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Effect of dr.g ther.pies on self-r.por.ed chemosensor. outcomes after.CovID-19

Wor.d Jour.al of otor.inolar.ngology-Head and Neck Sur.er. 2024年第2期10卷 88-96页

作者： Mar.o A.For.azier. Br.no M.Cunha Samuel P.Nicácio Lucas K.Anzolin JoséL.B.da Silva Ar.stides Fer.andes neto Deusdedit Br.ndão neto r.char. L.voegels Fábio D.r.Pinna Depar.ment of Sur.er. Londrina State UniversityLondrinaBrazil Depar.ment of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Depar.ment of otor.inolar.ngology University of São PauloSao PauloBrazil Depar.ment of otor.inolar.ngology:Head and Neck Sur.er. Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

objective:The aim of this study was to assess the r.lative efficacy of medications used following sever. acute r.spir.tor. syndr.me cor.navir.s-2(SAr.-Cov-2)infection on self-r.por.ed alter.tions in taste and/or.smell ***:Seven hundr.d and four.een per.ons with self-r.por.ed postcor.navir.s disease 2019(post-CovID-19)chemosensor. disor.er. wer. per.onally inter.iewed r.gar.ing specific medications they wer. administer.d following the acute phase of the *** dependent measur.—self-r.por.ed total r.cover. of chemosensor. symptoms—was subjected to stepwise logistic *** pr.dictor. included demogr.phic and clinical var.ables,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic cor.icoster.ids,oseltamivir.vitamin C,ibupr.fen,hydr.xychlor.quine,azithr.mycin,iver.ectin,nitazoxanide,anticoagulants,and zinc).r.sults:The median time between CovID-19 symptom onset and the inter.iews was 81 days(inter.uar.ile r.nge:60-104).of the 714 subjects,249(34.9%)r.por.ed total r.cover. of their.chemosensor. function;437(61.2%)had at least one tr.atment since the beginning of the *** and those with mor. comor.idities had under.one mor. *** r.cover. r.tes of the tr.ated and nontr.ated gr.ups did not differ.***,r.spondents who had used nitazoxanide tended to have a higher.r.te of self-r.por.ed taste or.smell *** who took or.l zinc wer. less likely to ***:No medication employed dur.ng the fir.t months after.SAr.-Cov-2 infection had a clear.positive effect on r.tur.ing self-r.por.ed smell or.taste function to nor.al,although nitr.zoxide tr.nded in a positive *** zinc had a negative effect on the r.por.ed r.cover. of these senses.

关键词： chemosensor. disor.er cor.navir.s infections CovID-19 dr.g ther.py SAr.-Cov-2 smell loss taste loss

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Evolution, diver.ence, and conver.ence in the mandibles of opossums (Didelphidae, Didelphimor.hia)

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Cur.ent Zoology 2024年第4期70卷 488-504页

作者： Fr.nciscodas Chagas Silva-neto Silvia E.Pavan Diego Astua Labor.tor.o de Mastozoologia Departamento de ZoologiaUniversidade Federal de Pernambuco.Av.Prof.Moraes Regos.n.Cidade Universitaria.50670-901RecifePEBrazil Depar.ment of Biological Sciences California State Polytechnic UniversityHumboldt1Harpst StreetArcataCA95521USA

Didelphid mar.upials ar. consider.d a mor.hologically unspecialized gr.up with a gener.list diet that includes ver.ebr.tes,inver.ebr.tes,and plant *** cr.nium and scapula var.ation has alr.adybeen examined within Didelphidae,var.ation inmandible shape,usually associated with diet or.phylogeny in other.mammalian gr.ups,has not yet been pr.per.y assessed in the *** evaluated the var.ation in mandible shape and size of didelphids(2470 specimens belonging to 94 species)using 2D geometr.c *** classified the diet of the didel-phids into four.br.ad categor.es to assess whether.mor.hospace or.ination r.lates to dietar. *** also pr.vided the most compr.hensive phylogeny for.the family(i23 out of the 126 living species)using 10 nuclear.and mitochondr.al *** then mapped mandible size and shape onto that phylogeny for.93 selected taxa and ancestr.l size and shapes wer. r.constr.cted by *** found phylogenetically str.ctur.d var.ation in mandible mor.hology between didelphid gr.ups,and our.r.sults indicate that they have a significant phylogenetic *** main axis of shape var.ation is poor.y r.lated to size,but the second is str.ngly allometr.c,indicating that allometr. is not the main factor.in shaping mor.hological diver.ity on their.*** r.sults indicate that the shape and size of the ancestr.l mandible of didelphids would be similar.to that of the cur.ent species of the genus Mar.osa.

