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Study on the structure and composition of aortic valve calcific deposits:Etiological aspects

Journal of Biophysical Chemistry 2011年第1期2卷 19-25页

作者： Rafael.M.Prieto I.Gomila o.Sohnel A.Costa-Bauza o.bonnin Felix Grases Laboratory of Renal Lithiasis Research University Institute of Health Sciences Research(IUNICS)University of Balearic IslandsPalma of MallorcaSpain CIBER Fisiopatología obesidad y Nutricion(CB06/03) Instituto de Salud Carlos IIIMadridSpain University of J.E.Purkyne Faculty of Environmental StudiesUsti n.L.Czech Republic University Hospital Son Dureta Palma of MallorcaSpain

The structures and chemical compositions of valve calcific deposits were investigated. The deposits was chosen arbitrarily and subjected to chemical analysis, observation with scanning microscope, semi-quantitative determination of Ca, Mg, Na, K, P and C elements by energy dispersive X-ray, X-ray diffraction and Fourier transform infrared spectroscopy carried out. These deposits were found to have non-uniform internal structures composed of layers of a structureless aspidinic inorganic material, substantial amounts of voluminous organic material and in a few samples small spheres were also present. Two groups of deposits with distinctly different chemical compositions were identified: one group with a low Ca/P molar ratio (1.59) and the other group with a high (1.82) Ca/P molar ratio. The deposits belonging to the group with a low Ca/P molar ratio contain higher concentration of magnesium and consist of increased amount of amorphous calcium phosphate. The deposits with a high Ca/P molar ratio contain low concentration of magnesium and consist predominantly of carbonated hydroxyapatite. The inorganic material was identified as a poorly crystalline carbonate hydroxyapatite containing molecular water of the average formula Ca9.1Mg0.4(Na,K)(Po4)5.8(Co3)0.3(oH)2. The actual chemical composition of the apatitic solid phase varies not only from deposit to deposit but also within the same deposit. The non-uniform internal structure of the deposits, the occasional presence of spherical particles and the variable point composition of the individual deposits indicate that their formation did not proceed under more or less constant conditions.

关键词： Mitochondrial Swelling Cytochrome C Release Calcium Alloxan Mitochondrial Permeability Transition

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Effects of some parameters on the divertor plasma sheath characteristics and fuel retention in castellated tungsten tile gaps

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Chinese Physics B 2014年第11期23卷 403-409页

作者：桑超峰戴舒宇孙继忠 bonnin Xavier 徐倩丁芳王德真 Key Laboratory of Materials Modification by Laser Ion and Electron Beams (Ministry of Education)School of Physics and Optoelectronic Engineering Dalian University of Technology LSPM-CNRS Universit Paris 13 Sorbonne Paris Cit Villetaneuse 93430 France Institute of Plasma Physics Chinese Academy of Sciences

Castellation of plasma facing components is foreseen as the best solution for ensuring the lifetime of future fusion devices. However, the gaps between the resulting surface elements can increase fuel retention and complicate fuel removal issues. To know how the fuel is retained inside the gaps, the plasma sheath around the gaps needs to be understood first. In this work, a kinetic model is used to study plasma characteristics around the divertor gaps with the focus on the H＋ penetration depth inside the poloidal gaps, and a rate-theory model is coupled to simulate the hydrogen retention inside the tungsten gaps. By varying the magnetic field strength and plasma temperature, we find that the H＋ cyclotron radius has a significant effect on the penetration depth. Besides, the increase of magnetic field inclination angle can also increase the penetration depth. It is found in this work that parameters as well as the penetration depth strongly affect fuel retention in tungsten gaps.

