis,organ failure,and ***:Of the 303 patiants,31(10.2%)were classified as having severe acute *** failure occurred in 23(7.6%)patients,pancreatic necrosis in 40(13.2%),and death in6(2.0%).A BISAP score of 2 was a statistically significant cutoff value for the diagnosis of severe acute pancreatitis,organ failure,and *** for BISAP predicting severe pancreatitis and death were 0.80 and 0.86,respectively,which were similar to those for APACHE-II(0.80,0.87)and Ranson criteria(0.74,0.74)and greater than AUCs for CTSI(0.67,0.42).The AUC for organ failure predicted by BISAP,APACHE-II,Ranson criteria,and CTSI was 0.93,0.95,0.84 and 0.57,*** for BISAP predicting severity,organ failure,and death were greater than those for CRP(0.69,0.80,0.72),hematocrit(0.45,0.35,0.14),and BMI(0.41,0.47,0.17).CONCLUSION:The BISAP predicts severity,death,and especially organ failure in acute pancreatitis as well as APACHE-II does and better than Ranson criteria,CTSI,CRP,hematocrit,and BMI.

关键词： acute pancreatitis scoring system pancreatic necrosis organ failure

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Adaptive Model Predictive Control for Yaw System of Variable-speed Wind Turbines

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Journal of Modern Power Systems and Clean Energy 2021年第1期9卷 219-224页

作者： Dongran Song Qing Chang Songyue Zheng Sheng Yang Jian Yang young Hoon joo the School of Automation Central South Universityand Hunan Provincial Key Laboratory of Power Electronics Equipment and GridChangsha 410083China the School of Energy Science and Engineering Central South UniversityChangsha 410083China the School of IT Information and Control Engineering Kunsan National UniversityKunsan 54150Korea

Due to varying characteristics of the wind condition, the performance of the wind turbines can be optimized by adapting the parameters of the control system. In this letter, an adaptive technique is proposed for the novel model predictive control(MPC) for the yaw system of the wind turbines. The control horizon is adapted to the one with the best predictive performance among multiple control horizons. The adaptive MPC is demonstrated by simulations using real wind data, and its performance is compared with the baseline MPC at fixed control horizon. Results show that the adaptive MPC provides better comprehensive performance than the baseline ones at different preview time of wind directions. Therefore, the proposed adaptive technique is potentially useful for the wind turbines in the future.

关键词： Wind turbine yaw system wind direction adaptive model predictive control

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Role of two-dimensional shear wave elastography in chronic liver diseases: A narrative review

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World Journal of Gastroenterology 2018年第34期24卷 3849-3860页

作者： Jae Yoon Jeong young Seo Cho joo Hyun Sohn Department of Internal Medicine Hanyang University Guri Hospital Hanyang University College of Medicine Department of Radiology Hanyang University Guri Hospital Hanyang University College of Medicine

Liver biopsy is the gold standard for evaluating the degree of liver fibrosis in patients with chronic liver disease. However, due to the many limitations of liver biopsy, there has been much interest in the use of noninvasive techniques for this purpose. Among these techniques real-time two-dimensional shear wave elastography(2D-SWE) has the advantage of measuring tissue elasticity with the guidance of B-mode images. Recently, many studies have been conducted on the application of 2D-SWE in patients with various liver diseases, and their validity has been confirmed. Here, we briefly discuss the role of 2D-SWE in patients with chronic liver diseases, particularly aspects of the examination techniques and clinical applications.