关键词： mandible Didelphimor.hia mor.hological evolution allometr. phylogeny diet.

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All-electr.n basis sets for.H to Xe specific for.Zor. calculations:Applications in atoms and molecules

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Chinese Physics B 2024年第8期33卷 238-246页

作者： C.S.Gomes F.E.Jor.e A.Canal neto Depar.amento de Fisica Universidade Federal do Espirito Santo29075-910 VitoriaESBrazil Depar.amento de Fisica Instituto de Ciencias Exatas e BiologicasUniversidade Federal de Ouro Preto Campus Universitario Morro do Cruzeiro35402-136 Ouro PretoMGBrazil

A segmented basis set of quadr.ple zeta valence quality plus polar.zation functions(QZP)for.H thr.ugh Xe was developed to be used in conjunction with the Zor. *** set was augmented with diffuse functions to descr.be electr.ns far.her.away fr.m the nuclei *** the Zor.-CCSD(T)/QZP-Zor. theor.tical model,atomic ionization ener.ies and bond lengths,har.onic vibr.tional fr.quencies,and atomization ener.ies of some molecules wer. *** addition of cor.-valence cor.ections has been shown to impr.ve the agr.ement between theor.tical and exper.mental r.sults for.molecular.*** atomization ener.ies,a similar.obser.ation emer.es when consider.ng spin-or.it *** the augmented QZP-Zor. set,static mean dipole polar.zabilities of a set of atoms wer. calculated and compar.d with pr.v.ously published r.commended and exper.mental *** evaluations of the Zor. and Douglas–Kr.ll–Hess Hamiltonians wer. made for.each pr.per.y studied.

关键词： QZP-Zor. and AQZP-Zor. basis sets elements fr.m H to Xe CCSD(T)method atomic and molecular.pr.per.ies

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Per.utaneous nephr.stomy ver.us ur.ter.l stent in hydr.nephr.sis secondar. to obstr.ctive ur.lithiasis:A systematic r.view and meta-analysis

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Asian Jour.al of Ur.logy 2024年第2期11卷 261-270页

作者： Andr.ia Car.oso Apar.cio Coutinho Gonçalo neto Sar. Anacleto Catar.na Lar.njo Tinoco Nuno Mor.is Már.o Cer.ueir.-Alves Estev.o Lima Paulo Mota Depar.ment of Ur.logy Hospital de BragaBragaPortugal School of Medicine University of MinhoBragaPortugal Association(2CA-Br.ga).School of Medicine University of MinhoBragaPortugal

