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灌注球囊在动静脉瘘狭窄中的临床前可行性研究

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中国医疗器械信息 2024年第15期30卷 61-63,123页

作者：邢智凯范亚倩查城上海微创心脉医疗科技(集团)股份有限公司上海201318

目前,每年全国都有大量的终末期肾病患者接受维持性血液透析,自体动静脉瘘是其首选的血液通路之一,长期反复的透析会造成部分患者不同程度的透析通路的狭窄。尽管有一些解决方案被用于临床实践中,但这些方案存在效果不佳或者价格昂贵的... 详细信息

目前,每年全国都有大量的终末期肾病患者接受维持性血液透析,自体动静脉瘘是其首选的血液通路之一,长期反复的透析会造成部分患者不同程度的透析通路的狭窄。尽管有一些解决方案被用于临床实践中,但这些方案存在效果不佳或者价格昂贵的缺点,开发一种具有较低价格并临床收益良好的器械刻不容缓。该文章通过设计一种新型灌注球囊,结合抗增殖药物紫杉醇注射液,通过体外模拟实验,初步验证了该新型设备存在临床可行性,为后续的动物体内验证以及未来的临床实验提供了有效的理论支撑。

关键词：灌注球囊自体动静脉瘘血液透析紫杉醇

西南地区典型小流域氮空间分布特征及非点源氮流失量估算研究

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环境科学与管理 2024年第7期49卷 56-60,87页

作者：高雅彭常康谷碧涵陶红上海城建职业学院市政与生态工程学院上海200438 上海理工大学环境与建筑学院上海200093

以西南地区典型小流域为研究对象,通过野外采样和实验分析,对流域土壤氮的含量、赋存形态及空间分布特征进行研究;利用修正的通用土壤流失方程和分布式水文模型对研究流域土壤中非点源氮的流失量进行估算,探讨不同土地利用类型产生的氮... 详细信息

以西南地区典型小流域为研究对象,通过野外采样和实验分析,对流域土壤氮的含量、赋存形态及空间分布特征进行研究;利用修正的通用土壤流失方程和分布式水文模型对研究流域土壤中非点源氮的流失量进行估算,探讨不同土地利用类型产生的氮负荷特征。研究区域总氮的含量处于相对较高的水平,以有机氮为主,茶园和耕地的总氮含量较高。流域土壤非点源氮的流失量为137.3 t/a,其中溶解态氮和吸附态氮的流失量分别为117.6 t/a和19.7 t/a。相对于吸附态氮,溶解态氮更易迁移至水体,造成水体污染。在吸附态氮流失中,以来自坡耕地的流失量最大,占比达69%,因此在小流域的水土保持和非点源控制工作中,还应重点加强对坡耕地区域的预防和治理。

关键词：西南地区非点源氮坡耕地流失量

Realization of an Automated Microassembly Task Involving Micro Adhesive Bonding

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International Journal of Automation and computing 2013年第6期10卷 545-551页

作者： Fu-Dong Li De Xu Zheng-TaoZhang ya-Li Shi Research Center of Precision Sensing and Control Institute of AutomationChinese Academy of Sciences

An automated approach is proposed for a microassembly task, which is to insert a 10 μm diameter glass tube into a 12 μm diameter hole in a silicon substrate, and bond them together with ultraviolet （UV） curable adhesive. Two three-degree-of-freedom micromanipulators axe used to move the glass tube and the dispensing needle, respectively. Visual feedback is provided by an optical microscope. The angle of the microscope axis is precisely calibrated using an autofocus strategy. Robust image segmentation method and feature extraction algorithm are developed to obtain the features of the hole, the glass tube and the dispensing needle. Visual servo control is employed to achieve accurate aligning for the tube and the hole. Automated adhesive dispensing is used to bond the glass tube and the silicon substrate together after the insertion. on-line monitoring ensures that the diameter of the adhesive spot is within a desired range. Experimental results demonstrate the effectiveness of the proposed strategy.

关键词： Micro adhesive bonding microassembly visual servo control image segmentation feature extraction.

Advanced therapeutic strategies for HBV-related acute-on-chronic liver failure

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Hepatobiliary & Pancreatic Diseases International 2015年第4期14卷 354-360页

作者： Xin-Yu Liu Feng Peng ya-Jie Pan Jun Chen Liver Diseases Center Second Xiangya Hospital Central South University Department of Infectious Diseases Third Xiangya Hospital Central South University

Acute-on-chronic liver failure （ACLF） is increasingly recognized as a distinct clinical entity and is as- sociated with a high short-term mortality. The most common cause of ACLF is chronic hepatitis B worldwide. Currently, there is no standardized approach for the management of ACLF and the efficacy and safety of therapeutic modalities are uncertain. DATA SoURCES： PubMed and Web of Science were searched for English-language articles. The search criteria focused on clinical trials and observational studies on the treatment of patients with HBV-related ACLF. RESULTS： Therapeutic approaches for ACLF in patients with chronic hepatitis B included nucleos（t）ide analogues, artificial liver support systems, immune regulatory therapy, stem cell therapy and liver transplantation. All of these therapeutic ap- proaches have shown the potential to improve liver function and increase patients＇ survival rate, but most of the studies were not randomized or controUed. CoNCLUSIoN： Substantial challenges for the treatment of HBV-related ACLF remain and further basic research and ran- domized controlled clinical trials are needed.