关键词： divertor gaps penetration depth plasma sheath fuel retention

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A Concept of Dynamically Reconfigurable Real-time Vision System for Autonomous Mobile Robotics

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International Journal of Automation and computing 2008年第2期5卷 174-184页

作者： Aymeric De Cabrol Thibault Garcia Patrick bonnin Maryline Chetto L2TI Université Paris 1399 avenue JB Clément93 430 Villetaneuse IRCCyN 1 rue de la No■BP 92 10144321 Nantes CEDEX 03

This paper describes specific constraints of vision systems that are dedicated to be embedded in mobile robots. If PC-based hardware architecture is convenient in this field because of its versatility, flexibility, performance, and cost, current real-time operating systems are not completely adapted to long processing with varying duration, and it is often necessary to oversize the system to guarantee fail-safe functioning. Also, interactions with other robotic tasks having more priority are difficult to handle. To answer this problem, we have developed a dynamically reconfigurable vision processing system, based on the innovative features of Cleopatre real-time applicative layer concerning scheduling and fault tolerance. This framework allows to define emergency and optional tasks to ensure a minimal quality of service for the other subsystems of the robot, while allowing to adapt dynamically vision processing chain to an exceptional overlasting vision process or processor overload. Thus, it allows a better cohabitation of several subsystems in a single hardware, and to develop less expensive but safe systems, as they will be designed for the regular case and not rare exceptional ones. Finally, it brings a new way to think and develop vision systems, with pairs of complementary operators.

关键词： Real-time vision dynamic reconfiguration embedded systems robustness real-time operating system

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Gene expression changes in blood RNA after swimming in a chlorinated pool

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Journal of Environmental Sciences 2017年第8期29卷 250-261页

作者： Lucas A.Salas Laia Font-Ribera Mariona Bustamante Lauro Sumoy Joan o.Grimalt Sarah bonnin Maria Aguilar Heidi Mattlin Manuela Hummel Anna Ferrer Manolis Kogevinas Cristina M.Villanueva ISGlobal Centre for Research in Environmental Epidemiology(CREAL)Barcelona Spain Department of Epiderniology The Geisel School of Medicine at Dartmouth Lebanon NH USA Universitat Pompeu Fabra (UPF) Barcelona Spain CIBER Epiclemiologia y Salud Publica (CIBERESP) Barcelona Spain IMIM (Hospital del Mar Medical Research Institute) Barcelona Spain Genomics and Disease Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology Barcelona Spain Genomics Core Facility Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology Barcelona Spain Institute of Predictive and Personalized Medicine of Cancer (IMPPC) Institut Germans Trias i Pujol (IGTP) Can Ruti Campus Badalona Spain Department of Environmental Chemistry Institute of Environmental Assessment and Water Research (CSIC) Barcelona Spain

Exposure to disinfection by-products（DBP） such as trihalomethanes（THM） in swimming pools has been linked to adverse health effects in humans, but their biological mechanisms are unclear. We evaluated short-term changes in blood gene expression of adult recreational swimmers after swimming in a chlorinated pool. Volunteers swam 40 min in an indoor chlorinated pool. Blood samples were drawn and four THM（chloroform,bromodichloromethane, dibromochloromethane and bromoform） were measured in exhaled breath before and after swimming. Intensity of physical activity was measured as metabolic equivalents（METs）. Gene expression in whole blood m RNA was evaluated using Illumina Human HT-12v3 Expression-Bead Chip. Linear mixed models were used to evaluate the relationship between gene expression changes and THM exposure. Thirty-seven before-after pairs were analyzed. The median increase from baseline to after swimming were： 0.7 to 2.3 for MET, and 1.4 to 7.1 μg/m^3 for exhaled total THM（sum of the four THM）.Exhaled THM increased on average 0.94 μg/m^3 per 1 MET. While 1643 probes were differentially expressed post-exposure. of them, 189 were also associated with exhaled levels of individual/total THM or MET after False Discovery Rate. The observed associations with the exhaled THM were low to moderate（Log-fold change range：-0.17 to 0.15）. In conclusion, we identified short-term gene expression changes associated with swimming in a pool that were minor in magnitude and their biological meaning was unspecific. The high collinearity between exhaled THM levels and intensity of physical activity precluded mutually adjusted models with both covariates. These exploratory results should be validated in future studies.

