检索结果-南通市图书馆

Impact of interferon-free antivirus therapy on lipid profiles in patients with chronic hepatitis C genotype 1b

World Journal of Gastroenterology 2017年第13期23卷 2355-2364页

作者： Daisuke Endo Kenichi Satoh noritomo shimada Atsushi Hokari Yoshio Aizawa Department of Gastroenterology and Hepatology Internal Medicine of Jikei University Katsushika Medical Center Department of Gastroenterology and Hepatology Internal Medicine of Otakanomori Hospital

AIM To investigate the influence of interferon-free antivirus therapy on lipid profiles in chronic hepatitis C virus genotype 1b(HCV1b) *** Interferon-free antiviral agents were used to treat 276 patients with chronic HCV1 b infection, and changes in serum lipids of those who achieved sustained virologic response(SVR) were examined. The treatment regimen included 24 wk of daclatasvir plus asunaprevir(DCV + ASV) or 12 wk of sofosbuvir plus ledipasvir(SOF + LDV). SVR was achieved in 121(85.8%) of 141 patients treated with DCV + ASV and 132(97.8%) of 135 patients treated with SOF + LDV. In the two patient groups(DCV + ASV-SVR and SOF + LDV-SVR), serum total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C), and triglycerides were measured at baseline during treatment and at 4 and 12 wk after treatment. Then, longitudinal changes in lipid profiles were *** Serum levels of TC, LDL-C, and HDL-C were significantly increased throughout the observation period in both the DCV + ASV-SVR and SOF + LDV-SVR groups. During antivirus treatment, the increases in TC and LDL-C were significantly greater in the SOF + LDVSVR group than in the DCV + ASV-SVR group(P < 0.001). At 4 and 12 wk after the therapy, serum levels of TC and LDL-C were similar between the two groups and were significantly greater than those at baseline. Approximately 75%-80% of the increase in TC was derived from an increased LDL-C. In multiple regression analysis, the difference in therapy protocol(DCA + ASV or SOF + LDV) was an independent predictor that was significantly associated with the increase in TC and LDL-C at 4 wk of *** Serum cholesterol significantly increased during SOF + LDV treatment. After treatment, HCV elimination was associated with a similar increase in cholesterol regardless of the therapy protocol.

关键词： Chronic hepatitis C Daclatasvir Asunaprevir Sofosbuvir Ledipasvir Total cholesterol Low-density lipoprotein cholesterol

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Several factors including ITPA polymorphism influence ribavirin-induced anemia in chronic hepatitis C

引用

World Journal of Gastroenterology 2012年第41期18卷 5879-5888页

作者： Akihito Tsubota noritomo shimada Hiroshi Abe Kai Yoshizawa Rie Agata Yoko Yumoto Makiko Ika Yoshihisa Namiki Keisuke Nagatsuma Hiroshi Matsudaira Kiyotaka Fujise Norio Tada Yoshio Aizawa Institute of Clinical Medicine and Research The Jikei University School of Medicine163-1 Kashiwa-shitaKashiwaChiba 277-8567Japan Division of Gastroenterology and Hepatology Kashiwa HospitalThe Jikei University School of Medicine163-1 Kashiwa-shitaKashiwaChiba 277-8567Japan Department of Gastroenterology Shinmatsudo Central General Hospital1-380 ShinmatsudoMatsudoChiba 270-0034Japan Division of Gastroenterology and Hepatology Katsushika Medical CenterThe Jikei University School of Medicine6-41-2 AotoKatsushika-kuTokyo 125-8506Japan

