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CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of pKm supports antitumor immunity

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Cellular & molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand p.Sharda mackenzie m.Lieberman Caitlin m.James Shivana m.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew m.Intlekofer Richard m.Higashi Teresa W.m.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin p.Lee Scott H.olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human oncology and pathogenesis program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA present address:University of Colorado Boulder BoulderCO 80309USA present address:Dana Farber Cancer Institute BostonMA 02215USA present address:massachusetts Institute of Technology BostonMA 02139USA present address:melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the m1 isoform of pyruvate kinase in favor of pKm2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,pKm alternative splicing occurred independently of CD28-driven pI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 pKm2

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Jianpi Decoction Combined with medroxyprogesterone Acetate Alleviates Cancer Cachexia and prevents muscle Atrophy by directly Inhibiting E3 Ubiquitin Ligase

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Chinese Journal of Integrative medicine 2024年第6期30卷 499-506页

作者： LI Qi KoNG Zhao-di WANG Huan GU Hong-hui CHEN Zhong Li Shi-guang CHEN Yi-qi CAI Yu YANG Zhen-jiang Department of oncology and Hematology Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong Province518033China College of pharmacy/International Cooperative Laboratory of Traditional Chinese medicine modernization and Innovative Drug Development of ministry of Education(moE)of China Jinan UniversityGuangzhou510632China Guangdong Key Lab of Traditional Chinese medicine Information Technology Jinan UniversityGuangzhou510632China

objectiveTo provide comprehensive evidence for the anti-cancer cachexia effect of Jianpi Decoction(Jp)and to explore its mechanism of anti-cancer *** mouse model of colon cancer(CT26)-induced cancer cachexia(CC)was used to investigate the anti-CC effect of Jp combined with medroxyprogesterone acetate(mpA).Thirty-six mice were equally divided into 6 groups:normal control,CC,mpA(100 mg·kg^(−1)·d^(−1)),mpA+low-dose(20 mg·kg^(−1)·d^(−1))Jp(L-Jp),mpA+medium-dose(30 mg·kg^(−1)·d^(−1))Jp(m-Jp),and mpA+high-dose(40 mg·kg^(−1)·d^(−1))Jp(H-Jp)*** successful modeling,the mice were administered by gavage for 11 *** body weight and tumor volume were measured and recorded every 2 d starting on the 8th day after *** liver,heart,spleen,lung,kidney,tumor and gastrocnemius muscle of mice were collected and *** pathological changes of the tumor was observed,and the cross-sectional area of the gastrocnemius muscle was *** protein expressions of STAT3 and E3 ubiquitinase in the gastrocnemius muscle were measured by Western *** addition,an in vitro C2C12 myotube formation model was established to investigate the role of Jp in hindering dexamethasone-induced muscle *** vitro experiments were divided into control,model,and Jp serum *** 2-d administration,microscopic photographs were taken and myotube diameters were *** blot was performed to measure the protein expressions of STAT3 and E3 *** combined with mpA restored tumor-induced weight loss(pmuscle fiber size(pmechanistically,Jp reduced the expression of atrophy-related proteins muRF1 and mAFbx in tumor-induced muscle atrophy in vivo(pdition,Jp reduced the expression of atrophy-related proteins muRF1 and mAFbx and p-STAT3 phosphorylation(por poup)in C2C12 myotubes treated with dexamethasone in *** of Jp combined with mpA restores t

关键词： cancer cachexia muscle atrophy Jianpi Decoction Chinese medicine E3 ubiquitin ligases

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profile of SARS-CoV-2 Infected patients Hospitalized at the Epidemic Treatment Center (ETC) in Saint-Louis, Senegal during the First Two Waves

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Advances in Infectious diseases 2024年第2期14卷 322-337页

