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以异常结肠动力模式解释排便梗阻患者的便秘

世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 32-32页

作者： Dinning P.G. Bampton P.A. Andre j. I.j. Cook 赵天智 Department of Gastroenterology The St. George HospitalUniversity of New SouthWales Kogarah NSW Australia

Background & Aims: The pathophysiology of constipation in the syndrome of obstructed defecation is unknown. Using 24-hour pancolonic manometric recordings of the unprepared colon to record basal pressures and spontaneous defecation episodes,we tested the hypothesis that the frequency, timing, or spatial distribution of propagating colonic pressure waves is abnormal in patients with obstructed defecation. Methods: In 11 patients with obstructed defecation and 16 healthy controls,pressures were recorded using a nasocolonic catheter that was positioned such that 16 recording sites spanned the unprepared colon at 7.5cm intervals. Results: The overall frequency of propagating sequences (PS) in the colon did not differ between patients and controls. When compared with controls, patients had a significant increase in the frequency of retrograde and antegrade PS (P< 0.05) in the left colon and a significant reduction in the amplitude of propagating pressure waves throughout the entire colon (P < 0.03). Defecation occurred in 6 of 11 patients and 9 of 16 controls. In the 15 minutes before defecation,controls showed a highly significant increase in frequency (P= 0.001) and amplitude (P = 0.01) of PS. In contrast, patients did not demonstrate this or the typical spatiotemporal organization of PS normally observed before expulsion of ***: Patients with obstructed defecation lack the normal predefecatory augmentation in frequency and amplitude of propagating pressure waves and lack the normal stereotypic spatiotemporal patterning of colonic pressure waves that would normally culminate in effective expulsion of stool.

关键词：结肠动力压力波记录点病理生理学空间时间全结肠空间分布

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Modeling sustainability:population,inequality,consumption,and bidirectional coupling of the Earth and Human Systems

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National Science Review 2016年第4期3卷 470-494页

作者： Safa Motesharrei j.rge Rivas Eugenia Kalnay Ghassem R.Asrar Antonio j.Busalacchi Robert F.Cahalan Mark A.Cane Rita R.Colwell Kuishuang Feng Rachel S.Franklin Klaus Hubacek Fernando Miralles-Wilhelm Takemasa Miyoshi Matthias Ruth Roald Sagdeev Adel Shirmohammadi j.gadish Shukla j.lena Srebric Victor M.Yakovenko Ning Zeng University of Maryland College Park Institute for Global Environment and Society 3. j.int Global Change Research Institute College Park 4. University Corporation for Atmospheric Research 5. Johns Hopkins University Applied Physics Laboratory NASA Goddard Space Flight Center Lamont–Doherty Earth Observatory of Columbia University 8. Spatial Structures in the Social Sciences/Population Studies and Training Center Brown University RIKEN Advanced Institute for Computational Science School of Public Policy and Urban Affairs and Department of Civil and Environmental EngineeringNortheastern University 11. Department of AtmosphericOceanicand Earth SciencesGeorge Mason University

Over the last two centuries,the impact of the Human System has grown dramatically,becoming strongly dominant within the Earth System in many diferent ***,inequality,and population have increased extremely fast,especially since about 1950,threatening to overwhelm the many critical functions and ecosystems of the Earth *** in the Earth System,in turn,have important feedback efects on the Human System,with costly and potentially serious ***,current models do not incorporate these critical *** argue that in order to understand the dynamics of either system,Earth System Models must be coupled with Human System Models through bidirectional couplings representing the positive,negative,and delayed feedbacks that exist in the real *** particular,key Human System variables,such as demographics,inequality,economic growth,and migration,are not coupled with the Earth System but are instead driven by exogenous estimates,such as United Nations population *** makes current models likely to miss important feedbacks in the real Earth–Human system,especially those that may result in unexpected or counterintuitive outcomes,and thus requiring diferent policy interventions from current *** importance and imminence of sustainability challenges,the dominant role of the Human System in the Earth System,and the essential roles the Earth System plays for the Human System,all call for collaboration of natural scientists,social scientists,and engineers in multidisciplinary research and modeling to develop coupled Earth–Human system models for devising efective science-based policies and measures to beneit current and future generations.