AIM： To construct formulae for predicting the likelihood of ribavirin-induced anemia in pegylated interferon plus ribavirin for chronic hepatitis C. METHODS： Five hundred and sixty-one Japanese patients with hepatitis C virus genotype lb who had received combination treatment were enrolled and as- signed randomly to the derivation and confirmatory groups. Single nucleotide polymorphisms at or nearby ITPA were genotyped by real-time detection poly- merase chain reaction. Factors influencing significant anemia （hemoglobin concentration 〈 10.0 g/dL at week 4 of treatment） and significant hemoglobin decline （declining concentrations 〉 3.0 g/dL at week 4） were analyzed using multiple regression analyses. Prediction formulae were constructed by significantly independent factors. RESULTS： Multivariate analysis for the derivation group identified four independent factors associated with significant hemoglobin decline： hemoglobin decline at week 2 [P = 3.29× 10^4, odds ratio （OR） = 7.54 （g/dL）], estimated glomerular filtration rate [P = 2.16× 10^4, OR = 0.962 （ml/min/1.73 m2）], rs1127354 （P = 5.75 × 10^4, OR = 10.94） and baseline hemoglobin [P = 7.86 × 10^4, OR = 1.50 （g/alL）]. Using the model constructed by these factors, positive and negative predictive values and predictive accuracy were 79.8%, 88.8% and 86.2%, respectively. For the confirmatory group, they were 83.3%, 91.0% and 88.3%. These factors were closely correlated with significant anemia. However, the model could not be constructed, because no patients with rs1127354 minor genotype CA/AA had significant anemia. CONCLUSION： Reliable formulae for predicting the likelihood of ribavirin-induced anemia were constructed. Such modeling may be useful in developing individual tailoring and optimization of ribavirin dosage.

关键词： Chronic hepatitis C virus infection Ribavi-rin Pegylated interferon Prediction model Hemolyticanemia Single nucleotide polymorphism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interferon-λ3 polymorphisms in pegylated-interferon-α plus ribavirin therapy for genotype-2 chronic hepatitis C

引用

World Journal of Gastroenterology 2015年第13期21卷 3904-3911页

作者： Haruya Ishiguro Hiroshi Abe Nobuyoshi Seki Tomonori Sugita Yuta Aida Munenori Itagaki Satoshi Sutoh noritomo shimada Tomomi Furihata Akihito Tsubota Yoshio Aizawa Division of Gastroenterology and Hepatology Department of Internal MedicineJikei University School of Medicine Katsushika Medical CenterTokyo 125-8506Japan Department of Gastroenterology and Hepatology Shinmatsudo Central General HospitalChiba 270-0034Japan Laboratory of Pharmacology and Toxicology Graduate School of Pharmaceutical SciencesChiba UniversityChiba 260-8675Japan Core Research Facilities for Basic Science Research Center for Medical ScienceJikei University School of MedicineTokyo 105-8461Japan

AIM: To evaluate interferon-λ3(IFNL3) polymorphisms in response-guided pegylated interferon-α plus ribavirin(Peg-IFNα/RBV) therapy for genotype 2(G2) chronic hepatitis ***: Between January 2006 and June 2012, a total of 180 patients with chronic infections of G2 hepatitis C virus(HCV) were treated with responseguided Peg-IFNα/RBV therapy. The treatment duration was 24 wk for patients who achieved rapid virologic response(RVR), and 36 or 48 wk for patients who did not. Then, the impact of the IFNL3 single nucleotide polymorphism genotype(TT/non-TT at rs8099917) on treatment outcomes was evaluated in the 180 patients, and between patients infected with either HCV subgenotype 2a or ***: Of the 180 patients evaluated, 111 achieved RVR, while the remaining 69 patients did not. In RVR patients, the sustained virologic response(SVR) rate was 96.4%, and the IFNL3 genotype did not influence the SVR rate(96.6% vs 95.8% in IFNL3 genotype TT vs non-TT). However, in non-RVR patients, the SVR rate decreased to 72.5%(P < 0.0001), and this rate was significantly different between the IFNL3 genotype TT and non-TT groups(80.0% vs 42.9%, P = 0.0146). Multivariate regression analysis in non-RVR patients identified the IFNL3 genotype TT as the only baseline-significant factor associated with SVR(OR = 5.39, 95%CI: 1.29-22.62; P = 0.0189). In analysis according to HCV sub-genotype, no significant difference in the SVR rate was found between HCV sub-genotypes 2a and ***: In response-guided Peg-IFNα/RBV combination therapy for chronically HCV G2-infected patients, the impact of the IFNL3 genotype on SVR was limited to non-RVR patients.

