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The metabolome identity:basis for discovery of biomarkers in neurodegeneration

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Neural Regeneration Research 2019年第3期14卷 387-390页

作者： Julie-Myrtille Bourgognon joern R.Steinert MRC Toxicology Unit University of Leicester

Neurodegenerative disorders are often associated with cellular dysfunction caused by underlying protein-misfolding signalling. Numerous neuropathologies are diagnosed at late stage symptomatic changes which occur in response to these molecular malfunctions and treatment is often too late or restricted only to the slowing of further cell death. Important new strategies to identify early biomarkers with predictive value to intervene with disease progression at stages where cell dysfunction has not progressed irreversibly is of paramount importance. Thus, the identification of these markers presents an essential opportunity to identify and target disease pathways. This review highlights some important metabolic alterations detected in neurodegeneration caused by misfolded prion protein and discusses common toxicity pathways identified across different neurodegenerative diseases. Thus, having established some commonalities between various degenerative conditions, detectable metabolic changes may be of extreme value as an early diagnostic biomarker in disease.

关键词： metabolome neurodegeneration neuroinflammation nitric oxide redox stress biomarker misfolded protein prion disease

Grasshoppers （Orthoptera： Acrididae） select vegetation patches in local-scale responses to foliar nitrogen but not phosphorus in native grassland

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Insect Science 2011年第5期18卷 533-540页

作者： Viviana Loaiza Jayne L. Jonas Anthony joern Division of Biology Kansas State University Manhattan Kansas USA

Key elements such as nitrogen （N） and phosphorus （P） are often limiting relative to the nutritional needs of herbivores that feed on them. While N often limits insect herbivores in natural terrestrial ecosystems, the effect of P is poorly studied in the field, even though compelling hypotheses from the ecological stoichiometry literature predict its importance. We evaluated small-scale spatial distributions of, and herbivory by, grasshoppers among neighboring plots that vary in foliar-N and -P in tallgrass prairie. Grasshopper densities were 67% greater in N-fertilized plots but detected no effect to grasshopper densities from P-fertilizer. Leaf damage to the dominant grass Andropogon gerardii was 32% greater in N-fertilized plots, but no response to foliar-P was detected. Herbivore damage to a common forb, goldenrod （Solidago missouriensis）, was not strongly linked by fertilizer treatments, although there was increased leaf damage in N-fertilizer treatments when no P was applied （a significant N ~ P interaction）. Under field conditions at local scales, we conclude that spatially heterogeneous distributions of grasshoppers are primarily affected by foliar-N in host plants with little evidence that P-levels contribute to the spatial patterns.

关键词： Andropogon gerardii ecological stoichiometry insect herbivory Konza Prairie N-P fertilization experiment Solidago rnissouriensis

Climate change in the North- past, present and future

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Episodes 2008年第1期31卷 163-167页

作者： joern Thiede Ola M. Johannessen Alfred-Wegner-Institute for Polar and Marine Research in the Helmholtz-Association Am Handelshafen 12 D-27570 Bremerhaven Germany. Nansen Environmental and Remote Sensing Centre （NERSC） Geophysical Institute University of Bergen Thormoehlensgate 47 N-5006 Bergen Norway.

The Nordic countries have produced famous polar explorers and researchers who have generated climate research schools at a variety of locations. The dependence of these countries with respect to the lifelihood of their societies, of their use of lands and seas, the exploitation of marine living and non-living resources have made climate research an eminent topic, and many outstanding discoveries of longand short-term climate change have been made for the first time in Scandinavia. These include early contributions to our understanding of the geological effects of continent-wide glaciations during the ice ages, the complex postglacial history of the Baltic Sea and the varved sediment sequences preserved from lakes with an extraordinary seasonality in their sediment input, as well as the detailed records of temperature, ice texture and impurities and greenhouse gas variations of the last Glacial and of the Holocene preserved in the ice cores from Greenland. Iceland with its volcanic sequences and intercalated sediment layers not only preserved the history of this subaerial segment of the mid-Atlantic Ridge, but also easily datable paleoclimate records. The fate of the Vikings, who settled during the Medieval climate optimum on Iceland and later on Greenland and who lost their habitat on Greenland at the beginning of the Little Ice Age, illustrates vividly the climate-dependent subsistence of the indigenous and non-indigenous Scandinavian populations. Modern Scandinavian climate research institutions also include sophisticated modelling groups.

