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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi pradeepkiran priyanka Rawat Arubala p.Reddy Erika orlov pHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAp-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

Development of lead-free multifunctional materials Bi(Co_(0.45Ti0.45Fe0.10)o3

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progress in Natural Science:Materials International 2018年第3期28卷 308-314页

作者： Nitin Kumar Alok Shukla R.N.p.choudhary Department of physics National Institute of Technology Mizoram Department of physics Siksha ‘O′Anusandhan University

A lead free multiferroic material,Bi(Co0.45Ti0.45Fe0.10)o3（BCTF45/10）was synthesized by a solid-state reaction route at high ***45/10 powder was prepared using appropriate raw maretials in oxide powders with methanol ***-prepared circular shaped pellets were sintered at 1053 K for 6 h to produce a compact *** structural properties and elemental analysis were determined using X-ray diffraction and energy-dispersive X-ray spectroscopy techniques respectively at room *** microstructure or surface morphology of the sintered sample was carried out by using field emission scanning electron microscope（FE-SEM）.The XRD analysis shows that the compound exhibits the single-phase of orthorhombic *** average crystallite size estimated using the Scherrer's technique was found to be 30 *** influence of Co and Ti substitution（at Bi and Ti sites of Bi Fe o3）on some physical and electrical properties of Bi Fe o3was examined by using phase sensitive multimeter in a wide frequency and temperature *** magnetic nature of the sample was studied using vibrating sample *** of room temperature magnetic hysteresis loop exhibits the enhanced ferromagnetic characteristic with saturation magnetization of 5.091 emu/g and coercive field of 0.213 k oe *** enhanced magnetic properties highlight various potential applications of Co/Ti doped BCTF45/10 materials.

关键词： Multifunctional material Dielectric constant and loss Electrical characteristics Impedance spectroscopy

Designing high-TC superconductors with BCS-inspired screening,density functional theory,and deep-learning

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npj Computational Materials 2022年第1期8卷 2331-2342页

作者： Kamal choudhary Kevin Garrity Material Measurement Laboratory GaithersburgMD20899USA National Institute of Standards and Technology GaithersburgMD20899USA Theiss Research La JollaCA92037USA

We develop a multi-step workflow for the discovery of conventional superconductors,starting with a Bardeen–Cooper–Schrieffer inspired pre-screening of 1736 materials with high Debye temperature and electronic density of ***,we perform electron-phonon coupling calculations for 1058 of them to establish a large and systematic database of BCS superconducting *** the McMillan-Allen-Dynes formula,we identify 105 dynamically stable materials with transition temperatures,TC≥5 ***,we analyze trends in our dataset and individual materials including MoN,VC,VTe,KB_(6),Ru_(3)NbC,V_(3)pt,ScN,LaN_(2),Ruo_(2),and *** demonstrate that deep-learning(DL)models can predict superconductor properties faster than direct first-principles ***,we find that by predicting the Eliashberg function as an intermediate quantity,we can improve model performance versus a direct DL prediction of *** apply the trained models on the crystallographic open database and pre-screen candidates for further DFT calculations.

关键词： database BCS faster

Electrical properties of rare earth based tungsten bronze vanadates

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Journal of Rare Earths 2012年第11期30卷 1134-1137页

作者： B.B.Mohanty p.S.Sahoo R.N.p.choudhary Department of physics Betnoti College Betnoti Department of physics ITER

Barium based tungsten bronze （TB） oxides having high dielectric constant and low loss, can be effectively used as transducers, actuators, capacitors and also in memory devices. All these characteristics stimulated the researchers to replace toxic and hazardous lead based materials by barium based TB materials from industry. In the present research work, polycrystalline samples of BaaSrRTi3VTo30 （R=Dy, Sm, La） were synthesized by a high temperature solid state reaction technique. preliminary structural （X-ray diffraction） analyses of these com- pounds showed the formation of single-phase orthorhombic structures at room temperature having average crystallite size of the order of some nanometer for all the compounds. The scanning electron micrographs （SEM） provided information on the quality of the samples and showed more or less homogeneous distribution of grains over the entire surface of the samples. Detailed dielectric study in a wide temperature range （30-500 ℃） showed ferro to para phase transition for Dy and Sm substituted samples whereas no such transition was observed for La substituted samples. Both the grain and grain boundary resistances exhibited negative temperature coefficient of resistance behavior much like semiconductors. The dc conductivity of all the compounds obeyed Arrhenius relation.