作者： Alassane dièye papa Latyr Junior diouf Bourama diémé moustapha diedhiou diatou dia-Gueye Amadou diop dia Samba Niang Ibrahima Louis martin dieng Ameth dieng Seynabou Lô Ndéye méry dia-Badiane Health Sciences Training and Research Unit Gaston Berger University Saint-Louis Senegal Emergency Department of Regional Hospital Center Saint-Louis Senegal Department of Infectious and Tropical diseases of Fann Dakar Senegal

Introduction: The SARS-CoV-2 infection is a major public health emergency. Several risk factors are involved in the occurrence of respiratory distress that can lead to death despite resuscitation measures. objectives: The aim of this study was to describe the epidemiological, clinical, paraclinical, therapeutic, and evolution profile of patients infected with SARS-CoV-2 hospitalized at the CTE of Saint-Louis (Senegal) during the first two waves. patients and methods: We conducted a retrospective, cross-sectional, descriptive, and analytical study that included all patients hospitalized at the ETC of Saint-Louis (Senegal) with SARS-CoV-2 infection from march 2020 to April 2021. Results: A total of 358 cases were collected, 256 (71.5%) during the first wave and 102 (28.5%) during the second wave. The mean age was 49.5 years (19.5). There was a male predominance (58.4%), with a sex ratio of 1.4. Hypertension was the main comorbidity, with 87 cases (24.3%). The most common functional signs were cough in 194 cases (54.2%), dyspnea in 143 cases (40%) and ageusia in 134 cases (37.4%). Thoracic CT scans were performed on 20 patients (5.6%), with severe involvement (50% - 75%) observed in 50% of cases. Hydroxychloroquine-azithromycin was prescribed to 351 patients (98%). overall, 338 (94.4%) recovered and 17 (4.7%) died. In multivariate analysis, factors associated with death were male sex [oR = 2.645;95% CI: 1.530 - 4.785;p = 0.011], age 60 years [oR = 1.039;95% CI: 0.564 - 1.914;p = 0.002], the presence of comorbidities [oR = 2.171;95% CI: 0.564 - 3.429;p = 0.033], Spo2 (ambient air) 95% [oR = 2.061;95% CI: 0.616 - 3.827;p = 0.03], acute respiratory distress syndrome (ARDS) [oR = 0.635;95% CI: 0.316 - 1.275;p = 0.001], severe form [oR = 1.664;95% CI: 0.298 - 2.478;p = 0.016], occurrence of complications [oR = 0.521;95% CI: 0.287 - 0.944;p = 0.032], high creatinine levels [oR = 2.061;95% CI: 1.616 - 3.827;p = 0.026], and lymphopenia [oR = 0.485;95% CI: 0.370 - 0.636;p = 0.0

关键词： SARS-CoV-2 Saint-Louis Senegal

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Development and performance evaluation of a culture-independent nanopore amplicon-based sequencing method for accurate typing and antimicrobial resistance profiling in Neisseria gonorrhoeae

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Science China(Life Sciences) 2024年第2期67卷 421-423页

作者： Chi Zhang Lulu Zhang Feng Wang Yaling Zeng Liying Sun di Wang Yamei Li Liqin Wang Junping peng NHC Key Laboratory of Systems Biology of pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100176China Key Laboratory of Respiratory disease pathogenomics Chinese Academy of Medical SciencesBeijing 100730China Shenzhen Center for Chronic disease Control Shenzhen 518020China

Dear Editor,Bacterial antimicrobial resistance(AmR)poses a serious threat to global human health(Antimicrobial Resistance Collaborators,2022).Comprehensive profiling of AmR and accurate molecular typing are important for tracking and controlling the emergence and dissemination of antibiotic-resistant bacteria(Yahara et al.,2021).We previously developed a multiplex amplicon sequencing-based method for directly sequencing AmR-related loci in *** from clinical samples(Zhang et al.,2021).