关键词： Shear wave elastography Liver disease Liver fibrosis Portal hypertension Hepatocelluar carcinoma

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Impact of statin intensity on adverse cardiac and cerebrovascular events in older adult patients with myocardial infarction

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Journal of Geriatric Cardiology 2021年第8期18卷 609-622页

作者： In Tae Moon Si-Hyuck Kang Wonjae Lee youngjin Cho Jin joo Park Yeonyee EYoon Il-young oh Chang-Hwan Yoon Jung-Won Suh Tae-Jin Youn In-Ho Chae Dong-Ju Choi young-Seok Cho Uijeongbu Eulji Medical Center Eulji University School of MedicineUijeongbuSouth Korea Seoul National University Bundang Hospital SeongnamSouth Korea Department of Cardiology Incheon Sejong HospitalIncheonSouth Korea

BACKGROUND There is insufficient evidence regarding the effect of high-intensity statin therapy in older *** study aimed to investigate the effects of high-intensity statin treatment on the clinical outcomes in older adults with myocardial infarc-tion(MI).METHODS Consecutive patients with MI aged at least 75 years were analyzed *** primary endpoint was major adverse cardiac and cerebrovascular events(MACCE),defined as a composite of all-cause death,MI,rehospitalization due to un-stable angina,repeat revascularization,and ischemic *** high-intensity group was compared to the low-to-moderate in-tensity group in the propensity score-matched *** Average age of total 546 patients was 81 *** them,84%of patients underwent percutaneous coronary *** unadjusted seven-year MACCE rate differed by statin intensity(high-intensity statin group:38%,moderate-intensity statin group:42%,low-intensity statin group:56%,and no-statin group:61%,P=0.004).However,among these groups,many baseline characteristics were significantly *** the 74 propensity score-matched pairs,which lacked any significant differences in all baseline characteristics,the high-intensity group had a significantly lower rate of MACCE than the low-to-moderate intensity group(37%vs.53%,P=0.047).Follow-up low-density lipoprotein cholesterol levels were significantly lower in the high-intensity group than that in the low-to-moderate intensity group(69.4±16.0 mg/dL vs.77.9±25.9 mg/dL,P=0.026).CONCLUSIONS In older adult patients with MI,the use of high-intensity statin caused significantly less occurrence of MACCE in comparison to that in low-to-moderate intensity for up to seven years of follow-up.

关键词： patients cardiac intensity

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Plasma levels of acylated ghrelin in patients with functional dyspepsia

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World Journal of Gastroenterology 2012年第18期18卷 2231-2237页

作者： Yeon Soo Kim joon Seong Lee Tae Hee Lee joo young Cho Jin oh Kim Wan Jung Kim Hyun Gun Kim Seong Ran Jeon Hoe Su Jeong Department of Internal Medicine Hallym University College of MedicineChuncheon Sacred Heart HospitalGangwon-do 200-704South Korea Department of Internal Medicine Soonchunhyang University College of MedicineSoonchunhyang University HospitalSeoul 140-743South Korea Department of Anatomy and Cell Biology Hanyang University College of Medicine222 Wangsimni-roSeongdong-guSeoul 133-792South Korea

AIM:To investigate the relationship between plasma acylated ghrelin levels and the pathophysiology of functional ***:Twenty-two female patients with functional dyspepsia and twelve healthy volunteers were recruited for the *** functional dyspepsia patients were each diagnosed based on the Rome Ⅲ *** patients completed a questionnaire concerning the severity of 10 *** acylated ghrelin levels before and after a meal were determined in the study participants using a commercial human acylated enzyme immunoassay kit;electrogastrograms were performed for 50 min before and after a standardized 10-min meal containing 265 ***:There were no significant differences in plasma acylated ghrelin levels between healthy volunteers and patients with functional ***,in patients with functional dyspepsia,there was a negative correlation between fasting plasma acylated ghrelin levels and the sum score of epigastric pain(r =-0.427,P = 0.047) and a positive correlation between the postprandial/fasting plasma acylated ghrelin ratio and the sum score of early satiety(r = 0.428,P =0.047).Additionally,there was a negative correlation between fasting acylated ghrelin plasma levels and fasting normogastria(%)(r =-0.522,P = 0.013).Interestingly,two functional dyspepsia patients showed paradoxically elevated plasma acylated ghrelin levels after the ***:Abnormal plasma acylated ghrelin levels before or after a meal may be related to several of the dyspeptic symptoms seen in patients with functional dyspepsia.

