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Risk Factors for Preeclampsia:Results from a Cohort of over 5000 Pregnancies in Spain

Maternal-Fetal Medicine 2021年第2期3卷 100-106页

作者： Diana Cuenca Valeria Rolle Katy de Paco Matallana nuria valiño Rocio Revello Begoña Adiego Manel Mendoza Belen Santacruz Maria del Mar Gil Department of obstetrics and Gynecology Hospital Universitario de TorrejonTorrejon de ArdozMadrid 28850Spain Bioestatistics and Epidemiology Platform at Fundacion para la Investigacion e Innovacion Biosanitaria del Principado de Asturias Oviedo 33011Spain Department of obstetrics and Gynecology Hospital Clínico Universitario“Virgen de la Arrixaca”El PalmarInstitute for Biomedical Research of MurciaIMIB-ArrixacaEl PalmarMurcia 30120Spain Department of obstetrics and Gynecology Complejo Hospitalario Universitario A CorunaA CorunaGalicia 15006Spain Department of obstetrics and Gynecology Hospital Universitario QuironPozuelo de AlarconMadrid 28223Spain Department of obstetrics and Gynecology Hospital Universitario Fundacion e AlcorconAlcorconMadrid 28922Spain Department of obstetrics and Gynecology Hospital Universitario Vall d’HebronBarcelona 08035Spain School of Medicine Universidad Francisco de VitoriaPozuelo de AlarconMadrid 28223Spain

objective:To determine the incidence of preeclampsia(PE)and preterm PE in Spain and to identify the risk factors for developing the ***:This is a multicenter prospective cohort study performed at six maternity units across *** with singleton pregnancies attending their first-trimester routine visit at the hospital were offered *** and pregnancy characteristics,including mean arterial pressure,as well as ultrasound findings were *** and multivariate logistic regression analyses were performed to identify independent risk factors for subsequent development of ***:A total of 5868 pregnancies were recruited for this study,including 174(3.0%)cases of PE,47(0.8%)cases of preterm PE and 127(2.2%)cases of term *** maternal age was 33.9 years(interquartile range:30.1 to 36.9)and median gestational age at the routine visit was 12.7 weeks(interquartile range:12.3 to 13.0).However,293(5.0%)of the women were on aspirin treatment during pregnancy,likely reducing the true incidence of the *** expected,increasing body mass index(Ponception(P=0.013),previous personal(Por family history of PE(P=0.024)and chronic hypertension(P=0.001)were identified as independent risk factors for developing subsequent PE during *** for PE by maternal factors alone leads to a detection rate of 36.8%(64/174)at 10.0%(587/5868)screen positive ***:In Spain,3.0%of singleton pregnancies are complicated by PE and 0.8%require delivery before term due to its *** of PE by risk factors alone is only able to detect about 40%of total PE at 10%screen-positive rate.

关键词： Pre-eclampsia Aspirin Risk factors Screening

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Connecting neurodevelopment to neurodegeneration:a spotlight on the role of kinesin superfamily protein 2A(KIF2A)

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Neural Regeneration Research 2024年第2期19卷 375-379页

作者： nuria Ruiz-Reig Janne Hakanen Fadel Tissir Universitécatholique de Louvain Institute of neuroscienceBrusselsBelgium College of Health and Life Sciences Hamad Bin Khalifa University(HBKU)DohaQatar

Microtubules play a central role in cytoskeletal changes during neuronal development and *** dynamics is essential to polarity and shape transitions underlying neural cell division,differentiation,motility,and *** superfamily protein 2A is a member of human kinesin 13 gene family of proteins that depolymerize and destabilize *** dividing cells,kinesin superfamily protein 2A is involved in mitotic progression,spindle assembly,and chromosome *** postmitotic neurons,it is required for axon/dendrite specification and extension,neuronal migration,connectivity,and *** with kinesin superfamily protein 2A mutations suffer from a variety of malformations of cortical development,epilepsy,autism spectrum disorder,and *** this review,we discuss how kinesin superfamily protein 2A regulates neuronal development and function,and how its deregulation causes neurodevelopmental and neurological disorders.