关键词：气候变化北方地区生存条件地质特征

A Vulnerability Assessment Framework for Cultural Heritage Sites:The Case of the Roman Ruins of Tróia

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International Journal of Disaster Risk Science 2023年第1期14卷 26-40页

作者： Marvin Ravan Maria João Revez Inês Vaz Pinto Patrícia Brum joern Birkmann Institute of Spatial and Regional Planning(IREUS) University of Stuttgart70569StuttgartGermany Nova Conservação S.A1200-872LisbonPortugal Troia Resort 7570-789CarvalhalGDLPortugal

This article contributes to developing an indicator-based vulnerability assessment framework for cultural heritage *** provides a vulnerability index for heritage sites potentially exposed to multiple hazards,including sudden-onset and slow-onset hazards,while considering climate change *** determining particular criteria and indicators,the Cultural Heritage Vulnerability Index incorporates structural and non-structural factors of the heritage site and its local and national *** assessment procedure was applied to the case of the Roman Ruins of Tróia in *** findings highlight those areas of sensitivity(e.g.,the existing deterioration patterns and types of foundation)and coping and adaptive capacities(e.g.,institutional setting and response plan)that significantly contribute to the level of vulnerability and *** results of vulnerability assessment will further enable determining priorities and developing risk mitigation and preparedness measures,in particular reducing structural sensitivity and promoting coping capacities.

关键词： Climate change Coping capacity Cultural heritage Risk assessment Roman Ruins of Tróia Vulnerability assessment

Influence of High-Speed Milling Process on Mechanical and Microstructural Properties of Ultrafine Grained Profiles Produced by Linear Flow Splitting

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Transactions of Nanjing University of Aeronautics and Astronautics 2017年第4期34卷 349-356页

作者： Abele Eberhard Müller Clemens Turan Emrah Niehuesbernd joern Bruder Enrico Falk Florian Institute of Production Management Technology and Machine Tools(PTW)Technische Universitt Darmstadt Physical Metallurgy(PhM) Technische Universitt Darmstadt

The effects of milling parameters on the surface quality,microstructures and mechanical properties of machined parts with ultrafine grained(UFG)gradient microstructures are *** effects of the cutting speed,feed per tooth,cutting tool geometry and cooling strategy are *** has been found that the surface quality of machined grooves can be improved by increasing the cutting ***,cryogenic cooling with CO_2 exhibits no significant improvement of surface *** and hardness investigations revealed similar microstructure and hardness variations near the machined groove walls for both utilized tool ***,cryogenic cooling can decrease more far-ranging hardness reductions due to high process temperatures,especially in the UFG regions of the machined parts,whilst it cannot prevent the drop in hardness directly at the groove walls.

关键词： high-speed milling ultrafine grained microstructure linear flow splitting hardness

Socioecological drivers facilitating biodiversity conservation in traditional farming landscapes

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Ecosystem Health and Sustainability 2015年第9期1卷 8-17页

作者： Ine Dorresteijn Jacqueline Loos Jan Hanspach joern Fischer Faculty of Sustainability Leuphana University LuneburgScharnhorststraße 121335 LuneburgGermany

Traditional farming landscapes have evolved as tightly coupled socioecological systems that support high ***,land-use change severely threatens the high biodiversity of these *** nature conservation in such landscapes requires a thorough understanding of the key drivers underpinning *** empirical research on mammals,birds,butterflies,and plants in a traditional cultural landscape in Romania,we revealed seven hypothesized drivers facilitating biodiversity *** proportions of three main land-use types support the landscape species pool,most likely through habitat connectivity and frequent spillover between land-use *** complementation and supplementation provide additional habitat for species outside their core *** of woody vegetation cover and gradients in land-cover heterogeneity provide mosaic landscapes with wide ranges of *** land-use practices underpin landscape heterogeneity,traditional land-use elements such as wood pastures,and human-carnivore ***-down predator control may limit herbivore ***,cultural ties between humans and nature have a central influence on people’s values and sustainable use of natural *** approaches should aim to maintain or restore these socioecological drivers by targeting the heterogeneous character of the forest-farmland mosaic at large scales through"broad and shallow"conservation *** large-scale measures should be complemented with"deep and narrow"conservation measures addressing specific land-use types,threats,or *** both cases,conservation measures should integrate the entire socioecological system,by recognizing and strengthening important links between people and the environment.

