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Pattern of intestinal helminth infections among school children in an urban community in Ibadan,Nigeria

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Asian Pacific Journal of Tropical Medicine 2008年第3期1卷 42-47页

作者： Fatiregun AA Oluwatoba oa Department of Epidemiology Medical Statistics and Environmental HealthFaculty of Public HealthCollege of MedicineUniversity of IbadanIbadanNigeria

Despite a substantial reduction in the incidence and prevalence of parasitic diseases in the industrialized world, they continue to be an important public health problem in many developing African countries,including Nigeria. However,estimates of the prevalence of such infections among school age children,who bear the greatest health burden due to these diseases,are hard to come *** objective of this study was therefore to determine the prevalence and type of intestinal helminth infections among primary school *** study was cross-sectional in *** participants included 266 pupils recruited from three government primary schools in the Mokola area of Ibadan,*** pupils were interviewed and their stool samples examined for eggs of common *** mean age of the pupils was 9.8±2.6 years,and 128(48.1%) were *** pupils(7.1%) had intestinal helminth *** lumbricoides was found in 17 pupils(6. 4%) and was the most prevalent helminth among the children,while Trichuris trichiura was found in only two subjects(0.8%).Previous infestations and the use of public toilets were found to be significantly associated with current infections(P<0.05).This study demonstrated that the prevalence of intestinal infections was low among the pupils studied,and that Ascaris infection was the commonest infestation.

关键词： prevalence intestinal helminths school children

The extract of Mucuna pruriens possesses histamine activity

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 29-31页

作者： Reginald NP Nwankwoala Georgewill oa Department of Pharmacology and Toxicology Faculty of Basic Medical SciencesUniversity of Port Harcourt

Objective:To investigate the activity of the active principle in the spines of the seed pods of Mucuna pruriens using contraction of guinea pig ileum as index of pharmacological activity. Methods:The active principle was extracted with 0.0015 M *** strips of guinea pig ileum were prepared and contractile responses were measured using a *** sets of experiment were conducted:（1）.The contraction of the ileum in presence of different concentrations of histamine,2-methylhistamine and the extract of Mucuna pruriens.（2）.The contractile response of the ileum in presence of different concentrations of the extract and antagonists including diphenhydramine,atropine and ***:（1） The extract of Mucuna pruriens hair, 2- methylhistamine and histamine produced dose dependent contraction of guinea pig ileum (Extract ED50 = 13.0μg/mL,2-methylhistamine ED50=8.5μg/mL and histamine ED50=10.0μg/ mL).（2） Diphenhydramine,an H,antagonist competitively blocked the contractile response of the Mucuna pruriens extract（3） Coadminstration of the Mucuna pruriens extract either with different doses of antimuscarinic agent atropine or 5-hydroxytryptamine blocking agent methysergide did not alter the extract induced contractile response of the guinea pig ***:These results demonstrate that the spines of Mucuna pruriens possess histamine activity which may contribute to its itching and painful irritation effects.

关键词： Mucuna pruriens Histamine activity Itching Irritation

Antiarthritic activity of Vernonia amygdalina in albino rats

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Asian Pacific Journal of Tropical Medicine 2009年第5期2卷 58-60页

作者： Georgewill oa Georgewill UO Department of Pharmacology and Toxicology Faculty of Basic Medical SciencesCollege of Health SciencesUniversity of Port HarcourtChobaNigeria

Objective:To evaluate the antiarthritic activity of water extract of leaves of Vernonia amygdalina(V.A.) on arthritis induced model of ***:Arthritis was induced in male albino Wister rats by injection of croton oil(0.1 mL) into the left foot pad of the *** with *** 200 and 400 mg/kg and standard Indomethacin(0.3 mg/kg) was started on the same day and continued up to the 12th *** paw volume was measured on the 1st,5th,12th and 21st day,respectively for both the paws and anti-arthritic activity was ***:The extract of *** reduction in the inflammation of the paw due to croton *** antiarthritic action started on the 5th day and continued till the 12th day and the activity was comparable to that of the standard on both *** inhibited adjuvant induced arthritis and had significant ant-inflammatory effect(P<0.05).Conclusion:This report therefore clearly showed that *** inhibited adjuvant induced arthritis in rats as it significantly reduced the paw volume on the 12th day and may explain the effectiveness of this plant when used in the tropics for the treatment of arthritis.

关键词： Vernonia amygdalina Antiarthritic effect Croton oil

Effect of extract of Abrus precatorius on blood glucose concentration of alloxan induced diabetic Albino Wistar Rats

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Asian Pacific Journal of Tropical Medicine 2009年第6期2卷 16-17页

作者： Georgewill oa Georgewill UO Department of Pharmacology and Toxicology

Objective:To evaluate the effect of extract of Abrus precatorius on blood glucose of alloxan induced albino wistar ***:Experimental animals received daily oral administration of extract of Abrus precatorius for 14 *** effect of 200 mg/kg dose was studied during the treatment ***:There was a significant reduction in blood glucose concentration(P < 0.05) with the mean blood glucose of the different groups as 5.0±0.3 for normal control,7.0±0.4 for diabetic control group and 4.0±0.2 for diabetic treated group. Conclusion:The findings of this study suggest that extract of Abrus precatorius has hypoglycemic effect.

