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Biomedical and Environmental Sciences 2010年第4期23卷 287-292页

作者： WEN-JUAN MA JUN-JIE WANG KATHLEEN-H. reilly AI-MEI BI GUo-WEI DING KUMI SMITH NING WANG School of Public Health Peking Union Medical College Tsinghua University Beijing 100730 China National Center for AIDS/STD Control and Prevention Beijing 102206 China Tulane University Health Sciences Center School of Public Health and Tropical Medicine New Orleans LA USA Kaiyuan Center for Disease Control and Prevention Kaiyuan 661600 Yunnan China University of North Carolina at Chapel Hill Chapel Hill NC USA

objective To estimate the probability of unprotected heterosexual vaginal transmission of HIV-1 from clients to Female Sex Workers （FSWs） in Kaiyuan County, Yunnan province, China, and analyze factors which impact the transmission probability. Methods An open cohort research of FSWs in Kaiyuan was created from surveys conducted in April 2008, october 2008, and April 2009. Two cross-sectional surveys of local clients were also carried out in May 2008 and November 2008. A model was developed to estimate the probability of unprotected heterosexual vaginal transmission of HIV-1 from clients to FSWs. Results The transmission probability from clients to FSWs was estimated as 0.0023 [95% CI 0.0014-0.0032] per unprotected heterosexual act. Conclusion The transmission probability among this group engaging in commercial sex in Yunnan province differs from that found in studies from other countries, and future studies should estimate the influence factors of HIV-1 transmission probability, such as stage of HIV infection, co-morbid sexually transmitted infections （STIs）.

关键词： Transmission Probability HIV/AIDS Model FSW Clients

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镜子背后

疯狂英语（初中天地） 2007年第3期 29-31页

作者： Laura reilly Darren

当我还是一个小女孩的时候,我们家住在纽约市里,和外公外婆家只相隔一个街区。外公每天晚上都会出去散步锻炼身体,有时我也会跟着他去。一天晚上,我和外公像往常一样去散步,我问起他小时候的生活是怎样的。他告诉我,那时候没有抽水马桶... 详细信息

当我还是一个小女孩的时候,我们家住在纽约市里,和外公外婆家只相隔一个街区。外公每天晚上都会出去散步锻炼身体,有时我也会跟着他去。一天晚上,我和外公像往常一样去散步,我问起他小时候的生活是怎样的。他告诉我,那时候没有抽水马桶,人们要到户外上厕所;

关键词：孤儿院

Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus

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Cellular & Molecular Immunology 2012年第3期9卷 255-266页

作者： Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M reilly Virginia Tech-Wake Forest School of Biomedical Engineering and Science Virginia Polytechnic Institute and State University Blacksburg VA USA Department of Biomedical Sciences and Pathobiology Virginia-Maryland Regional College of Veterinary Medicine Blacksburg VA USA Edward Via College of osteopathic Medicine Blacksburg VA USA Department of Mechanical Engineering Virginia Polytechinc Institue and State University Blacksburg VA USA

Elevated expression of heat shock protein 90 （HSP90） has been found in kidneys and serum of systemic lupus erythematosus （SLE） patients and MRLIMp-FasIprIFasJpr（MRLIIpr） autoimmune mice. We investigated if inhibition of HSP90 would reduce disease in MRL/ Ipr mice. In vitro, pretreatment of mesangial cells with HSP90 inhibitor Geldanamycin prior to immune-stimulation showed reduced expression of IL-6, IL-12 and No. In vivo, we found HSP90 expression was elevated in MRL/Ipr kidneys when compared to C57BL/6 mice and MRIJIpr mice treated with HSP90 inhibitor 17-DMAG. MRIJIpr mice treated with 17-DMAG showed decreased proteinuria and reduced serum anti-dsDNA antibody production. Glomerulonephritis and glomerular IgG and C3 were not significantly affected by administration of 17-DMAG in MRIJIpr. 17-DMAG increased CD8＋ T cells, reduced double-negative T cells, decreased the CD4/CD8 ratio and reduced follicular B cells. These studies suggest that HSP90 may play a role in regulating T-cell differentiation and activation and that HSP90 inhibition may reduce inflammation in lupus.

