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Phenotypic heterogeneity in amyotrophic lateral sclerosis type 8 and modifying mechanisms of neurodegeneration

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Neural Regeneration Research 2021年第9期16卷 1776-1778页

作者： Danyllo oliveira Sergio Verjovski-Almeida Mayana Zatz Human Genome and Stem Cell Research Center Department of Genetics and Evolutionary BiologyInstitute of BiosciencesUniversity of São PauloSão PauloSPBrazil Laboratório de Expressão Gênica em Eucariotos Instituto Butantan Departmento de Bioquímica Instituto de QuímicaUniversidade de São PauloSão PauloSPBrazil

In his accounts "On longevity and shortness of life", Aristotle considered how diseased states could be interchangeably associated with long and short lifespans. He believed that the presence of opposite elements and ... 详细信息

关键词： opposite elements states

Proximal Methods with Bregman Distances to Solve VIP on Hadamard Manifolds with Null Sectional Curvature

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Journal of the Operations Research Society of China 2021年第3期9卷 499-523页

作者： Erik Alex Papa Quiroz Paulo Roberto oliveira Universidad Nacional Mayor de San Marcos Universidad Privada del NorteLimaPeru PESC-COPPE Federal University of Rio de JaneiroRio de Janeiro CEP 21941-972Brazil

We present an extension of the proximal point method with Bregman distances to solve variational inequality problems(VIP)on Hadamard manifolds with null sectional *** some natural assumptions,as for example,the existence of solutions of the VIP and the monotonicity of the multivalued vector field,we prove that the sequence of the iterates given by the method converges to a solution of the ***,this convergence is linear or superlinear with respect to the Bregman distance.

关键词： Proximal point methods Hadamard manifolds Bregman distances Variational inequality problems Monotone vector field

THE EFFECT OF MEMORY TERMS IN DIFFUSION PHENOMENA

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Journal of Computational Mathematics 2006年第1期24卷 91-102页

作者： A. Araújo J.A. Ferreira P. oliveira Departamento de Matemática Universidade de Coimbra Portugal

In this paper the effect of integral memory terms in the behavior of diffusion phenomena is studied. The energy functional associated with different models is analyzed and stability inequalities are established. Approximation methods for the computation of the solution of the integro-differential equations are constructed. Numerical results are included.

关键词： Heat propagation Integro-differential equation Numerical approximation,Splitting method

Portugal's first major forensic case and the genesis of forensic toxicology:10 years of research to reconstruct the event

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Forensic Sciences Research 2019年第1期4卷 69-81页

作者： Ricardo Jorge Dinis-oliveira Department of Sciences IINFACTS–Institute of Research and Advanced Training in Health Sciences and TechnologiesUniversity Institute of Health Sciences(IUCS)CESPUCRLGandraPortugal UCIBIO-REQUIMTE Laboratory of ToxicologyDepartment of Biological SciencesFaculty of PharmacyUniversity of PortoPortoPortugal Department of Public Health and Forensic Sciences and Medical EducationFaculty of MedicineUniversity of PortoPortoPortugal

The"Crime of Flores Street"is one of the most famous cases of poisoning to divide public opinion in Portugal in the late 19th century, and it also demonstrated the weaknesses of the Portuguese medicolegal system and attested to the importance of toxicological analysis. Vicente Urbino de Freitas was a prominent doctor, graduating from the Faculty of Medicine of the University of Coimbra in 1875. He later became Professor of Physiology at the Porto Medical-Surgical School and author of a number of books on leprosy. In 1877, he married Maria das Dores Basto Sampaio Freitas, and this was followed by the death of a number of her close relatives in suspicious circumstances, notably her brother José António Sampaio Junior and nephew Mário Guilherme Augusto de Sampaio. This review aims to retell the story of Portugal's first significant medicolegal case as well as the accompanying judicial drama that gave birth to Forensic Toxicology in Portugal and prompted the medicolegal organization that exists today. This research was carried out over a 10-year period and repre-sents undeniable historical value given the rarity of the facts compiled. At the heart of this forensic case was the use of toxicological analyses in court for which the Chemist Antònio Joaquim Ferreira da Silva played a key role. This toxicological report revealed high concen-trations of morphine, delphinine and narceine in viscera and in Mario's urine. The Mario's cause of death was attributed to poisoning by opium alkaloids. Despite the strong judicial evidence, doubts still remains as to whether Vicente Urbino de Freitas was a"monster"or a victim of circumstances and a hapless martyr.

