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Journal of Biosciences and Medicines 2022年第9期10卷 48-59页

作者： Ezunu Ngozi Esther Ezunu Emmanuel Okechukwu Aigbokhaode Adesuwa Queen Agbele Theresa Okwudishu Marian Ngozi ogwuazor phillipa Iwebelua Rosemary Ngozi Ofilli Antoinette Ngozi Appiah Stella Osiatuma Victor Azubuike Federal Medical Centre Asaba Nigeria Department of Public Health & Community Medicine University of Benin Teaching Hospital Benin City Nigeria Valley View University Accra Ghana

Background: COVID-19 is a respiratory tract infection which is responsible for the recent Pandemic with its socioeconomic and Health consequences. One way to control the spread of the disease is through hand hygiene. This study was done to examine the knowledge and practice of hand washing to limit COVID-19. Method: An institutional-based, cross-sectional study carried out among 247 Health care workers using systemic sampling. A standardized questionnaire used in a previous study was used to collect data. SPSS version 25 was used for data analysis. Statistical significance was set at 0.05. Results: Health care workers had good knowledge (92.0%) and practice (99.0%) of hand washing, respondent’s profession (chi-square value = 618, p value = 0.001), and Gender (chi-square = 5234, p-value = 0.022) were statistically significant. Conclusion: Knowledge and practice of hand-washing were generally good in Federal Medical Centre Asaba. However, conscious and targeted efforts should be maintained by hospital organizations in organizing regular training on Infection, Prevention. They should also make available running water and consumables for hand-washing exercises.

关键词： Asaba Hand-Washing Healthcare-Workers Knowledge Practice

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The Perfect Village?

新高考(英语进阶) 2016年第Z2期 58-59页

作者： phillipa Roberts

Titus salt and his material factory Named after both the man who built it and the river it sits on,Saltaire was created in 1851,when Victoria was *** our tour of the village near Bradford in Yorkshire,the heart of nor... 详细信息

关键词： work very

Utility of tissue microarrays for profiling prognostic biomarkers in clinically localized prostate cancer： the expression of BCL-2, E-cadherin, Ki-67 and p53 as predictors of biochemical failure after radical prostatectomy with nested control for clinical and pathological risk factors

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Asian Journal of Andrology 2009年第1期11卷 109-118页

作者： Joseph Nariculam Alex Freeman Simon Bott phillipa Munson Noriko Cable Nicola Brookman-Amissah Magali Williamson Roger S. Kirby John Masters Mark Feneley Institute of Urology Prostate Cancer Research Centre London W1 W 7E J UK Histopathology Diagnostics Statistics University College London London W1 W 7ET UK Prostate Cancer Research Centre London W1 G 8GT UK

A cure cannot be assured for all men with clinically localized prostate cancer undergoing radical treatment. Molecular markers would be invaluable if they could improve the prediction of occult metastatic disease. This study was carried out to investigate the expression of BCL-2, Ki-67, p53 and E-cadherin in radical prostatectomy specimens. We sought to assess their ability to predict early biochemical relapse in a specific therapeutic setting. Eighty-two patients comprising 41 case pairs were matched for pathological stage, Gleason grade and preoperative prostate-specific antigen （PSA） concentration. One patient in each pair had biochemical recurrence （defined as PSA ≥ 0.2 ng mL^-1 within 2 years of surgery） and the other remained biochemically free of disease （defined as undetectable PSA at least 3 years after surgery）. Immunohistochemical analysis was performed to assess marker expression on four replicate tissue microarrays constructed with benign and malignant tissue from each radical prostatectomy specimen. Ki-67, p53 and BCL-2, but not E-cadherin, were significantly upregulated in prostate adenocarcinoma compared with benign prostate tissue （P 〈 0.01）. However, no significant differences in expression of any of the markers were observed when comparing patients who developed early biochemical relapse with patients who had no biochemical recurrence. This study showed that expression of p53, BCL-2 and Ki-67 was upregulated in clinically localized prostate cancer compared with benign prostate tissue, with no alteration in E-cadherin expression. Biomarker upregulation had no prognostic value for biochemical recurrence after radical prostatectomy, even after considering pathological stage, whole tumour Gleason grade and preoperative serum PSA level.

