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Short-term effectiveness of golimumab for ulcerative colitis: Observational multicenter study

World Journal of Gastroenterology 2016年第47期22卷 10432-10439页

作者： Marta Maia Bosca-Watts Xavier Cortes Marisa Iborra Jose Maria Huguet Laura Sempere Gloria Garcia Rafa Gil Mari Fe Garcia Marga Munoz Pedro Almela nuria Maroto Jose Maria Paredes Inflammatory Bowel Disease Unit Digestive Disease DepartmentUniversity of ValenciaUniversity Clinic Hospital of Valencia46010 ValenceiaSpain Digestive Disease Department Hospital of Sagunto46010 ValenciaSpain Gastroenterology Department and CIBEREHD Hospital Universitari i Politecnic La Fe46026 ValenciaSpain Digestive Disease Department General Hospital of Valencia46014 ValenciaSpain Digestive Disease Department General Hospital of Alicante03010 AlacantSpain Digestive Disease Department San Juan University Hospital of Alicante46015 ValenciaSpain Digestive Disease Department Arnau Hospital of Valencia Digestive Disease Department General University Hospital of Elche03203 AlicaneSpain Digestive Disease Department General Hospital of Castellon12004 Castellón de la PlanaSpain Digestive Disease Department Hospital of Manises46940 ManisesSpain Digestive Disease Department Peset University Hospital of Valencia46017 ValenciaSpain

AIM To evaluate the real-world effectiveness of golimumab in ulcerative colitis(UC) and to identify predictors of *** We conducted an observational, prospective and multi-center study in UC patients treated with golimumab, from September 2014 to September 2015. Clinical activity was assessed at wk 0 and 14 with the physician's global clinical assessment(PGA) and the partial Mayo score. Colonoscopies and blood tests were performed, following daily-practice clinical criteria, and the results were recorded in an SPSS *** Thirty-three consecutive patients with moderately to severely active UC were included. Among them, 54.5% were female and 42 years was the average age. Thirty percent had left-sided UC(E2) and 70% had extensive UC(E3). All patients had an endoscopic Mayo score of 2 or 3 at baseline. Twenty-seven point three percent were anti-tumor necrosis factor(TNF) treatment na?ve, whereas 72.7% had previously received infliximab and/or adalimumab. Sixty-nine point seven percent showed clinical response and were steroid-free at wk 14(a decrease from baseline in the partial Mayo score of at least 3 points). Based on PGA, the clinical remission and clinical response rates were 24% and 55% respectively. Withdrawal of corticosteroids was observed in 70.8% of steroid-dependent patients at the end of the study. Three out of 10 clinical non-responders needed a colectomy. Mean fecal calprotectin value at baseline was 300 μg/g, and 170.5 μg/g at wk 14. Being anti-TNF treatment na?ve was a protection factor, which was related to better chances of reaching clinical remission. Twenty-seven point three percent of the patients required treatment intensification at 14 wk of followup. Only three adverse effects(AEs) were observed during the study; all were mild and golimumab was not *** This real-life practice study endorses golimumab's promising results, demonstrating its short-term effectiveness and confirming it as a safe drug during t

关键词： Golimumab Ulcerative colitis Real-life results

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Transcriptome‑wide mapping of milk somatic cells upon subclinical mastitis infection in dairy cattle

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2630-2648页

作者： Vittoria Bisutti nuria Mach Diana Giannuzzi Alice Vanzin Emanuele Capra Riccardo Negrini Maria Elena Gelain Alessio Cecchinato Paolo Ajmone‑Marsan Sara Pegolo DAFNAE University of PadovaViale Dell’Universita 16LegnaroPD 35020Italy. IHAP Universite de ToulouseINRAEENVT23 Chemin Des CapellesToulouse 31300France. IBBA National Research CouncilVia EinsteinLodi 26900Italy. DIANA Universita Cattolica del Sacro CuoreVia E.Parmense 84Piacenza 29122Italy. BCA University of PadovaViale Dell’Universita 16LegnaroPD 35020Italy.

