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Classification of hepatic venous tumor thrombus in hepatocellular carcinoma: should it describe tumor status or predict patient survival?

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 534-536页

作者： norihiro kokudo Wei Tang Takashi kokudo Department of HPB Surgery National Center for Global Health and MedicineTokyoJapan

Tumor thrombus in the hepatic veins or inferior vena cava(HVTT/IVCTT)is the second most common of the three types of vascular invasion by hepatocellular carcinoma(HCC).According to the most recent nationwide survey in Japan,vascular invasion of the portal vein(PVTT)is present 13.2%of newly diagnosed HCCs,followed by HVTT/IVCTT(6.2%)and bile duct tumor thrombus(BDTT,3.4%)based on imaging findings(1).

关键词： thrombus invasion hepatic

Added value of indocyanine green fluorescence imaging in liver surgery

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 310-317页

作者： Nobuyuki Takemura Kyoji Ito Fuyuki Inagaki Fuminori Mihara norihiro kokudo Department of Surgery Hepato-Biliary Pancreatic Surgery DivisionNational Center for Global Health and Medicine1-21-1 ToyamaShinjyuku-kuTokyo162-8655Japan

Recently,indocyanine green(ICG)fluorescence imaging has been widely used as a substitute for cholangiography in hepatobiliary surgery,to detect hepatic tumors,for accurate anatomical hepatectomy,and to increase the safety and accuracy of minimally invasive(laparoscopic and robotic)*** clinical relevance of this method has been increasing gradually,as new procedures develop in this *** important roles and the latest added value of ICG fluorescence imaging in liver surgery are discussed in this report.

关键词： Florescence imaging Indocyanine green Hepatocellular carcinoma Colorectal metastasis Hepatectomy Minimally invasive surgery

New ‘multi-omics' approach and its contribution to hepatocellular carcinoma in China

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Chinese Journal of Cancer Research 2014年第6期26卷 639-640页

作者： Yoshinori Inagaki Peipei Song norihiro kokudo Wei Tang Hepato-Biliary-Pancreatic Surgery Division Department of Surgery Graduate School of Medicine the University of Tokyo Hongo 7-3-1 Bunkyo-ku Tokyo 113-8655 Japan

Hepatocellular carcinoma（HCC）is one of the most common liver neoplasms worldwide,and 70-80%cases are accounted in Asian countries（1）.Etiological background of HCC patients is different in each country or *** China,infection of hepatitis B virus （HBV） is a main etiological factor of increased incidence of HCC. In fact, 93 million HBV carriers are Chinese, accounting for 2/3 of such patients worldwide, and about 20 million of these people have chronic HBV infection （2）. Chronic HBV infection is a high risk factor for development of HCC. Therefore, the follow-up of those chronic viral hepatitis type B patients and the early-detection of HCC in those patients are pressing tasks to reduce the incidence of HCC in China （3）.

关键词： neoplasms accounted recurrence fetoprotein New multi-omics multifocal physiological incidence metastatic

Inhibition of KL-6/MUC1 glycosylation limits aggressive progression of pancreatic cancer

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World Journal of Gastroenterology 2014年第34期20卷 12171-12181页

作者： Huan-Li Xu Xin Zhao Ke-Ming Zhang Wei Tang norihiro kokudo Department of Pharmacology School of Basic Medical SciencesCapital Medical University Department of Hepatobiliary Surgery 302 Hospital of Chinese People’s Liberation Army Hepato-Biliary-Pancreatic Surgery Division Department of SurgeryGraduate School of MedicineUniversity of TokyoTokyo 113-8654Japan

AIM: To evaluate the significance of KL-6/MUC1 (a type of MUC1) glycosylation in pancreatic cancer progression.

关键词： Benzyl-N-acetyl-alpha-galactosaminide Glycosylation KL-6/MUC1 Pancreatic carcinoma Tunicamycin

Clinicopathological utility of sialoglycoconjugates in diagnosing and treating colorectal cancer

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World Journal of Gastroenterology 2014年第20期20卷 6123-6132页

作者： Yoshinori Inagaki Jianjun Gao Peipei Song norihiro kokudo Munehiro Nakata Wei Tang Hepato-Biliary-Pancreatic Surgery Division Department of Surgery Graduate School of Medicine the University of Tokyo Tokyo 113-8655 Japan Department of Applied Biochemistry Tokai University Hiratsuka Kanagawa 259-1292 Japan

Aberrant expression of glycoconjugates occurs during malignant transformation of cancer *** of sialoglycoconjugates in particular may play an important role in the progression,i.e.,invasion or metastasis,of *** types of sialoglycoconjugates have been investigated to clarify their biological significance and clinical utility in diagnosing and treating colorectal *** review focuses specifically on expression of mucin(MUC)1 and it suggests that MUC1with the specific structure of a sialo-oligosaccharide has biological significance in determining the metastatic potential of colorectal cancer cells and clinicopathological utility in evaluating the effectiveness of treatments and the prognosis for patients with colorectal *** studies are expected to contribute to the expanded use of cancer-associated sialoglycoconjugates in cancer diagnosis and therapy.

