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IMP & HIRFL Annual Report 2011年第1期 165-165页

作者： He Jinpeng Ding Nan Ye Wenling Pei Hailong Ye Caiyong Wang Jufang yoshiya Furusawa Zhou Guangming

自噬使肿瘤细胞产生高LET射线辐射抗性(英文)

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IMP & HIRFL Annual Report 2011年 140-140页

作者：金晓东 Yoshitaka Matsumoto yoshiya Furusawa National Institute of Radiological Sciences

The role of autophagy in radiotherapy remains controversial. Constitutive autophagy may be a necessary homeostatic process which removes damaged organelles and recycles macromolecules, thus protects against radiation and DNA damage. On the other hand, some results show that induction of excessive autophagy and type II PCD may also be the major cell death mechanism that takes over when apoptosis is unavailable. Autophagic cell death has been reported to be induced by a number of chemotherapeutic agents or radiation in mammalian cells. Recent studies suggest that death due to autophagy may be as unobtrusive as apoptosis and may also induce clearance signals that facilitate the removal of the dying cell. Therefore, the present study was undertaken to clarify whether autophagy induced by high-LET radiation represents a survival mechanism or rather contributes to cell death.

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细胞周期停顿:一个G2期阻滞后的细胞过程(英文)

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IMP & HIRFL Annual Report 2009年 175-175页

作者：周光明 Ryoichi Hirayama yoshiya Furusawa Research Center for Charged Particle Therapy National Institute of Radiological Sciences

Cell cycle checkpoint is a self-protective mechanism for cells to monitor genome integrity and ensure the high-fidelity transmission of genetic information to daughter *** function of cell cycle checkpoints has been d...

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Treatment of colorectal carcinoids:A new paradigm

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World Journal of Gastrointestinal Surgery 2010年第5期2卷 153-156页

作者： Tsuyoshi Konishi Toshiaki Watanabe Hirokazu Nagawa Masatoshi Oya Masashi Ueno Hiroya Kuroyanagi yoshiya Fujimoto Takashi Akiyoshi Toshiharu Yamaguchi Tetsuichiro Muto Department of Gastroenterological Surgery Cancer Institute Hospital Department of Surgical Oncology University of Tokyo Department of Surgery Teikyo University School of Medicine

It is often difficult to evaluate the grade of malignancy and choose an appropriate treatment for colorectal carcinoids in clinical settings. Although tumor size and depth of invasion are evidently not enough to stratify the risk of this rare tumor, the present guidelines or staging systems do not mention other clinicopathological variables. Recent studies, however, have shed light on the impact of lymphovascular invasion on the outcome of colorectal carcinoids. It has been revealed that the presence of lymphovascular invasion was among the strongest risk factors for metastasis along with tumor size and depth of invasion. Furthermore, tumors smaller than 1 cm, within submucosal invasion and without lymphovascular invasion, carry minimal risk for metastasis with 100% 5-year survival in the studies from Japan as well as from the USA. This would suggest that these tumors could be curatively treated by endoscopic resection or transanal local excision. On the other hand, colorectal carcinoids with either lymphovascular invasion or tumor size larger than 1 cm carry the risk for metastasis equivalent to adenocarcinomas. Therefore, it should be emphasized that histological examination of lymphovascular invasion is mandatory in the specimens obtained by endoscopic resection or transanal local excision, as this would provide useful information for determining the need for additional radical surgery with regional lymph node dissection. Although the present guidelines or TNM staging system do not mention the impact of lymphovascular invasion, this would be among the next promising targets in order to establish better guidelines and staging systems, particularly in early-stage colorectal carcinoids.

关键词： Lymphovascular invasion Neuroendocrine tumor Carcinoid Colorectal cancer

高LET射线诱导肿瘤细胞自噬的研究(英文)

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IMP & HIRFL Annual Report 2011年 139-139页

作者：金晓东 Yoshitaka Matsumoto yoshiya Furusawa National Institute of Radiological Sciences

Autophagy is an evolutionary conserved, dynamic, and lysosome-mediated process that begins with the formation of double or multilayer membranous structures and is induced by poor nutrient conditions. During autophagy, the cytoplasmic components, including organelles, such as mitochondria, are engulfed by the membranous vacuoles often called autophagosomes, which fuse with lysosomes where the contents are degraded by the lysosomal proteases. Autophagic response has been observed in response to various cancer-relevant stimuli, including Ras activation, nutrient deprivation, and treatment with endostatin, radiation, tumor necrosis factor-a (TNF-a), ceramide, rapamycin, arsenic trioxide, or tamoxifen.

