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Asian Pacific Journal of Tropical Biomedicine 2016年第10期6卷 896-902页

作者： Hafiz Irfan Muhammad Mohd Zaini Asmawi nurzalina abdul karim khan Discipline of Pharmacology School of Pharmaceutical Sciences Universiti Sains Malaysia Department of Pharmacology Faculty of Pharmacy University of Sargodha Discipline of Pharmaceutical Technology School of Pharmaceutical Sciences Universiti Sains Malaysia

Plants have provided sources to find novel compounds. These plants are being used as therapeutic purposes since the birth of mankind. The traditional healers normally utilize medicinal plants as crude drugs while scientists using the folk claim as guides to explore medicinal plants. Moringa oleifera is a famous edible plant having therapeutic and nutritive values. The present study was designed to cumulate the research data regarding to what extent, phytochemical, nutritional and glycemic control studies has been explored using its different extracts. The articles indicated that the powder, aqueous, methanol and ethanol extracts of Moringa oleifera(leaves, pods, seeds, stem and root bark) have significant therapeutic herbal potential to treat diabetes mellitus. Collectively, the mechanism behind is intestinal glucose inhibition, insulin release as well as decrease in insulin resistance probably regeneration of b-cells of pancreas, increase in glutathione and reduction in malondialdehyde. Conclusively, this article give descriptive information about antidiabetic effect, claimed marker compounds and proposed antihyperglycemic mechanism of a single plant. It can be suggested a potential herbal source to treat diabetes mellitus as being widely accepted by major population as nutrition and therapeutic agent.

关键词： Antihyperglycemic Aqueous Ethanol Moringa oleifera Antidiabetic

Effects of vitamin E on stroke: a systematic review with meta- analysis and trial sequential analysis

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Stroke & Vascular Neurology 2021年第1期6卷 109-120页

作者： Hong Chuan Loh Renly Lim Kai Wei Lee Chin Yik Ooi Deik Roy Chuan Irene Looi Yuen Kah Hay nurzalina abdul karim khan Clinical Research Center Hospital Seberang JayaMinistry of Health MalaysiaSeberang JayaMalaysia Clinical and Health Sciences University of South AustraliaAdelaideSouth AustraliaAustralia Department of Pre-Clinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul Rahman-Kampus Bandar Sungai LongKajangMalaysia Medical Department Hospital Seberang JayaMinistry of Health MalaysiaSeberang JayaMalaysia School of Pharmaceutical Sciences Universiti Sains MalaysiaMindenMalaysia

There are several previous studies on the association of vitamin E with prevention of stroke but the findings remain *** have conducted a systematic review,meta-analysis together with trial sequential analysis of randomised controlled trials to evaluate the effect of vitamin E supplementation versus placebo/no vitamin E on the risk reduction of total,fatal,non-fatal,haemorrhagic and ischaemic *** studies were identified by searching online databases through Medline,PubMed and Cochrane Central Register of Controlled Trials.A total of 18 studies with 148016 participants were included in the *** was no significant difference in the prevention of total stroke(RR(relative risk)=0.98,95% CI 0.92-1.04,p=0.57),fatal stroke(RR=0.96,95% CI 0.77-1.20,p=0.73)and non-fatal stroke(RR=0.96,95% CI 0.88-1.05,p=0.35).Subgroup analyses were performed under each category(total stroke,fatal stroke and non-fatal stroke)and included the following subgroups(types of prevention,source and dosage of vitamin E and vitamin E alone vs control).The findings in all subgroup analyses were statistically *** stroke subtypes analysis,vitamin E showed significant risk reduction in ischaemic stroke(RR=0.92,95% CI 0.85-0.99,p=0.04)but not in haemorrhagic stroke(RR=1.17,95%CI 0.98-1.39,p=0.08).However,the trial sequential analysis demonstrated that more studies were needed to control random *** of this study include the following:trials design may not have provided sufficient power to detect a change in stroke outcomes,participants may have had different lifestyles or health issues,there were a limited number of studies available for subgroup analysis,studies were mostly done in developed countries,and the total sample size for all included studies was insufficient to obtain a meaningful result from *** conclusion,there is still a lack of statistically significant evidence of the effects of vitamin E on the risk reduction of str

