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Rapidly deforming gastric carcinosarcoma with osteoblastic component:An autopsy case report

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World Journal of Gastroenterology 2012年第30期18卷 4064-4068页

作者： Hiroshi Yoshida noriyuki Tanaka Naobumi Tochigi Yoshio suzuki Department of Pathology Asahi General HospitalChiba 289-2511Japan

Carcinosarcomas are rare,malignant,biphasic tumors simultaneously comprising carcinoma and sarcoma in a single tumor.We present an extremely rare case of gastric carcinosarcoma with an osteoblastic component that drastically changed its shape within 2 mo.A 59-year-old male patient presented to the emergency outpatient unit with a complaint of black stool.Gastrointestinal endoscopy showed an ulcerated mass in the cardia of the lesser curvature of the stomach.Biopsy specimens revealed only adenocarcinoma.Two months later,the ulcerated lesion drastically changed its shape into an exophytic tumor.Total gastrectomy was performed.In the resected specimen,the gastric tumor contained both adenocarcinoma and sarcoma components with lace-like osteoid.The patient died 7 mo after the operation,and an autopsy was performed.In the autopsy,widespread metastases were present in the liver,lung,lymph nodes and peritoneum.In this report,we describe a case of gastric carcinosarcoma and presume its tumorigenesis based on the autopsy findings.

关键词：组成部分成骨细胞胃肠道肉瘤尸检变形胃肿瘤溃疡病

Metallacyclic Compounds Derived from Group 4 Metals and [n]Cumulenes （n=3,5）

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Metallacyclic Compounds Derived from Group 4 Metals and [n]C...

Treatment strategy for metastatic prostate cancer with extremely high PSA level： reconsidering the value of vintage therapy

中国化学会第27届学术年会

作者： Noriyuki Suzuki Department of Materials and Life Sciences Faculty of Science and Technology Sophia University

＜正＞We recently reported that five-membered metallacycloalkynes, 1-metallacyclopent-3-ynes, could be synthesized from group 4 metallocenes and [3]cumulenes （= butatrienes）（eq 1）.1 These molecules are

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Asian Journal of Andrology 2018年第5期20卷 432-437页

作者： Yasutaka Yamada Shinichi Sakamoto Yoshiyasu Amiya Makoto Sasaki Takayuki Shima Akira Komiya Noriyuki Suzuki Koichiro Akakura Tomohiko Ichikawae Hiroomi Nakatsu Department of Urology Asahi General Hospital Asahi 289-2511 Japan Department of Urology Chiba University Graduate School of Medicine Chiba 260-8677 Japan Department of Urology Japan Community Healthcare Organization Tokyo Shinjuku Medical Center Tokyo 162-8543 Japan

The prognostic significance of initial prostate-specific antigen （PSA） level for metastatic prostate cancer remains uncertain. We investigated the differences in prognosis and response to hormonal therapies of metastatic prostate cancer patients according to initial PSA levels. We analyzed 184 patients diagnosed with metastatic prostate cancer and divided them into three PSA level groups as follows： low （〈100 ng ml-1）, intermediate （100–999 ng ml-1）, and high （≥1000 ng ml-1）. All patients received androgen deprivation therapy （ADT） immediately. We investigated PSA progression-free survival （PFS） for first-line ADT and overall survival （OS） within each of the three groups. Furthermore, we analyzed response to antiandrogen withdrawal （AW） and alternative antiandrogen （AA） therapies after development of castration-resistant prostate cancer （CRPC）. No significant differences in OS were observed among the three groups （P = 0.654）. Patients with high PSA levels had significantly short PFS for first-line ADT （P = 0.037）. Conversely, patients in the high PSA level group had significantly longer PFS when treated with AW than those in the low PSA level group （P = 0.047）. Furthermore, patients with high PSA levels had significantly longer PFS when provided with AA therapy （P = 0.049）. PSA responders to AW and AA therapies had significantly longer survival after CRPC development than nonresponders （P = 0.011 and P 〈 0.001, respectively）. Thus, extremely high PSA level predicted favorable response to vintage sequential ADT and AW. The current data suggest a novel aspect of extremely high PSA value as a favorable prognostic marker after development of CRPC.

