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The effects of aqueous extracts of Tetracarpidium conophorum seeds on the hormonal parameters of male guinea pigs

Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 21-24页

作者： obianime aw Uche FI Department of Pharmacology University of Port Harcourt Department of Pharmacognosy and Ethno Therapy University of Port Harcourt

Objective:To investigate the effects of the aqueous extracts of the seeds of Tetracarpidium conophorum and the effect of Proviron(12.5 mg/kg)(as standard) on the hormonal parameters of male guinea pigs,compare the effects of the seeds of Tetracarpidium conophorum and Proviron,and screen the phytochemical constituents of the seeds of Tetracarpidium ***:The hormonal effects of the Tetracarpidium conophorum and Proviron were tested by hormonal assay,using enzyme immuno assay *** was done by reaction of antibody with serum testosterone and testosterone label,magnetic solid phase separation and colour development *** screening was done using standard procedures. Results:The aqueous extract of the Tetracarpidium conophorum seeds(100-400 mg/kg) caused a statistically significant increase(P<0.05,ANOVA) in the level of testosterone of male guinea pigs,from(2.60±0.06) ng/mL to(3.40±0.05) ng/mL,(3.00±0.60) ng/mL and(3.30±0.45) ng/mL on the 7th,14th and 21st day of the administration of the extracts,*** highest increase was obtained after the 7th day of treatment[(3.40±0.05) ng/mL].These effects were very comparable to the effects of Proviron on the testosterone of male guinea pigs,which were obtained to be(2.80±0.01) ng/mL,(2.90±0.16) ng/mL and(3.10±0.30) ng/mL on the 7th, 14th and 21st day,*** effects were dose-and *** optimum effect on testosterone level under dose-dependent study f(4.70±0.45) ng/mL]was obtained at 300 mg/kg of Tetracarpidium conophorum after 7 days ***,the phytochemical screening of the seeds of Tetracarpidium conophorum revealed the presence of flavonoids, tannin,alkaloids,carbohydrate,volatile oils,terpenoids,saponins and cardiac glycosides. Conclusion:This study supports the claims on the use of the seeds of this plant by traditional medicine practitioners as a fertility ***,further studies need to be done to isolate and characterize the active pri

关键词： Tetracarpidium conophorum Hormonal parameters Male guinea pigs

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The phytoconstituents and the comparative effects of aqueous extract of Irvingia gabonensis seeds and proviron on the biochemical parameters of male guinea pigs

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 101-104页

作者： obianime aw Uche FI Department of Pharmacology University of Port Harcourt Department of Pharmacognosy and Phytotherapy University of Port Harcourt

Objective:To investigate the phytochemical screening and the effects of the aqueous extracts of the seeds of Irvingia gabonensis on the biochemical parameters of male guinea ***: The biochemical parameters were assayed using Randox Diagnostic kits,Phenolphthalein method and colorimetric *** phytochemical screening was carried out using standard ***:Phytochemical investigations revealed the presence of flavonoids,tannins, carbohydrate,alkaloids,terpenoids,steroids,volatile oils,saponins and cardiac *** aqueous extract of Irvingia gabonensis seeds(SO - 400 mg/kg) caused a statistically significant(P< 0.05 ANOVA) decrease in the levels of total cholesterol,urea,uric acid,total protein,prostatic, alkaline,and acid *** highest reduction effect was obtained with uric acid at 400 mg/kg of Irvingia gabonensis extract while the least effect was observed in total cholesterol. These effects were dose- and time- ***:This shows that the seeds of Irvingia gabonensis have hepatoprotective,nephroprotective and cardio protective *** study therefore,supports the claims on the use of the seeds of this plant by traditional medicine practitioners as a hepatoprotective and nephroprotective agent Although further studies need to be done to isolate,identify and characterize the active principles in the seeds of this plant.

关键词： Irvingia gabonensis Phytoconstituents Biochemical parameters Proviron Male guinea pigs

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The comparative effects of aqueous extract of Tetracarpidium conophorum seeds and Proviron on the sperm parameters of male guinea pigs

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Asian Pacific Journal of Tropical Medicine 2009年第6期2卷 11-15页

作者： obianime aw Uche FI Department of Pharmacology University of Port HarcourtNigeria Department of Pharmacognosy and Ethno Therapy University of Port Harcourt Nigeria

Objective:To investigation the comparative effects of the aqueous extracts of the seeds of Tetracarpidium conophorum (***) and Proviron on the sperm parameters of male guinea pigs,and screen phytochemical constituents of the seeds of ***:The sperm count,motility and morphology of the male guinea pigs were done using Neubauer chamber(Haemocytometer),light microscope and dilute carbol Fuchsin(1:20) method,*** screening was done by standard ***: The aqueous extract of the *** seeds(100 -400 mg/kg) caused statistically significant increase (P < 0.05,ANOVA) in the sperm count and motility,from 67.7±2.10 and 56.5±2.40 to 78.0±3.5 and 75.0±2.8,*** highest effect was obtained at 300 mg/kg of *** this dose, the sperm count and motility of the male guinea pigs administered with *** were the same with the group administered 12.5 mg/kg *** values were 78.0±3.50 and 75.0±2.80,respectively for sperm count and motility(P <0.001,ANOVA).At 400 mg/kg,*** caused a slight decline in sperm count and *** effects were dose-dependent and comparable to the observed effects of Proviron (12.5 mg/kg) on sperm parameters of male guinea *** time-dependent study,the observed effect of T. conophorum(300 mg/kg) and Proviron on the values of sperm count and motility at 14th day were almost the *** values are 58.0±1.80 and 70.0±2.60,respectively for sperm motility and ***, on the 7th day of treatment,*** exhibited highest effect which was higher than that of Proviron. These effects decreased progressively from the 14th to the 28th *** Proviron showed the highest effect on the 28th *** effects were all time-dependent and statistically significant at P < 0.05(ANOVA).Finally, the phytochemical screening of the seeds of *** revealed the presence of flavonoids,tannins, alkaloids,terpenoids,carbohydrates,volatile oil

关键词： Tetracarpidium conophorum Sperm parameters Proviron Male guinea pigs Phytochemical screening

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