关键词： Functional dyspepsia Acylated ghrelin Electrogastrogram Rome Ⅲ criteria Dyspeptic symptoms

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Celecoxib attenuates 5-fluorouracil-induced apoptosis in HCT-15 and HT-29 human colon cancer cells

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World Journal of Gastroenterology 2007年第13期13卷 1947-1952页

作者： Yun Jeong Lim Jong Chul Rhee young Mee Bae Wan joo Chun Department of Internal Medicine Dongguk University International Hospital Dongguk University College of Medicine Goyang Korea Division of Gastroenterology Department of Internal Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Department of Parasitology Seoul National University College of Medicine Seoul Korea Department of Pharmacology Kangwon National University College of Medicine Chuncheon Korea

AIM： To investigate the combined chemotherapeutic effects of celecoxib when used with 5-FU in vitro. METHODS： Two human colon cancer cell lines （HCT-15 and HT-29） were treated with 5-FU and celecoxib, alone and in combination. The effects of each drug were evaluated using the MTT （3-（4, 5-dimethylthiazol-2-yl）-2, 5-diphenyltetrazolium bromide） assay, flow cytometry, and western blotting. RESULTS： 5-FU and celecoxib showed a dosedependent cytotoxic effect. When treated with 10-3 mol/L 5-FU （IC50） and celecoxib with its concentration ranging from 10.8 mol/L to 10.4 mol/L of celecoxib, cells showed reduced cytotoxic effect than 5-FU （10.3 mol/L） alone. Flow cytometry showed that celecoxib attenuated 5-FU induced accumulation of cells at subG1 phase. Western blot analyses for caspase-3 and poly （ADP-ribose） polymerase （PARP） cleavage showed that celecoxib attenuated 5-FU induced apoptosis. Western blot analyses for cell cycle molecules showed that G2/M arrest might be possible cause of 5-FU induced apoptosis and celecoxib attenuated 5-FU induced apoptosis via blocking of cell cycle progression to the G2/M phase, causing an accumulation of cells at the GI/S phase. CONCLUSION： We found that celecoxib attenuated cytotoxic effect of 5-FU. Celecoxib might act via inhibition of cell cycle progression, thus preventing apoptosis induced by 5-FU.

关键词： Antagonism Celecoxib Colorectal neoplasms Fluorouracil

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Flow characteristics of aluminum coated boron steel in hot press forming

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中国有色金属学会会刊：英文版 2009年第4期19卷 913-916页

作者： Jeong-Hwan JANG Jae-Ho LEE Bye ong-Don joo young-Hoon MOON School of Mechanical Engineering Pusan National University

The flow characteristics of aluminum coated boron steel in hot press forming were ***,the effects of aluminum coated layer on press forming were analyzed during deep *** results show that aluminum coated boron steel exhibits a high sensitivity on temperature and strain *** coating layer appears in surface flaking in a temperature range of 700-800 ℃,but smooth surface is formed above 900 ℃.

关键词：热压成型流动特性铝涂层硼钢表面剥落温度范围冲压成形高灵敏度

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Effect of Ca addition on the microstructure and mechanical properties of heat-treated Mg-6.0Zn-1.2Y-0.7Zr alloy

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Journal of Magnesium and Alloys 2021年第5期9卷 1636-1648页

作者： young Gil Jung Wonseok Yang Yong joo Kim Shae.K.Kim young Ok Yoon Hyunkyu Lim Do Hyang Kim Advanced Materials and Process R&D Department Korea Institute of Industrial Technology156Gaetbeol-roIncheon 21999Republic of Korea Department of Metallurgical Engineering Yonsei University50Yonsei-roSeoulSeodaemun-gu 03722Republic of Korea