关键词： Hepatitis C virus genotype 2 Interferon-λ3 single

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mission of the National Cancer Center Hospital in Japan to promote clinical trials for precision medicine

引用

Cancer Biology & Medicine 2024年第1期21卷 1-3页

作者： Kazuaki shimada Kenichi Nakamura Noboru Yamamoto Department of Hepatobiliary and Pancreatic Surgery National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan

Precision medicine is a growing field *** its potential benefit to many patients,several major obstacles must be overcome before precision medicine can be more widely used in clinical *** main obstacles are associated... 详细信息

关键词： clinical Cancer overcome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Therapeutic efficacy of ramucirumab after lenvatinib for post-progression treatment of unresectable hepatocellular carcinoma

引用

Gastroenterology Report 2021年第2期9卷 133-138,I0002页

作者： Atsushi Hiraoka Takashi Kumada Toshifumi Tada Chikara Ogawa Joji Tani Shinya Fukunishi Masanori Atsukawa Masashi Hirooka Kunihiko Tsuji Toru Ishikawa Koichi Takaguchi Kazuya Kariyama Ei Itobayashi Kazuto Tajiri noritomo shimada Hiroshi Shibata Hironori Ochi Kazuhito Kawata Hidenori Toyoda Hideko Ohama Kazuhiro Nouso Akemi Tsutsui Takuya Nagano Norio Itokawa Korenobu Hayama Taeang Arai Michitaka Imai Yohei Koizumi Shinichiro Nakamura Kojiro Michitaka Yoichi Hiasa Masatoshi Kudo Gastroenterology Center Ehime Prefectural Central HospitalEhimeJapan Department of Gastroenterology and Hepatology Ogaki Municipal HospitalGifuJapan Department of Internal Medicine Himeji Red Cross HospitalHyogoJapan Department of Gastroenterology and Hepatology Takamatsu Red Cross HospitalTakamatsuJapan Department of Gastroenterology and Hepatology Kagawa universityKagawaJapan Department of Gastroenterology Osaka Medical CollegeOsakaJapan Division of Gastroenterology and Hepatology Department of Internal MedicineNippon Medical SchoolTokyoJapan Department of Gastroenterology and Metabology Ehime University Graduate School of MedicineEhimeJapan Center of Gastroenterology Teine Keijinkai HospitalSapporoJapan Department of Gastroenterology Saiseikai Niigata HospitalNiigataJapan Department of Hepatology Kagawa Prefectural Central HospitalTakamatsuJapan Department of Gastroenterology Okayama City HospitalOkayamaJapan Department of Gastroenterology Asahi General HospitalAsahiJapan Department of Gastroenterology Toyama University HospitalToyamaJapan Division of Gastroenterology and Hepatology Otakanomori HospitalKashiwaJapan Department of Gastroenterology Tokushima Prefectural Central HospitalTokushimaJapan Hepato-biliary Center Matsuyama Red Cross HospitalMatsuyamaJapan Department of Hepatology Hamamatsu University School of MedicineHamamatsuJapan Department of Gastroenterology Kindai UniversityOsakaJapan

Background:Lenvatinib is used for unresectable hepatocellular carcinoma(u-HCC)as first-line,as well as second-and third-line therapy in *** evaluated the therapeutic efficacy of newly developed ramucirumab when given after lenvatinib for post-progression ***:Of 385 patients with u-HCC and treated with lenvatinib at 16 different institutions in Japan between May 2018 and January 2020,28 who received ramucirumab as the next treatment were enrolled and therapeutic responses were evaluated in a retrospective ***:The median age of the 28 patients given ramucirumab was 70 years and the median albumin-bilirubin score *** the 28 patients,23 were male,21 were classified as Child-Pugh A and 7 as Child-Pugh B,and 25 were Barcelona Clinic Liver Cancer Stage *** was given as second-line therapy in 14,third-line in 9,and fourth-line in *** response was obtained in only 26 patients;the objective response rate was 3.8%(1/26)and the disease-control rate was 42.3%(11/26),with a median period to progression of 2.0 *** reasons for discontinuation of ramucirumab were progression of disease in 16 and Grade 3 adverse events(gastrointestinal bleeding,ascites)in ***:The anticipated therapeutic efficacy of ramucirumab for post-progression treatment following lenvatinib was not seen in our early experience.

关键词： hepatocellular carcinoma ramucirumab lenvatinib sorafenib

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Comparative Study of Two Tree-Based Models for Predicting Flyrock Velocity at Open Pit Bench Mining

引用

Open Journal of Applied Sciences 2024年第2期14卷 267-287页

作者： Ezatullah Rawnaq Bassir Esmatyar Akihiro Hamanaka Takashi Sasaoka Hideki shimada Department of Earth Resources Engineering Kyushu University Fukuoka Japan Department of Mining and Mineral Engineering Suleyman Demirel University Isparta Türkiye