关键词： chronic hepatitis B acute-on-chronic liver failure therapy

Growth characteristics and sedimentary mode of Permian reefs,Lengwu,Tonglu,Zhejiang Province,southern China

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Journal of Palaeogeography 2016年第4期5卷 409-422页

作者： Ling Liu ya-Sheng Wu Hong-Xia Jiang Hong Liu Institute of Geology and Geophysics CASKey Laboratory of Petroleum Resource ResearchChinese Academy of Sciences

organic reefs are favourabte accumulation spaces for hydrocarbons and various mineral resources. A complete Permian organic reef profile about 44 m thick with distribution area no more than 1 km2 is exposed near Lengwu, Tongtu, Zhejiang Province. Examination of outcrops and thin sections revealed that the main reef-building organisms are catcisponges, with inozoans as dominant type. Five types of rocks have been recognized in the reef, and they are catcisponge framestone, catcisponge bafflestone, bindstone, rudstone and bioctastic wackestone. The profile was constructed in three reef-building stages. The thickness of the second stage is largest, followed by the first stage and the third stage is smallest. Each stage started with a frame-stone or bafflestone, ended as the reef grew near the sea-level, and died because of influx of terrigenous sediments. The development of the Lengwu reef is controlled by biological factors and sea-level changes. Based on the study a reef sedimentary model is established.

关键词： Reef Rock types Calcisponges Sedimentary model Permian Lengwu Southern China

Impact of Antimicrobial Stewardship Programs on Antibiotic Use and Drug Resistance:Analysis of Data from Maternal and Child Health Care Hospitals in Hubei Province,China

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Current Medical Science 2022年第5期42卷 1106-1110页

作者： ya-zheng ZHAo Ting-ting LI Wei FU Department of Pharmacy Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

objectiveTo evaluate the impact of Antimicrobial Stewardship Programs(ASPs)on antibiotic use and drug *** was a retrospective,multicenter,management intervention *** data from 85 maternity hospitals(maternal and child health care hospitals)in Hubei province from 2012 to 2019 were *** indicators related to antimicrobial drug use included the utilization rate of different grades of antimicrobial drugs,the intensity of antimicrobial agent use,the rational use of prophylactic antimicrobial agents before class I surgical incision,and pathogenic detection and consultation rates before antimicrobial drug *** the implementation,the purchase of antimicrobial agents in hospitals has been maintained within the prescribed range,and the defined daily dose system(DDDs)of antimicrobial agents has been reduced,prophylactic use and accurate treatment of antimicrobial agents related to class I surgical incision have been more *** the implementation of ASPs,the detection rate of imipenem-resistant Acinetobacter baumannii,cefotaxime-resistant Escherichia coli,and methicillin-resistant Staphylococcus aureus has been decreased in China from national bacterial resistance surveillance *** have positive effects on antibiotic use and drug resistance in 85 maternity hospitals(maternal and child health care hospitals).

关键词： Antimicrobial Stewardship Program antimicrobial resistance maternal and child health care hospitals

Removal of tetrachlorobisphenol A and the effects on bacterial communities in a hybrid sequencing biofilm batch reactor-constructed wetland system

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Frontiers of Environmental Science & Engineering 2019年第1期13卷 147-157页

作者： Xiaohui Wang Shuai Du Tao ya Zhiqiang Shen Jing Dong Xiaobiao Zhu Department of Environ mental Scie nee and Engineering College of Chemical Engineering Beijing University of Chemical TechnologyBeijing 100029 China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Beijing 100012 China Beijing Municipal Research Institute of Environmental Protection Beijing 100037 China

Tetrachlorobisphenol A (TCBPA) released into the sewage may cause environmental pollution and health risk to human beings. The objective of this study was to investigate the removal ofTCBPA and bacterial community structures in a laboratory-scale hybrid sequencing biofilm batch reactor (SBBR)- constructed wetland (CW) system. The results showed that the removal efficiency of chemical oxidation demand (CoD), ammonia, total nitrogen and total phosphorus in the SBBR-CW system was 96.7%, 97.3%, 94.4%, and 8&6% respectively. At the stable operation stage, the system obtained a 71.7%±1.8% of TCBPA removal efficiency with the influent concentration at 200μg/L. Illumina MiSeq sequencing of 16S rRNA gene revealed that the presence of TCBPA not only reduced the bacterial diversity in the SBBR-CW system, but also altered the composition and structure of bacterial community. After the addition of TCBPA, Proteobacteria increased from 31.3% to 38.7%, while Acidobacteria and Parcubacteria decreased greatly in the SBBR. In contrast, Acidobacteria replaced Proteobacteria as the dominant phylum in the upper soils of CW. The results indicated that TCBPA stimulated the growth of GAos in the SBBR without deteriorating the phosphorus removal due to the presence of sufficient carbon sources. The ammonia oxidizing bacteria, Nitrosomonas, and denitrification bacteria, Hyphomicrobium and Pseudomonas, were inhibited by TCBPA, resulting in a decreasing the removal efficiency of TN and ammonia.