关键词： gonorrhoeae resistance

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Impact of CoVID-19-related lifestyle changes on diabetic macular edema

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International Journal of ophthalmology(English edition) 2024年第1期17卷 97-106页

作者： Bryce p.Johnson Yu-Guang He Zachary m.Robertson Angeline Wang Rafael L.Ufret-Vincenty Department of ophthalmology UT Southwestern Medical CenterDallasTexas 75390-9057USA

AIm:To assess diabetic macular edema(DmE)progression during the early phases of the CoVID-19 pandemic,when severe societal restrictions raised the concern of possible deterioration of health in patients with systemic conditions,particularly those requiring frequent office ***:This is a multicenter retrospective chart review of 370 patients(724 eyes)with an established diagnosis of DmE seen on 3 separate visits between January 2019 and July *** 1 was January 2019 to February 2020(considered pre-CoVID-19),period 2 was march 2020 to December 2020(considered the height of the pandemic;highest level of pandemic-related clinical and societal regulations)and period 3 was January 2021 to July 2021(re-adjustment to the new“pandemic norms”).main outcome measures included visual acuity,body mass index(BmI),blood pressure(Bp),hemoglobin A1c(HbA1c),macular thickness,patient adherence to scheduled ophthalmology visits,and DmE treatment(s)received at each *** facilitate measurement of macular thickness,each macula was divided into 9 Early Treatment diabetic Retinopathy Study(ETDRS)-defined macular sectors as measured by oCT ***:There was no change of BmI,systolic Bp,and diastolic Bp between any of the time ***1c showed a very small increase from period 1(7.6%)to period 2(7.8%,p=0.015)and decreased back to 7.6%at period 3(p=0.12).macular thickness decreased for 100%of macular *** central macular thickness decreased across all 3 periods from 329.5 to 316.6μm(p=0.0045).After analysis of multiple variables including HbA1c,BmI,adherence to scheduled appointments,different clinic centers,and treatment interventions,there was no easily identifiable subgroup of patients that experienced the increase in ***:DmE doesn’t worsen during the CoVID-19 pandemic,instead sustaining a very small but statistically significant *** identifying a mechanism behind our findings is beyond the scope of this study,potential explanat

关键词： CoVID-19 diabetic macular edema diabetic retinopathy optical coherence tomography

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Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression

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Neural Regeneration Research 2024年第12期19卷 2750-2759页

作者： Fahaid H.A.L-Hashem Salah o.Bashir Amal F.Dawood moutasem S.Aboonq Ismaeel Bin-Jaliah Abdulaiziz m.Al-Garni mohamed D.morsy Department of physiology College of MedicineKing Khalid UniversityAbhaSaudi Arabia Department of Basic medical Sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of physiology College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia Department of medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

memory loss and dementia are major public health concerns with a substantial economic *** stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory *** investigate whether the antioxidant and anti-inflammatory compound vanillyla cetone(zingerone) can protect against hippocampal damage and memory loss induced by cadmium chloride(CdCl_(2)) administration in rats,we explo red the potential involvement of the nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathway,which is known to modulate oxidative stress and *** healt hy male Wistar rats were divided into five groups:vehicle-treated(control),vanillylacetone,CdCl_(2),vanillylacetone+ CdCl_(2),vanillylacetone+ CdCl_(2)+ brusatol(a selective pharmacological N rf2inhibitor) *** effectively attenuated CdCl_(2)-induced damage in the dental gyrus of the hippocampus and improved the memory function assessed by the morris Water maze ***,vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers(interleukin-6,tumor necrosis factor-α,intracellular cell adhesive molecules) and apoptosis biomarkers(Bax and cleaved caspase-3).The control and CdCl_(2)-treated groups treated with va nillylacetone showed reduced generation of reactive oxygen species,decreased malondialdehyde levels,and increased superoxide dismutase and glutathione activities,along with significant elevation of nuclear Nrf2 mRNA and protein expression in hippocampal *** the protective effects of vanillylacetone we re substantially blocked by the co-administration of brusatol(a selective N rf2 inhibitor).Va nillylacetone mitigated hippocampal damage and memory loss induced by CdCl_(2),at least in part, by activating the nuclear transcription factor ***,vanillylacetone exerted its potent antioxidant and antiinflammatory actions.

