Congenital Cytomegalovirus Infection and Maternal Varicella during *** There a Coincidence?A Case Report

作     者：Claire Périllaud-Dubois Elise Bouthry Francois-Charles Javaugue Alexandra Letourneau Aurore Bonnin Emmanuelle Letamendia Christelle Vauloup-Fellous 

作者机构：AP-HPWHO Rubella National Reference LaboratoryDepartment of VirologyPaul-Brousse HospitalVillejuifFrance Groupe de Recherche sur les Infections pendant la Grossesse(GRIG)ParisFrance IAMEINSERM UMR1137University Paris DiderotParisFrance AP-HPService de Gynécologie-ObstétriqueAntoine Béclère HospitalClamartFrance AP-HPService de NéonatologieAntoine Béclère HospitalClamartFrance INSERM U1193University Paris SudVillejuifFrance 

出 版 物：《Open Journal of Obstetrics and Gynecology》 (妇产科期刊（英文）)

年 卷 期：2019年第9卷第9期

页      面：1221-1225页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：cCMV VZV Intercurrent Infection Asymptomatic Congenital CMV Infection 

摘      要：Background: Co-infections may represent substantial diagnostic and treatment challenges. Aim: To the better of our knowledge, we describe the first case in the literature of congenital Cytomegalovirus (CMV) infection following maternal CMV non primary infection contemporary to varicella during pregnancy. Case Presentation: A pregnant woman had a varicella during her pregnancy. Congenital CMV infection was fortuitously discovered in the neonate owing to a universal CMV screening. Retrospective analysis of maternal serums during pregnancy showed CMV reactivation. We aim to highlight that CMV reactivation could be due to varicella and discuss if it could facilitate the transplacental transmission of CMV. Conclusion: This case report emphasizes neonatal CMV screening, and warns against dual maternal infection especially because this may be at particular risk of transmission to the fetus.