In this study,the effects of Ca addition on the microstructure,thermal properties,and mechanical properties of a Mg-6.0Zn-1.2Y-0.7Zr(ZWK611)alloy at room temperature and 150℃ were *** an increase in the Ca content,the ignition resistance of the ZWK611 alloy improved and the grains became *** as-cast ZWK611 alloy consisted mainly of the dendriticα-Mg matrix and I-phase(Mg_(3)Zn_(6)Y)at the grain *** the other hand,theτ-(Ca_(2)Mg_(6)Zn_(3))and I-phases were formed in the Ca-added ZWK611 *** fraction of theτ-phase increased with an increase in the Ca *** the solid-solution treatment,these phases remained partially at the grain boundaries of the Ca-added ZWK611 alloys and an additional W-phase(Mg_(3)Zn_(3)Y)was *** phases remaining at the grain boundaries restricted the grain growth through the grain boundary pinning *** aging treatment resulted in the formation of MgZn'precipitates in theα-Mg matrix of the *** precipitates were more uniformly distributed in the Ca-added alloys than in the alloys without ***,the heat treatment-induced precipitation improved the tensile and creep properties of the T6-treated *** T6-treated ZWK611+0.7Ca alloy exhibited the best mechanical properties at room temperature and 150℃ among all the tested alloys.

关键词： Mg-Zn-Y alloys Heat-treatment Precipitate Mechanical properties Thermal analysis

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pH-induced structural changes of surface immobilized poly (L-lysine) by two-dimensional (2D) infrared correlation study

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Chinese Chemical Letters 2015年第2期26卷 173-176页

作者： Eun joo Yoo Boknam Chae young Mee Jung Seung Woo Lee School of Chemical Engineering Yeungnam University Pohang Accelerator Laboratory Department of Chemistry Kangwon National University

This paper reports the pH-induced structural changes in the surface immobilized poly（L-lysine）（PLL）***-dimensional（2D） correlation analysis was applied to the Fourier transform infrared（FTIR）spectra of the surface-immobilized PLL film to examine the spectral changes induced by the alternations of the protonation state of the amino group in the side *** spectral changes in the FTIR spectra of the PLL film were observed between pH 7 and *** decrease in the protonation state of the amino group in the side chain induced spectral changes in the amino group as well as conformational changes in the alky]group in the side *** pH 1-8,the spectral changes in the amino and alkyl groups in the side chain occurred before those of the amide group in the main chain of the surface immobilized PLL film.

关键词： Poly(L-lysine)(PLL) Surface-immobilized polypeptide FT-IR spectroscopy 2D correlation spectroscopy

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On-skin and tele-haptic application of mechanically decoupled taxel array on dynamically moving and soft surfaces

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npj Flexible Electronics 2022年第1期6卷 964-972页

作者： Se young Kwon Gyeongsuk Park Hanbit Jin Changyeon Gu Seung Jin oh joo Yong Sim Wooseup Youm Taek-Soo Kim Hye Jin Kim Steve Park Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Electronics and Telecommunications Research Institute(ETRI) Daejeon 34129Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Mechanical Systems Engineering Sookmyung Women’s UniversityDaejeon 04313Republic of Korea

To accurately probe the tactile information on soft skin,it is critical for the pressure sensing array to be free of noise and inter-taxel crosstalk,irrespective of the measurement ***,on dynamically moving and soft surfaces,which are common conditions for on-skin and robotic applications,obtaining precise measurement without compromising the sensing performance is a significant challenge due to mechanical coupling between the sensors and with the moving *** this work,multi-level architectural design of micro-pyramids and trapezoid-shaped mechanical barrier array was implemented to enable accurate spatiotemporal tactile sensing on soft surfaces under dynamic ***-off relationship between limit of detection and bending insensitivity was discovered,which was overcome by employing micropores in barrier ***,in-situ pressure mapping on dynamically moving soft surfaces without signal distortion is demonstrated while human skin and/or soft robots are performing complicated tasks such as reading Braille and handling the artificial organs.

关键词： artificial moving dynamically

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