关键词： vitamin prevention dosage

Comprehensive Review:Diagnosis,Classification,and Risk Factors of Peritoneal Dialysis-Associated Peritonitis

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Journal of Clinical and Nursing Research 2024年第7期8卷 1-9页

作者： Lingling Guo Sairah abdul karim Post Graduate Centre Management&Science University40100 Shah AlamSelangorMalaysia School of Nursing Jiangsu Medical College224005 YanchengJiangsu ProvinceChina Faculty of Health and Life Sciences Management&Science University40100 Shah AlamSelangorMalaysia

Peritoneal dialysis(PD)is a predominant modality of renal replacement therapy(RRT)for individuals suffering from end-stage renal disease(ESRD).Peritoneal dialysis-associated peritonitis(PDAP)represents a frequent complication among patients undergoing PD,significantly contributing to adverse clinical *** review comprehensively examines the diagnosis,classification,and risk factors associated with PDAP,aiming to offer clinical practitioners essential guidance and a foundational framework for effective clinical management.

关键词： Research progress Risk factors Peritoneal dialysis-associated peritonitis

Development of a Lightweight Model for Handwritten Dataset Recognition: Bangladeshi City Names in Bangla Script

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Computers, Materials & Continua 2024年第8期80卷 2633-2656页

作者： MdMahbubur Rahman Tusher Fahmid Al Farid MdAl-Hasan Abu Saleh Musa Miah Susmita Roy Rinky Mehedi Hasan Jim Sarina Mansor MdAbdur Rahim Hezerul abdul karim Department of Computer Science and Engineering Bangladesh Army University of Science and Technology(BAUST)Saidpur5310Bangladesh Faculty of Engineering Multimedia UniversityCyberjaya63100Malaysia Pabna University of Science and Technology Pabna6600Bangladesh

The context of recognizing handwritten city names,this research addresses the challenges posed by the manual inscription of Bangladeshi city names in the Bangla *** today’s technology-driven era,where precise tools for reading handwritten text are essential,this study focuses on leveraging deep learning to understand the intricacies of Bangla *** existing dearth of dedicated datasets has impeded the progress of Bangla handwritten city name recognition systems,particularly in critical areas such as postal automation and document ***,no prior research has specifically targeted the unique needs of Bangla handwritten city name *** bridge this gap,the study collects real-world images from diverse sources to construct a comprehensive dataset for Bangla Hand Written City name *** emphasis on practical data for system training enhances *** research further conducts a comparative analysis,pitting state-of-the-art(SOTA)deep learning models,including EfficientNetB0,VGG16,ResNet50,DenseNet201,InceptionV3,and Xception,against a custom Convolutional Neural Networks(CNN)model named“Our CNN.”The results showcase the superior performance of“Our CNN,”with a test accuracy of 99.97% and an outstanding F1 score of 99.95%.These metrics underscore its potential for automating city name recognition,particularly in postal *** study concludes by highlighting the significance of meticulous dataset curation and the promising outlook for custom CNN *** encourages future research avenues,including dataset expansion,algorithm refinement,exploration of recurrent neural networks and attention mechanisms,real-world deployment of models,and extension to other regional languages and *** recommendations offer exciting possibilities for advancing the field of handwritten recognition technology and hold practical implications for enhancing global postal services.