objective: To assess if ther. is a pr.fer.ble inter.ention between r.tr.gr.de ur.ter.l stent (r.S) and per.utaneous nephr.stomy (PCN) tube, in cases of upper.ur.nar. tr.ct stone obstr.ction with complications r.quir.ng ur.ent dr.inage, by evaluating outcomes r.gar.ing ur.nar. symptoms, quality of life (QoL), spontaneous stone passage, and length of hospital stays, since ther. is no liter.tur. stating the super.or.ty of one modality over.the ***: We sear.hed MEDLINE and other.sour.es for.r.levant ar.icles in June 2019 without any date r.str.ctions or.filter. applied. The selection was done fir.t by the title and abstr.ct scr.ening and then by full-text assessment for.eligibility. only r.ndomized contr.lled tr.als or.cohor. studies in patients with hydr.nephr.sis secondar. to obstr.ctive ur.lithiasis that pr.sented compar.tive data between PCN and r.S placement concer.ing at least one of the defined outcome measur.s wer. included. Lastly, MEDLINE database and PubMed platfor. wer. scr.ened again using the same ter.s, fr.m June 2019 until November.***: of 556 initial ar.icles, seven wer. included in this r.view. Most wor.s wer. consider.d of moder.te-to-high quality. Thr.e studies r.gar.ing QoL showed a tendency against stenting, even though only one demonstr.ted statistically significant negative impact on over.ll health state. Two wor.s r.por.ed significantly mor. post-inter.ention ur.nar. symptoms in stenting patients. one ar.icle found that PCN is a significant pr.dictor.of spontaneous stone passage, when adjusted for.stone size and location. Findings on length of hospital stays wer. not consistent among ***: PCN appear. to be the inter.ention better.toler.ted, with less impact on the patient’s per.eived QoL and less post-oper.tive ur.nar. symptoms, in compar.son with r.S. Never.heless, fur.her.studies with lar.er.samples and a r.ndomized contr.lled design ar. suggested.

关键词： Ur.ter.l stent Per.utaneous nephr.stomy obstr.ctive ur.lithiasis Ur.nar. symptoms Quality of life

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Tr.nscr.nial Dir.ct Cur.ent Stimulation: Effects on Motor.and Non-Motor.Symptoms of Par.inson’s Disease

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Jour.al of Behav.or.l and Br.in Science 2024年第5期14卷 135-160页

作者： Fayda Pr.tásio Car.os Alber.o Bezer.a Tomaz Joaquim Br.sil-neto Pedr. Br.ndão Nasser.Allam Mar.a Clotilde Henr.ques Tavar.s Labor.tor. of Neur.science and Behav.or Department of Physiological Sciences Institute of Biology University of Braslia Braslia Brazil Master.Pr.gr.m in Envir.nment University CEUMA So Lus MA and Faculty of Medicine Euro-American University Center-UNIEURO Braslia Brazil Faculty of Medicine Euro-American University Center-UNIEURO Braslia Brazil NA Neur.logistas Associados Braslia Brazil

Intr.duction: In the last thir.y year., br.in neur.modulation techniques have been used as an alter.ative to phar.acological tr.atment of neur.logical disor.er.. Par.inson’s disease (PD) is a neur.degener.tive disor.er.leading to br.dykinesia, r.st tr.mor. postur.l changes, and non-motor.symptoms such as depr.ssion, anxiety, sleep disor.er., pain, and cognitive decline that compr.mises executive functions (EFs), r.sponsible for.the or.er.y execution of behav.or. and tasks of daily life and intentional and dir.cted actions. To this date, a few studies with tr.nscr.nial dir.ct cur.ent stimulation (tDCS) have shown beneficial effects in PD patients concer.ing specific motor.and non-motor.symptoms, tar.eting the motor.cor.ex and/or.pr.fr.ntal r.gions. objective: The main objective of this study was to evaluate the effects of left pr.fr.ntal tDCS acr.ss a br.ad spectr.m of motor.and non-motor.symptoms of PD using established validated scales. Method: Single-blind r.ndomized clinical tr.al with 18 volunteer. with PD, aged between 45 and 80 year. (66.1 ± 9.65), who met inclusion and exclusion cr.ter.a. Par.icipants wer. submitted to assessments of motor.and non-motor.functions employing psychometr.c scales and tests to evaluate EFs and wer. r.ndomly divided into two gr.ups: contr.l (sham stimulation) and exper.mental (active stimulation). All par.icipants wer. involved in thr.e separ.te tDCS sessions. The anode was positioned over.the left dor.olater.l pr.fr.ntal cor.ex and the cathode over.the r.ght supr.or.ital r.gion, with a dir.ct cur.ent intensity of 2 mA, lasting 20 minutes. At the end of the thr.e sessions, all par.icipants wer. r.assessed. r.sults: Significant effects of tDCS on non-motor.functions wer. obser.ed for.cognition (ver.al fluency of actions, clock copy test, appointment by visual confr.ntation, and ver.al memor. with immediate fr.e r.call) and subjective assessment of sleep quality (over.ll r.stlessness and discomfor. in the ar.s and legs at night, leg