关键词： Trihalomethanes Disinfection by-products Gene expression Swimming pools Metabolic rate

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In vitro gastrointestinal digestion study of two wheat cultivars and evaluation of xylanase supplementation

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Journal of Animal Science and Biotechnology 2015年第3期6卷 355-368页

作者： Mickael Lafond Bernard Bouza Sandrine Eyrichine Friedrich Rouffineau Luc Saulnier Thierry Giardina Estelle bonnin Aurélie Preynat iSm2-BiosCiences UMR 7313 Aix Marseille Université Adisseo France S.A.S. Centre d'Expertise et de Recherche en Nutrition INRA UR 1268-BiopolymeresInteractions-Assemblages

Background： The filamentous fungus Talaromyces versatifis is known to improve the metabolizable energy of wheat- based poultry diets thanks to its ability to produce a pool of CAZymes and particularly endo-β（1,4）-xylanases. In order to appreciate their in vivo mode of action, the supplementation effect of two of its xylanases, XynD and XynB from families GH10 and GHll respectively, have been evaluated on two different wheat cultivars Caphorn and Isengrain, which were chosen amongst 6 varieties for their difference in non starch polysaccharides content and arabinoxylan composition. Results： Polysaccharides digestion was followed during 6 h along the digestive tract using the TNo gastrointestinal model-1, to mimic monogastric metabolism. Polysaccharide degradation appeared to occur mainly at the jejunal level and was higher with Isengrain than with Caphorn. For both cultivars, XynD and XynB supplementation increased notably the amount of reducing end sugars into the jejuno-ileal dialysates, which has been confirmed by a valuable increase of the soluble glucose into the jejunal dialysates. Conclusions： The amounts of arabinose and xylose into the dialysates and ileal deliveries increased consequently mainly for Caphorn, suggesting that XynD and XynB supplementation in wheat-based diet could alleviate the anti-nutritional effects of arabinoxylans by limiting the physical entrapment of starch and could increase the available metabolizable energy.

关键词： in vitro TNo gastrointestinal model-1 Talaromyces versatilis Wheat cultivars XynB XynD

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上山下乡运动再评价

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社会学研究 2005年第5期20卷 154-181页

作者：潘鸣啸法国社会科学高等研究院近代现代中国研究中心

上山下乡运动作为一场大规模的社会试验,以往外国学者的研究都将解决城市就业和人口问题作为领导人发动这场运动的动机。现在可参考的资料并不支持这种似乎合理的解释,因为正是在城镇青年下放的同时,发生了大规模的城乡劳动力的对流。... 详细信息

上山下乡运动作为一场大规模的社会试验,以往外国学者的研究都将解决城市就业和人口问题作为领导人发动这场运动的动机。现在可参考的资料并不支持这种似乎合理的解释,因为正是在城镇青年下放的同时,发生了大规模的城乡劳动力的对流。本文重点分析了1968至1980年的上山下乡运动,认为毛泽东防止修正主义的意识形态和建立政治新秩序的动机起了最关键的作用。但是这个政策并没有取得预想的成功。它没有得到知青和他们的父母的拥护,从70年代末开始,公开的抵制出现,最终以上山下乡政策的结束而告终。虽然这场运动的确培养了很独特的一代,但是下乡城市青年没有变成“社会主义新农民”,他们中的大部分人没有获得正常的教育机会。这对他们,对国家都是很重大的损失。

关键词： “上山下乡运动” 1968—1980年中国政治运动人口迁移知识青年

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Association of colorectal cancer with pathogenic Escherichia coli: Focus on mechanisms using optical imaging

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World Journal of Clinical oncology 2016年第3期7卷 293-301页

作者： Julie Veziant Johan Gagnière Elodie Jouberton Virginie bonnin Pierre Sauvanet Denis Pezet Nicolas Barnich Elisabeth Miot-Noirault Mathilde Bonnet UMR1071 Inserm/Université d’Auvergne and INRA USC2018 Clermont Université Service de Chirurgie Digestive Centre Hospitalier Universitaire UMR990 Inserm/Université d’Auvergne Clermont Université Service de Médecine Nucléaire Centre Jean Perrin