Background Subclinical intramammary infection(IMI)represents a significant problem in maintaining dairy cows’*** severity and extent depend on the interaction between the causative agent,environment,and *** investigate the molecular mechanisms behind the host immune response,we used RNA-Seq for the milk somatic cells(SC)transcriptome profiling in healthy cows(n=9),and cows naturally affected by subclinical IMI from Proto-theca spp.(n=11)and Streptococcus agalactiae(***;n=11).Data Integration Analysis for Biomarker discov-ery using Latent Components(DIABLO)was used to integrate transcriptomic data and host phenotypic traits related to milk composition,SC composition,and udder health to identify hub variables for subclinical IMI *** A total of 1,682 and 2,427 differentially expressed genes(DEGs)were identified when comparing Prototheca *** *** to healthy animals,***-specific pathway analyses evidenced that Proto-theca’s infection upregulated antigen processing and lymphocyte proliferation pathways while *** induced a reduction of energy-related pathways like the tricarboxylic acid cycle,and carbohydrate and lipid *** integrative analysis of commonly shared DEGs between the two pathogens(n=681)referred to the core-mastitis response genes,and phenotypic data evidenced a strong covariation between those genes and the flow cytometry immune cells(r2=0.72),followed by the udder health(r2=0.64)and milk quality parameters(r2=0.64).Variables with r≥0.90 were used to build a network in which the top 20 hub variables were identified with the Cytoscape cyto-hubba *** genes in common between DIABLO and cytohubba(n=10)were submitted to a ROC analysis which showed they had excellent predictive performances in terms of discriminating healthy and mastitis-affected animals(sensitivity>0.89,specificity>0.81,accuracy>0.87,and precision>0.69).Among these genes,CIITA could play a key role in re

关键词： Data integration Immune response Milk somatic cells RNA-sequencing Subclinical mastitis

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Risk Factors for Preeclampsia:Results from a Cohort of Over 5000 Pregnancies in Spain

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Maternal-Fetal Medicine 2021年第2期3卷 100-106页

作者： Diana Cuenca Valeria Rolle Katy de Paco Matallana nuria Valiño Rocio Revello Begoña Adiego Manel Mendoza Belen Santacruz Maria del Mar Gil Department of Obstetrics and Gynecology Hospital Universitario de TorrejonTorrejon de ArdozMadrid 28850Spain Bioestatistics and Epidemiology Platform at Fundacion para la Investigacion e Innovacion Biosanitaria del Principado de Asturias Oviedo 33011Spain Department of Obstetrics and Gynecology Hospital Clínico Universitario“Virgen de la Arrixaca”El PalmarInstitute for Biomedical Research of MurciaIMIB-ArrixacaEl PalmarMurcia 30120Spain Department of Obstetrics and Gynecology Complejo Hospitalario Universitario A CorunaA CorunaGalicia 15006Spain Department of Obstetrics and Gynecology Hospital Universitario QuironPozuelo de AlarconMadrid 28223Spain Department of Obstetrics and Gynecology Hospital Universitario Fundacion e AlcorconAlcorconMadrid 28922Spain Department of Obstetrics and Gynecology Hospital Universitario Vall d’HebronBarcelona 08035Spain School of Medicine Universidad Francisco de VitoriaPozuelo de AlarconMadrid 28223Spain