关键词： Geldanamycin heat shock protein 90 MRUIpr systemic lupus erythematosus 17-DMAG

IN VIVo NEAR-INFRAREDFLUoRESCENCEIMAGING oF HUMANCoLoNADENoCARCINoMABY SPECIFIC IMMUNoTARGETINGoFA TUMoR-ASSoCIATEDMUCIN

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Journal of Innovative optical Health Sciences 2009年第4期2卷 407-422页

作者： RALPH S.DACoSTA YING TANG TUULA KALLIoMAKI RAYMoND M.reilly RoBERT WEERSINK ALISHA R.ELFoRD NoRMAN E.MARCoN BRIAN C.WILSoN Division of Biophysics and Bioimaging Ontario Cancer Institute 610 University of TorontoTorontoOntarioM5G 2M9Canada Department of Medical Biophysics University of Toronto Princess Margaret Hospital/Ontario Cancer Institute University Health NetworkTorontoOntarioCanada NIH/NCI Radiation Oncology Branch BethesdaMDUSA Division of Clinical Investigation and Human Physiology Toronto General Hospital Research Institute and University of Toronto Leslie Dan Faculty of Pharmacy TorontoOntarioCanada Laboratory for Applied Biophotonics University Health Network TorontoOntarioCanada Campbell Family Institute for Breast Cancer Research University Health Network/ontario Cancer Institute Department of Medical Biophysics and Immunology Toronto OntarioCanada St.Michael’s Hospital Center for Therapeutic Endoscopy and Endoscopic oncology Toronto OntarioCanada

Background and Aims: Accurate endoscopic detection of premalignant lesions and earlycancers in the colon is essential for cure, since prognosis is closely related to lesion size andstage. Although it has great clinical potential, autofluorescence endoscopy has limited tumorto-normal tissue image contrast for detecting small preneoplastic lesions. We have developed amolecularly specific, near-infrared fluorescent monoclonal antibody (CC49) bioconjugate whichtargets tumor-associated glycoprotein 72 (TAG72), as a contrast agent to improve fluorescencebased endoscopy of colon cancer. Methods: The fluorescent anti-TAG72 conjugate was evaluated in vitro and in vivo in athymic nude mice bearing human colon adenocarcinoma (LS174T)subcutaneous tumors. Autofluorescence, a fluorescent but irrelevant antibody and the free fluorescent dye served as controls. Fluorescent agents were injected intravenously, and in vivowhole body fluorescence imaging was performed at various time points to determine pharmacokinetics, followed by ex vivo tissue analysis by confocal fluorescence microscopy and histology Results: Fluorescence microscopy and histology confirmed specific LS174T cell membrane targeting of labeled CC49 in vitro and ex vivo. In vivo fluorescence imaging demonstrated significant tumor-to-normal tissue contrast enhancement with labeled-CC49 at three hours postinjection, with maximum contrast after 48 h. Accumulation of tumor fluorescence demonstratedthat modification of CC49 antibodies did not alter their specific tumor-localizing properties, andwas antibody-dependent since controls did not produce detectable tumor fluorescence. Conclusions: These results show proof-of-principle that our near-infrared fluorescent-antibody probetargeting a tumor-associated mucin detects colonic tumors at the molecular level in real time,and offer a basis for future improvement of image contrast during clinical fluorescence endoscopy.

关键词： Autofluorescence imaging endoscopy colon adenocarcinoma TAG72 CC49 mucin monoclonal antibody conjugate confocal fluorescence microscopy.

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Btrieve文件剖析

微型计算机 1994年第4期14卷 73-76页

作者： reilly,D 闵珍晖

药理学方法研究自由基和其它氧代谢物介导的组织损伤

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国外医学（创伤与外科基本问题分册） 1991年第3期12卷 166-169页

作者： reilly PM 侯虹鲁

氧的高毒性代谢产物常由细胞有氧代谢产生,且因疾病而大大增加。当氧化物数量超出多种内源性抗氧化物的抗氧化能力时,出现组织损伤。采用药物(如氧反应代谢清除剂、有毒代谢产生物阻滞剂或内源性抗氧能力增强剂)干扰损伤过程的动物实验... 详细信息

氧的高毒性代谢产物常由细胞有氧代谢产生,且因疾病而大大增加。当氧化物数量超出多种内源性抗氧化物的抗氧化能力时,出现组织损伤。采用药物(如氧反应代谢清除剂、有毒代谢产生物阻滞剂或内源性抗氧能力增强剂)干扰损伤过程的动物实验已获成功,并已应用于临床对照试验,亦取得良好效果。

关键词：药理学方法自由基组织损伤

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访问NetWare SQL文件

微型计算机 1995年第4期15卷 75-78页

作者： reilly,D 邵华开

Metalorganic chemical vapor deposition of InN quantum dots and nanostructures

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Light(Science & Applications) 2021年第8期10卷 1409-1420页