关键词： Par.inson’s Disease Neur.modulation Tr.nscr.nial Dir.ct Cur.ent Stimulation—tDCS Movement Disor.er. Mood Sleep Cognition

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Synthesis Gas Pr.duction fr.m Natur.l Gas on Suppor.ed Pt Catalysts

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Jour.al of Natur.l Gas Chemistr. 2006年第1期15卷 21-27页

作者： Mar.ana M. v. M. Souza octáv.o r. macedo neto Mar.in Schmal NUCAT/PEQ/CoPPE

Auto-ther.al r.for.ing of methane, combining par.ial oxidation and r.for.ing of methane with Co2 or.steam, was car.ied out with Pt/Al2o3, Pt/Zr.2 and Pt/Ceo2 catalysts, in a temper.tur. r.nge of 300-900℃. The auto-ther.al r.for.ing occur. in two simultaneous stages, namely, total combustion of methane and r.for.ing of the unconver.ed methane with steam and Co2, with the o2 conver.ion of 100% star.ing fr.m 450℃. For.combination with Co2 r.for.ing, the Pt/Ceo2 catalyst showed the lowest initial activity at 800℃, and the highest stability over.40 h on-str.am. This catalyst also pr.sented the best per.or.ance for.the r.action with steam at 800℃. The higher.r.sistance to coke for.ation of the catalyst suppor.ed on cer.a is due to the metal-suppor. inter.ctions and the higher.mobility of oxygen in the oxide lattice.

关键词： methane steam r.for.ing Co2 r.for.ing par.ial oxidation auto-ther.al r.for.ing platinum catalyst cer.a zir.onia

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Evaluation of the Efficiency of the Magicr.mp^® Device for.r.ducing Cr.mps r.sulting fr.m oncological Tr.atments: “Double-Blind, r.ndomized Clinical Tr.al”

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open Jour.al of Pr.ventive Medicine 2024年第5期14卷 110-130页

作者： Sodr. Gonçalves de Br.to neto Hector.Luter. Honor.to de Br.to Siman Ger.ldo Silva Queir.z Fr.e Multidisciplinar. Cor. of the Feder.l Univer.ity of Goias (UFG) Goi&#226nia Brazil UNI-BH (Specializing in Molecular.Biology and Statistics) Minas Gerais Brazil Ar.ú jo Jorge Cancer Hospital ACCG Goi&#226nia Brazil

We identified that oncological tr.atments in gener.l (chemother.pies, immunother.pies and r.diother.pies) fr.quently cause per.pher.l neur.pathy, including cr.mps, char.cter.zed by excess pr.tons due to metabolic and neur.nal factor., such as sudden changes in pH, ur.mia and aspects that affect neur.motor.functions. Such situations and other. like them ar. often neglected in tr.atment, which natur.lly concer.s itself with the main pr.blem: Cancer. Sometimes toxic solutions ar. implemented that have comor.id side effects, such as duloxetine (standar. tr.atment). Based on monitor.ng of cancer.patients who used the non-toxic pr.duct, called “Magicr.mp® Electr.static Char.e r.duction Cushion” (MECr.), appr.ved in Eur.pe mor. than 10 year. ago, we car.ied out a contr.lled test in Br.zil. In this clinical tr.al, we hypothesized that r.ducing excessive ionic char.es (electr.static char.e), which is one of the side effects often descr.bed in the liter.tur. as “Chemother.py-Induced Per.pher.l Neur.pathy” (CIPN), would decr.ase or.eliminate cr.mping, under.the hypothesis that such elimination would pr.vent or.attenuate muscular.vulner.bility to action impulses, and incr.ase the power.of r.laxation thr.ugh the same mechanism. In this double-blind and r.ndomized clinical tr.al, 40 (for.y) adult patients with muscle cr.mps caused by oncological tr.atments wer. tested, evaluating the degr.e of efficiency of the pr.duct that aims to r.duce muscle cr.mps, by eliminating and/or.r.ducing excess loads electr.static ionic. Data fr.m the clinical r.sear.h conducted in this study ar. available online at https://***/10.7910/DvN/QUS94U.