关键词： Abrus precatorius Hypoglycemia Diabetes Hyperglycemia

Anti-inflammatory effects of Morninga oleifera lam extract in rats

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 133-135页

作者： Georgewill oa Georgewill UO Nwankwoala RNP Department of Pharmacology College of Health SciencesUniversity of Port Harcourt

Objective:To investigate the acute and delayed anti-inflammatory effects of Morning oleifera lam（MOL） crude methanolic ***:Compared the anti-inflammatory effects of MOL with that of standard anti-inflammatory agents like indomethacin and hydrocortisone using Air Pouch ***:In both acute and delayed inflammation,the MOL extract produced dose dependent anti-inflammatory effect[acute IC50=（399.30±5.43） mg/kg;delayed IC50=（510.26±4.53） mg/kg].The order of anti-inflammatory potency for the three drugs was hydrocortisone> indomethacin > ***:These observations indicate that MOL possesses potential anti-inflammatory property.

关键词： Extract Moringa oleifera lam Anti-nflammatory,indomethacin Hydrocortisone

Aspergillus gaarensis,a new addition to section Circumdati from soil of Lake El-Gaar in Wadi-El-Natron,Egypt

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Studies in Fungi 2020年第1期5卷 59-65页

作者： Al-Bedak oa Moubasher AH Assiut University Mycological Centre(AUMC) Assiut UniversityAssiut 71511Egypt Department of Botany and Microbiology Faculty of ScienceAssiut UniversityAssiutEgypt

In the present study,a novel fungus belonging to the genus Aspergillus section Circumdati was isolated from a cultivated soil sample close to El-Gaar lake in Wadi-El-Natron region,*** of the internal transcribed spacer(ITS)gene of its DNA showed that the isolate differs from all known Aspergillus species in section *** novel Aspergillus species is described here as Aspergillus *** characteristics and molecular data were applied to determine its novel taxonomic *** macro and micro characteristics of the novel species are presented in the current study.

关键词： ITS new taxon phylogeny saline

Paracremonium moubasheri,a new species from an alkaline sediment of Lake Hamra in Wadi-El-Natron,Egypt with a key to the accepted species

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Studies in Fungi 2019年第1期4卷 216-222页

作者： Al-Bedak oa Ismail MA Mohamed RA Assiut University Mycological Centre(AUMC) Assiut UniversityAssiutEgypt Department of Botany and Microbiology Faculty of ScienceAssiut UniversityAssiutEgypt

During surveys of extremophilic fungi in hypersaline,alkaline lakes of Wadi-El-Natron,Egypt,an interesting fungus was recovered from a mud sample collected from Lake Hamra in Wadi-El-Natron,*** likelihood analysis of Internal Transcribed Spacer(ITS)gene along with morphological comparisons of related taxa revealed a novel taxon,Paracremonium moubasheri which is described and illustrated in the current *** moubasheri can be distinguished from the known species of the genus by its large conidia,in addition to the presence of chlamydospores.

关键词： Acremonium-like Hypersaline Hypocreales new taxon Phylogeny

Resolution pattern of jaundice among children presenting with severe malaria in rural South-West Nigeria

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Asian Pacific Journal of Tropical Biomedicine 2012年第7期2卷 551-553页

作者： Osonuga oa Osonuga A Osonuga AA Osonuga IO Department of Pharmacology and Physiology University of Cape Coast School of Medical Sciences University of Cape Coast Department of Nursing University of Cape Coast Olabisi Onabanjo University Remo Campus

Objective:To compare the pattern of jaundice resolution among children with severe malaria treated with quinine and ***:Thirty two children who fulfilled the inclusion criteria were recruited for the study from two hospitals with intensive care *** were divided into two groups:'Q' and 'A',receiving quinine and *** was assessed by clinical ***:Sixteen out of 32 children recruited(representing50%) presented with jaundice on the dav of *** mean age was(7.00±2.56) *** day 3,tour patients in 'A' and six patients in 'O' had *** day *** child had ***:The study has shown that hoth drugs resolve jaundice although artemether relatively resolves it faster by the third day.

关键词： Jaundice Quinine Artemether Severe malaria South-west Nigeria

Antidiabetic and haematological effect of aqueous extract of stem bark of Afzelia africana(Smith) on streptozotocin-induced diabetic Wistar rats

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Asian Pacific Journal of Tropical Biomedicine 2011年第5期1卷 353-358页

作者： Oyedemi SO Adewusi EA Aiyegoro oa Akinpelu DA School of Biological Sciences University of Fort Hare Department of Microbiology Obafemi Awolowo University

Objective:To investigate the antidiabetic properties of aqueous extract of stem bark of Afzelia africana(***)and its beneficial effect on haematological parameters in streptozotocin induced diabetic ***:A total of 30 rats including 24 diabetic and 6 normal rats were used for this *** was induced in male Wistar rats by intraperitoneal injection of *** being confirmed diabetic,animals were orally treated with distilled water or extracts at 100 or 200 mg/kg body weight daily for 10 *** haematological parameters including red blood and white blood cells and their functional indices were evaluated in diabetic treated groups compared with the ***:The extract significantly reduced the blood glucose levels while the best result was obtained at 200 mg/kg body weight The feed and water intake in diabetic rats were significantly reduced while weight loss was minimized at both ***,the levels of red blood,white blood cells and their functional indices were significantly improved after extract administration at both ***:It can be concluded that the aqueous extract of bark of *** possesses antihyperglycemic *** addition,the extract can prevent various complications of diabetes and improve some haematological *** experimental investigation is needed to exploit its relevant therapeutic effect to substantiate its ethnomedicinal usage.

关键词： Afzelia africana Diabetes mellitus Haematology Antidiabetic property Aqueous extract Beneficial effect Haematological parameter Ethnomedicinal usage Wistar rat