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A case of toxic epidermal necrolysis complicated by severe liver damage and hemophagocytic syndrome of unknown pathogenesis

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A case of toxic epidermal necrolysis complicated by severe l...

CYP3A5 and MDR1 Polymorphisms are Associated with Calcineurin Inhibitor-related Neurotoxicity after Allogenic Stem Cell Transplantation in Children

The Second Eastern Asia Dermatology Congress(EADC2012)

作者： Toshifumi Yamaoka hiroaki Azukizawa Atsushi Tanemura Hiroyuki Murota Tomoya Hirose Koichi Hayakawa Takeshi Shimazu Naoki Wada Eiichi Morii Ichiro Katayama Department of Dermatology Course of Integrated MedicineOsaka University Graduate School of Medicine Department of Traumatology and Acute Critical Medicine Osaka University Graduate School of Medicine Department of Pathology Osaka University Graduate School of Medicine

＜正＞A 76-year-old Japanese woman who had received Etodolac for cervical spondylosis over the previous 2 weeks, developed a cough and a sore throat associated with common cold in the previous 10 *** consulted out-patient clinic of other hospital and admitted with the findings of severe liver *** was found to have confluent targetoid

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Seasonal variations in the onset of ulcerative colitis in Japan

第五届亚洲儿科研究大会

作者： Masakatsu Yanagimachi Takuya Naruto Reo Tanoshima Hiromi Kato Tomoko Yokosuka Hisaki Fujii hiroaki Goto Tatsuhiko Yagihashi Kenjiro Kosaki Shumpei Yokota Department of Pediatrics Yokohama City University School of Medicine

＜正＞Calcineurin inhibitors such as cyclosporine（CsA） and tacrolimus（FK506） are widely used as prophylactics and for treatment of graft-versus-host disease（GVHD） after hematopoietic stem cell transplantation（HSCT）.One severe side effect of these calcineurin inhibitors is *** substances are substrates for CYP3A5 and P-glycoprotein,the product of multidrug resistance gene （MDR1）.The effect of the polymorphisms,such as CYP3A5 6986G＞A,MDR1 1236C＞T,2677G＞A/T and

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World Journal of Gastroenterology 2013年第47期19卷 9063-9068页

作者： Shigeo Koido Toshifumi Ohkusa hiroaki Saito Tetsuji Yokoyama Tomoyoshi Shibuya Naoto Sakamoto Kan Uchiyama Hiroshi Arakawa Taro Osada Akihito Nagahara Sumio Watanabe Hisao Tajiri Division of Gastroenterology and Hepatology Department of Internal Medicinethe Jikei University School of MedicineChiba 277-8567Japan Department of Gastroenterology Juntendo University School of MedicineTokyo 113-8421Japan Department of Health Promotion National Institute of Public HealthSaitama 351-0197Japan

AIM:To investigate seasonal variations in the onset and relapse of ulcerative colitis(UC)in Japanese ***:Between 1994 and 2006,198 Japanese patients diagnosed with UC according to conventional criteria in an academic hospital were enrolled for onset *** 265 Japanese patients with UC who were observed for more than 12 mo,165 patients relapsed(239 times)and were enrolled for relapse *** patients’symptoms were recorded each month for 12 consecutive ***:There was monthly seasonality in symptom onset during October and March for *** onset of symptoms in UC patients frequently occurred during the *** in UC onset was observed according to both month(P=0.015)and season(P=0.048).Relapse commonly occurred in October,and variations in relapse were not significant either in month(P=0.52)or season(P=0.12).Upper respiratory inflammation was the main factor responsible for ***:Our results suggest that environmental factors associated with winter and spring seasonality may be responsible for triggering the clinical onset of UC in Japan.

关键词： Japanese population Onset Relapse Seasonal variations Ulcerative colitis

Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer

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World Journal of Gastroenterology 2015年第34期21卷 9966-9973页

作者： Masatsune Shibutani Kiyoshi Maeda Hisashi Nagahara Hiroshi Ohtani Katsunobu Sakurai Sadaaki Yamazoe Kenjiro Kimura Takahiro Toyokawa Ryosuke Amano hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa Department of Surgical Oncology Osaka City University Graduate School of Medicine

AIM:To evaluate the prognostic significance of the lymphocyte to monocyte ratio(LMR) in patients with unresectable metastatic colorectal cancer who received palliative ***:A total of 104 patients with unresectable metastatic colorectal cancer who underwent palliative chemotherapy were enrolled. The LMR was calculated from blood samples by dividing the absolute lymphocyte count by the absolute monocyte count. Pretreatment LMR values were measured within one week before the initiation of chemotherapy,while posttreatment LMR values were measured eight weeks after the initiation of ***:The median pre-treatment LMR was 4.16(range:0.58-14.06). We set 3.38 as the cut-off level based on the receiver operating characteristic curve. Based on the cut-off level of 3.38,66 patients were classified into the high pre-treatment LMR group and 38 patients were classified into the low pretreatment LMR group. The low pre-treatment LMR group had a significantly worse overall survival rate(P = 0.0011). Moreover,patients who demonstrated low pre-treatment LMR and normalization after treatmentexhibited a better overall survival rate than the patients with low pre-treatment and post-treatment LMR ***:The lymphocyte to monocyte ratio is a useful prognostic marker in patients with unresectable metastatic colorectal cancer who receive palliative chemotherapy.