关键词： ceramics X-ray diffraction dielectric properties electrical conductivity rare earths

Atomistic Line Graph Neural Network for improved materials property predictions

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npj Computational Materials 2021年第1期7卷 1691-1698页

作者： Kamal choudhary Brian DeCost Materials Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Theiss ResearchLa Jolla California 92037USA DeepMaterials LLC Silver SpringMD 20906USA

Graph neural networks(GNN)have been shown to provide substantial performance improvements for atomistic material representation and modeling compared with descriptor-based machine learning *** most existing GNN models for atomistic predictions are based on atomic distance information,they do not explicitly incorporate bond angles,which are critical for distinguishing many atomic ***,many material properties are known to be sensitive to slight changes in bond *** present an Atomistic Line Graph Neural Network(ALIGNN),a GNN architecture that performs message passing on both the interatomic bond graph and its line graph corresponding to bond *** demonstrate that angle information can be explicitly and efficiently included,leading to improved performance on multiple atomistic prediction *** ALIGNN models for predicting 52 solid-state and molecular properties available in the JARVIS-DFT,Materials project,and QM9 *** can outperform some previously reported GNN models on atomistic prediction tasks by up to 85%in accuracy with better or comparable model training speed.

关键词： explicitly property passing

Temporal and spatial compliance behaviour of pedestrians under the influence of time pressure at signalized intersections:A pedestrian simulator study

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 55-68页

作者： Apurwa Dhoke pushpa choudhary Department of Civil Engineering Indian Institute of Technology RoorkeeRoorkee 247667India

pedestrian safety is at high stakes due to the non-compliance practices of pedestrians at signalized ***,when pedestrians are hurrying,they deliberately engage in such unsafe ***,the purpose of this study was to understand how time pressure(i.e.,feeling of hurry or saving time)affected pedestrians'decisions to follow traffic rules at signalized *** achieve the study objectives,a pedestrian simulator setup was used to collect the crossing behaviour of forty participants at a four-legged signalized ***-compliance,one of the riskiest pedestrian behaviours,was examined with respect to three different forms,comprising dangerous temporal non-compliance(D-TNC),non-dangerous temporal non-compliance(ND-TNC),and spatial non-compliance(SNC)behaviour under two distinct conditions:baseline(i.e.,no time pressure)and time pressure *** effects of demographics,usual walking features,and time pressure on D-TNC and ND-TNC were investigated using a multinomial regression model,while SNC behaviour was investigated using a binary regression *** was interesting to note that the majority of the factors related to pedestrians’usual walking behaviour had an impact on all kinds of non-compliance ***,the results also showcased that time pressure had a contrasting impact on D-TNC and ND-TNC behaviour whereas SNC behaviour increased under time ***,the varying impacts of D-TNC,ND-TNC,and SNC were also reflected in the occurrence of the crashes,which were probably triggered by discrepancies in the influence of time pressure on non-compliance *** findings highlight the need for technical solutions,educational outreach,and efficient enforcement practices to reduce pedestrians'non-compliant behaviour.

关键词： Signalized intersection Time pressure pedestrians Temporal compliance Spatial compliance pedestrian simulator

Response of the low-pressure hot-filament discharge plasma to a positively biased auxiliary disk electrode

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plasma Science and Technology 2022年第1期24卷 53-60页

作者： Mangilal choudhary poyyeri Kunnath SREEJITH Institute of Advanced Research KobaGandhinagarGujarat 382426India Indian Institute of Technology Madras ChennaiTamil Nadu 600036India

In a steady-state plasma,the loss rate of plasma particles to the chamber wall and surfaces in contact with plasma is balanced by the ionization rate of background neutrals in the hot-filament *** balance between the loss rate and ionization rate of plasma particles(electrons and ions)maintains quasi-neutrality of the bulk *** the presence of an external perturbation,it tries to retain its quasi-neutrality *** this work,we studied how the properties of bulk plasma are affected by an external DC potential *** auxiliary biased metal disk electrode was used to introduce a potential perturbation to the plasma medium.A single Langmuir probe and an emissive probe,placed in the line of the discharge axis,were used for the characterization of the bulk *** is observed that only positive bias to the auxiliary metal disk increases the plasma potential,electron temperature,and plasma density but these plasma parameters remain unaltered when the disk is biased with a negative potential with respect to plasma *** observed plasma parameters for two different-sized,positively as well as negatively biased,metal disks are compared and found inconsistent with the existing theoretical model at large positive bias *** role of the primary energetic electrons population in determining the plasma parameters is *** experimentally observed results are qualitatively explained on the basis of electrostatic confinement arising due to the loss of electrons to a biased metal disk electrode.

关键词： hot-filament discharge plasma response plasma parameters positively biased electrode

Adding new dimension to non-directed C（sp3）–H functionalizations

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Science China Chemistry 2025年

作者： Konstantin p.Bryliakov Laboratory of Selective oxidation Catalysis N.D.Zelinsky Institute of Organic Chemistry RAS

Aliphatic C–H groups are among the most abundant yet least reactive functional groups in organic molecules. Nature has evolved metalloenzymes such as those of the cytochrome p450 superfamily that efficiently activate individual tertiary（3） and secondary （2） C（sp3）–H bonds in complex molecules with the highest level of regio-and stereoselectivity [1], thus encouraging studies aimed at engineering artificial metalloenzymes for synthetic applications [2].

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