关键词： SBBR Constructed wetland Tetrachlorobisphenol A Microbial community structure

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儿童非伤寒沙门菌胃肠炎抗感染治疗研究进展

中国药业 2024年第17期33卷 152-152,I0001-I0005页

作者：李高芬李俊邱秀燕杨雅中国人民解放军陆军军医大学第二附属医院重庆400037 重庆医科大学附属儿童医院·国家儿童健康与疾病临床医学研究中心·儿童发育疾病研究教育部重点实验室·儿童感染与免疫罕见病重庆市重点实验室重庆401122

目的为儿童非伤寒沙门菌(NTS)胃肠炎抗感染治疗提供参考。方法采用计算机检索PubMed,Web of Science,The Cochrane Library和中国知网数据库中自建库起至2023年12月的儿童NTS胃肠炎抗感染治疗相关文献,从NTS的微生物学特点、流行病学、... 详细信息

目的为儿童非伤寒沙门菌(NTS)胃肠炎抗感染治疗提供参考。方法采用计算机检索PubMed,Web of Science,The Cochrane Library和中国知网数据库中自建库起至2023年12月的儿童NTS胃肠炎抗感染治疗相关文献,从NTS的微生物学特点、流行病学、耐药性及抗感染治疗方案进行总结。结果儿童是NTS感染的高危人群;在非免疫缺陷情况下,儿童NTS胃肠炎感染程度通常较轻,具有自限性,无须治疗;重度感染、新生儿和低于3月龄、先天性或医源性免疫缺陷患儿需抗感染治疗。目前,第3代头孢菌素、喹诺酮类和大环内酯类抗菌药物为主要治疗药物,具体用法用量应遵循相关指南,疗程以7~10 d为宜。结论应严格把握儿童NTS胃肠炎抗感染治疗指征,制订合理的抗感染治疗方案,以规范抗菌药物的合理使用,遏制细菌耐药。

关键词：儿童非伤寒沙门菌胃肠炎抗感染进展

obesity paradox among elderly patients with coronary artery disease undergoing non-cardiac surgery

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Journal of Geriatric Cardiology 2018年第9期15卷 598-604页

作者： Lu CHE Li XU Ming-ya WANG Yu-Guang HUANG Department of Anesthesiology Peking Union Medical College Hospital Beijing China Department of Anesthesiology State Key Laboratory of Translational Cardiovascular Medicine Fuwai Hospital & Cardiovascular Institute Chinese Academy of Medical Science Peking Union Medical College Beijing China

Background High body mass index （BMI） is a risk factor for chronic cardiac disease. However, mounting evidence supports that high BMI is associated with less risk of cardiac morbidity and mortality compared with normal BMI, also known as the obesity paradox. There- fore, we sought to determine the existence of the obesity paradox in regard to perioperative 30-day cardiac events among elderly Chinese patients with known coronary artery disease undergoing non-cardiac surgery. Methods A post-hoc analysis of a prospective, multi-institutional cohort study was performed. Patients aged 〉 60 years with a history of coronary artery disease and undergoing non-cardiac surgery were grouped according to BMI： underweight （〈 18.5 kg/m2）, normal weight （18.5-24.9 kg/m2）, overweight （25-29.9 kg/m2） and obese （≥ 30 kg/m2）. Demographic information, perioperative clinical variables and incidence of 30-day postoperative cardiac adverse event were retrieved from a research database. Results We identified 1202 eligible patients （BMI： 24.3 ± 3.8 kg/m2）. Across BMI groups, a U-shaped distribution pattern of incidence of 30-day postoperative major cardiac events was observed, with the lowest risk in the overweight group. When using the normal-weight group as a reference, no difference was found in either the obesity or overweight groups in terms of a major cardiac adverse event （MACE）. However, risk of a 30-day postoperative MACE was significantly higher in the underweight group （odds ratio [oR] 2.916, 95% confidence interval [CI]： 1.072-7.931, P = 0.036）. Conclusion Although not statistically significant, the U-shaped relation between BMI and cardiac complications indicates the obesity paradox possibly exists.

关键词： Body mass index Major cardiac event Non-cardiac surgery The elderly