关键词： Handwritten recognition Bangladeshi city names Bangla handwritten city name automated postal services

An Enhanced Hybrid Model Based on CNN and BiLSTM for Identifying Individuals via Handwriting Analysis

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1689-1710页

作者： Md.Abdur Rahim Fahmid Al Farid Abu Saleh Musa Miah Arpa Kar Puza Md.Nur Alam Md.Najmul Hossain Sarina Mansor Hezerul abdul karim Department of Computer Science and Engineering Pabna University of Science and TechnologyPabna6600Bangladesh Faculty of Engineering Multimedia UniversityCyberjaya63100Malaysia Department of Computer Science and Engineering Bangladesh Army University of Science and TechnologySaidpur5311Bangladesh Department of Mathematics Pabna University of Science and TechnologyPabna6600Bangladesh Department of Electrical Electronic and Communication EngineeringPabnaUniversity of Science and TechnologyPabna6600Bangladesh Department of Electrical and Communication Engineering Pabna University of Science and TechnologyPabna6600Bangladesh

Handwriting is a unique and significant human feature that distinguishes them from one *** are many researchers have endeavored to develop writing recognition systems utilizing specific signatures or symbols for person identification through ***,such systems are susceptible to forgery,posing security *** response to these challenges,we propose an innovative hybrid technique for individual identification based on independent handwriting,eliminating the reliance on specific signatures or *** response to these challenges,we propose an innovative hybrid technique for individual identification based on independent handwriting,eliminating the reliance on specific signatures or *** innovative method is intricately designed,encompassing five distinct phases:data collection,preprocessing,feature extraction,significant feature selection,and *** key advancement lies in the creation of a novel dataset specifically tailored for Bengali handwriting(BHW),setting the foundation for our comprehensive ***-preprocessing,we embarked on an exhaustive feature extraction process,encompassing integration with kinematic,statistical,spatial,and composite *** meticulous amalgamation resulted in a robust set of 91 *** enhance the efficiency of our system,we employed an analysis of variance(ANOVA)F test and mutual information scores approach,meticulously selecting the most pertinent *** the identification phase,we harnessed the power of cutting-edge deep learning models,notably the Convolutional Neural Network(CNN)and Bidirectional Long Short-Term Memory(BiLSTM).These models underwent rigorous training and testing to accurately discern individuals based on their handwriting ***,our methodology introduces a groundbreaking hybrid model that synergizes CNN and BiLSTM,capitalizing on fine motor features for enhanced individual ***,our experimental results unde

关键词： Bengali handwriting(BHW) person identification convolutional neural network(CNN) BiLSTM

National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Abbas Irfan Ahmed Muhammad Atique Usman Iqbal Aujla Muhammad Azeemuddin Zeba Aziz Abu Bakar Hafeez Bhatti Tariq Ali Bangash Amna Subhan Butt Osama Tariq Butt abdul Wahab Dogar Javed Iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan abdul Jabbar Aman Nawaz khan Muhammad Shoaib khan Muhammad Yasir khan Amer Latif Nasir Hassan Luck Ahmad karim Malik Kamran Rashid Sohail Rashid Mohammad Salih abdullah Saeed Amjad Salamat Ghias-un-Nabi Tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic Biliary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic Biliary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic Biliary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan Rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the Bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma Bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

Comparative Transcriptomic Analysis of Two Tomato Cultivars with Different Shelf-Life Traits

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 2075-2093页

作者： abdul karim Amin Yan He Xianglong Wang Pengwei Li Muhammad Ahmad Hassan Mohammad Yousof Soltani Yiling Zhang Mohammad Alem Amin Ahmad Shah Ahmadzai Yajing Liu Songhu Wang Anhui Province Key Laboratory of Horticultural Crop Quality Biology School of HorticultureAnhui Agricultural UniversityHefei230036China Anhui Academy of Agricultural Sciences Hefei230001China Anhui Province Key Laboratory of Soybean Molecular Breeding and Crop Quality Biology School of AgronomyAnhui Agricultural UniversityHefei230036China Department of Horticulture Ghazni UniversityGhazni2301Afghanistan State Key Laboratory of Crop Genetics and Germplasm Enhancement College of HorticultureNanjing Agricultural UniversityNanjing210095China