关键词： brain disorders cortical malformations kinesin microtubules neurodegeneration neurodevelopment

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Charting the course to solid-state dual-ion batteries

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Carbon Energy 2024年第3期6卷 132-177页

作者： Habtom D.Asfaw Antonia Kotronia nuria Garcia-Araez Kristina Edström Daniel Brandell Department of Chemistry Ångström LaboratoryUppsala UniversityUppsalaSweden Department of Chemistry University of SouthamptonSouthamptonUK

An electrolyte destined for use in a dual-ion battery(DIB)must be stable at the inherently high potential required for anion intercalation in the graphite electrode,while also protecting the Al current collector from anodic dissolution.A higher salt concentration is needed in the electrolyte,in comparison to typical battery electrolytes,to maximize energy density,while ensuring acceptable ionic conductivity and operational *** recent years,studies have demonstrated that highly concentrated organic electrolytes,ionic liquids,gel polymer electrolytes(GPEs),ionogels,and water-in-salt electrolytes can potentially be used in *** can help reduce the use of solvents and thus lead to a substantial change in the Coulombic efficiency,energy density,and long-term cycle life of ***,GPEs are suited to manufacture compact DIB designs without separators by virtue of their mechanical strength and electrical *** this review,we highlight the latest advances in the application of different electrolytes in DIBs,with particular emphasis on GPEs.

关键词： anion intercalation concentrated electrolytes dual-ion battery graphite ionic liquids polymer electrolyte

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Kentish Plover(Charadrius alexandrinus) and Little Tern(Sternula albifrons) prefer shells for nesting:A field experiment

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Avian Research 2024年第1期15卷 55-59页

作者： Macarena Castro Andrés De la Cruz nuria Martin-Sanjuan Alejandro Pérez-Hurtado Instituto Universitario de Investigacion Marina(INMAR) Campus de Excelencia Internacional del Mar(CEIMAR)Departamento de BiologíaUniversidad de CadizPuerto RealSpain Servicios centrales de Investigacion Salinas de la Esperanza Universidad de CadizPuerto RealSpain

Shorebird populations are declining worldwide,mainly due to human disturbances and loss of coastal ***,supratidal habitats as saltpans could play a role in buffering human *** have shown to be important as feeding or breeding sites of some shorebird species.A potential conservation strategy to increase shorebird populations in saltpans is to manipulate the cues that birds use to select optimal breeding *** it is hypothesized that shorebirds are attracted to bivalve shells due to the advantages they *** this hypothesis,we supplemented a restored saltpan in 2019 and 2021 with bivalve shells,expecting an increase in the number of breeding birds’ *** than 75% of Kentish Plover(Charadrius alexandrinus) and Little Tern(Sternula albifrons) nests were found in patches with shells in both *** best model for both species indicates that the presence of shells is the factor that most correlates with the location of *** probability of choosing one place over another to settle their nest increases in areas with an abundance of shells,double in the case of the Kentish Plover and triple in the case of the Little *** result of this study may constitute a valuable tool for attracting birds to restored saltpans and could contribute to the success of expensive restoration projects where time is usually a constraint.

关键词： Habitat management Nest site selection Saltpan restoration Shell supplementation Shorebirds

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Potential of guar gum as a leaky gut model in broilers: Digestibility,performance, and microbiota responses

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Animal Nutrition 2024年第2期17卷 177-187页

作者： Amine Mellouk Tahir Mahmood Maamer Jlali nuria Vieco-Saiz Virginie Michel Pierre Cozannet Sarper ozbek Yves Mercier Estelle Devillard Jessika Consuegra Department of R&I in Monogastric Animal Nutrition European Laboratory of Innovation Science & Expertise (ELISE)