关键词： Earth and Human System Models population migration inequality data assimilation bidirectional couplings and feedbacks sustainability

支气管和非支气管动脉介入栓塞治疗咯血的短期与长期疗效研究

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国际医学放射学杂志 2010年第3期 290-291页

作者：葛莹 j.Y. Chun A.M. Belli Department of Radiology St George’s Hospital

摘要目的本研究旨在评估动脉栓塞介入治疗咯血的短期及长期预后疗效,并确定其影响因素。方法回顾性分析了50例咯血

关键词：咯血支气管动脉栓塞曲菌球非支气管动脉

Electrical programmable multilevel nonvolatile photonic random-access memory

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Light(Science & Applications) 2023年第11期12卷 2325-2334页

作者： j.awei Meng Yaliang Gui Behrouz Movahhed Nouri Xiaoxuan Ma Yifei Zhang Cosmin-Constantin Popescu Myungkoo Kang Mario Miscuglio Nicola Peserico Kathleen Richardson j.ej.n Hu Hamed Dalir Volker j.Sorger Department of Electrical and Computer Engineering George Washington UniversityWashington DC 20052USA Florida Semiconductor Institute University of FloridaGainesvilleFL 32603USA Department of Electrical and Computer Engineering University of FloridaGainesvilleFL 32603USA Department of Materials Science&Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA CREOL The College of Optics&PhotonicsUniversity of Central FloridaOrlandoFL 32816USA

Photonic Random-Access Memories(P-RAM)are an essential component for the on-chip non-von Neumann photonic computing by eliminating optoelectronic conversion losses in data *** Phase-Change Materials(PCMs)have been showed multilevel memory capability,but demonstrations still yield relatively high optical loss and require cumbersome WRITE-ERASE approaches increasing power consumption and system package *** we demonstrate a multistate electrically programmed low-loss nonvolatile photonic memory based on a broadband transparent phase-change material(Ge2Sb2Se5,GSSe)with ultralow absorption in the amorphous state.A zero-staticpower and electrically programmed multi-bit P-RAM is demonstrated on a silicon-on-insulator platform,featuring efficient amplitude modulation up to 0.2 dB/μm and an ultralow insertion loss of total 0.12 dB for a 4-bit memory showing a 100×improved signal to loss ratio compared to other phase-change-materials based photonic *** further optimize the positioning of dual microheaters validating performance *** we demonstrate a half-a-million cyclability test showcasing the robust approach of this material and ***-loss photonic retention-of-state adds a key feature for photonic functional and programmable circuits impacting many applications including neural networks,LiDAR,and sensors for example.

关键词： retention random eliminating

冠状动脉CTA联合CT心肌灌注成像与有创性冠状动脉造影联合负荷SPECT心肌灌注显像预测主要心血管不良事件的价值:CORE320多中心研究

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国际医学放射学杂志 2017年第5期 586-586页

作者： M.Y.Chen C.E.Rochitte A.Arbab-Zadeh M.Dewey R.T.george j.M.Miller 樊响 j.hns Hopkins Hospital and School of Medicine

摘要目的比较CTA联合负荷CT心肌灌注成像与有创性冠状动脉造影(ICA)联合负荷SPECT心肌灌注显像的预后价值[到发生主要心血管不良事件(MACE)的时间]。材料

关键词：主要心血管不良事件冠状动脉造影心肌灌注显像 CORE320 CT 心肌灌注成像 SPECT CTA

Erratum to “BME 2.0: Engineering the Future of Medicine”

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Biomedical Engineering Frontiers 2023年第1期4卷 29-29页

作者： Michael I.Miller Andrew O.Brightman Frederick H.Epstein K.j.ne Grande-Allen j.rdan j.Green Eileen Haase Cato T.Laurencin Elizabeth Logsdon Feilim Mac Gabhann Brenda Ogle Chun Wang george R.Wodicka Raimond L.Winslow Department of Biomedical Engineering Johns Hopkins UniversityBaltimoreMDUSA Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteINUSA Biomedical Engineering University of VirginiaCharlottesvilleVAUSA Department of Bioengineering Rice UniversityHoustonTXUSA Department of Biomolecular Engineering and Department of Orthopaedic Surgery University of ConnecticuttStorrsCTUSA Department of Biomedical Engineering University of Minnesota-Twin CitiesMinneapolisMNUSA

In the article“BME 2.0:Engineering the Future of Medicine”[1],the competing interests statement was inadvertently omitted by the publisher from the published version of the *** has now been corrected in the PDF and ... 详细信息

关键词： HTML BME text

Establishing the presence or absence of chronic kidney disease:Uses and limitations of formulas estimating the glomerular filtration rate

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World j.urnal of Methodology 2017年第3期7卷 73-92页

作者： Ahmed Alaini Deepak Malhotra Helbert Rondon-Berrios Christos P Argyropoulos Zeid j.Khitan Dominic SC Raj.Mark Rohrscheib j.seph I Shapiro Antonios H Tzamaloukas Division of Nephrology Department of MedicineUniversity of New Mexico School of Medicine Division of Nephrology Department of MedicineUniversity of Toledo School of Medicine Renal and Electrolyte Division Department of MedicineUniversity of Pittsburgh School of Medicine Division of Nephrology Department of MedicineJoan C. Edwards School of Medicine Division of Nephrology Department of MedicineGeorge Washington University Marshall University j.an C. Edwards School of Medicine Nephrology Section Medicine ServiceRaymond G. Murphy VA Medical Center Department of Medicine University of New Mexico School of Medicine