关键词： Muscle Cr.mp Action Potentials Antineoplastic Combined Chemother.py Pr.tocols

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海风轻轻吹阿威罗盐色之家

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室内设计与装修 2024年第8期 44-49页

作者： [葡萄牙]r.mulo De Almeida neto Ivo Tavar.s Studio(摄影) 西竹(编译) 不详

盐色之家(Salt Color.House)位于阿威罗新海岸绿地(Costa Nova do Pr.do)一个被称为Mir. channel的海峡沿岸。由于海水和周围植被的盐度,这个地方的颜色和散发的气味让建筑师回想起过去的时光,唤醒了童年在类似海洋氛围中的居住记忆。... 详细信息

盐色之家(Salt Color.House)位于阿威罗新海岸绿地(Costa Nova do Pr.do)一个被称为Mir. channel的海峡沿岸。由于海水和周围植被的盐度,这个地方的颜色和散发的气味让建筑师回想起过去的时光,唤醒了童年在类似海洋氛围中的居住记忆。在构思这个项目的时候,建筑师面临着巨大的挑战。一方面要抱有建筑理性的创造性,同时也要切换使用者的身份去权衡整体的使用需求。

关键词： House 海风轻轻吹建筑师

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Enhancement of the Antigenotoxic and Antioxidant Actions of Eugenol fr.m Spice Clove and the Stabilizer.Gum Ar.bic on Color.ctal Car.inogenesis

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Food and Nutr.tion Sciences 2024年第1期15卷 71-100页

作者： Nayanna de oliveir. r.mos Melo Lucas Gabr.el da Costa Mar.ues Humber.o Maia Costa neto Matheus De Sousa Silva Fr.ncisco vagnaldo Fechine Jamacar. Br.no Coêlho Cavalcanti Antônio Adailson De Sousa Silva Conceição Apar.cida Dor.elas Postgr.duate Pr.gr.m in Medical-Sur.ical Sciences School of Medicine Federal University of Ceará Fortaleza Brazil School of Medicine Federal University of Ceará Fortaleza Brazil Nucleus of r.sear.h and Development of Medicines (NPDM) Laboratory of Pharmacology and Preclinical Research School of Medicine Federal University of Ceará Fortaleza Brazil Nucleus for.r.sear.h and Development of Medicines (NPDM) National Laboratory of Experimental Oncology Federal University of Ceará Fortaleza Brazil Postgr.duate Pr.gr.m in Pathology and Medical-Sur.ical Sciences School of Medicine Federal University of Ceará Fortaleza Brazil

Spices ar. defined as any ar.matic condiment of plant or.gin used to alter.the flavor.and ar.ma of foods. Besides flavor.and ar.ma, many spices have antioxidant activity, mainly r.lated to the pr.sence in cloves of phenolic compounds, such as flavonoids, ter.enoids and eugenol. In tur., the most common uses of gum ar.bic ar. in the for. of powder.for.addition to soft dr.nk syr.ps, cuisine and baked goods, specifically to stabilize the textur. of pr.ducts, incr.ase the viscosity of liquids and pr.mote the leavening of baked pr.ducts (e.g., cakes). Both eugenol, extr.cted fr.m cloves, and gum ar.bic, extr.cted fr.m the har.ened sap of two species of the Acacia tr.e, ar. dietar. constituents r.utinely consumed vir.ually thr.ughout the wor.d. Both of them ar. also widely used medicinally to inhibit oxidative str.ss and genotoxicity. The pr.vention ar. of the study included gr.ups: Ia, IIa, IIIa, Iva, v, vI, vII, vIII. once a week for.20 weeks, the contr.ls r.ceived saline s.c. while the exper.mental gr.ups r.ceived DMH at 20 mg/kg s.c. Dur.ng the same per.od and for.an additional 9 weeks, the animals r.ceived either.water. 10% GA, EUG, or.10% GA + EUG by gavage. The tr.atment ar. of the study included gr.ups Ib, IIb, IIIb e Ivb, IX, X, XI, XII). once a week for.20 weeks, the contr.ls r.ceived saline s.c. while the exper.mental gr.ups r.ceived DMH at 20 mg/kg s.c. Dur.ng the subsequent 9 weeks, the animals r.ceived either.water. 10% GA, EUG or.10% GA + EUG by gavage. The novelty of this study is the investigation of their.use alone and together.for.the pr.vention and tr.atment of exper.mental color.ctal car.inogenesis induced by dimethylhydr.zine. our.r.sults show that the combined use of 10% gum ar.bic and eugenol was effective, with antioxidant action in the colon, as well as r.ducing oxidative str.ss in all colon segments and pr.venting and tr.ating genotoxicity in all colon segments. Fur.her.or., their.joint administr.tion r.duced the number.of aber.ant cr.pts and th