关键词： alternative antiandrogen therapy antiandrogen withdrawal hormonal therapy metastatic prostate cancer prostate-specificantigen

Outcomes of patients older than 75 years with non-metastatic prostate cancer

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Asian Journal of Urology 2017年第2期4卷 102-106页

作者： Yoshiyasu Amiya Yasutaka Yamada Masahiro Sugiura Makoto Sasaki Takayuki Shima Noriyuki Suzuki Hiroomi Nakatsu Shino Murakami Jun Shimazaki Department of Urology Asahi General HospitalAsahiJapan Department of Urology Graduate School of MedicineChiba UniversityChibaJapan

Objective:Prostate cancer in elderly patients was formerly treated with androgen deprivation therapy.Since the latter of the 1990s new technologies were introduced into treatments,then strategies have varied.We aimed to observe the outcomes of elderly patients treated during transition period and compare each stage with others.Methods:During 2008 and 2010,255 patients with prostate cancer older than 75 years were sequentially treated.With exception of patients with bone and/or visceral metastasis,outcomes of 199 patients with localized and locally advanced stages were examined.Complete records were obtained by the end of 2015.Results:In total,122(61%),28(14%),37(19%)and 12(6%)of patients were in stages T1c-T2a,T2b-c,T3 and T4,respectively.Patients generally presented with abnormal screening or lower urinary tract symptom.Seventy-one percent of patients received androgen deprivation therapy as monotherapy and 22% of the radiation-treated patients added androgen deprivation therapy.Patients in stage T1c-T2a and T2b-c showed a favorable prognosis.Some cancer death appeared in patients with T3 and T4 during observation periods.Twenty-seven percent of patients died from prostate cancer-independent complications:pneumonia,heart disease,and brain vascular disease.Tendency is similar to that of Japanese elderly male population.No remarkable side effects from androgen deprivation therapy were noticed.

关键词： Prostate cancer Elderly Androgen deprivation Non-metastatic prostate cancer Radiation therapy

西南日本秋吉带石炭系高山(Ko-yama)灰岩群的石炭纪(Visean-Moscovian)牙形石序列(英文)

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地球学报 2012年第S1期33卷 25-28页

作者： Keisuke ISHIDA Sigeyuki suzuki noriyuki INADA Shinji YAMASHITA Laboratory of Geology Institute of SASTokushima University770-8502TokushimaJapan Dept.Earth Sci. Okayama University700-8530OkayamaJapan

The Carboniferous conodont faunal succession of the lower part of Ko-yama Limestone Group was studied.The confirmed upper Visean-lower Moscovian lithostratigraphy of the group is characterized by the clastic carbonates with common association of the basaltic pyroclastics and some intercalation of spicular chert beds.The faunal succession of Gnathodus semiglaber(upper Visean),Gnathodus praebilineatus-Lochriea multinodosa(upper Visean),Lochriea ziegleri-Gnathodus girtyi girtyi s.l.(lower Serpukhovian),Neoganthodus symmetricus-Idiognathodus primulus(middle-upper Bashkirian),and Idiognathoides convexus-Gondolella clarki(lower Moscovian) faunas,appears in concordance with the lithostratigraphic order.The faunas are correlative with those from the conodont zones of the Hina,Atetsu,Akiyoshi and Omi limestone groups in the Akiyoshi Belt.The Visean/Serpukhovian boundary of the section was recognized by the FAD of Lochriea ziegleri.

关键词： conodont Ko-yama Limestone Carboniferous Akiyoshi Belt SW Japan

Assessment of Regional Dietary Exposure to Dioxins in Seafood in Japan

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Assessment of Regional Dietary Exposure to Dioxins in Seafoo...

Absence of asymptomatic unruptured renal artery pseudoaneurysm on contrast-enhanced computed tomography after robot-assisted partial nephrectomy without parenchymal renorrhaphy

首届风险分析与危机反应国际学术研讨会

作者： Noriyuki Suzuki Takeo Sakurai National Institute for Environmental Studies 16-2 OnogawaTsukubaIbaraki305-8506Japan National Institute for Environmental Studies 16-2 OnogawaTsukubaIbaraki305-8506Japan

＜正＞This paper presents a method of estimating dietary exposure to dioxins in specific region from monitoring data of dioxins concentration in seafood by catching area and information of seafood circulation.Monte- Carlo method was applied to take into account both the uncertainty of measured value of dioxins levels in fishes and variability between fish species.The seafood circulation was simulated with a linear programming （LP） model.Dietary exposure to dioxins in seafood in seven regions in Japan was estimated and compared with the results of Total Dietary Studies （TDS）.No significant geographical variability of dietary exposure to dioxins in seafood was observed for general population in Japan.