关键词： countryside biogeography coupled human and natural systems cultural landscapes human–environment systems landscape ecology resilience Romania Special Feature:Ecosystem Management in Transition in Central and Eastern Europe Transylvania

The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes

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Cellular & Molecular Immunology 2021年第5期18卷 1211-1221页

作者： Carolin Wiechers Mangge Zou Eric Galvez Michael Beckstette Maria Ebel Till Strowig Jochen Huehn joern Pezoldt Department Experimental Immunology Helmholtz Centre for Infection ResearchBraunschweigGermany Department Microbial Immune Regulation Helmholtz Centre for Infection ResearchBraunschweigGermany Department of Computational Biology for Individualised Medicine Centre for Individualised Infection MedicineHelmholtz Centre for Infection Research and Hannover Medical SchoolHannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical SchoolHannoverGermany Laboratory of Systems Biology and Genetics École Polytechnique Fédérale de LausanneLausanneSwitzerland

Intestinal Foxp3+regulatory T cell(Treg)subsets are crucial players in tolerance to microbiota-derived and food-borne antigens,and compelling evidence suggests that the intestinal microbiota modulates their generation,functional specialization,and *** bacterial species and microbiota-derived metabolites,such as short-chain fatty acids(SCFAs),have been reported to promote Treg homeostasis in the intestinal lamina ***,gut-draining mesenteric lymph nodes(mLNs)are particularly efficient sites for the generation of peripherally induced Tregs(pTregs).Despite this knowledge,the direct role of the microbiota and their metabolites in the early stages of pTreg induction within mLNs is not fully ***,using an adoptive transfer-based pTreg induction system,we demonstrate that neither transfer of a dysbiotic microbiota nor dietary SCFA supplementation modulated the pTreg induction capacity of *** mice housed under germ-free(GF)conditions displayed equivalent pTreg induction within *** molecular characterization of these de novo induced pTregs from mLNs by dissection of their transcriptomes and accessible chromatin regions revealed that the microbiota indeed has a limited impact and does not contribute to the initialization of the Treg-specific epigenetic ***,our data suggest that the microbiota is dispensable for the early stages of pTreg induction within mLNs.

关键词： Peripheral regulatory T cells Microbiota Tolerance

AI art in architecture

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AI in Civil Engineering 2023年第1期2卷 12-22页

作者： joern Ploennigs Markus Berger AI for Sustainable Construction University of RostockRostockGermany

Recent diffusion-based AI art platforms can create impressive images from simple text *** makes them powerful tools for concept design in any discipline that requires creativity in visual design *** is also true for early stages of architectural design with multiple stages of ideation,sketching and *** this paper,we investigate how applicable diffusion-based models already are to these *** research the applicability of the platforms Midjourney,DALL·E 2 and Stable Diffusion to a series of common use cases in architectural design to determine which are already solvable or might soon *** novel contributions are:(i)a comparison of the capabilities of public AI art platforms;(ii)a specification of the requirements for AI art platforms in supporting common use cases in civil engineering and architecture;(iii)an analysis of 85 million Midjourney queries with Natural Language Processing(NLP)methods to extract common usage *** this we derived(iv)a workflow for creating images for interior designs and(v)a workflow for creating views for exterior design that combines the strengths of the individual platforms.

关键词： Image generation Diffusion models Natural language processing Architecture

Experimental Study of Energy Consumption Variation in Recurring Driving Trips

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Journal of Electrical Engineering 2017年第5期5卷 253-261页

作者： joern Adermann Julian Kreibich Markus Lienkamp Institute of Automotive Tech. Technical University of Munich Garching 85748 Germany

With a growing consumer market of battery electric vehicles, customers＇ demand for technology and features is on the rise. The range and, to a certain extent, the range estimation will play a key factor in customers＇ purchase decisions. In order to guarantee a precise range estimation over the usage life of battery electric vehicles, a method is presented that combines adaptive filter algorithms with statistical approaches. The statistical approach uses recurring driving cycles over the lifetime in order to derive the aging status of the traction battery. It is implied that the variance of the energy usage of these driving cycles is within certain bounds. This fact should be proven by an experimental case study. The dataset used in this paper is open to the public.

关键词： SOH (state of health) estimation traction battery battery electric vehicle recurring cycles energy consumption.