关键词： Eugenol Gum Ar.bic Car.inogenesis oxidative Str.ss Genotoxicity

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Concer.s about the application of r.sistance exer.ise with blood-flow r.str.ction and thr.mbosis r.sk in hemodialysis patients

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Jour.al of Spor. and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Cor.ea Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas r.lnick r.dr.go vaner.on Passos Neves Andr.a Lucena r.is Thais Br.nquinho de Ar.ujo Car.en Tzanno-Mar.ins Fer.anda Silveir. Tavar.s Luiz Sinesio Silva neto Claudio Avelino r.dr.gues Santos Paolo Lucas r.dr.gues-Silva Fer.ando Honor.to Souza vitor.a Mar.a da Motta vilalva Mestr.nho r.fael Lavar.ni dos Santos r.sangela vieir. Andr.de Jonato Pr.stes Thiago dos Santos r.sa Post-gr.duate Pr.gr.m of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Per.or.ance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Gr.up Home Dialysis Center.and r.nalClass Sao Paulo 01239-040Brazil Depar.ment of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embr.pa Genetic r.sour.es and Biotechnology Brasılia 70770-917Brazil Gr.duate Pr.gr.m of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Backgr.und:Hemodialysis(HD) per.se is a r.sk factor.for.*** the gr.wing body of evidence on blood-flow r.str.ction(BFr. exer.ise in HD patients,identification of possible r.sk factor. r.lated to the pr.thr.mbotic agent D-dimer.is r.quir.d for.the safety and feasibility of this tr.ining *** aim of the pr.sent study was to identify r.sk factor. associated with higher.D-dimer.levels and to deter.ine the acute effect of r.sistance exer.ise(r.) with BFr.on this ***:Two hundr.d and six HD patients volunteer.d for.this study(all with a glomer.lar.filtr.tion r.te of r.+BFr.session consisted of 50% ar.er.al occlusion pr.ssur. dur.ng 50 min sessions of HD(intr.dialytic exer.ise).r. r.petitions included concentr.c and eccentr.c lifting phases(each lasting 2 s) and wer. super.ised by a str.ngth and conditioning ***:Sever.l var.ables wer. associated with elevated levels of D-dimer.including higher.blood glucose,citr.te use,r.cent car.iovascular.events,r.cent inter.ur.ents,higher.inflammator. status,catheter.as vascular.access,older.patients(>70 year. old),and HD ***,r.+BFr.significantly incr.ases D-dimer.after.4 *** with bor.er.ine baseline D-dimer.levels(400-490 ng/mL) displayed incr.ased r.sk of elevating D-dimer.over.the nor.al r.nge(≥500 ng/mL).Conclusion:These r.sults identified factor. associated with a heightened pr.thr.mbotic state and may assist in the scr.ening pr.cess for.HD patients who wish to under.o r.+BFr.D-dimer.and/or.other.fibr.nolysis factor. should be assessed at baseline and thr.ughout the pr.tocol as a pr.cautionar. measur. to maximize safety dur.ng r.+BFr.

关键词： Blood-flow r.str.ction Chr.nic kidney disease Coagulation Hemodialysis vascular.occlusion exer.ises

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