Blasting is a cost-effective technique to break hard rock volumes by using explosives in the mining and civil engineering realms. Moreover, although blasting is a designed process and plays an indispensable role in these industries, it can also have multiple adverse environmental impacts. One such effect is flyrock, which poses risks to nearby machinery, and residential structures, and can even lead to injuries or fatalities. To optimize blasting efficiency as well as restrict side effects, prediction of the blast aftereffects is vital. Therefore, the present work focuses on using two machine learning methods to predict the velocity of flyrock in the open pit mine. To address this issue, a comprehensive dataset was gathered from the open pit mine. Then, Decision Tree and Random Forest algorithms were employed to predict flyrock velocity. The Random Forest model demonstrated superior performance compared to the Decision Tree model. Nonetheless, the performance of the Decision Tree model was deemed satisfactory, as evidenced by its coefficient of determination value of 0.83, mean squared error (MSE) of 4.2, and mean absolute percentage error (MAPE) of 5.6%. Considering these metrics, it is reasonable to conclude that tree-based algorithms can be effective in predicting flyrock velocity.

关键词： Flyrock Machine Learning Bench Blasting Coefficient of Determination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rational double points on Enriques surfaces

引用

Science China Mathematics 2021年第4期64卷 665-690页

作者： Ichiro shimada Department of Mathematics Graduate School of ScienceHiroshima UniversityHigashi-Hiroshima 739-8526Japan

We classify,up to some lattice-theoretic equivalence,all possible configurations of rational double points that can appear on a surface whose minimal resolution is a complex Enriques surface.

关键词： Enriques surface rational double points hyperbolic lattice

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynkin diagrams of rank 20 on supersingular K3 surfaces

引用

Science China Mathematics 2015年第3期58卷 543-552页

作者： shimada Ichiro ZHANG De-Qi Department of Mathematics Graduate School of Science Hiroshima University Department of Mathematics National University of Singapore

We classify normal supersingular K 3 surfaces Y with total Milnor number 20 in characteristic p,where p is an odd prime that does not divide the discriminant of the Dynkin type of the rational double points on *** pap... 详细信息

关键词： supersingular K3 surface supersingular K3 surface normal K3 surface

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hand-holding and releasing between the anion and cation to change their macroscopic behavior in water

引用

Green Energy & Environment 2019年第2期4卷 127-130页

作者： Kosuke Kuroda Yumiko shimada Kenji Takahashi Faculty of Biological Science and Technology Institute of Science and Engineering Kanazawa University

Despite the similarity of ionic liquid and zwitterion, their some properties such as conductivity and hydrophobicity are different. Here we developed a novel phosphonium salt having a dynamic covalent bond between anion and cation, enabling reversible structural shift between free ion pair and zwitterion. With the phosphonium salt, control of the macroscopic phase behavior in aqueous solution, i.e. forming mono-or biphasic systems, upon exposure to an acid or base was reversibly achieved, based on the structural shift of the phosphonium salt. CO_2/N_2 bubbling reversibly changed the phase behavior as well as acid/base, leading to green separation systems.

关键词： Ionic liquid Zwitterion Phase separation Dynamic covalent bond

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Fine-Grained Runtime Power/Performance Optimization Method for Processors with Adaptive Pipeline Depth

引用

Journal of Computer Science & Technology 2011年第2期26卷 292-301页

作者：姚骏 Shinobu Miwa Hajime shimada Shinji Tomita Graduate School of Information Science Nara Institute of Science and Technology School of Engineering Tokyo University of Agriculture and Technology Graduate School of Informatics Kyoto University Institute for Integrated Cell-Material Sciences Kyoto University

Recently, a method known as pipeline stage unification （PSU） has been proposed to alleviate the increasing energy consumption problem in modern microprocessors. PSU achieves a high energy efficiency by employing a changeable pipeline depth and its working scheme is eligible for a fine control method. In this paper, we propose a dynamic method to study fine-grained program interval behaviors based on some easy-to-get runtime processor metrics. Using this method to determine the proper PSU configurations during the program execution, we are able to achieve an averaged 13.5% energydelay-product （EDP） reduction for SPEC CPU2000 integer benchmarks, compared to the baseline processor. This value is only 0.14% larger than the theoretically idealized controlling. Our hardware synthesis result indicates that the proposed method can largely decrease the hardware overhead in both area and delay costs, as compared to a previous program study method which is based on working set signatures.

关键词： dynamic optimization energy saving fine-grained pipeline stage unification workload analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：