关键词： hippocampus neuroprotective Nrf2 gene oxidative stress vanillylacetone

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In vivo and in vitro study of resorbable magnesium wires for medical implants:mg purity,surface quality,Zn alloying and polymer coating

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Journal of magnesium and Alloys 2024年第6期12卷 2472-2488页

作者： K.Tesar J.Luňácková m.Jex m.Žaloudková R.Vrbová m.Bartoš p.Klein L.Vištejnová J.Dušková E.Filová Z.Sucharda m.Steinerová S.Habr K.Balík A.Singh Department of materials Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Institute of physics Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Institute of Dental medicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic Department of physics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic Department of Composites and Carbon materials Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Institute of Anatomy First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biomedical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic Department of pathological physiology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Department of Histology and Embryology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Institute of pathology First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic Department of Biomaterials and Tissue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Research Center for Structural materials National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone ***,localized corrosion and H_(2)generation limit the potential of mg-based *** low-alloyed mg-Zn wires can strongly reduce problems with large H_(2)bubbles and improve the mechanical properties considerably while maintaining excellent long-term *** pickling and a polymer coating can be effectively used to lower the rate of in vivo *** this work,microstructural,mechanical,and in vitro characterization of 250μm and 300μm extruded wires made from ultra-pure mg,commercially pure mg,mg-0.15Zn,mg-0.4Zn and mg-1Zn was ***,mg-0.4Zn wires together with a variant coated with a copolymer of L-lactide andε-caprolactone were tested in vivo on artificially damaged Wistar rat *** on the observed mg-induced osteogenesis,polymer-coated mg wires with a small addition of Zn are a perspective material for bone-support applications,such as cerclage and fixation wires.

关键词： magnesium Resorbable mg wire mg-Zn implant degradation Biocompatibility study Zn grain boundary segregation

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organic-inorganic hybrid materials and architectures in optoelectronic devices: Recent advancements

ChemPhysMater

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Chemphysmater 2024年第3期3卷 252-272页

作者： m.Arya S.Heera p.meenu K.G.Deepa Department of physics University of KeralaThiruvananthapuram 695581India Department of Nanoscience and Nanotechnology University of KeralaThiruvananthapuram 695581India

organic-inorganic hybrids are next-generation materials for use in high-performance optoelectronic devices owing to their adaptabilities in terms of design and *** article reviews the application of hybrid materials and layers in several widely used optoelectronic devices,i.e.,light amplification by stimulated emission of radiation(LASER),solar cells,and light-emitting diodes(LEDs).The effects of the incorporation of inorganic particles on photostability and optical gain are analyzed in the first section with reference to dye and perovskite ***,the strategies used in blending inorganic nanostructures into organic solar cells and bulk heterojunctions are *** use of various organic layers as electron-and hole-transport materials in Si heterojunction solar cells is reviewed in ***,the benefits of the presence of organic components in quantum-dot-and perovskite-based LEDs are derived from the *** integration of organic and inorganic components with optimal interfaces and morphologies is a challenge in developing hybrid materials with improved efficiencies.

关键词： optoelectronics Hybrid material Device performance photostability Advantages

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pyrolysis behaviour and kinetic analysis of waste polylactic acid composite reinforced with reed straw processing residue

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Carbon Resources Conversion 2024年第3期7卷 74-83页

作者： Bo Chen Sen ma Sachin Kumar Zhitong Yao Wanqi Feng Jianbo Zhao Xu Zhang di Cai Hui Cao Ian Watson Systems Power and Energy Research DivisionJames Watts School of EngineeringCollege of Science and EngineeringJames Watt SouthUniversity of GlasgowGlasgow G128QQUnited Kingdom College of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029PR China College of Energy State Key Laboratory of Physical Chemistry of Solid SurfacesXiamen UniversityXiamen 361102PR China Department of Energy Engineering Centre of Excellence-Green and Efficient Energy Technology(CoE-GEET)Central University of JharkhandRanchi 835205India College of materials Science and Environmental Engineering Hangzhou Dianzi UniversityHangzhou 310018PR China College of Chemistry and Chemical Engineering Tarim UniversityAlarXinjiang 843300PR China National Energy R&D Center for Biorefinery Beijing University of Chemical TechnologyBeijing 100029PR China

