The comparative effects of aqueous extract of Tetracarpidium conophorum seeds and Proviron on the sperm parameters of male guinea pigs

作     者：Obianime AW Uche FI 

作者机构：Department of PharmacologyUniversity of Port HarcourtNigeria Department of Pharmacognosy and Ethno Therapy University of Port HarcourtNigeria 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2009年第2卷第6期

页      面：11-15页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Tetracarpidium conophorum Sperm parameters Proviron Male guinea pigs Phytochemical screening 

摘      要：Objective:To investigation the comparative effects of the aqueous extracts of the seeds of Tetracarpidium conophorum (***) and Proviron on the sperm parameters of male guinea pigs,and screen phytochemical constituents of the seeds of ***:The sperm count,motility and morphology of the male guinea pigs were done using Neubauer chamber(Haemocytometer),light microscope and dilute carbol Fuchsin(1:20) method,*** screening was done by standard ***: The aqueous extract of the *** seeds(100 -400 mg/kg) caused statistically significant increase (P 0.05,ANOVA) in the sperm count and motility,from 67.7±2.10 and 56.5±2.40 to 78.0±3.5 and 75.0±2.8,*** highest effect was obtained at 300 mg/kg of *** this dose, the sperm count and motility of the male guinea pigs administered with *** were the same with the group administered 12.5 mg/kg *** values were 78.0±3.50 and 75.0±2.80,respectively for sperm count and motility(P 0.001,ANOVA).At 400 mg/kg,*** caused a slight decline in sperm count and *** effects were dose-dependent and comparable to the observed effects of Proviron (12.5 mg/kg) on sperm parameters of male guinea *** time-dependent study,the observed effect of T. conophorum(300 mg/kg) and Proviron on the values of sperm count and motility at 14th day were almost the *** values are 58.0±1.80 and 70.0±2.60,respectively for sperm motility and ***, on the 7th day of treatment,*** exhibited highest effect which was higher than that of Proviron. These effects decreased progressively from the 14th to the 28th *** Proviron showed the highest effect on the 28th *** effects were all time-dependent and statistically significant at P 0.05(ANOVA).Finally, the phytochemical screening of the seeds of *** revealed the presence of flavonoids,tannins, alkaloids,terpenoids,carbohydrates,volatile oil