关键词： Colorectal cancer Prognosis Unresectable Chemother

丙型肝炎病毒截短型核心基因表达载体的构建与表达

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同济大学学报（医学版） 2009年第5期30卷 50-53页

作者：孙贝贝张敬石红军 hiroaki Kohno 张军同济大学基础医学院生物学教研室上海200092 同济大学生命科学与技术学院上海200092 日本协和梅迪克斯株式会社

目的构建重组丙型肝炎病毒核心基因表达载体pVec-core,并进行原核表达。方法人工合成丙型肝炎病毒截短型核心基因至pUC57载体上,经双酶切后,将其克隆至原核表达质粒pVec中,测序正确后将重组质粒pVec-core转化入表达宿主菌BL21,经IPTG诱... 详细信息

目的构建重组丙型肝炎病毒核心基因表达载体pVec-core,并进行原核表达。方法人工合成丙型肝炎病毒截短型核心基因至pUC57载体上,经双酶切后,将其克隆至原核表达质粒pVec中,测序正确后将重组质粒pVec-core转化入表达宿主菌BL21,经IPTG诱导表达核心蛋白,SDS-PAGE检测目的蛋白的表达情况。采用GST亲和层析方法纯化融合蛋白并进行Western印迹法验证。结果丙型肝炎病毒核心基因表达载体构建成功,重组菌表达出相对分子质量约为40.6 kD重组融合蛋白,并以可溶形式存在于菌体中。蛋白经谷胱甘肽琼脂糖凝胶纯化,得到纯度较高的目的蛋白。经Western印迹分析,该蛋白可与HCV患者阳性血清发生特异性结合反应,具有良好的抗原活性。结论核心抗原表达载体在原核表达系统中高效表达,为利用其作为诊断抗原及研究核心蛋白的其他生物学功能奠定了基础。

关键词：丙型肝炎病毒核心蛋白原核表达纯化

Clinical Feature of Japanese Patients with Fulminant Myocarditis—Myocarditis in Japanese Patients

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International Journal of Clinical Medicine 2011年第3期2卷 260-263页

作者： hiroaki Kawano Yasuhiro Nagayoshi Sunao Kojima Nahoko Kakihara Satoshi Sakuma Masumi Uchino Aiko Komatsu Machiko Asaka Mitsuhiro Shimomura Hiroshige Yamabe Hisao Ogawa Koichi Node Department of Cardiovascular Medicine Saga University Saga Japan

Fulminant myocarditis is commonly recognized as an acute myocarditis with cardiogenic shock requiring mechanical support systems. Before the development of mechanical assist devices, previous study described that most of patients with fulminant myocarditis die at acute phase because of rapidly progressive cardiac decompensation. To investigate the feature of myocarditis, we checked consecutive 18 patients (10 men, 8 women, 12yr-80yr) from April in 2001 to September 2008 in University. Of these patients 3 needed intraaortic balloon pumping (IABP) (2 men, 1 woman), 6 did both IABP and percutaneous cardiopulmonary support (PCPS) (2 men, 4 women). Three patients who need both IABP and PCPS died (2 men, 49yr and 65yr, 1 woman, 54yr) because of uncontrolled bacterial infection. No patients whose age was under 40yr (5 men, 4 women) died although a man needed IABP and 3 women did both IABP and PCPS. Sixteen patients were able to resume a normal life although 1 male patient needed permanent pacemaker, 1 female did cardiac resynchronization therapy, and a male and a female had left ventricular systolic dysfunction. In conclusion, the young patients had better prognosis than older even if mechanical assist is needed. Although half of patients needed mechanical assist, the prevention of multi-organ complications including bacterial infection is one of the most important keys in the treatment of fulminant myocarditis.

关键词： Myocarditis Mechanical Support Immunosuppressive Therapy Immunomodulation Therapy

Synthesis of Titanium Phosphates with Additives and Their Powder Properties for Cosmetics

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Synthesis and Pigmental Properties of Nickel Phosphates by the Substitution with Tetravalent Cerium Cation

Materials Sciences and Applications（材料科学与应用期刊） 2012年第1期

作者： hiroaki Onoda Taisuke Yamaguchi

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Synthesis of Novel Dark Red Phosphate Pigments in Imitation of Natural Ore

Materials Sciences and Applications（材料科学与应用期刊） 2011年第11期

作者： hiroaki Onoda Takeshi Sakumura

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材料科学与工程（中英文B版） 2019年第1期9卷 1-5页

作者： hiroaki Onoda Syohei Fujikado Department of Informatics and Environmental Sciences Kyoto Prefectural University1-5Shimogamo Nakaragi-cyoSakyo-ku Kyoto 606-8522Japan

As novel dark red pigment,sodium manganese phosphate,NaMnPO4,imitated with Natrophilite,was synthesized by heating at various *** heating temperature and time,volume of water,phosphorus resource were studied in this *** obtained powders were estimated with X-ray diffraction(XRD),Infrared(IR)spectra,ultraviolet-visible(UV-Vis)reflectance spectra,and L^*a^*b^*color ***,similar chemical compositions with NaMnPO4 were also studied in the same *** obtained samples had weak peaks of NaMnPO4 in XRD *** synthesized in Na/Mn=1/1 at 700℃for 6 hours indicated high redness,a^*value.

关键词： Dark red pigment natural ores phosphate materials