关键词： immunohistochemistry prostate cancer prostatectomy

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数学与其它科学之间的新伙伴关系

数学译林 2003年第4期22卷 289-295,351页

作者： phillipa.Griffiths 陆柱家胥鸣伟

Systematic review of evidence for different treatment settings in anorexia nervosa

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World Journal of Psychiatry 2015年第1期5卷 147-153页

作者： Sloane Madden phillipa Hay Stephen Touyz Department of Psychological Medicine Sydney Children’s Hospital Network Faculty of Medicine University of Sydney Centre for Health Research School of MedicineUniversity of Western Sydney School of Medicine James Cook University School of Psychology and Centre for Eating and Dieting Disorders University of Sydney

AIM: To compare outcomes in anorexia nervosa(AN) in different treatment settings: inpatient, partial hospitalization and outpatient. METHODS: Completed and published in the English language, randomized controlled trials comparing treatment in two or more settings or comparing different lengths of inpatient stay, were identified by database searches using terms "anorexia nervosa" and "treatment" dated to July 2014. Trials were assessed for risk of bias and quality according to the Cochrane handbook by two authors(Madden S and Hay P) Data were extracted on trial quality, participant features and setting, main outcomes and attrition. RESULTS: Five studies were identified, two comparing inpatient treatment to outpatient treatment, one study comparing different lengths of inpatient treatment, one comparing inpatient treatment to day patient treatment and one comparing day patient treatment with outpatient treatment. There was no difference in treatment outcomes between the different treatment settings and different lengths of inpatient treatment. Both outpatient treatment and day patient treatment were significantly cheaper than inpatient treatment. Brief inpatient treatment followed by evidence based outpatient care was also cheaper than prolonged inpatient care for weight normalization also followed by evidence based outpatient care. CONCLUSION: There is preliminary support for AN treatment in less restrictive settings but more research is needed to identify the optimum treatment setting for anorexia nervosa.

关键词： Anorexia nervosa Treatment Inpatient Outpatient Day patient

赖脯胰岛素75/25与人胰岛素70/30对糖尿病患者餐后血糖波动的影响

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中华内分泌代谢杂志 2007年第2期23卷 143-144页

作者：毕宇芳吴松华郭晓蕙宁光项坤三高妍张翼飞李鸣张俊清孙忻艺周小京 phillipa Clarke Caroline Markey 郑以漫陈家伦上海交通大学医学院附属瑞金医院内分泌代谢科上海市内分泌代谢病临床医学中心上海市内分泌代谢病研究所200025 上海交通大学附属第六人民医院内分泌科北京大学第一医院内分泌科美国礼来公司

报道一项有106例1型或2型糖尿病患者参加的为期1个月的多中心、开放自身对照研究,比较赖脯胰岛素75/25与人胰岛素70/30改善餐后2h血糖波动的疗效。由人胰岛素70/30转为赖脯胰岛素75/25治疗,餐后2h血糖水平及血糖波动均显著降低,且无任... 详细信息

报道一项有106例1型或2型糖尿病患者参加的为期1个月的多中心、开放自身对照研究,比较赖脯胰岛素75/25与人胰岛素70/30改善餐后2h血糖波动的疗效。由人胰岛素70/30转为赖脯胰岛素75/25治疗,餐后2h血糖水平及血糖波动均显著降低,且无任何显著性不良事件或持久性低血糖的发生。问卷显示更多患者倾向于应用赖脯胰岛素75/25。

关键词：赖脯胰岛素糖尿病血糖波动患者倾向性

White matter alterations in anorexia nervosa: A systematic review of diffusion tensor imaging studies

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World Journal of Psychiatry 2016年第1期6卷 177-186页

作者： Beatriz Martin Monzon phillipa Hay Nasim Foroughi Stephen Touyz Centre for Health Research School of MedicineWestern Sydney University School of Psychology Faculty of ScienceUniversity of Sydney

AIM: To identify findings concerning white matter(WM) fibre microstructural alterations in anorexia nervosa(AN).METHODS: A systematic electronic search was undertaken in several databases up to April 2015. The search strategy aimed to locate all studies published in English or Spanish that included participants with AN and which investigated WM using diffusion tensor imaging(DTI). Trials were assessed for quality assessment according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses checklist and a published quality index guideline. RESULTS: A total of 6 studies met the inclusion criteria, four of people in the acute state of the illness, one included both recovered and unwell participants, and one included people who had recovered. Participants were female with ages ranging from 14 to 29 years. All studies but one measured a range of psychopathological features. Fractional anisotropy and mean diffusivity were the main DTI correlates reported. Alterations were reported in a range of WM structures of the limbicsystem, most often of the fornix and cingulum as well as the fronto-occipital fibre tracts, i.e., regions associated with anxiety, body image and cognitive function. Subtle abnormalities also appeared to persist after ***: This diversity likely reflects the symptom complexity of AN. However, there were few studies, they applied different methodologies, and all were cross-sectional.

关键词： Eating disorder Diffusion tensor imaging Weight/shape overvaluation Food anxiety

应用低混合赖脯胰岛素治疗1型和2型糖尿病的有效性和安全性研究

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应用低混合赖脯胰岛素治疗1型和2型糖尿病的有效性和安全性研究