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中国野生大豆与栽培大豆等位酶、RFLP和RAPD标记的遗传多样性与演化趋势分析

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中国农业科学 1999年第6期32卷 16-22页

作者：许东河高忠盖钧镒张志永陈受宜北岛俊二福士泰史阿部纯岛本义也中国科学院遗传研究所北海道大学农学院!札幌060 南京210095 南京农业大学大豆研究所!农业部国家大豆改良中心日本

选用来自全国各地野生大豆和栽培大豆地方品种中有代表性的材料,分析其在等位酶、细胞器DNA RFLP和细胞核DNA RAPD标记位点上的群体遗传表现。结果表明:野生大豆在上述标记位点上的综合遗传多样性水平高于栽培大豆,二者的综合遗传丰富... 详细信息

选用来自全国各地野生大豆和栽培大豆地方品种中有代表性的材料,分析其在等位酶、细胞器DNA RFLP和细胞核DNA RAPD标记位点上的群体遗传表现。结果表明:野生大豆在上述标记位点上的综合遗传多样性水平高于栽培大豆,二者的综合遗传丰富度和遗传离散度分别为180(95.2% )和154(81.5% )及0.2891 和0.2091。野生大豆与栽培大豆群体在所分析的大多数位点上等位基因的分布频率差异明显,其中差异较大的标记位点有Idh1、Aph、Idh2 和Dia(等位酶);cpⅠ、cpⅢ、m tⅣa 和m tⅣb(细胞器DNA RFLP);OPAP4-8,OPAP5-1,OPAP9-8和OPAP20-8(细胞核DNA RAPD)。这些标记位点可作为进化的标记性状,以研究大豆的起源和演化问题。

关键词：野生大豆(GlycinesojaSieb.etZucc.) 栽培大豆〔Glycinemax(L.)Merr.〕遗传多样性遗传演化

In Vitro Evaluation System of Pharmacokinetics and Irradiation Effect in Boron Neutron Capture Therapy (BNCT) Using Three-Dimensional Artificial Human Tumor Tissue Model

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Scoring criteria for determining the safety of liver resection for malignant liver tumors

Journal of Cancer Therapy（癌症治疗） 2019年第10期

作者： Shintaro Ishiyama yoshiya Asano Minoru Suzuki Mitsuru Akashi Hiroshi Shimoda

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World Journal of Meta-Analysis 2019年第5期7卷 234-248页

作者： Kohei Harada Minoru Nagayama yoshiya Ohashi Ayaka Chiba Kanako Numasawa Makoto Meguro Yasutoshi Kimura Hiroshi Yamaguchi Masahiro Kobayashi Koji Miyanishi Junji Kato Toru Mizuguchi Departments of Surgery Surgical Scienceand OncologySapporo Medical UniversitySapporoHokkaido 060-8556Japan Division of Radiology Sapporo Medical University HospitalSapporoHokkaido 060-8556Japan Sapporo Medical University Postgraduate School of Health Science and Medicine Sapporo Medical UniversitySapporoHokkaido 060-8556Japan Research and Education Center for Clinical Pharmacy Kitasato University School of PharmacyTokyo 108-8641Japan Department of Internal Medicine IV Sapporo Medical UniversitySapporoHokkaido 060-8556Japan Department of Nursing and Surgical Science Sapporo Medical UniversitySapporo 0608543Japan

BACKGROUND Liver resection has become safer as it has become less ***,the minimum residual liver volume(RLV)required to maintain homeostasis is ***,the formulae used to calculate standard liver volume(SLV)are *** To review previously reported SLV formulae and the methods used to evaluate the minimum RLV,and explore the association between liver volume and *** A systematic review of Medline,PubMed,and grey literature was *** in the retrieved articles were cross-checked manually to obtain further *** last search was conducted on January 20,*** developed an SLV formula using data for 86 consecutive patients who underwent hepatectomy at our institution between July 2009 and August *** Linear regression analysis revealed the following formula:SLV(mL)=822.7×body surface area(BSA)?183.2(R2=0.419 and R=0.644,P<0.001).We retrieved 25 studies relating to SLV formulae and 12 studies about the RLV required for safe liver *** the previously reported formulae included various coefficient and constant values,a simplified version of the SLV,the common SLV(cSLV),can be calculated as follows:cSLV(mL)=710 or 770×*** minimum RLV for normal and damaged livers ranged from 20%-40%and 30%-50%,*** Sapporo score indicated that the minimum RLV ranges from 35%-95%depending on liver *** We reviewed SLV formulae and the minimum RLV required for safe liver *** Sapporo score is the only liver function-based method for determining the minimum RLV.

关键词： Standard liver volume Residual liver volume Hepatectomy Mortality Liver failure Liver function

HeLa细胞中抑制自噬增加碳离子辐射敏感性的研究(英文)

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IMP & HIRFL Annual Report 2012年 164-164页

作者：金晓东 Liu Yan Li Qiang Yoshitaka Matsumoto yoshiya Furusawa National Institute of Radiological Sciences

In cancer therapy,the role of autophagy is *** some reports,autophagy appears to function as a protective mechanism against cellular ***,the induction of autophagy still plays a pivotal role in cell death induced by radiations or reagents in other ***,whether autophagy helps to kill cancer cells or to sustain their survival under stressful conditions remains *** assess whether autophagy contributes to the resistance or sensitivitv of tumor cells to high-LET

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Dosimetric Effect of Cobalt-Chrome Stabilization Hardware in Paraspinal Radiation Treatments

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