Objective:To determine the incidence of preeclampsia(PE)and preterm PE in Spain and to identify the risk factors for developing the ***:This is a multicenter prospective cohort study performed at six maternity units across *** with singleton pregnancies attending their first-trimester routine visit at the hospital were offered *** and pregnancy characteristics,including mean arterial pressure,as well as ultrasound findings were *** and multivariate logistic regression analyses were performed to identify independent risk factors for subsequent development of ***:A total of 5868 pregnancies were recruited for this study,including 174(3.0%)cases of PE,47(0.8%)cases of preterm PE and 127(2.2%)cases of term *** maternal age was 33.9 years(interquartile range:30.1 to 36.9)and median gestational age at the routine visit was 12.7 weeks(interquartile range:12.3 to 13.0).However,293(5.0%)of the women were on aspirin treatment during pregnancy,likely reducing the true incidence of the *** expected,increasing body mass index(P<0.001),uterine artery pulsatility index(P=0.011)and mean arterial pressure(P<0.001),assisted conception(P=0.013),previous personal(P<0.001)or family history of PE(P=0.024)and chronic hypertension(P=0.001)were identified as independent risk factors for developing subsequent PE during *** for PE by maternal factors alone leads to a detection rate of 36.8%(64/174)at 10.0%(587/5868)screen positive ***:In Spain,3.0%of singleton pregnancies are complicated by PE and 0.8%require delivery before term due to its *** of PE by risk factors alone is only able to detect about 40%of total PE at 10%screen-positive rate.

关键词： Pre-eclampsia Aspirin Risk factors Screening

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Hepatitis B surface antigen and hepatitis B core-related antigen kinetics after adding pegylated-interferon to nucleos(t)ids analogues in hepatitis B e antigen-negative patients

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World Journal of Hepatology 2020年第11期12卷 1076-1088页

作者： Teresa Broquetas Montserrat Garcia-Retortillo Miquel Mico Lidia Canillas Marc Puigvehi nuria Canete Susana Coll Ana Viu Juan Jose Hernandez Xavier Bessa JoseA Carrion Department of Gastroenterology Liver SectionHospital del Mar Medical Research InstituteBarcelona 08003Spain Departament of de Medicina Universitat Autònoma de BarcelonaBarcelona 08003Spain Laboratori de Referencia de Catalunya El Prat de LlobregatBarcelona 08820Spain

BACKGROUND Hepatitis B e antigen-negative chronic hepatitis B patients under nucleos(t)ids analogues(NAs)rarely achieve hepatitis B surface antigen(HBsAg)*** To evaluate if the addition of pegylated interferon(Peg-IFN)could decrease HBsAg and hepatitis B core-related antigen(HBcrAg)levels and increase HBsAg loss rate in patients under NAs *** Prospective,non-randomized,open-label trial evaluating the combination of Peg-IFN 180μg/week plus NAs during forty-eight weeks vs NAs in *** B e antigen-negative non-cirrhotic chronic hepatitis B patients of a tertiary hospital,under NAs therapy for at least 2 years and with undetectable viral load,were *** with hepatitis C virus,hepatitis D virus or human immunodeficiency virus co-infection and liver transplanted patients were *** and HBcrAg levels(log10 U/mL)were measured at baseline and during ninety-six *** loss rate was evaluated in both *** events were recorded in both *** kinetic of HBsAg for each treatment group was evaluated from baseline to weeks 24 and 48 by the slope of the HBsAg decline(log10 IU/mL/week)using a linear regression *** Sixty-five patients were enrolled,61%receiving tenofovir and 33%***-six(55%)were included in Peg-IFN-NA group and 29(44%)in NA *** matching by age and treatment duration,baseline HBsAg levels were comparable between groups(3.1 vs 3.2)(P=0.25).HBsAg levels at weeks 24,48 and 96 declined in Peg-IFN-NA group(-0.26,-0.40 and-0.44)and remained stable in NA group(-0.10,-0.10 and-0.10)(P<0.05).The slope of HBsAg decline in Peg-IFN-NA group(-0.02)was higher than in NA group(-0.00)(P=0.015).HBcrAg levels did not ***(22%)patients discontinued Peg-IFN due to adverse *** HBsAg loss was achieved in 3(8.3%)patients of the Peg-IFN-NA group and 0(0%)of the NA *** The addition of Peg-IFN to NAs caused a greater and faster decrease of HBsAg levels compared to N

关键词： Chronic hepatitis B Hepatitis B e antigen-negative Hepatitis B surface antigen Hepatitis B core-related antigen Pegylated-interferon Nucleos(t)ids analogues©The Author(s)2020.Published by Baishideng Publishing Group Inc.All rights reserved