关键词： Seafood Dioxins Regional dietary exposure Monte-Carlo analysis

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Asian Journal of Urology 2020年第1期7卷 24-28页

作者： Yoichiro Tohi Shiori Murata noriyuki Makita Issei suzuki Masashi Kubota Yoshio Sugino Koji Inoue Hiroyuki Ueda Mutsushi Kawakita Department of Urology Kobe City Medical Center General Hospital2-1-1 Minatojimaminami-choChuo-kuKobe CityJapan Department of Diagnostic Radiology Kobe City Medical Center General Hospital2-1-1 Minatojimaminami-choChuo-kuKobe CityJapan

Objective:To assess the incidence of asymptomatic unruptured renal artery pseudoaneurysm(RAP)on contrast-enhanced computed tomography(CE-CT)after robot-assisted partial nephrectomy(RAPN)without parenchymal renorrhaphy.Methods:From May 2016 to December 2017,78 patients underwent RAPN for renal tumors.Inner suture was performed in the opened collecting system or renal sinus,whereas parenchymal renorrhaphy was not.For hemostasis,the soft coagulation system was used,and absorbable hemostats were placed on the resection bed.CE-CT was carried out within 7 days after surgery.Data on these patients were prospectively collected.A single radiologist determined the diagnosis of RAP.Results:Median(range)data were as follows:Patient age,65(19-82)years;radiographic tumor size,30(12-95)mm;operating time,166(102-294)min;warm ischemic time,16(7-67)min;and blood loss,15(0-4450)mL.One patient(1.6%)required a perioperative blood transfusion.No patient required conversion to open surgery or nephrectomy.CE-CT was carried out at median 6(3-7)days after surgery.CE-CT showed no RAP development in all 61 patients.Urinary leakage was not observed.One patient had acute cholecystitis,a postoperative complication classified as Clavien-Dindo grade higher than 3,which was treated with cholecystectomy.Positive surgical margin was identified in four patients(6.6%).Conclusion:RAPN using soft coagulation and absorbable hemostats without renorrhaphy appears to be feasible and safe.Our technique could eliminate the risk of RAP.

关键词： Pseudoaneurysm Partial nephrectomy Robot-assisted Renorrhaphy

西南日本秋吉带石炭系高山(Ko-yama)灰岩群的褶皱构造(英文)

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西南日本秋吉带石炭系高山(Ko-yama)灰岩群的褶皱构造(英文)

西南日本秋吉带石炭系高山(Ko-yama)灰岩群的褶皱构造(英文)

国际地学计划IGCP-589项目“亚洲特提斯域的演化：成因，过程和结果”第一次国际学术研讨会

作者： noriyuki INADA Shigeyuki suzuki Keisuke ISHIDA Shinji YAMASHITA Dept. Earth Sci. Okayama University700-8530OkayamaJapan Laboratory of Geology Institute of SASTokushima University770-8502TokushimaJapan

The study area is located in Kawakami-cho,Okayama Prefecture,which is occupied by Lower Carboniferous to Middle Permian Ko-yama Limestone Group (Yokoyama et al.,1979),Permian Yoshii Group (Sano et

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地球学报 2012年第S1期33卷 24-24页

作者： noriyuki INADA Shigeyuki suzuki Keisuke ISHIDA Shinji YAMASHITA Dept.Earth Sci. Okayama University700-8530OkayamaJapan Laboratory of Geology Institute of SASTokushima University770-8502TokushimaJapan

The study area is located in Kawakami-cho, Okayama Prefecture,which is occupied by Lower Carboniferous to Middle Permian Ko-yama Limestone Group(Yokoyama et al.,1979),Permian Yoshii Group (Sano et al.,1987) and Triass... 详细信息

关键词： folded structure Ko-yama Limestone Carboniferous Akiyoshi Belt