AIM: To investigate the molecular or cellular mechanisms related to the infection of epithelial colonic mucosa by pks-positive Escherichia coli(E. coli) using optical ***: We choose to evaluate the tumor metabolic activity using a fluorodeoxyglucose analogue as 2-deoxyglucosone fluorescent probes and to correlate it with tumoral volume(mm^3). Inflammation measuring myeloperoxidase(MPo) activity and reactive oxygen species production was monitored by a bioluminescent(BLI) inflammation probe and related to histological examination and MPo levels by enzyme-linked immunosorbent assay(ELISA) on tumor specimens. The detection and quantitation of these two signals were validated on a xenograft model of human colon adenocarcinoma epithelial cells(HCT116) in nude mice infected with a pks-positive E. coli. The inflammatory BLI signal was validated intra-digestively in the colitisCEABAC10 DSS models, which mimicked Crohn's disease. RESULTS: Using a 2-deoxyglucosone fluorescent probe, we observed a high and specific HCT116 tumor uptake in correlation with tumoral volume(P = 0.0036). Using the inflammation probe targeting MPo, we detected a rapid systemic elimination and a significant increase of the BLI signal in the pks-positive E. coli-infected HCT116 xenograft group(P onfirmed that MPo levels were significantly higher(1556 ± 313.6 vs 234.6 ± 121.6 ng/m L P = 0.001) in xenografts infected with the pathogenic E. coli strain. Moreover, histological examination of tumor samples confirmed massive infiltration of pks-positive E. coli-infected HCT116 tumors by inflammatory cells compared to the uninfected group. These data showed that infection with the pathogenic E. coli strain enhanced inflammation and RoS production in tumors before tumor growth. Moreover, we demonstrated that the intra-digestive monitoring of inflammation is feasible in a reference colitis murine model(CEABAC10/DSS).CoNCLUSIoN: Using BLI and fluorescence optical imaging, we provided

关键词： Colorectal carcinoma Escherichia coli Colibactin Myeloperoxidase In vivo optical imaging

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失落的一代

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作者： (法)潘鸣啸(Michel bonnin)

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Sildenafil and neuronal protection after neonatal hypoxia-ischemia

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中华物理医学与康复杂志 2014年第6期36卷 444-444页

作者： Charriaut-Marlangue C Nguyen T bonnin P

BACKGRoUND AND oBJECTIVE Neonatal hypoxia-ischemia(HI)is one of the most common causes of severe neurologic handicap among *** decreased cerebral blood flow during reperfusion in the first 12 to 24 hours indicates a p... 详细信息

关键词：缺氧缺血性脑病西地那非新生儿神经元磷酸二酯酶保护系统障碍 cGMP

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Congenital Cytomegalovirus Infection and Maternal Varicella during *** There a Coincidence?A Case Report

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open Journal of obstetrics and Gynecology 2019年第9期9卷 1221-1225页

作者： Claire Périllaud-Dubois Elise Bouthry Francois-Charles Javaugue Alexandra Letourneau Aurore bonnin Emmanuelle Letamendia Christelle Vauloup-Fellous AP-HP WHO Rubella National Reference LaboratoryDepartment of VirologyPaul-Brousse HospitalVillejuifFrance Groupe de Recherche sur les Infections pendant la Grossesse(GRIG) ParisFrance IAME INSERM UMR1137University Paris DiderotParisFrance AP-HP Service de Gynécologie-ObstétriqueAntoine Béclère HospitalClamartFrance AP-HP Service de NéonatologieAntoine Béclère HospitalClamartFrance INSERM U1193 University Paris SudVillejuifFrance

Background: Co-infections may represent substantial diagnostic and treatment challenges. Aim: To the better of our knowledge, we describe the first case in the literature of congenital Cytomegalovirus (CMV) infection following maternal CMV non primary infection contemporary to varicella during pregnancy. Case Presentation: A pregnant woman had a varicella during her pregnancy. Congenital CMV infection was fortuitously discovered in the neonate owing to a universal CMV screening. Retrospective analysis of maternal serums during pregnancy showed CMV reactivation. We aim to highlight that CMV reactivation could be due to varicella and discuss if it could facilitate the transplacental transmission of CMV. Conclusion: This case report emphasizes neonatal CMV screening, and warns against dual maternal infection especially because this may be at particular risk of transmission to the fetus.

关键词： cCMV VZV Intercurrent Infection Asymptomatic Congenital CMV Infection

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