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Cardiac monitoring for patients with palpitations

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World Journal of Cardiology 2021年第11期13卷 608-627页

作者： Jaume Francisco-Pascual Javier Cantalapiedra-Romero Jordi Pérez-Rodon Begoña Benito Alba Santos-Ortega Jenson Maldonado Ignacio Ferreira-Gonzalez nuria Rivas-Gándara Unitat d'Arritmies Servei de CardiologiaHospital Universitari Vall d'HebronVall d’Hebron Institut de Recerca(VHIR)Vall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Facultat de Medicina Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain CIBER de Enfermedades Cardiovasculares(CIBERCV) Instituto de Salud Carlos IIIMadrid 28029Spain

Palpitations are one of the most common reasons for medical consultation. Theytend to worry patients and can affect their quality of life. They are often asymptom associated with cardiac rhythm disorders, although there are otheretiologies. For diagnosis, it is essential to be able to reliably correlate the symptomswith an electrocardiographic record allowing the identification or rulingout of a possible rhythm disorder. However, reaching a diagnosis is not alwayssimple, given that they tend to be transitory symptoms and the patient isfrequently asymptomatic at the time of assessment. In recent years, electrocardiographicmonitoring systems have incorporated many technical improvements thatsolve several of the 24-h Holter monitor limitations. The objective of this review isto provide an update on the different monitoring methods currently available,remarking their indications and limitations, to help healthcare professionals toappropriately select and use them in the work-up of patients with palpitations.

关键词： Palpitation Cardiac monitoring Electrocardiogram Loop recorder

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Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada

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World Journal of Gastroenterology 2018年第11期24卷 1216-1227页

作者： Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua British Columbia Centre for Disease Control Vancouver BC V5Z4R4Canada School of Population and Public Health University of British ColumbiaVancouver BC V6T1Z3Canada Division of Population and Public Health Ministry of HealthVictoria BC V8W9P1Canada Department of Pathology and Laboratory Medicine University of British ColumbiaVancouver BC V6T1Z2Canada

AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since *** data were integrated with prescription drug,medical visit,hospitalization and mortality *** cases were classified as acute or chronic according to provincial *** compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative ***46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic *** alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative *** multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug *** odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic *** with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV *** odds increased with increasing socioeconomic *** Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,preven

关键词： Hepatitis B virus Ethnicity Drug use Acute hepatitis B BC Hepatitis Testers Cohort North America

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Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes

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Protein & Cell 2014年第1期5卷 59-68页

作者： Ying Gut Guang-Hui Liu Nongluk Plongthongkum' Christopher Benner Fei Yi Jing Qu Keiichiro Suzuki Jiping Yang Weiqi Zhang Mo Li nuria Montserrat Isaac Crespo Antonio del Sol Concepcion Rodriguez Esteban Kun Zhang Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA National Laboratory of Biomacromolecules institute of Biophysics Chinese Academy of Sciences Beijing 100101 China ' State key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Department of Bioengineering University of California at San Diego La Jolla CA 92093 USA center of Regenerative Medicine in Barcelona Dr. Aiguader 88 08003 Barcelona Spain Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN) Poeta MarianoEsquillor s/n 50018 Sargossa Spain Luxembourg Centre for Systems Biomedicine (LCSB) University of Luxembourg Walferdange Luxembourg

With defined culture protocol, human embryonic stem cells （hESCs） are able to generate cardiomyocytes in vitro, therefore providing a great model for human heart development, and holding great potential for car- diac disease therapies. In this study, we successfully generated a highly pure population of human cardio- myocytes （hCMs）（〉95% cTnT＋） from hESC line, which enabled us to identify and characterize an hCM-specific signature, at both the gene expression and DNA meth- ylation levels. Gene functional association network and gene-disease network analyses of these hCM-enriched genes provide new insights into the mechanisms of hCM transcriptional regulation, and stand as an informative and rich resource for investigating cardiac gene func- tions and disease mechanisms. Moreover, we show that cardiac-structural genes and cardiac-transcription fac- tors have distinct epigenetic mechanisms to regulate their gene expression, providing a better understandingof how the epigenetic machinery coordinates to regulate gene expression in different cell types.