关键词： Sialoglycoconjugates Sialic acid Mucin 1 Colorectal cancer Invasion Metastasis

Recurrence of cholestatic liver disease after living donor liver transplantation

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World Journal of Gastroenterology 2008年第33期14卷 5105-5109页

作者： Sumihito Tamura Yasuhiko Sugawara Junichi Kaneko Junichi Togashi Yuichi Matsui Noriyo Yamashiki norihiro kokudo Masatoshi Makuuchi Artificial Organ and Transplantation Division Department of Surgery Graduate School of Medicine University of Tokyo7-3-1 Hongo Bunkyo-ku Tokyo 113-8655 Japan Japanese Red Cross Medical Center 4-1-22 Hiroo Shibuya-ku Tokyo 150-8935 Japan

End-stage liver disease, due to cholestatic liver diseases with an autoimmune background such as primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), is considered a good indication for liver transplantation. Excellent overall patient and graft outcomes, based mostly on the experience from deceased donor liver transplantation (DDLT), have been reported. Due to the limited number of organ donations from deceased donors in most Asian countries, living donor liver transplantation (LDLT) is the mainstream treatment for end-stage liver disease, including that resulting from PBC and PSC. Although the initial experiences with LDLT for PBC and PSC seem satisfactory or comparable to that with DDLT, some aspects, including the timing of transplantation, the risk of recurrent disease, and its long-term clinical implications, require further evaluation. Whether or not the long-term outcomes of LDLT from a biologically related donor are equivalent to that of DDLT requiresfurther observations. The clinical course following LDLT may be affected by the genetic background shared between the recipient and the living related donor.

关键词： Liver transplantation Primary biliary cirrhosis Primary sclerosing cholangitis Living donor Recurrence

Clinical significance of subcellular localization of KL-6 mucin in primary colorectal adenocarcinoma and metastatic tissues

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World Journal of Gastroenterology 2006年第1期12卷 54-59页

作者： Qian Guo Wei Tang Yoshinori Inagaki Yutaka Midorikawa norihiro kokudo Yasuhiko Sugawara MunehiroNakata Toshiro Konishi Hirokazu Nagawa Masatoshi Makuuchi Hepatobiliary-Pancreatic Surgery Division Department of Surgery GraduateSchool of Medicine the University of Tokyo 7-3-1 HongoBunkyo-ku Tokyo 113-8655 Japan Department of Applied Biochemistry and Institute of Glycotechnology Tokai University Hiratsuka Kanagawa 259-1292 Japan Kanto Medical Center NTT EC 5-9-22 Higashigotanda Shinagawa-ku Tokyo 141-8625 Japan Surgical Oncology Division Department of Surgery Graduate School of Medicine the University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655 Japan

AIM： To assess subcellular localization of KL-6 mucin and its clinicopathological significance in colorectal carcinoma as well as metastatic lymph node and liver tissues. METHODS： Colorectal carcinoma tissues as well as metastatic lymph node and liver tissues were collected from 82 patients who underwent colorectomy or hepatectomy. Tissues were subjected to immunohistochemical analysis using KL-6 antibody. RESULTS： Of the 82 colorectal carcinoma patients, 6 showed no staining, 29 showed positive staining only in the apical membrane, and 47 showed positive staining in the circumferential membrane and/or cytoplasm. Positive staining was not observed in non-cancerous colorectal epithelial cells surrounding the tumor tissues. The five-year survival rate was significantly lower in cases showing positive staining in the circumferential membrane and/or cytoplasm （63.0%） than those showing positive staining only in the apical membrane （85.7%） and those showing no staining （100%）. Statistical analysis between clinicopathological factors and subcellular localization of KL-6 mucin showed that KL-6 localization in the circumferential membrane and/or cytoplasm was significantly associated with the presence of venous invasion （P = 0.0003）, lymphatic invasion （P 〈 0.0001）, lymph node metastasis （P〈0.0001）, liver metastasis （P = 0.058）, and advanced histological stage （P〈 0.0001）. Positive staining was observed in all metastatic lesions tested as well as in the primary colorectal carcinoma tissues. CONCLUSION： The subcellular staining pattern of KL-6 in colorectal adenocarcinoma may be an important indicator for unfavorable behaviors such as lymph node and liver metastasis, as well as for the prognosis of patients.

关键词： KL-6 mucin Colorectal carcinoma Metasta-sis Prognosis Immunohistochemistry

KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression

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World Journal of Gastroenterology 2005年第35期11卷 5450-5454页

作者： Wei Tang Yoshinori Inagaki norihiro kokudo Qian Guo Yasuji Seyama Munehiro Nakata Hiroshi Imamura Keiji Sano Yasuhiko Sugawara Masatoshi Makuuchi Hepato-Biliary-Pancreatic Surgery Division Department of Surgery1Graduate School of Medicine the University of Tokyo 7-3-1 HongoIBunkyo-ku Tokyo 113-8655 Japan Department of Applied Biochemistry TokaiUniversity Hiratsuka Kanagawa 259-1292 Japan Department of Applied-Biochemistry andInstitute of Glycotechnology Tokai University HiratsukaKanagawa 259-1292 Japan

AIM： To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater. METHODS： Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody. RESULTS： Positive staining of ampullary carcinoma cells was observed in 26 （68.4%） cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis （P = 0.020）, pancreatic invasion （P = 0.016）, duodenal invasion （P = 0.034）, and advanced stage of TNM clinical classification （P = 0.010）. Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis （P = 0.029）. CONCLUSION： The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of cardnoma of the ampulla of Vater.

关键词： KL-6 mucin Carcinoma of the ampulla of Vater Invasion Metastasis Prognosis

Des-gamma-carboxy prothrombin induces angiogenesis in human vascular endothelial cells

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Des-gamma-carboxy prothrombin induces angiogenesis in human ...