Diet is a major modulator of animal resilience and its three pillars: host?s immune response, gut microbiota, and intestinal barrier. In the present study, we endeavour to delineate a challenging condition aimed to degrade these pillars and elucidate its impact on broiler performance and nutrient digestibility. To attain this objective, we opted to use guar gum(GG) as a source of galactomannan. A series of three in vivo experiments were conducted employing conventional or semi-purified diets, supplemented with or without GG during the grower phase(14-28 d). our findings demonstrate a substantial decline in animal performance metrics such as body weight(reduced by 29%, P onversion ratio(up to 58% increase, P of GG at 2%. The supplementation of a semi-purified diet with incremental doses of GG resulted in a linear reduction(P otal tract digestibility of dry matter and apparent metabolisable energy. Additionally, a marked reduction in ileal endogenous losses, as well as apparent and standardised digestibility of all amino acids with varying proportions(P observed. These alterations were accompanied by disrupted gut integrity assessed by fluorescein isothiocyanate-dextran(FITC-d)(P ory status characterised by elevated levels of acute-phase proteins,namely orosomucoid and serum amyloid A in the sera(P = 0.03), and increased m RNA expression levels of IL-1, IL-6, IL-8, Inos, and K203 genes in the ileum, along with a decrease in Ig A levels in the gut lumen(P obial ecology and activity were characterised by reduced diversity and richness(Shannon index, P = 0.005) in the presence of GG. Consequently, our results revealed diminished levels of shortchain fatty acids(P = 0.01) and their producer genera, such as Clostridium＿XIVa and Blautia, in the gut caeca, coupled with excessive accumulation of lactate(17-f

关键词： Animal resilience Guar gum Broilers' gut health Performance Digestibility Microbiota

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A Tutorial on Federated Learning from Theory to Practice:Foundations,Software Frameworks,Exemplary Use Cases,and Selected Trends

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 824-850页

作者： M.Victoria Luzón nuria Rodríguez-Barroso Alberto Argente-Garrido Daniel Jiménez-López Jose M.Moyano Javier Del Ser Weiping Ding Francisco Herrera Department of Software Engineering Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Computer Science and Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Communications Engineering University of the Basque Country(UPV/EHU)and also with TECNALIABasque Research&Technology Alliance(BRTA)Spain School of Information Science and Technology Nantong UniversityNantong 226019China

When data privacy is imposed as a necessity,Federated learning(FL)emerges as a relevant artificial intelligence field for developing machine learning(ML)models in a distributed and decentralized *** allows ML models to be trained on local devices without any need for centralized data transfer,thereby reducing both the exposure of sensitive data and the possibility of data interception by malicious third *** paradigm has gained momentum in the last few years,spurred by the plethora of real-world applications that have leveraged its ability to improve the efficiency of distributed learning and to accommodate numerous participants with their data *** virtue of FL,models can be learned from all such distributed data sources while preserving data *** aim of this paper is to provide a practical tutorial on FL,including a short methodology and a systematic analysis of existing software ***,our tutorial provides exemplary cases of study from three complementary perspectives:i)Foundations of FL,describing the main components of FL,from key elements to FL categories;ii)Implementation guidelines and exemplary cases of study,by systematically examining the functionalities provided by existing software frameworks for FL deployment,devising a methodology to design a FL scenario,and providing exemplary cases of study with source code for different ML approaches;and iii)Trends,shortly reviewing a non-exhaustive list of research directions that are under active investigation in the current FL *** ultimate purpose of this work is to establish itself as a referential work for researchers,developers,and data scientists willing to explore the capabilities of FL in practical applications.

关键词： Data privacy distributed machine learning federated learning software frameworks

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Typhoon-and pollution-driven enhancement of reactive bromine in the mid-latitude marine boundary layer

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National Science Review 2024年第4期11卷 93-101页