关键词： human cardiomyocyte DNA methylation,microarray heart development

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Indigestible fraction of guava fruit:Phenolic profile,colonic fermentation and effect on HT-29 cells

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Food Bioscience 2022年第2期46卷 563-571页

作者： Francisco J.Blancas-Benitez Jara P´erez-Jim´enez JAdriana Sa˜nudo-Barajas nuria E.Rocha-Guzm´an Gustavo A.Gonz´alez-Aguilar Juscelino Tovar Sonia G.S´ayago-Ayerdi Tecnol´ogico Nacional de M´exico/Instituto Tecnol´ogico de Tepic Laboratorio Integral de Investigaci´on en AlimentosAv.Tecnol´ogico 2595CP 63175TepicNayaritMexico Institute of Food Science Technology and Nutrition(ICTAN-CSIC)Jos´e Antonio Novais 1028040MadridSpain Centro de Investigaci´on en Alimentaci´on y Desarrollo A.C.Unidad Culiac´an.ApdoPostal 32-A.80129Culiac´anSinaloaMexico Tecnol´ogico Nacional de M´exico/Instituto Tecnol´ogico de Durango Departamento de Ingenierías Química y Bioquímica BlvdFelipe Pescador 1830Ote.Col.Nueva VizcayaCP 3408078000DurangoDgo.Mexico Coordinaci´on de Tecnología de Alimentos de Origen Vegetal Lab.de Antioxidantes y Alimentos FuncionalesCentro de Investigaci´on en Alimentaci´on y DesarrolloA.C.Carretera a la Victoria Km 0.6Col.La VictoriaHermosillo Sonora83000Mexico Department of Food Technology Engineering and NutritionLund UniversityP.O.Box 124SE-22100LundSweden

Guava fruit is rich in phenolic compounds(PCs),whose metabolic fate has not been ***-digestible carbohydrates and PCs in whole guava(WG)and seedless guava(SG)were submitted to an in vitro colonic fermentation,followed by evaluation of the anti-proliferative activity of the fermentation extracts in HT-29 cancer cell *** main PCs in both samples were(+)-gallocatechin and gallic acid,while procyanidin B was the most abundant one associated with soluble indigestible fraction and quercetin predominated in the insoluble indigestible *** fermentability index at 24 h was 78.84%in WG and 84.74%for SG,near to the value for raffinose used as reference,with butyric acid as the main short chain fatty acids(SCFA)*** greatest antiproliferative effects were observed in the SG at 12 h of fermentation and WG at 24 h of *** results allow to suggest consumption of guava fruit,either with or without seeds,as a feasible way to maintain colonic health.

关键词： Short chain fatty acids(SCFA) Phenolic compounds Indigestible fraction In vitro colonic fermentation Antiproliferative Psidium guajava L

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Endoscopic response to tumor necrosis factor inhibitors predicts long term benefits in Crohn's disease

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World Journal of Gastroenterology 2019年第14期25卷 1764-1774页

作者： Ignacio Alfaro Maria Carme Masamunt nuria Planell Alicia López-García Jesús Castro Marta Gallego Rebeca Barastegui Angel Giner Alejandro Vara Azucena Salas Elena Ricart Julián Panés Ingrid Ordás Gastroenterology Department Hospital Clínic de Barcelona Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) University of Barcelona