Tomato(Solanum lycopersicum)is a perishable fruit because of its fast water loss and susceptibility to pathogens in the post-harvest stage,which leads to huge economic losses every *** this study,firstly from 19 tomato cultivars,we screened out two cultivars,Riogrand and SalarF1,having long and short shelf-life spans,***,shelf-life analysis was carried out for both cultivars at room *** exhibited that Riogrand showed higher firmness and less weight loss than *** ethylene production was higher in SalarF1,compared with Riogrand during post-harvest *** performed transcriptomic analysis of both cultivars in different storage *** discovered 2913,2188,and 11,119 differentially expressed genes(DEGs)for three post-harvest stages(0,20,and 40 Days Post-Harvest(DPH)),*** genes are enriched in ethylene biosynthesis and response,as well as cell wall-related *** response factor(ERF)ERF2 and ERF4 were highly expressed in SalarF1 with a short shelf life in 40 DPH,and the ethylene biosynthetic genes ACO1,ACO4,ACS6,and ACS2 were significantly upregulated in *** cell wall loosening and cell wall-related genes XTH3,XTH7,XTH23,1,3;1,4-β-D-Gluc-like,pGlcT1,Cellulase,PGH1,PL5,PL-like 1,PL-like 2 exhibited the highest levels of significance,being notably upregulated in the last stage of *** quantitative real-time polymerase chain reaction(qRT-PCR)analysis validated these gene expressions,which is in line with the transcriptome *** findings suggested that the extension of tomato fruit shelf life is mostly dependent on ethylene biosynthesis,signaling pathway genes,cell wall loosening,and cell wall-associated genes.

关键词： Shelf life transcriptome analysis tomato differentially expressed genes(DEGs) ethylene

Identifying Malaria Hotspots Regions in Ghana Using Bayesian Spatial and Spatiotemporal Models

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Infectious Diseases & Immunity 2024年第2期4卷 69-78页

作者： abdul-karim Iddrisu Dominic Otoo Gordon Hinneh Yakubu Dekongmene Kanyiri Kanimam Yaaba Samuel Cecilia Kubio Francis Balungnaa Dhari Veriegh Department of Mathematics and Statistics University of Energy and Natural ResourcesSunyani 233Ghana Department of Statistical Service Ghana Statistical ServiceBono RegionSunyani 233Ghana Department of Mathematics and ICT Gambaga College of EducationSunyani 233Ghana Human Resources Division University of Energy and Natural ResourcesSunyani 233Ghana Department of Biological Science University of Energy and Natural ResourcesSunyani 233Ghana.

Background:Malaria remains a significant public health concern in Ghana,with varying risk levels across different geographical *** affects millions of people each year and imposes a substantial burden on the health care system and *** risk estimation and mapping are crucial for effectively allocating resources and implementing targeted interventions to identify regions with disease *** study aimed to identify regions exhibiting elevated malaria risk so that public health interventions can be implemented,and to identify malaria risk predictors that can be controlled as part of public health interventions for malaria ***:The data on laboratory-confirmed malaria cases from 2015 to 2021 were obtained from the Ghana Health Service and Ghana Statistical *** studied the spatial and spatiotemporal patterns of the relative risk of malaria using Bayesian spatial and spatiotemporal *** malaria risk for each region was mapped to visually identify regions with malaria *** and heterogeneity of disease risks were established using correlated and uncorrelated structures via the conditional autoregressive and Gaussian models,*** estimates from the marginal posterior distribution were estimated within the Integrated Nested Laplace Approximation using the R ***:The spatial model indicated an increased risk of malaria in the North East,Bono East,Ahafo,Central,Upper West,Brong Ahafo,Ashanti,and Eastern *** spatiotemporal model results highlighted an elevated malaria risk in the North East,Upper West,Upper East,Savannah,Bono East,Central,Bono,and Ahafo *** spatial and spatiotemporal models identified the North East,Upper West,Bono East,Central,and Ahafo Regions as hotspots for malaria *** variations in risk were evident across regions(H=104.9,P<0.001).Although climatic and economic factors influenced malaria infection,statistical significance was not