The lignocellulose reinforced composites are commonly used sustainable materials with good mechanical and physical *** to properly dispose and recover the potential value of discarded lignocellulose reinforced composites,the pyrolysis behaviour and kinetics of reed straw processing residual/polylactic acid(RSpR/pLA)composites,a typical 3D printing material,was *** on the TG-FTIR results,the synergistic effects between RSpR and pLA during the pyrolysis process were *** with the FTIR spectra of pLA,the absorption peaks of Co and Co_(2)disappear in the FTIR spectra of RSpR/pLA composite,which indicates RSpR provides additional free radicals for the free radical reaction of pLA,and further promoting the *** apparent activation energy of the RSpR/pLA composite pyrolysis was calculated by two iso-conversional methods including Flynn-Wall-ozawa(FWo)and Kissinger-Akahira-Sunose(KAS).The average Ea of the RSpR/pLA composite(122.6 kJ mol^(-1)(FWo)and 117.9 kJ mol^(-1)(KAS))was lower than that of solo pyrolysis of RSpR(138.5 kJ mol^(-1)(FWo)and 135.4 kJ mol^(-1)(KAS))and the pure pLA(197.0 kJ mol^(-1)(FWo)and 196.6 kJ mol^(-1)(KAS)).The master plot method results suggested the pyrolysis of RSpR/pLA composite followed the one-dimensional(D1)diffusion *** work provides an environmentally friendly strategy to effective thermo-chemical upgrading of the value of discarded lignocellulose reinforced composite material.

关键词： Biobased composite pyrolysis conversion Synergy Bio-oil Reaction kinetics

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Effects of fertilization on radial growth of pinus pinea explored hourly using dendrometers

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Ecological processes 2024年第1期 25-39页

作者： Verónica Loewe-mu?oz Rodrigo del Río millar Claudia Delard Rodriguez mónica Balzarini Chilean Forest Institute (INFoR) Metropolitan Office Centro Nacional de Excelencia para la Industria de la madera(CENAmAD) Pontificia Universidad Católica de Chile Consejo Nacional de Investigaciones Científicas y Técnicas (CoNICET ) Universidad Nacional de Córdoba Ciudad Universitaria

Background Stone pine(pinus pinea), a drought-resistant species, has significant socio-economic benefits and increasing interest for the establishment of productive plantations in several countries, especially in a climate change context. monitoring hourly stem diameter variations contributes to the understanding of the tree-growth response to changes in environmental conditions and management. By monitoring the diameter expansion of tree stems, high-resolution band dendrometers were used to study the development of adult trees growing in a semi-arid coastal environment of central Chile under fertilized and non-fertilized soil conditions through the span of a *** Short cycles(on-fertilized trees(6 and 4, respectively), whereas long cycles(> 28 h) occurred at a higher frequency in fertilized trees(16 vs 6). most of the circadian cycles were regular(24 ± 3 h). The longest cycle duration(59 h) was observed in fertilized trees during spring. In all seasons, each phase of the circadian cycle, especially during the stem diameter increment phase(p3, irreversible growth), started earlier in fertilized than in control trees. p3 duration was significantly longer in fertilized than in control trees in springtime. The maximum shrinkage(p1) was observed in summer for both treatments. Stem diameter increased faster in fer-tilized than in control trees throughout the year, with the highest accumulation occurring in spring and the lowest in autumn. The daily variability pattern showed lower growth under high temperature across *** This study highlights the importance of fertilization in enhancing stone pine diameter growth. This cultural practice should be further explored to contribute to the mitigation of climate change effects in semi-arid environments.

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