关键词： Forensic sciences forensic toxicology Vicente Urbino de Freitas António Joaquim Ferreira da Silva Medical-Surgical School Mário Guilherme Augusto de Sampaio

Finding my way: The role of dirigent proteins in lignin assembly

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Molecular Plant 2024年第2期17卷 230-232页

作者： Dyoni M.oliveira Igor Cesarino Department of Plant Biotechnology and Bioinformatics Ghent University9052 GhentBelgium VIB Center for Plant Systems Biology 9052 GhentBelgium Departamento de Botanica Instituto de BiocienciasUniversidade de Sao PauloRua do Matao277Sao Paulo 05508-090Brazil Synthetic and Systems Biology Center InovaUSPAvenida Professor Lucio Martins Rodrigues370SaoPaulo 05508-020Brazil

Lignin emerged around 450 million years ago in early tracheophytes and played a pivotal role in the colonization of terrestrial ecosystems by *** aromatic biopolymer provides mechanical strength to supportive tissues and hydrophobicity to water-transporting vasculature and acts as a physical barrier against herbivores and pathogens(Renault et al.,2019).The deposition of lignin in cell walls for proper cellular functionalization involves several molecular steps,including the tight regulation of tissue-or cell-type-specific expression of lignin biosynthetic genes,the biosynthesis of distinct lignin monomers and their transportation to the apoplast,and the polymerization of monomer radicals to produce tissue-or cell-type-dependent polymers with distinct physico-chemical properties.

关键词： properties. lignin walls

Herbivore performance and plant defense after sequential attacks by inducing and suppressing herbivores

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Insect Science 2019年第1期26卷 108-118页

作者： Elisa Faria de oliveira Angelo Pallini Arne Janssen Department of Entomology Federal University of VicosaVicosaMGBrazil Department of Entomology Federal University of Lavras LavrasMGBrazil Section Population Biology Institute for Biodiversity and Ecosystem DynamicsUniversity of Amsterdam Amsterdamthe Netherlands

It is well known that herbivore-induced plant defenses alter host plant quality and can affect the behavior and performance of later arriving *** of sequential attacks by herbivores that either suppress or induce plant defenses are less well *** sequentially infested leaves of tomato plants with a strain of the phytophagous spider mite Tetranychus urticae that induces plant defenses and the closely related Tetranychus evansi, which suppresses plant *** quality was quantified through oviposifion of both spider mite species and by measuring proteinase inhibitor activity using plant material that had been sequentially attacked by both herbivore ***-mite oviposifion data show that *** could suppress an earlier induction of plant defenses by ***,and *** could induce defenses in plants previously attacked by *** in 1 *** attacks by the second species did not result in further changes in *** inhibitor activity levels showed that *** suppressed the high activity levels induced by *** to constitutive levels in 1 day,and further suppressed activity to levels similar to those in plants attacked by *** *** by *** induced proteinase inhibitor activity in plants previously attacked by ***,eventually to similar levels as induced by *** ***,plant quality and plant defenses were significantly affected by sequential attacks and the order of attack does not affect subsequent performance,but does affect proteinase inhibitor activity *** on our results,we discuss the evolution of suppression of plant defenses.