BACKGROUND Identifying predictors of therapeutic response is the cornerstone of personalized *** To identify predictors of long-term mucosal healing(MH) in patients with Crohn's disease(CD) treated with tumor necrosis factor α(TNF-α) *** Prospective single center study. Consecutive patients with clinically active CD requiring treatment with a TNF-α inhibitor were included. A baseline segmental CD Endoscopic Index of Severity(CDEIS) ≥ 10 in at least one segment or the presence of ulcerations were required for inclusion. Clinical, biological and endoscopic data were obtained at baseline, weeks 14 and 46. Endoscopic response(ER) was defined as a decrease ≥ 50% from baseline CDEIS and MH as partial CDEIS ≤ 5 in all *** Of 62 patients were included. At baseline, median CD Activity Index and CDEIS were 201 and 6.7, respectively with a significant reduction after one year of treatment(53 and 3.0 respectively, P < 0.001). At week 14, 56% of patients achieved ER and 34% MH. At week 46, the corresponding percentages were 52%and 44%. Baseline disease characteristics or biomarkers did not predict MH. A decrease from baseline CDEIS at week 14 of at least 80% was the best predictor of MH at week 46(59% sensitivity and 91% specificity; area under the curve =0.778).CONCLUSION Clinical and biomarker data are not useful predictors of response to TNF-αinhibitors in CD, whereas ER to induction therapy, defined as 80% reduction in global CDEIS, is a robust predictor of long-term MH. Achievement of this endoscopic endpoint may be considered as a therapeutic target for anti-TNF-αtherapy.

关键词： Crohn’s disease Endoscopy Mucosal healing Crohn’s Disease Endoscopic Index of Severity Tumor necrosis factor

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Open versus laparoscopic cholecystectomies in patients with or without type 2 diabetes mellitus in Spain from 2003 to 2013

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Hepatobiliary & Pancreatic Diseases International 2016年第5期15卷 525-532页

作者： JoséM de Miguel-Yanes Manuel Méndez-Bailón Rodrigo Jiménez-García Valentín Hernández-Barrera Napoleón Pérez-Farinós Fernando Turégano nuria Munoz-Rivas Ana López-de-Andrés Internal Medicine Department Hospital General Universitario“Gregorio Maranón”46Doctor Esquerdo28007MadridSpain Internal Medicine Department Hospital Clínico San CarlosCalle Profesor Martín Lagos28040MadridSpain Preventive Medicine and Public Health Department Health Sciences FacultyRey Juan Carlos UniversityAvenida de AtenasAlcorcón28292MadridSpain Spanish Agency of Alimentary Safety and Nutrition Ministry of HealthSocial Policy and Equality56Alcalá28071MadridSpain Internal Medicine Department Hospital Infanta Leonor80Avenida Gran Vía del Este28031MadridSpain Surgery Department Hospital General Universitario“Gregorio Maranón”46Doctor Esquerdo28007MadridSpain

BACKGROUND: This study aimed to compare the rates of open and laparoscopic cholecystectomies and outcomes in patients with or without type 2 diabetes mellitus (T2DM) in Spain from 2003 to 2013. METHODS: We collected all cases of open and laparoscopic cholecystectomies using national hospital discharge data and evaluated the annual cholecystectomy rates stratiifed by T2DM status. We analyzed tendency for in-hospital mortality (IHM). We also analyzed the impact of T2DM on IHM in patients who underwent cholecystectomies. RESULTS: We identiifed 611 533 cholecystectomies (71.3%laparoscopic) in the patients, in whom 78 227 (12.8%) patients had T2DM. The rates of open cholecystectomies were 3-fold higher (130.0/105 vs 41.1/105) in patients with T2DM than in those without T2DM, and the rate of laparoscopic cholecys-tectomies was almost 2-fold higher (195.2/105 vs 111.8/105) in patients with T2DM. The annual rate of laparoscopic pro-cedures showed an 11-year relative increase of 88.3% (from 117.0/105 to 220.3/105) in T2DM and 49.2% (from 79.2/105 to 118.2/105) in patients without T2DM (P CONCLUSION: The rate of cholecystectomy was higher in patients with T2DM, and laparoscopic cholecystectomy was p

关键词： diabetes mellitus cholecystectomy mortality in-hospital mortality

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