作者： Shanshan Wang Qinyi Li Ruifeng Zhang Anoop Sharad Mahajan Swaleha Inamdar nuria Benavent Sanbao Zhang Ruibin Xue Jian Zhu Chenji Jin Yan Zhang Xiao Fu Alba Badia Rafael P.Fernandez Carlos A.Cuevas Tao Wang Bin Zhou Alfonso Saiz-Lopez Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3) Department of Environmental Science and Engineering Fudan University Institute of Eco-Chongming(IEC) Department of Atmospheric Chemistry and Climate Institute of Physical Chemistry Blas CabreraCSIC Department of Civil and Environmental Engineering The Hong Kong Polytechnic University Environment Research Institute Shandong University Centre for Climate Change Research Indian Institute of Tropical MeteorologyMinistry of Earth Sciences Department of Chemistry University of Colorado Boulder Institute of Environment and Ecology Tsinghua Shenzhen International Graduate SchoolTsinghua University Sostenipra Research Group Institute of Environmental Science and Technology(ICTA)Universitat Autonoma de Barcelona(UAB) Institute for Interdisciplinary Science (ICB) National Research Council (CONICET)

Tropospheric reactive bromine is important for atmospheric chemistry,regional air pollution,and global *** studies have reported measurements of atmospheric reactive bromine species in different environments,and proposed their main sources,***-salt aerosol（SSA）,oceanic biogenic activity,polar snow/ice,and *** and other strong cyclonic activities（***） induce abrupt changes in different earth system processes,causing widespread destructive ***,the role of typhoons in regulating reactive bromine abundance and sources remains ***,we report field observations of bromine oxide（Bro）,a critical indicator of reactive bromine,on the Huaniao Island（HNI）in the East China Sea in July *** observed high levels of Bro below 500 m with a daytime average of9.7±4.2 pptv and a peak value of ～26 pptv under the influence of a *** field measurements,supported by model simulations,suggest that the typhoon-induced drastic increase in wind speed amplifies the emission of SSA,significantly enhancing the activation of reactive bromine from SSA *** also detected enhanced Bro mixing ratios under high Noxconditions（ppbv level） suggesting a potential pollution-induced mechanism of bromine release from *** elevated levels of atmospheric bromine noticeably increase ozone destruction by as much as ～40% across the East China *** the high frequency of cyclonic activity in the northern hemisphere,reactive bromine chemistry is expected to play a more important role than previously thought in affecting coastal air quality and atmospheric oxidation *** suggest that models need to consider the hitherto overlooked typhoon-and pollution-mediated increase in reactive bromine levels when assessing the synergic effects of cyclonic activities on the earth system.

关键词： reactive bromine atmospheric chemistry marine boundary layer atmospheric oxidation capacity marine emission

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Potential relevance of pig gut content transplantation for production and research

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Journal of Animal Science and Biotechnology 2019年第3期10卷 540-558页

作者： nuria Canibe Mark o’Dea Sam Abraham Department of Animal Science Aarhus UniversityAU-FOULUMPO BOX 508830 TjeleDenmark Antimicrobial Resistance and Infectious Disease laboratory College of ScienceHealthEngineering and EducationMurdoch UniversityWestern AustraliaAustralia

It is becoming increasingly evident that the gastrointestinal microbiota has a significant impact on the overall health and production of the *** has led to intensified research on the composition of the gastrointestinal microbiota,factors affecting it,and the impact of the microbiota on health,growth performance,and more recently,behavior of the *** production research has been heavily focused on assessing the effects of feed additives and dietary modifications to alter or take advantage of select characteristics of gastrointestinal microbes to improve health and feed conversion *** on faecal microbiota transplantation(FMT) as a possible tool to improve outcomes in pigs through manipulation of the gastrointestinal microbiome is very recent and limited data is *** on FMT in humans demonstrating the transfer of phenotypic traits from donors to recipients and the high efficacy of FMT to treat Clostridium difficile infections in humans,together with data from pigs relating GI-tract microbiota composition with growth performance has likely played an important role in the interest towards this strategy in pig ***,several factors can influence the impact of FMT on the recipient,and these need to be identified and optimized before this tool can be applied to pig *** are obvious inherent biosecurity and regulatory issues in this strategy,since the donor's microbiome can never be completely screened for all possible non-desirable ***,considering the success observed in humans,it seems worth investigating this strategy for certain applications in pig ***,FMT research may lead to the identification of specific bacterial group(s) essential for a particular outcome,resulting in the development of banks of clones which can be used as targeted therapeutics,rather than the broader approach applied in *** review examines the factors associated with the use of FMT,and its pote