关键词： plant defense plant-herbivore interactions plant quality sequential attack Tetranychus evansi Tetranychus urticae

Supercritical fluid technology as a sustainable alternative method for textile dyeing:An approach on waste,energy,and CO_(2)emission reduction

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Journal of Environmental Sciences 2024年第6期140卷 123-145页

作者： Carlos Rafael Silva de oliveira Patrícia Viera de oliveira Leandro Pellenz Catia Rosana Lange de Aguiar Afonso Henrique da Silva Júnior Federal University of Santa Catarina Textile Engineering Department2514 João Pessoa St.BlumenauSC89036-004Brazil Federal University of Santa Catarina Chemical Engineering DepartmentS/n Biotério Central St.FlorianópolisSC88040-900Brazil

The clothing industry is considered one of the most polluting industries on the planet due to the high consumption of water,energy,chemicals/dyes,and high generation of solid waste and *** with environmental concerns,the textile ennoblement sector is the most critical of the textile production chain,especially the traditional dyeing *** an alternative to current problems,dyeing with supercritical CO_(2)(scCO_(2))has been presented as a clean and efficient process for a sustainable textile *** fluid dyeing(SFD)has shown a growing interest due to its significant impact on environmental preservation and social,economic,and financial *** main SFD benefits include economy and reuse of non-adsorbed dyes;reduction of process time and energy expenditure;capture of atmospheric CO_(2)(greenhouse gas);use and recycling of CO_(2)in SFD;generation of carbon credits;water-free process;effluent-free process;reduction of CO_(2)emission and auxiliary *** being still a non-scalable and evolving technology,SFD is the future of *** review presented a comprehensive overview of the environmental impacts caused by traditional processes and confronted the advantages of *** SFD technique was introduced,along with its latest advances and future *** and environmental gains were also discussed.

关键词： Textile industry Supercritical dyeing Sustainable processes Water free dyeing Energy saving Cleaner production

Iron toxicity resistance strategies in tropical grasses:The role of apoplastic radicular barriers

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Journal of Environmental Sciences 2019年第4期31卷 257-266页

作者： Advanio Inacio Siqueira-Silva Camilla oliveira Rios Eduardo Gusmao Pereira Institute of Biological and Health Sciences Federal University of Vicosa (UFV)Campus Florestal Minas Gerais Brazil Federal University of Western Para (UFOPA) University Campus of JurutiPara Brazil Postgradute Program in Management and Conservation of Natural and Agrarian Ecosystems UFV Campus Florestal Florestal Minas Gerais Brazil

The revegetation of mined areas poses a great challenge to the iron ore mining *** initial recovery process in degraded areas might rely on the use of Fe-resistant *** grasses, such as Paspalum densum and Echinochloa crus-galli, show different resistance strategies to iron toxicity; however, these mechanisms are poorly *** Fe-resistance mechanisms and direct iron toxicity as a function of root apex removal were investigated. To achieve this purpose, both grass species were grown for up to 480 hr in a nutrient solution containing 0.019 or 7 mmol/L Fe-EDTA after the root apices had been removed or maintained. Cultivation in the presence of excess iron-induced leaf bronzing and the formation of iron plaque on the root surfaces of both grass species, but was more significant on those plants whose root apex had been removed. Iron accumulation was higher in the roots, but reached phytotoxic levels in the aerial parts as well. It did not hinder the biosynthesis of chloroplastidic pigments. No significant changes in gas exchange and chlorophyll a fluorescence occurred in either grass when their roots were kept intact; the contrary was true for plants with excised root apices. In both studied grasses, the root apoplastic barriers had an important function in the restriction of iron translocation from the root to the aerial plant parts, especially in E. crus-galli. Root apex removal negatively influenced the iron toxicity resistance mechanisms(tolerance in P. densum and avoidance in E. crus-galli).

关键词： Paspalum densum Echinochloa crus-galli Apoplastic barrier Iron toxicity

Biomaterials and emerging technologies for tissue engineering and in vitro models

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Bio-Design and Manufacturing 2024年第3期7卷 237-239页

作者： J.Miguel oliveira Rui L.Reis 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal

The latest advances in the field of biomaterials have opened new avenues for scientific breakthroughs in tissue engineer-ing which greatly contributed for the successful translation of tissue engineering products into the market/***-materials are easily processed to become similar to natural extracellular matrix,making them ideal temporary supports for mimicking the three-dimensional(3D)microenvironment required for maintaining the adequate cell/tissue functions both in vitro and in vivo^([1]).

关键词： breakthrough biomaterials engineer