作者： Caroline E.reilly Stacia Keller Shuji Nakamura Steven P.DenBaars Materials University of CaliforniaSanta BarbaraCA 93106USA Electrical and Computer Engineering University of CaliforniaSanta BarbaraCA 93106USA

Using one material system from the near infrared into the ultraviolet is an attractive goal,and may be achieved with(ln,AI,Ga)***Ⅲ-N material system,famous for enabling blue and white solid-state lighting,has been pushing towards longer wavelengths in more recent *** a bandgap of about 0.7 eV,InN can emit light in the near infrared,potentially overlapping with the part of the electromagnetic spectrum currently dominated byⅢ-As andⅢ-P *** has been the case in these otherⅢ-V material systems,nanostructures such as quantum dots and quantum dashes provide additional benefits towards optoelectronic *** the case of InN,these nanostructures have been in the development stage for some time,with more recent developments allowing for InN quantum dots and dashes to be incorporated into larger device *** review will detail the current state of metalorganic chemical vapor deposition of InN nanostructures,focusing on how precursor choices,crystallographic orientation,and other growth parameters affect the *** optical properties of InN nanostructures will also be assessed,with an eye towards the fabrication of optoelectronic devices such as light-emitting diodes,laser diodes,and photodetectors.

关键词： optoelectronic quantum chemical

Prevention of Deep Vein Thrombosis by Panax Notoginseng Saponins Combined with Low-Molecular-Weight Heparin in Surgical Patients

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Chinese Journal of Integrative Medicine 2022年第9期28卷 771-778页

作者： WANG Chun-mei GUo Xiang-feng LIU Li-min HUANG Ying MENG Liang SoNG Li-po WU Ying-feng NING Ya-chan Kathleen H.reilly WANG Hai-bo Department of Vascular Surgery Xuanwu HospitalCapital Medical UniversityBeijing100053China Children’s Hospital Capital Institute of Pediatrics Beijing100020China Department of orthopaedics Xuanwu HospitalCapital Medical UniversityBeijing100053China Centers for Disease Control and Prevention New York CityNY12237USA Peking University Clinical Research Institute Peking University First HospitalBeijing100191China

objective:To evaluate the efficacy of deep vein thrombosis(DVT)prevention among realworld surgical inpatients who received panax notoginseng saponins(PNS)combined with low-molecularweight heparin(LMWH).Methods:A prospective cohort study was conducted among surgical patients between January 2016 and November 2018 in Xuanwu Hospital,Capital Medical University,Beijing,*** received LMWH alone or PNS combined with LMWH for preventing *** primary outcome was incidence of lower extremity DVT,which was screened once a *** in the LMWH group were given LMWH(enoxaparin)via hypodermic injection,4000-8000 AxalU once *** in the exposure group received PNS(Xuesaitong oral tablets,100 mg,3 times daily)combined with LMWH given the same as LMWH ***:of the 325 patients screened for the study,281 participants were included in the final *** cohort was divided into PNS+LMWH group and LMWH group with 134 and 147 participants,*** was a significant difference of DVT incidence between two groups(P=0.01),with 21(15.7%)incident DVT in the PNS+LMWH group,and 41(27.9%)incident DVT in the LMWH *** with participants without DVT,the participants diagnosed with DVT were older and had higher D-dimer *** multivariate logistic regression moclel showed a significant lower risk of incident DVT among participants in the PNS+LMWH group compared with the LMWH group(odds ratio 0.46,95%confidence interval,0.25-0.86).There were no significant differences in thromboelaslography values(including R,K,Angle,and MA)and differences in severe bleeding between two *** symptomatic pulmonary embolism occurred during the ***:Combined application of PNS and LMWH can effectively reduce the incidence of DVT among surgical inpatients compared with LMWH monotherapy,without increased risk of bleeding.

关键词： panax notoginseng saponins deep vein thrombosis low-molecular-weight heparin thromboelastography risk factor

Dynamic mathematical models of HIV/AIDS transmission in China

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Chinese Medical Journal 2010年第15期123卷 2120-2127页

作者： WANG Jun-jie Kathleen Heather reilly LUo Jing ZANG Chun-peng WANG Ning National Center for AIDS/STD Control and Prevention China Center for Disease Control and Prevention Beijing 102206 China Tulane University Health Sciences Center School of Public Health and Tropical Medicine New Orleans LA USA University of Illinois at Chicago College of Medicine USA

Social, cultural, and political aspects of the disease may alter the dynamics of *** the early 1980s, China＇s first outbreak of HIV was found in intravenous drug users （IDUs） and in the mid-1990s,there was a concen... 详细信息

关键词： HIV dynamic model transmission