关键词： Clostridium difficile Faecal-microbiota-transplantation Feed conversion Gastrointestinal tract Health Microbiota Pig model Pigs

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Ionic liquids as boundary additives in water-based and PAo lubricants

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Friction 2022年第9期10卷 1405-1423页

作者： Wahyu WIJANARKo Hamid KHANMoHAMMADI nuria ESPALLARGAS Norwegian Tribology Center Department of Mechanical and Industrial EngineeringNorwegian University of Science and Technology(NTNU)Trondheim 7491Norway Department of Mechanical Engineering Sepuluh Nopember Institute of Technology(ITS)Surabaya 6011Indonesia

Ionic liquids have been widely discussed as potential lubricants,however,their properties make them also very good potential candidates as lubricant additives(e.g.,friction modifiers and anti-wear).In this work,the tribological study of two ionic liquids(tributylmethylphosphonium dimethylphosphate(PP),and 1-butyl-1-methylpyrrolidinium tris(pentafluoroethyl)trifluorophosphate(BMP))as lubricant additives has been performed on stainless steel(AISI 316L)exposed to polar(water-glycol)and non-polar(polyalphaolefin)based lubricants under boundary lubricating *** performance of these ionic liquids as lubricant additives has been compared to a classical organic friction modifier(dodecanoic acid(C12)).The water–glycol lubricant formulated with the two ionic liquids showed friction values higher than the same base lubricant formulated with dodecanoic acid,however,opposite results were observed for polyalphaolefin(PAo).A detailed surface chemical analysis using X-ray photoelectron spectroscopy(XPS)revealed differences in the passive/tribofilm thickness and chemical composition of the stainless steel surface tested in all *** the case of the polar lubricant additivated with ionic liquids,the tribochemical reaction accompanied by a tribocorrosion process led to the formation of an unstable passive/tribofilm resulting in high friction and ***,in the absence of tribocorrosion process(polyalphaolefin base lubricant),the tribochemical reaction led to the formation of a stable passive/tribofilm resulting in low friction and wear.A detailed surface and subsurface investigation of the microstructure using scanning electron microscopy equipped with a focused ion beam(SEM-FIB)showed that high wear rates resulted in thicker recrystallization region under the wear track *** all lubricant additives tested in this work,BMP in non-polar lubricant media showed the best tribological performance.

关键词： water lubricant polyalphaolefin(PAo) ionic liquids tribochemistry tribocorrosion tribofilm

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Polycaprolactone/mesoporous silica MCM-41 composites prepared by in situ polymerization

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Particuology 2017年第1期15卷 135-143页

作者： Laura Lopez-Figueras nuria Navascues Silvia Irusta Department of Chemical Engineering Nanoscience Institute of Aragon (INA) University of Zaragoza 50018 Zaragoza Spain Networking Research Center on Bioengineering Biomaterials and Nanomedicine CIBER-BBN 50018 Zaragoza Spain

Composites of polycaprolactone （PCL） with mesoporous silica MCM-41 and N-[3- （trimethoxysilyl）propyl]-ethylenediamine （EPTES）-functionalized MCM-41 （EPTES/MCM-41） were prepared by in situ polymerization. The thermal properties of the composites were characterized by thermogravimetric analysis. There was an increase in the thermal decomposition temperature of PCL by more than 55 ℃, when the EPTES/MCM-41 loading was higher than 2 wt%. Tensile test results indicated that adding MCM-41 increased the brittleness of the PCL matrix, while adding 8 wt% of EPTES/MCM-41 increased the Young＇s modulus by 26%. Incorporating MCM-41 increased the crystallinity of the resulting PCL composite, compared with that of PCL. Incorporating up to 5 wt% EPTES/MCM-41 slightly reduced the crystallinity of PCL. The different effects of MCM-41 and EPTES/MCM-41 on the composite reflected the degree of interaction and dispersion of the silica filler in the polymer matrix, as evidenced by results from transmission electron microscopy and atomic force microscopy.

关键词： Nanocomposite Mesoporous silica Polycaprolactone

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