关键词： Malaria Disease hotspot Bayesian modeling Conditional auto-regressive Integrated Nested Laplace Approximation Spatial and spatiotemporal models

Deep-piRNA:Bi-Layered Prediction Model for PIWI-Interacting RNA Using Discriminative Features

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Computers, Materials & Continua 2022年第8期72卷 2243-2258页

作者： Salman khan Mukhtaj khan Nadeem Iqbal Mohd Amiruddin Abd Rahman Muhammad Khalis abdul karim Department of Computer Science Abdul Wali Khan University MardanKhyber Pakhtunkhwa23200Pakistan Department of Information Technology University of HaripurKhyber Pakhtunkhwa22620Pakistan Faculty of Science Universiti Putra MalaysiaUPM Serdang43400Malaysia

Piwi-interacting Ribonucleic acids(piRNAs)molecule is a wellknown subclass of small non-codingRNAmolecules that are mainly responsible for maintaining genome integrity,regulating gene expression,and germline stem cell maintenance by suppressing transposon *** piRNAs molecule can be used for the diagnosis of multiple tumor types and drug *** to the vital roles of the piRNA in computational biology,the identification of piRNAs has become an important area of research in computational *** paper proposes a two-layer predictor to improve the prediction of piRNAs and their function using deep learning *** proposed model applies various feature extraction methods to consider both structure information and physicochemical properties of the biological sequences during the feature extraction *** outcome of the proposed model is extensively evaluated using the k-fold cross-validation *** evaluation result shows that the proposed predictor performed better than the existing models with accuracy improvement of 7.59%and 2.81%at layer I and layer II *** is anticipated that the proposed model could be a beneficial tool for cancer diagnosis and precision medicine.

关键词： Deep neural network DNC TNC CKSNAP PseDPC cancer discovery Piwi-interacting RNAs Deep-piRNA

DNA Barcoding of Insects and Its Direct Application for Plant Protection

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Open Journal of Applied Sciences 2024年第3期14卷 676-686页

作者： Peter Quandahor Iddrisu Yahaya Francis Kusi Issah Sugri Julius Yirzagla abdul karim Alhassan Jerry A. Nboyine George Y. Mahama Godwin Opoku Mohammed Mujitaba Dawuda Asieku Yahaya Theophilus Kwabla Tengey Rofela Combey John Abraham CSIR-Savanna Agricultural Research Institute Tamale Ghana Faculty of Agriculture Food and Consumer Science University for Development Studies Tamale Ghan Department of Conservational Biology and Entomology School of Biological Sciences University of Cape Coast Ghana

The introduction of invasive insect pests across national borders has become a major concern in crop production. Accordingly, national plant protection organizations are challenge to reinforce their monitoring strategies, which are hampered by the weight and size of inspection equipment, as well as the taxonomic extensiveness of interrupted species. Moreover, some insect pests that impede farmer productivity and profitability are difficult for researchers to address on time due to a lack of appropriate plant protection measures. Farmers’ reliance on synthetic pesticides and biocontrol agents has resulted in major economic and environmental ramifications. DNA barcoding is a novel technology that has the potential to improve Integrated Pest Management decision-making, which is dependent on the ability to correctly identify pest and beneficial organisms. This is due to some natural traits such as phenology or pesticide susceptibility browbeaten by IPM strategies to avert pest establishment. Specifically, Deoxyribonucleic acid (DNA) sequence information was applied effectively for the identification of some micro-organisms. This technology, DNA barcoding, allows for the identification of insect species by using short, standardized gene sequences. DNA barcoding is basically based on repeatable and accessible technique that allows for the mechanisation or automation of species discrimination. This technique bridges the taxonomic bio-security gap and meets the International Plant Protection Convention diagnostic standards for insect identification. This review therefore discusses DNA barcoding as a technique for insect pests’ identification and its potential application for crop protection.

关键词： DNA Barcoding Integrated Pest Management Taxonomy Biosecurity Crop Protection