The development of formulas estimating glomerular filtration rate(eG FR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease(CKD),which is based on e GFR values and *** scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course. Disagreements between creatinine-based and cystatin-based e GFR values and between e GFR values and measured GFR have been reported in various cohorts. These disagreements are the consequence of variations in the rate of production and in factors, other than GFR, affecting the rate of removal of creatinine and cystatin C. The disagreements create limitations for all e GFR formulas developed so far. The main limitations are low sensitivity in detecting early CKD in several subj.cts, e.g., those with hyperfiltration, and poor prediction of the course of CKD. Research efforts in CKD are currently directed towards identification of biomarkers that are better indices of GFR than the current biomarkers and,particularly, biomarkers of early renal tissue inj.ry.

关键词： Chronic kidney disease Serum creatinine Creatinine clearance Creatinine excretion Estimated glomerular filtration rate Cystatin C Renal imaging Hyperfiltration Biomarkers of chronic kidney disease

A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis

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Research 2023年第1期2023卷 1-13页

作者： Bohua Zhang Huaiyu Wu Howuk Kim Phoebe j.Welch Ashley Cornett Greyson Stocker Raul G.Nogueira j.nwook Kim Gabe Owens Paul A.Dayton Zhen Xu Chengzhi Shi Xiaoning j.ang Department of Mechanical&Aerospace Engineering North Carolina State UniversityRaleighNCUSA Department of Mechanical Engineering Inha University IncheonRepublic of Korea george W.Woodruff School of Mechanical Enginering Grgia lnstitute of TechnlogyAtlantaGAUSA Department of Biomedical Engineering University of Michigan Ann ArborMIUSA Department of Neurology Universityof Pittsburgh Medical CenterPttsburghPA USA Department of Biomedical Engineering University of North CarolinaChapel HillNCUSA Parker H.Petit Institute for Bioengineering and Bioscience Georgia Institute of TechnologyAtlantaGAUSA

This research aims to demonstrate a novel vortex ultrasound enabled endovascular thrombolysis method designed for treating cerebral venous sinus thrombosis(CVST).This is a topic of substantial importance since current treatment modalities for CVST still fail in as many as 20%to 40%of the cases,and the incidence of CvST has increased since the outbreak of the coronavirus disease 2019 *** with conventional anticoagulant or thrombolytic drugs,sonothrombolysis has the potential to remarkably shorten the required treatment time owing to the direct clot targeting with acoustic ***,previously reported strategies for sonothrombolysis have not demonstrated clinically meaningful outcomes(e.g.,recanalization within 30 min)in treating large,completely occluded veins or ***,we demonstrated a new vortex ultrasound technique for endovascular sonothrombolysis utilizing wavematter interaction-induced shear stress to enhance the lytic rate *** in vitro experiment showed that the lytic rate was increased by at least 64.3%compared with the nonvortex endovascular ultrasound treatment.A 3.1-g,7.5-cm-long,completely occluded in vitro 3-dimensional model of acute CVST was fully recanalized within 8 min with a record-high lytic rate of 237.5 mg/min for acute bovine clot ***,we confirmed that the vortex ultrasound causes no vessel wall damage over ex vivo canine *** vortex ultrasound thrombolysis technique potentially presents a new life-saving tool for severe CVST cases that cannot be efficaciously treated using existing therapies.

关键词： thrombolysis drugs vortex

ERCP in acute biliary pancreatitis

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World j.urnal of Gastrointestinal Endoscopy 2010年第1期2卷 25-28页

作者： Dimitrios j.Kapetanos Gastroenterology Department George Papanikolaou HospitalThessaloniki 57010Greece

The role of urgent endoscopic retrograde cholangiopancreatography(ERCP) in acute biliary pancreatitis is for many years a subj.ct for disagreement among *** the evidence seemed to be in favor of performing ERCP,endoscopists usually hesitate to conform to the *** is an invasive procedure,with complications which can affect patients' *** evidence suggests that we should probably modify our policy,recruiting less invasive procedures,like magnetic resonance cholangiopancreatography and endoscopic ultrasound,before conducting ERCP in patients with acute biliary *** this editorial the different aspects regarding the role of ERCP in acute biliary pancreatitis are discussed.

关键词： Endoscopic retrograde cholangiopancreatogr aphy Acute pancreatitis Gallstone Magnetic resonance cholangiopancreatography Endoscopic ultrasound